The association between diabetes mellitus and musculoskeletal disorders

The association between diabetes mellitus and musculoskeletal disorders

Fuente:Frontiers in Endocrinology

Tipo de trabajo:Revisión sistemática

Extracto: In conclusion, the results of this meta-analysis suggest that there may be an association between MSDs and diabetes in people with diabetes. These findings add to the existing knowledge on this topic and highlight the importance of recognition and management of MSDs in people with DM. There is a need for further research to investigate the underlying mechanisms and to develop targeted interventions for the prevention and management of MSDs in this population. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=381787, identifier CRD42022381787.

Claves:complications, diabetes mellitus, evidence synthesis, meta-analysis, musculoskeletal disorders

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1320468.

Autor/es:Azami, Mobin (a)
Moradkhani, Asra (b)

institución:(a) Student of the Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
(b) Student of the Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1320468

Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2.

Fuente:Frontiers in Endocrinology

Extracto: Bone manifestations are prevalent, heterogeneous, and silent in CGL1 and CGL2. Osteolytic lesions are the most common, followed by osteosclerosis and pseudo-osteopoikilosis. Bone mass is high in most cases. There was no pain complaint related to bone lesions. Thus, systematic assessment of bone manifestations in CGL is essential. Studies are needed to better understand its pathogenesis and clinical consequences.

Claves:Berardinelli-Seip syndrome, bone, bone cyst, bone mineral density, lipodystrophy

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1326700.

Autor/es:Freire, Erika Bastos Lima (a)
Brasil d'Alva, Catarina (b)

institución:(a) Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Fortaleza, Brazil.
(b) Clinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará/EBSERH, Fortaleza, CE, Brazil.

Conflicto:RMMJ has received grant support and has served as an advisor and/or a consultant to Amryt Pharma, PTC Therapeutics and NovoNordisk. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1326700

Gestational and neonatal outcomes of women with partial Dunnigan lipodystrophy.

Fuente:Frontiers in Endocrinology

Tipo de trabajo:Revisión

Extracto: Our data showed a high frequency of fetal complications in women with FPLD2. However, no instances of infertility or prolonged attempts to conceive have been reported, highlighting the significance of employing effective contraception strategies to plan pregnancies at optimal times for managing metabolic comorbidities.

Claves:Dunnigan, FPLD2, gestational diabetes mellitus, lipodystrophy, pregnancy

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1359025.

Autor/es:Valerio, Cynthia M (a)
Muniz, Raquel Beatriz Gonçalves (b)

institución:(a) Department of Metabolism, Institute of Diabetes and Endocrinology of Rio de Janeiro (IEDE), Rio de Janeiro, Brazil.
(b) Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Fortaleza, Brazil.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1359025

Food deserts exposure, density of fast-food restaurants, and park access: Exploring the association of food and recreation environments with obesity and diabetes using global and local regression models.

Food deserts exposure, density of fast-food restaurants, and park access: Exploring the association of food and recreation environments with obesity and diabetes using global and local regression models.

Fuente:Plos One

Extracto: These findings will help policymakers and public health agencies in determining which geographic areas need to be prioritized when implementing public interventions such as promoting healthy food access, limiting unhealthy food options, and increasing park access.

Cita:PLoS One 2024; 19 (4) : e0301121.

Autor/es:Oh, Jae In (a)
Lee, KangJae Jerry (b)

institución:(a) Department of Parks, Recreation & Tourism Management, North Carolina State University, Raleigh, North Carolina, United States of America.
(b) Department of Parks, Recreation & Tourism Management, North Carolina State University, Raleigh, North Carolina, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301121

Twenty-Four week Taichi training improves pulmonary diffusion capacity and glycemic control in patients with Type 2 diabetes mellitus.

Fuente:Plos One

Extracto: Variation of DLCO is explained by improved insulin sensitivity and endothelial function, and reduced inflammatory markers, including TNF-α, vWF, and IL-6.

Cita:PLoS One 2024; 19 (4) : e0299495.

Autor/es:Liu, Xiaoli (a)
Zhu, Huan (b)

institución:(a) Department of Physical Education, Xihua University, Chengdu, Sichuan, China.
(b) Department of Physical Education, Hubei Minzu University, Enshi, Hubei, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299495

Bioinformatics pipeline for the systematic mining genomic and proteomic variation linked to rare diseases: The example of monogenic diabetes.

Fuente:Plos One

Extracto: Our open and flexible implementation using Jupyter notebooks enables tailoring and modifying the pipeline and its application to other rare diseases.

Cita:PLoS One 2024; 19 (4) : e0300350.

