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Application of propofol-remifentanil intravenous general anesthesia combined with regional block in pediatric ophthalmic surgery.
Application of propofol-remifentanil intravenous general anesthesia combined with regional block in pediatric ophthalmic surgery.
Fuente:Bmc Anesthesiology
Extracto:
Propofol-remifentanil intravenous anesthesia combined with
long-acting local anesthetic regional block anesthesia, combined with laryngeal
mask ventilation technology without muscle relaxants, can be safely used in
pediatric eye surgery to achieve rapid and smooth recovery from general
anesthesia and better postoperative analgesia. This anesthesia scheme can improve
the comfort and safety of children in perioperative period, and has a certain
clinical popularization value.
institución:(a) Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 5 Jingyuan Street, Beijing, 100043, China. (b) Department of Anesthesiology, Eye Hospital China Academy of Chinese Medical Sciences, Beijing, 100040, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Burden of antimicrobial prescribing in primary care attributable to sore throat
Burden of antimicrobial prescribing in primary care attributable to sore throat
Fuente:Bmc Primary Care
Tipo de trabajo:Estudio de cohortes
Extracto:
Frequency of antibiotic
prescribing for sore throat is high and broad, despite Australian Therapeutic
guideline recommendations. Multiple, sustained interventions to reduce
prescribing, including availability of effective S. pyogenes vaccines that could
reduce the incidence of streptococcal pharyngitis, could obviate the need to
prescribe antibiotics and support ongoing efforts to promote antimicrobial
stewardship.
Claves:Streptococcus pyogenes, Antimicrobial prescribing, Primary care, Sore throat, URTI
Cita:BMC Prim Care 2024 Apr 17; 25 (1) : 117.
Autor/es:Carville, Kylie S (a) Meagher, Niamh (b)
institución:(a) Doherty Epidemiology, Victorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. (b) Department of Infectious Diseases, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Respiratory Syncytial Virus Hospital-Based Burden of Disease in Children Younger Than 5 Years, 2015-2022.
Respiratory Syncytial Virus Hospital-Based Burden of Disease in Children Younger Than 5 Years, 2015-2022.
Fuente:Jama Network Open
Extracto:
AND RELEVANCE:
Hospitalizations for RSV and bronchiolitis demonstrated atypical seasonality in
2021 and 2022, with an overall increase in RSV encounters. Postpandemic RSV
hospitalization increased for all ages, but especially among older children,
whereas bronchiolitis hospitalization was decreased or unchanged compared with
earlier seasons. These findings suggest some of the observed increase in RSV
hospital use may be due to increased testing.
Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e247125.
Autor/es:Suss, Robert J (a) Simões, Eric A F (b)
institución:(a) Department of Pediatric Infectious Diseases, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora. (b) Department of Pediatric Infectious Diseases, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora.
Health care utilisation of asylum seekers and refugees in the South-West of Germany.
Health care utilisation of asylum seekers and refugees in the South-West of Germany.
Fuente:Plos One
Tipo de trabajo:Estudio de cohortes
Extracto:
Though
seasonal variation and referral practices must be considered, a high rate of
revisits to the ICF were recorded. While visits to the LED decreased after the
implementation of the ICF, visits returned to the pre-ICF levels during the
routine running of the ICF. The results show that AS&R require reliable access to
health care, yet the needs of specific groups of migrants may be different,
especially those with language barriers, minority groups or those from certain
regions. As such, care should be migrant sensitive and adapt to the changing
needs of the population. Though more research is required to better understand
the differing needs of migrants, this study may help to inform guidelines
surrounding migrant sensitive standards of care in Germany.
institución:(a) Department of Medicine II, Division of Infectious Diseases, Medical Centre-University Hospital Freiburg, Faculty of Medicine, Freiburg, Germany. (b) PhD Programme "Epidemiology" Braunschweig-Hannover, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prevalence of autoimmune thyroiditis among children with autoimmune hepatitis.
Prevalence of autoimmune thyroiditis among children with autoimmune hepatitis.
Fuente:Italian Journal of Pediatrics
Extracto:
Autoimmune hepatitis in
Egyptian children is commonly associated with other autoimmune diseases.
Autoimmune thyroiditis is the most common to be associated with AIH in pediatric
patients. As it is not usually clinically manifesting, regular screening for AIT
in children with AIH is mandatory.
Claves:Autoimmune diseases, Autoimmune hepatitis, Autoimmune thyroiditis, Children
Cita:Ital J Pediatr 2024 Apr 18; 50 (1) : 72.
