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MODULAÇÃO DA SECREÇÃO DO HORMÔNIO DE CRESCIMENTO PELA GHRELINA E OUTROS SECRETAGOGOS (especial para SIIC © Derechos reservados) |
| Apresenta-se uma revisão sobre a ghrelina, os mecanismos de ação e possível papel fisiológico dos secretagogos de hormônio de crescimento e da ghrelina na secreção de hormônio de crescimento e os efeitos da administração endovenosa destes peptideos sobre a secreção de hormônio de crescimento no homem. |
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Autor: Ana-maria J. Lengyel Columnista Experta de SIIC Institución: Universidade Federal de São Paulo Artículos publicados por Ana-maria J. Lengyel |
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Coautor Paiva Cunha de Sá Larissa Bianca* Pós graduanda, Universidade Federal de São Paulo, São Paulo, Brasil* |
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Recepción del artículo 10 de Marzo, 2008 |
Aprobación 4 de Abril, 2008 |
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Primera edición 15 de Abril, 2009 |
Segunda edición, ampliada y corregida 21 de Agosto, 2009 |
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ResumoA secreção de hormônio de crescimento é modulada pelo hormônio liberador de hormônio de crescimento e pela somatostatina. Na ultima década foi descoberto um terceiro mecanismo de controle, envolvendo os secretagogos de hormônio de crescimento. A ghrelina é um peptídeo acilado, descoberto recentemente, que é produzido no estômago, porém também é sintetizado no hipotálamo. Este peptídeo é capaz de liberar hormônio de crescimento, além de aumentar a ingesta alimentar. A ghrelina endógena parece amplificar o padrão básico de secreção de hormônio de crescimento, ampliando a resposta do somatotrófo ao hormônio liberador de hormônio de crescimento. Este peptídeo estimula multiplas vias intracelulares interdependentes no somatotrófo, envolvendo a proteina quinase C, proteina quinase A, e sistemas moduladores de cálcio extracelular. Entretanto, como a liberação de GH induzida pela ghrelina in vivo é mais acentuada que in vitro, seu local de atuação predominante é no hipotálamo. No presente trabalho apresentamos uma revisão sobre a descoberta da ghrelina, os dados existentes sobre os mecanismos de ação e possível papel fisiológico dos secretagogos de hormônio de crescimento e da ghrelina na secreção de hormônio de crescimento e, finalmente, os efeitos da administração endovenosa destes peptideos sobre a secreção de hormônio de crescimento no homem.
Palabras claveghrelina, GH, secretagogos do hormônio de crescimento, GHS Clasificación en siicsalud Artículos originales > Expertos de Iberoamérica > página www.siicsalud.com/des/expertocompleto.php/ Especialidades 
Principal: Endocrinología y Metabolismo
Relacionadas: Bioquímica,
Diagnóstico por Laboratorio,
Medicina Interna,
Pediatría
Enviar correspondencia a:Ana-Maria J., Lengyel, Universidade Federal de São Paulo Escola Paulista de Medicina, Rua Pedro de Toledo, 910, 04039-002, São Paulo, Brasil, E-mail: amlengyel@rocketmail.com
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