ALTERED SUBCELLULAR DISTRIBUTION OF DISC1, CAMP LEVELS, AND NEURONAL MIGRATION IN SCHIZOPHRENIA AND BIPOLAR DISORDER
DISC1 (disrupted-in-schizophrenia-1) is considered a genetic risk factor for neuropsychiatric disorders. In this study, analysis in human olfactory neuronal precursors of schizophrenia and bipolar disorder patients showed decreased DISC1 levels in the cytoplasm, cAMP accumulation and diminished cell migration. The results suggest that these disorders share common molecular pathways that could hinder the neurodevelopmental process.

Jesús Muñoz-Estrada
México, México

     

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  LA PSIQUIATRÍA DE ENLACE Y EL DIAGNÓSTICO DEL DELIRIUM TREMENS
La manifestación clínica más grave y potencialmente fatal de la abstinencia de alcohol es el delirium tremens, cuadro observado en aproximadamente el 5% al 10% de los pacientes con trastorno por consumo de alcohol que requieren hospitalización.

Subho Chakrabarti
Chandigarh, India

           

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  PSYCHIATRIC MORBIDITY IN IDIOPATHIC TRANSVERSE MYELITIS
Consecutive patients with idiopathic transverse myelitis and first-episode stroke (30 each) underwent two-stage screening for psychiatric morbidity. A high prevalence of psychological distress, psychiatric morbidity (principally major depression), and cognitive impairment was found in idiopathic TM, comparable to that found among patients with stroke. This morbidity was associated with greater disability.

Subho Chakrabarti
Chandigarh, In

  

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  MECANISMO DE ACCIÓN DE LA PAROXETINA
La paroxetina actúa sobre varios sistemas de neurotransmisión, además del serotoninérgico, y esas acciones contribuyen a sus efectos antidepresivos y ansiolíticos. Por otra parte, además de los efectos beneficiosos sobre las manifestaciones clínicas, en los pacientes con comorbilidades es importante tener en cuenta la probabilidad de interacciones farmacológicas y efectos adversos.

J Franco-Perez
Mexico DF, México

     

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  MARITAL ADJUSTMENT OF SUBSTANCE DEPENDENCE, SCHIZOPHRENIA AND BIPOLAR DISORDER PATIENTS
Substance dependence patients have significant better marital adjustment compared with bipolar affective disorder patients. Substance dependence patients have significantly better social and sexual adjustment than patients with bipolar affective disorder as well as significantly better sexual adjustment than schizophrenia patients.

Suprakash Chaudhury
Loni, In

  

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