Autor/es:Mogahed, Engy Adel (a) Soliman, Hend M (b)
institución:(a) Department of Pediatrics, New Children Hospital, Cairo University, Cairo, Egypt. (b) Department of Pediatrics, New Children Hospital, Cairo University, Cairo, Egypt.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
"Quality of Life in Epidermolysis Bullosa" and "Epidermolysis Bullosa Burden of Disease": Italian translation, cultural adaptation, and pilot testing of two disease-specific questionnaires.
"Quality of Life in Epidermolysis Bullosa" and "Epidermolysis Bullosa Burden of Disease": Italian translation, cultural adaptation, and pilot testing of two disease-specific questionnaires.
Fuente:Italian Journal of Pediatrics
Tipo de trabajo:Guía
Extracto:
The Italian versions of the QOLEB and
EB-BoD provide valuable tools in everyday clinical practice of reference centers,
and they allow the participation in multicenter international real-life
observational studies as well as in controlled clinical trials. They enable the
identification of disease-specific psychological and socioeconomic challenges for
EB patients and their families, guiding targeted interventions to ensure
appropriate and timely care.
Claves:Dermatology, Dystrophic epidermolysis bullosa, Epidermolysis bullosa simplex, Family burden, Inherited epidermolysis bullosa, Junctional epidermolysis bullosa, Kindler epidermolysis bullosa, Quality of life
Cita:Ital J Pediatr 2024 Apr 19; 50 (1) : 76.
Autor/es:Hachem, May El (a) Diociaiuti, Andrea (b)
institución:(a) Dermatology Unit and Genodermatosis Research Unit, Translational Paediatrics and Clinical Genetics Research Division, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165, Rome, Italy. (b) Dermatology Unit and Genodermatosis Research Unit, Translational Paediatrics and Clinical Genetics Research Division, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165, Rome, Italy. andrea.diociaiuti@opbg.net.
Conflicto:He authors declare that they have no competing interests.
Clinical phenotype of a Kallmann syndrome patient with IL17RD and CPEB4 variants.
Clinical phenotype of a Kallmann syndrome patient with IL17RD and CPEB4 variants.
Fuente:Frontiers in Endocrinology
Extracto:
Bioinformatics analysis shows that the IL17RD protein undergoing
Gly701Ser mutation and is speculated to be phosphorylated and modified, thereby
disrupting fibroblast growth factor signaling. This study also suggested that the
CPEB4 might play a crucial role in the key signaling process affecting olfactory
bulb morphogenesis. Overall, the findings of this study broaden the gene
expression profile of KS-related pathogenic genes. This offers a new avenue for
exploring the pathogenic mechanism of KS and provides valuable insights for
precise clinical diagnosis and treatment strategies for this condition.
institución:(a) Department of Pediatric Endocrinology and Genetics, Hangzhou Children's Hospital, Hangzhou, Zhejiang, China. (b) Department of Pediatric Endocrinology and Genetics, Hangzhou Children's Hospital, Hangzhou, Zhejiang, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Anastrozole monotherapy further improves near-adult height after the initial combined treatment with leuprorelin and anastrozole in early-maturing girls with compromised growth prediction: results from the second phase of the GAIL study.
Anastrozole monotherapy further improves near-adult height after the initial combined treatment with leuprorelin and anastrozole in early-maturing girls with compromised growth prediction: results from the second phase of the GAIL study.
Fuente:Frontiers in Endocrinology
Extracto:
In early-maturing girls with
compromised growth potential, the combined treatment with leuprorelin and
anastrozole for 2 years or until the age of 11 years resulted in a total gain in
height of +9.7 cm when continuing anastrozole monotherapy until the attainment of
NAH, as opposed to +7.4 cm if they do not continue with the anastrozole
monotherapy and +3.6 cm when treated with leuprorelin alone. Thus, the combined
intervention ends at the shortest distance from the target height if continued
with anastrozole monotherapy until BA 14 years.
Autor/es:Papadimitriou, Dimitrios T (a) Dermitzaki, Eleni (b)
institución:(a) Department of Pediatrics, Faculty of Medicine, University of Thessaly, Larisa, Greece. (b) Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
institución:(a) Department of Pharmacy Practice, Institute of Pharmacy, Nims University Rajasthan, Jaipur, India. (b) Department of Pharmacy Practice, Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Genetic diagnosis of endocrine disorders in Cyprus through the Cyprus Institute of Neurology and Genetics: an ENDO-ERN Reference Center.