Autor/es:Kuznetsova, Ksenia G (a)
Vašíček, Jakub (b)

institución:(a) Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
(b) Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300350

The predictive power of data: machine learning analysis for Covid-19 mortality based on personal, clinical, preclinical, and laboratory variables in a case-control study.

The predictive power of data: machine learning analysis for Covid-19 mortality based on personal, clinical, preclinical, and laboratory variables in a case-control study.

Fuente:Bmc Infectious Diseases

Extracto: This study highlights the potential of ML analysis to improve the accuracy of COVID-19 mortality prediction and emphasizes the need for a comprehensive approach that considers multiple feature categories. It highlights the critical role of data quality and quantity in improving model performance and contributes to our understanding of the multifaceted factors that influence COVID-19 outcomes.

Claves:Coronavirus disease, Data quality, Machine learning, Performance, Predictive model

Cita:BMC Infect Dis 2024 Apr 18; 24 (1) : 411.

Autor/es:Seyedtabib, Maryam (a)
Najafi-Vosough, Roya (b)

institución:(a) Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
(b) Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12879-024-09298-w

The use of late preterm antenatal corticosteroids in women with gestational diabetes a puzzle worth solving.

The use of late preterm antenatal corticosteroids in women with gestational diabetes a puzzle worth solving.

Fuente:Bmc Pregnancy and Childbirth

Tipo de trabajo:Estudio de cohortes

Extracto: Antenatal corticosteroid treatment at or after 34 0/7 weeks of gestation in women with gestational diabetes mellitus who had a late preterm delivery was not associated with improvement in adverse neonatal outcomes. Decreasing gestational age at birth was the only independent risk factor predicting composite neonatal and composite respiratory outcomes.

Claves:Antenatal corticosteroids, Gestational diabetes mellitus, Hyperbilirubinemia, Late preterm, Neonatal outcome

Cita:BMC Pregnancy Childbirth 2024 Apr 18; 24 (1) : 286.

Autor/es:Özkan, Sadullah (a)
Dereli, Murat Levent (b)

institución:(a) Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik Lady Zübeyde Maternity and Women's Health Teaching and Research Hospital, P.O. box 06010, New Etlik Street No:55 Etlik, Keçiören, Ankara, Turkey. sadullahozkan@gmail.com.
(b) Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik Lady Zübeyde Maternity and Women's Health Teaching and Research Hospital, P.O. box 06010, New Etlik Street No:55 Etlik, Keçiören, Ankara, Turkey.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12884-024-06510-2

Correlation between fat-to-muscle mass ratio and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study.

Correlation between fat-to-muscle mass ratio and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study.

Fuente:Bmc Geriatrics

Extracto: Elderly T2DM men with high FMR had unfavorable cognitive function. FMR is independently associated with an increased risk of CI in male T2DM patients regardless of BMI.

Claves:Body composition, Cognitive impairment, Fat-to-muscle mass ratio, Sex, Type 2 diabetes mellitus

Cita:BMC Geriatr 2024 Apr 18; 24 (1) : 352.

Autor/es:Wu, Fan (a)
Liu, Yanlan (b)

institución:(a) Department of Endocrinology, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
(b) Department of Endocrinology, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12877-024-04941-2

Undiagnosed type 2 diabetes is common - intensified screening of established risk groups is imperative in Sweden: the SDPP cohort.

Undiagnosed type 2 diabetes is common - intensified screening of established risk groups is imperative in Sweden: the SDPP cohort.

Fuente:Bmc Medicine

Extracto: Nearly half of individuals who develop T2D during 10 years in Stockholm County are undiagnosed, emphasizing a need for intensified screening of T2D within primary healthcare. Screening can be targeted to individuals who have at least two prominent risk factors.

Claves:Healthcare, Public health, Risk factors, Screening, Type 2 diabetes, Undiagnosed

Cita:BMC Med 2024 Apr 19; 22 (1) : 168.

Autor/es:Gudjonsdottir, Hrafnhildur (a)
Tynelius, Per (b)

institución:(a) Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden. hrafnhildur.gudjonsdottir@ki.se.
(b) Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. hrafnhildur.gudjonsdottir@ki.se.

Conflicto:None to declare.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12916-024-03393-0

Implementation and evaluation of the centering pregnancy group prenatal care model in pregnant women with diabetes: a convergent parallel mixed methods study protocol.

Implementation and evaluation of the centering pregnancy group prenatal care model in pregnant women with diabetes: a convergent parallel mixed methods study protocol.

Fuente:Reproductive Health

Tipo de trabajo:Estudio clínico

Extracto: URL: https://irct.behdasht.gov.ir/trial/74206 .

