Conceptos Categóricos

Oncología

LOS CAMBIOS BIOLÓGICOS MÁS EVIDENTES EN EL PROCESO DE DIFERENCIACIÓN CELULAR
El artículo analiza los principales elementos biológicos subcelulares y moleculares que suceden en el proceso de diferenciación celular, particularmente la programación y reprogramación genómica, epigenómica y proteómica, que conducen al fenotipo celular en la pruripotencialidad y unipotencialidad, la división celular asimétrica y la regulación selectiva genética y epigenética de la transcripción génica.

Victor Manuel Valdespino Gomez
Ciudad de México, México

           
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  SMOKELESS TOBACCO BUT NOT "HARMLESS"
Smokeless tobacco is a major etiological agent of many potentially malignant disorders and oral cancer. It exhibits various early signs and symptoms which need to be understood and diagnosed at an early stage, much before the debilitating disease has taken its course. It is the duty of the clinician to identify the disease using various diagnostic adjuncts and intervene at the appropriate stage of the disease to make the society a disease free society.

Jagriti Gupta
Lucknow, In

  
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  SMOKELESS TOBACCO BUT NOT "HARMLESS"
Smokeless tobacco is a major etiological agent of many potentially malignant disorders and oral cancer. It exhibits various early signs and symptoms which need to be understood and diagnosed at an early stage, much before the debilitating disease has taken its course. It is the duty of the clinician to identify the disease using various diagnostic adjuncts and intervene at the appropriate stage of the disease to make the society a disease free society.

Jagriti Gupta
Lucknow, In

  
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DIFFERENTIAL DIAGNOSIS OF LUNG CARCINOMA WITH LABEL-FREE IMAGING
This report describes a new class of endomicroscopy that combines chemical selective molecular vibrational imaging techniques, such as coherent anti-Stokes Raman scattering (CARS) imaging, with fiber optic delivery and quantitative analytics for obtaining histology-like images from inside the human body in real-time with no label. Endomicroscopes generally can achieve a resolution on the order of a µm and have a field-of-view of several hundred µm. Current endomicroscope products, however, often require fluorophores, which are excitable using laser lights, and limit their applications in clinics. The objective of the proposed label-free endomicroscope is to sidestep the use of flourophores by visualizing morphological patterns and detecting intrinsic biomarkers of cells and tissues via high-speed, chemical selective CARS imaging. The label-free endomicroscope is developed to post-process and characterize CARS images and provide diagnostic information using disease-related features and classification. The prototype device has shown high accuracy and specificity for differential lung cancer diagnosis and thus demonstrated its potential for clinical translations.

Stephen Wong
Houston, Us

  
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O CONTROLE DA (EL CONTROL DE LA) EXPRESSÃO GÊNICA POR MICRORNAS E SUA (Y SU) IMPORTÂNCIA PARA A (LA) MEDICINA
A possibilidade do uso dos (La posibilidad del uso de los) miRNAs para silenciar ou ativar (o activar) genes específicos é uma atual e (es una actual y) promissora ferramenta que permite o desenvolvimento (el desarrollo) de novas estratégias terapêuticas baseadas na (basadas en la) condição específica de cada paciente.

Vagner Oliveira-Carvalho
São Paulo, Brasil

           
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