Genetic diagnosis of endocrine disorders in Cyprus through the Cyprus Institute of Neurology and Genetics: an ENDO-ERN Reference Center.
Fuente:Orphanet Journal of Rare Diseases
Extracto:
Lastly, MGFT over the last few years has established an esteemed diagnostic and
research program on premature puberty with emphasis on the implication of MKRN3
gene on the onset of the disease and the identification of other prognosis
biomarkers.As an Endo-ERN member MGFT department belongs to this large European
network and holds the same humanistic ideals which aim toward the improvements of
health care for patients with rare endocrine conditions in respect to improved
and faster diagnosis.
institución:(a) Department of Molecular Genetics, Function and Therapy, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. (b) Department of Molecular Genetics, Function and Therapy, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Turning the tides: achieving rapid and safe glucose control in adolescents with suboptimally controlled type 1 diabetes using advanced hybrid closed loop systems.
Turning the tides: achieving rapid and safe glucose control in adolescents with suboptimally controlled type 1 diabetes using advanced hybrid closed loop systems.
Fuente:Frontiers in Endocrinology
Extracto:
AHCL systems provide a significant, rapid, and
safe improvement in glucose control. This marks a pivotal advancement in
technology that primarily benefited those who were already compliant.
Claves:Automated insulin delivery (AID), HbA1c (A1C), Type 1 diabetes (or diabetes), adolescence, glucose risk index, time in range (TIR)
Autor/es:Castorani, Valeria (a) Rigamonti, Andrea (b)
institución:(a) Department of Pediatrics, Pediatric Diabetes Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy. (b) Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Child Opportunity Index and clinical characteristics at diabetes diagnosis in youth: type 1 diabetes versus type 2 diabetes.
Child Opportunity Index and clinical characteristics at diabetes diagnosis in youth: type 1 diabetes versus type 2 diabetes.
Fuente:Bmj Open Diabetes Research & Care
Extracto:
COI is associated with differing
characteristics at diagnosis in youth-onset T1D and T2D but is worse among youth
with T2D overall. These findings underscore the need to address socioeconomic
adversity when designing interventions to reduce T2D risk and to improve outcomes
at diabetes diagnosis in youth.
Claves:Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Ketoacidosis, Pediatric Obesity
Cita:BMJ Open Diabetes Res Care 2024 Apr 17; 12 (2)
Autor/es:Hoyek, Kim (a) Libman, Ingrid (b)
institución:(a) Center for Pediatric Research in Obesity and Metabolism, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. (b) Division of Pediatric Endocrinology, Diabetes, and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications.
Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications.
Fuente:Scientific Reports
Extracto:
Further
research is warranted to improve accurate diagnosis of pediatric diabetes type.
Claves:Diabetes, Misdiagnosis, Pediatric diabetes, Type 1 diabetes, Type 2 diabetes
Cita:Sci Rep 2024 Apr 17; 14 (1) : 8876.
Autor/es:Tosur, Mustafa (a) Huang, Xiaofan (b)
institución:(a) The Division of Diabetes and Endocrinology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 77030, USA. mustafa.tosur@bcm.edu. (b) Children's Nutrition Research Center, Baylor College of Medicine, USDA/ARS, Houston, TX, 77030, USA. mustafa.tosur@bcm.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2.
Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2.
Fuente:Frontiers in Endocrinology
Extracto:
Bone
manifestations are prevalent, heterogeneous, and silent in CGL1 and CGL2.
Osteolytic lesions are the most common, followed by osteosclerosis and
pseudo-osteopoikilosis. Bone mass is high in most cases. There was no pain
complaint related to bone lesions. Thus, systematic assessment of bone
manifestations in CGL is essential. Studies are needed to better understand its
pathogenesis and clinical consequences.
Claves:Berardinelli-Seip syndrome, bone, bone cyst, bone mineral density, lipodystrophy
Autor/es:Freire, Erika Bastos Lima (a) Brasil d'Alva, Catarina (b)
institución:(a) Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Fortaleza, Brazil. (b) Clinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará/EBSERH, Fortaleza, CE, Brazil.
Conflicto:RMMJ has received grant support and has served as an advisor and/or a consultant to Amryt Pharma, PTC Therapeutics and NovoNordisk. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry.
Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry.