Claves:Antenatal care, Diabetes, Group care, Pregnancy

Cita:Reprod Health 2024 Apr 18; 21 (1) : 54.

Autor/es:Maghalian, Mahsa (a)
Abbasalizadeh, Fatemeh (b)

institución:(a) Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.
(b) Women's Reproductive Health Research Center, Department of Perinatology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12978-024-01792-3

Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry.

Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry.

Fuente:Italian Journal of Pediatrics

Extracto: Maintaining an evidence-based approach is essential to safeguard the well-being of transgender and gender diverse adolescents.

Claves:Adolescence, Gender dysphoria, Gender incongruence, Gender-affirming care, Gender-affirming hormone therapy, GnRH analogs, Pediatrics

Cita:Ital J Pediatr 2024 Apr 18; 50 (1) : 73.

Autor/es:Calcaterra, Valeria (a)
Tornese, Gianluca (b)

institución:(a) Pediatric Department, Buzzi Children's Hospital, Milano, Italy.
(b) Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

Conflicto:Giovanni Corsello is Editor in Chief of the Italian Journal of Pediatrics and Giorgio Perilongo is Associate Editor of the Italian Journal of Pediatrics. Other authors declare that they have no competing interests

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13052-024-01644-7

Cellular therapeutics and immunotherapies in wound healing - on the pulse of time?

Cellular therapeutics and immunotherapies in wound healing - on the pulse of time?

Fuente:Military Medical Research

Extracto: Ultimately, we hope this line of research may serve as an evidence-based foundation to guide further experimental and translational approaches and optimize patient care long-term.

Claves:Biofilm, Cellular therapies, Chronic wounds, Immunotherapies, Wound healing, Wound healing disorder

Cita:Mil Med Res 2024 Apr 18; 11 (1) : 23.

Autor/es:Huelsboemer, Lioba (a)
Knoedler, Leonard (b)

institución:(a) Division of Reconstructive and Plastic Surgery, Yale School of Medicine, New Haven, CT, 06510, USA.
(b) Division of Reconstructive and Plastic Surgery, Yale School of Medicine, New Haven, CT, 06510, USA.

Conflicto:Not applicable.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s40779-024-00528-5

Changes in acromegaly comorbidities, treatment, and outcome over three decades

Changes in acromegaly comorbidities, treatment, and outcome over three decades

Fuente:Frontiers in Endocrinology

Tipo de trabajo:Estudio de cohortes

Extracto: Modern medical treatment regimens of acromegaly as well as increased awareness and improved diagnostics for its comorbidities have led to better disease control, fewer patients with severe hypopituitarism, and declining mortality in the Danish cohort of acromegaly patients. The risk of cancer did not increase over the study period.

Claves:acromegaly, acromegaly and cancer, acromegaly comorbidities, acromegaly treatment, cancer endocrinology, pituitary adenomas

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1380436.

Autor/es:Rosendal, Christian (a)
Arlien-Søborg, Mai Christiansen (b)

institución:(a) Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
(b) Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1380436

An updated systematic review and Meta-analysis of the prevalence of type 2 diabetes in Iran, 1996-2023.

An updated systematic review and Meta-analysis of the prevalence of type 2 diabetes in Iran, 1996-2023.

Fuente:Frontiers in Public Health

Tipo de trabajo:Revisión sistemática

Extracto: The prevalence of type 2 diabetes was estimated at 10.8%, highlighting variations across gender, age groups, and geographic regions that underscore the necessity for specific interventions. These findings advocate for proactive measures, including tailored screening and lifestyle modification programs. The notable temporal increase from 2013 to 2017 signals the need for policymakers and healthcare practitioners to develop effective strategies, anticipating and addressing the potential future burden on the healthcare system. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023437506, identifier: CRD42023437506.

Claves:Iran, diabetes mellitus, epidemiology, meta-analysis, prevalence

Cita:Front Public Health 2024; 12 : 1322072.

Autor/es:Hazar, Narjes (a)
Jokar, Mohammad (b)

institución:(a) Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
(b) Young Researchers and Elite Club, Islamic Azad University of Karaj, Karaj, Iran.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2024.1322072

Noncontact optical device for measuring blood glucose in aqueous humor: a pilot clinical study investigating correlation with blood glucose levels.

Noncontact optical device for measuring blood glucose in aqueous humor: a pilot clinical study investigating correlation with blood glucose levels.

Fuente:Journal of Biomedical Optics

Extracto: This NCGM may offer a convenient, pain-free, and rapid tool for measuring blood glucose levels in diabetic patients. The device could represent a significant advancement in noncontact hybrid optical glucose measurement systems.

Claves:aqueous humor, blood, diabetes, glucose, monitoring, noncontact, optical

Cita:J Biomed Opt 2024 Apr; 29 (4) : 047001.

Autor/es:Kang, Eugene Yu-Chuan (a)
Shen, Chia-Rui (b)

institución:(a) Chang Gung Memorial Hospital, Linkou Medical Center, Department of Ophthalmology, Taoyuan, Taiwan.
(b) Chang Gung University, College of Medicine, School of Medicine, Taoyuan, Taiwan.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1117/1.JBO.29.4.047001

Effect of Nutrition and Behavior Modification Program (NBMP) on maternal and neonatal outcomes among hyperglycemic mothers.

Effect of Nutrition and Behavior Modification Program (NBMP) on maternal and neonatal outcomes among hyperglycemic mothers.

Fuente:European Review For Medical and Pharmacological Sciences

Extracto: The study's conclusions draw attention to the possible roles that maternal wellness, physical activity, and diet may have in reducing risks for both hyperglycemic mothers and their newborns. The NBMP resulted in higher adherence to lifestyle changes. Further research on a larger sample of hyperglycemic mothers is recommended to expand the generalizability of the findings.

Cita:Eur Rev Med Pharmacol Sci 2024 Apr; 28 (7) : 2750-2759.

Autor/es:Premalatha, P (a)
Maha, H M A (b)

institución:Premalatha, P (a)
Maha, H M A (b)

Formato:Informe impreso

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.26355/eurrev_202404_35903

Evaluation of prediabetes patients in terms of metabolic syndrome.

Fuente:European Review For Medical and Pharmacological Sciences

Extracto: Hypertension, dyslipidemia, abdominal obesity, and metabolic obesity increased in the coexistence of prediabetes and MetS. At the same time, the coexistence of prediabetes and MetS was associated with higher systolic blood pressure, postprandial blood sugar, and LDL levels. Prediabetic individuals accompanied by MetS are at greater metabolic risk.

Cita:Eur Rev Med Pharmacol Sci 2024 Apr; 28 (7) : 2760-2769.

Autor/es:Genc, S (a)
Evren, B (b)

institución:Genc, S (a)
Evren, B (b)

Formato:Informe impreso

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.26355/eurrev_202404_35904

Shifts in Diagnostic Testing for Headache in the Emergency Department, 2015 to 2021.

Shifts in Diagnostic Testing for Headache in the Emergency Department, 2015 to 2021.

Fuente:Jama Network Open

Tipo de trabajo:Estudio de cohortes

Extracto: AND RELEVANCE: In this cohort study of ED patients with headache, increases in CT cerebral angiography use were associated with fewer lumbar punctures and higher detection of unruptured intracranial aneurysms, with no significant change in missed diagnoses of subarachnoid hemorrhage or bacterial meningitis. While this shift in diagnostic strategy appeared safe in the short-term, the long-term consequences remain unclear.

Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e247373.

Autor/es:Mark, Dustin G (a)
Horton, Brandon H (b)

institución:(a) Department of Emergency Medicine, Kaiser Permanente Medical Center, Oakland, California.
(b) Department of Critical Care Medicine, Kaiser Permanente Medical Center, Oakland, California.

Conflicto:Conflict of Interest Disclosures: Dr Reed reported receiving grants from the National Institute of Diabetes Digestive and Kidney Diseases, the Agency for Healthcare Research and Quality, the National Institute of Aging, and the Patient Centered Outcomes Research Institute outside the submitted work. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.7373

Prevalence and associated risk factors of resistant hypertension among Chinese hypertensive patients in primary care setting.

Fuente:Bmc Primary Care

Extracto: The prevalence of RHT among Chinese hypertensive patients in primary care setting of Hong Kong is 7.43%. RHT is more common in male patients, patients with longer duration of hypertension, concomitant T2DM and CHF. Clinicians should be vigilant when managing these groups of patients and provide aggressive treatment and close monitoring.

Claves:Prevalence, Primary care, Resistant hypertension, Risk factors

Cita:BMC Prim Care 2024 Apr 19; 25 (1) : 120.

Autor/es:Chan, Kilpatrick Kiupak (a)
Chiang, Lapkin (b)

institución:(a) Department of Family Medicine and General Outpatient Clinics, Kowloon Central Cluster, Hospital Authority, Kowloon, Hong Kong SAR, China.
(b) Department of Family Medicine and General Outpatient Clinics, Kowloon Central Cluster, Hospital Authority, Kowloon, Hong Kong SAR, China. lapkinchiang@gmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12875-024-02366-9