Fuente:Italian Journal of Pediatrics
Extracto:
Maintaining an evidence-based approach is essential to safeguard the
well-being of transgender and gender diverse adolescents.
institución:(a) Pediatric Department, Buzzi Children's Hospital, Milano, Italy. (b) Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Conflicto:Giovanni Corsello is Editor in Chief of the Italian Journal of Pediatrics and Giorgio Perilongo is Associate Editor of the Italian Journal of Pediatrics. Other authors declare that they have no competing interests
The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Estudio clínico
Extracto:
Obesity-associated
glycine deficiency impairs the human body's ability to eliminate endogenous and
exogenous metabolites/compounds via the glycine conjugation pathway. This
impairment is ameliorated when glycine supply is restored after bariatric
surgery. These findings imply that dietary glycine supplementation could treat
obesity-associated metabolic complications due to the accumulation of
intramitochondrial toxic metabolites. CLINICAL TRIAL REGISTRATION:
https://clinicaltrials.gov/study/NCT04660513, identifier NCT04660513.
Claves:acylglycine, bariatric surgery, class III obesity, glycine conjugation, glycine deficiency
institución:(a) Department of Endocrinology, Singapore General Hospital, Singapore, Singapore. (b) Children's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Racial Discrimination and Metabolic Syndrome in Young Black Adults.
Racial Discrimination and Metabolic Syndrome in Young Black Adults.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: This study suggests
that racial discrimination in late adolescence is associated with MetS among
Black young adults through biobehavioral pathways. Thus, health interventions for
MetS in Black adults will need to contend with sleep behaviors and inflammatory
intermediaries as well as address and reduce exposure to racial discrimination to
narrow disparities and promote health equity.
Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e245288.
Autor/es:Heard-Garris, Nia (a) Yu, Tianyi (b)
institución:(a) Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois. (b) Division of Advanced General Pediatrics and Primary Care, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Clinical features of plastic bronchitis in children after congenital heart surgery.
Clinical features of plastic bronchitis in children after congenital heart surgery.
Fuente:Italian Journal of Pediatrics
Tipo de trabajo:Estudio de cohortes
Extracto:
Children with airway
abnormalities or right ventricular dysfunction after CHS should be alerted to the
development of PB. Pharmacological treatment such as anti-infection,
corticosteroids, or improvement of right ventricular function is the basis of PB
treatment, while fiberoptic bronchoscopy is an essential tool for the diagnosis
and treatment of PB. ECMO assistance is a vital salvage treatment for recurrent
critically ill PB patients.
institución:(a) Department of Cardiac Intensive Care Unit, Shanghai Children' s Medical Center, Shanghai Jiaotong University School of Medicine, 1678 Dongfang Road, 200127, Shanghai, PR China. (b) Department of Cardiac Intensive Care Unit, Shanghai Children' s Medical Center, Shanghai Jiaotong University School of Medicine, 1678 Dongfang Road, 200127, Shanghai, PR China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Potential application of mesenchymal stromal cells as a new therapeutic approach in acute respiratory distress syndrome and pulmonary fibrosis.
Potential application of mesenchymal stromal cells as a new therapeutic approach in acute respiratory distress syndrome and pulmonary fibrosis.
Fuente:Respiratory Research
Extracto:
Although further investigations and shared protocols
are still needed, the safety of MSC therapy has been recurrently shown, and its
potential in treating ARDS and preventing PF might represent a new therapeutic
strategy.
institución:(a) SC Anestesia e Rianimazione 2, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, PV, 27100, Italy. giulia.gazzaniga@libero.it. (b) Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. giulia.gazzaniga@libero.it.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Tri-ponderal mass index and left ventricular hypertrophy in a cohort of caucasian children and adolescents with obesity.
Tri-ponderal mass index and left ventricular hypertrophy in a cohort of caucasian children and adolescents with obesity.
Fuente:Italian Journal of Pediatrics
Extracto:
Left ventricular remodeling is
associated with the cardio-metabolic risk markers WC and WHR, but not with the
adiposity index TMI among children with obesity.
Claves:Cardiovascular risk, Left ventricular hypertrophy, Left ventricular mass index, Pediatric obesity, Tri-ponderal mass index
Cita:Ital J Pediatr 2024 Apr 19; 50 (1) : 75.
Autor/es:Vizzuso, Sara (a) Torto, Alberico Del (b)
institución:(a) Department of Pediatrics, Buzzi Children's Hospital, University of Milan, Milan, Italy. sara.vizzuso@asst-fbf-sacco.it. (b) Centro Cardiologico Monzino IRCCS, Milan, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación