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Effects of Hormone Replacement Therapy on Bone Mineral Density in Korean Adults With Turner Syndrome.
Effects of Hormone Replacement Therapy on Bone Mineral Density in Korean Adults With Turner Syndrome.
Fuente:Journal of Korean Medical Science
Extracto:
Early onset and appropriate duration of hormone
replacement therapy is important for increasing bone mineral density in patients
with Turner syndrome. Also, ERT affects differently to TS patients according to
mosaicism.
Claves:Bone Mineral Density, Estrogen, Hormone Replacement Therapy, Mosaicism, Turner Syndrome
Cita:J Korean Med Sci 2024 Jan 8; 39 (1) : e9.
Autor/es:Kim, SunYoung (a) Kim, Heeyon (b)
institución:(a) Dream Foret Obstetrics and Gynecology, Jeju, Korea. (b) Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Conflicto:The authors have no potential conflicts of interest to disclose.
Exploratory Biomarker Analysis Using Plasma Angiogenesis-Related Factors and Cell-Free DNA in the TRUSTY Study: A Randomized, Phase II/III Study of Trifluridine/Tipiracil Plus Bevacizumab as Second-Line Treatment for Metastatic Colorectal Cancer.
Exploratory Biomarker Analysis Using Plasma Angiogenesis-Related Factors and Cell-Free DNA in the TRUSTY Study: A Randomized, Phase II/III Study of Trifluridine/Tipiracil Plus Bevacizumab as Second-Line Treatment for Metastatic Colorectal Cancer.
Fuente:Targeted Oncology
Tipo de trabajo:Estudio clínico
Extracto:
Low
baseline plasma concentrations of HGF and IL-8 may predict better DCR and PFS in
patients with mCRC receiving FTD/TPI plus bevacizumab, however further studies
are warranted. CLINICAL TRIAL REGISTRATION NUMBER: jRCTs031180122.
Cita:Target Oncol 2024 Jan; 19 (1) : 59-69.
Autor/es:Sunakawa, Yu (a) Kuboki, Yasutoshi (b)
institución:(a) Department of Clinical Oncology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan. y.sunakawa@marianna-u.ac.jp. (b) Department of Experimental Therapeutics, National Cancer Center Hospital East, Kashiwa, Japan.
Duration of osteoporosis treatment to reduce the risk of subsequent osteoporotic fracture and all-cause mortality in elderly hip fracture patients in a Korean real-world study.
Duration of osteoporosis treatment to reduce the risk of subsequent osteoporotic fracture and all-cause mortality in elderly hip fracture patients in a Korean real-world study.
Fuente:Archives of Osteoporosis
Extracto:
These findings underscore the
importance of early and continuous osteoporosis treatment for elderly patients
with hip fracture to improve health outcomes. The benefits of long-term
osteoporosis treatment should be discussed in clinical practice to improve
overall health outcomes.
Claves:All-cause mortality, Hip fracture, Osteoporosis, South Korea, Subsequent osteoporotic fracture, Treatment duration
Cita:Arch Osteoporos 2024 Jan 10; 19 (1) : 9.
Autor/es:Lee, Soong Joon (a) Cho, Minjoon (b)
institución:(a) Department of Orthopedic Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea. (b) Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Conflicto:H Lee and H Lim are employees of Amgen Korea. S J Lee, M J Cho, and J H Lee have nothing to disclose.
Analysis of factors influencing the intravertebral shell phenomenon after posterior reduction internal fixation of thoracolumbar fracture: a retrospective study.
Analysis of factors influencing the intravertebral shell phenomenon after posterior reduction internal fixation of thoracolumbar fracture: a retrospective study.
Fuente:Bmc Musculoskeletal Disorders
Tipo de trabajo:Revisión
Extracto:
In clinical management,
surgeons need to focus on risk factors for ISP, which include decreased bone
density, preoperative vertebral overcompression, intraoperative vertebral
overextension, screw insertion depth, and the degree of vertebral repositioning.
At the 1-year postoperative follow-up, some of the vertebrae with ISP failed to
heal or even showed vertebral cleft enlargement, which would affect the stability
of the internal fracture fixation device and the quality of the patient's daily
life.
Cita:BMC Musculoskelet Disord 2024 Jan 10; 25 (1) : 49.
Autor/es:Fang, Yao (a) Zhang, Sining (b)
institución:(a) Department of Clinical Medicine, Faculty of Clinical Medicine, Fujian Medical University, Fuzhou, PR China. (b) Mindong Hospital Affiliated to Fujian Medical University, Ningde, PR China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Early bone loss in patients with obstructive sleep apnea: a cross-sectional study.
Early bone loss in patients with obstructive sleep apnea: a cross-sectional study.
Fuente:Bmc Pulmonary Medicine
Extracto:
In non-elderly
male populations, OSA patients tended to have lower vBMD, Tb.Th and Ct.Th than
non-OSA patients. The negative effect of OSA may mainly affect the osteogenesis
process, and is presumed to be related to sleep-related hypoxemia and sleep
efficiency.
Claves:Bone metabolism, Bone mineral density, High resolution peripheral quantitative computed tomography, Obstructive sleep apnea, Osteoporosis
Cita:BMC Pulm Med 2024 Jan 11; 24 (1) : 28.
Autor/es:Qiao, Yixian (a) Guo, Junwei (b)
institución:(a) Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. (b) Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Characteristics of the synovial microenvironment and synovial mesenchymal stem cells with hip osteoarthritis of different bone morphologies.
Characteristics of the synovial microenvironment and synovial mesenchymal stem cells with hip osteoarthritis of different bone morphologies.
Fuente:Arthritis Research & Therapy
Extracto:
Upregulation of
AP-1 family genes in the synovium and increased concentrations of CXCL8, MMP9,
and VEGF were detected in the synovial fluid of the hypertrophic group of HOA
patients, potentially stimulating the differentiation of SMSCs towards the
cartilage and thereby contributing to severe osteophyte formation.
institución:(a) Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo, Japan. (b) Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Impact of Folate Intake on Bone Mineral Density in Patients with Inflammatory Bowel Disease.
Impact of Folate Intake on Bone Mineral Density in Patients with Inflammatory Bowel Disease.
Fuente:Nutrients
Extracto:
Insufficient folate intake is
common in patients with IBD and healthy individuals. The impact of folate on BMD
in IBD is not clear. We need more studies on the association between folate
intake, folic acid concentration, and BMD in IBD.
Claves:Crohn’s disease, bone mineral density, folic acid, inflammatory bowel disease, osteoporosis, ulcerative colitis
Cita:Nutrients 2023 Dec 19; 16 (1)
Autor/es:Ratajczak-Pawłowska, Alicja Ewa (a) Szymczak-Tomczak, Aleksandra (b)
institución:(a) Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Poznan, Poland. (b) Poland Doctoral School, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The Importance of Nutrition in Menopause and Perimenopause-A Review.
The Importance of Nutrition in Menopause and Perimenopause-A Review.
Fuente:Nutrients
Extracto:
In summary, during the period of perimenopause and menopause,
many lifestyle factors can reduce the risk of developing all the diseases
(cardiovascular disease, insulin resistance, type 2 diabetes mellitus,
osteoporosis, and tumors) and symptoms characteristic of this period.
Fuente:International Journal of Molecular Sciences
Extracto:
Therefore, TAM
receptors emerge as new key players of the regulatory cytokine network of
osteoblasts and osteoclasts and represent accessible targets for pharmacologic
therapy for a broad set of different bone diseases, including primary and
metastatic bone tumors, rheumatoid arthritis, or osteoporosis.
Claves:AXL, GAS6, MERTK, PROS1, TAM receptors, TYRO3, bone, bone metastasis, cancer, multiple myeloma, osteoblasts, osteoclasts
Cita:Int J Mol Sci 2023 Dec 23; 25 (1)
Autor/es:Engelmann, Janik (a) Ragipoglu, Deniz (b)
institución:(a) Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. (b) Department of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Bisphosphonates as Radiopharmaceuticals: Spotlight on the Development and Clinical Use of DOTAZOL in Diagnostics and Palliative Radionuclide Therapy.
Bisphosphonates as Radiopharmaceuticals: Spotlight on the Development and Clinical Use of DOTAZOL in Diagnostics and Palliative Radionuclide Therapy.
Fuente:International Journal of Molecular Sciences
Extracto:
Particular
attention is also paid to the development of DOTAZOL, with emphasis on the
radiochemistry and quality control aspects of its preparation, before outlining
the preclinical and clinical data obtained so far with this radiopharmaceutical
candidate.
Claves:177Lu, 68Ga, DOTAZOL, bisphosphonates, bone metastases, nuclear medicine, theranostics
institución:(a) Nuclear Medicine Department, Institut Régional du Cancer de Montpellier (ICM), University Montpellier, 34298 Montpellier, France. (b) Nuclear Medicine Department, Institut Régional du Cancer de Montpellier (ICM), University Montpellier, 34298 Montpellier, France.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Visualizing the 4D Impact of Gold Nanoparticles on DNA.
Visualizing the 4D Impact of Gold Nanoparticles on DNA.
Fuente:International Journal of Molecular Sciences
Extracto:
Moreover,
it actively contributes to the continuous endeavors aimed at fully harnessing the
capabilities of AuNPs across diverse biomedical fields, promising transformative
healthcare solutions.
Claves:AFM, AuNPs, COVID-19, Lewis acid, ROS, atomic force microscope, biosensors, cancer, genotoxicity, gold nanoparticles
institución:(a) Department of Physiology and Pharmacology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX 77304, USA. (b) Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities
The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities
Fuente:International Journal of Molecular Sciences
Tipo de trabajo:Revisión
Extracto:
Consequently, the components of the NLRP3 inflammasome signaling pathway
represent promising therapeutic targets, and ongoing research might lead to the
development of new, effective treatments for RA and its comorbidities.
institución:(a) Rheumatology and Immunology Center, China Medical University Hospital, No. 2, Yude Road, Taichung 40447, Taiwan. (b) College of Medicine, China Medical University, Taichung 40447, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Relationship between DXA measured systemic bone mineral density and subchondral bone cysts in postmenopausal female patients with knee osteoarthritis: a cross-sectional study Osteoarthritis cysts and bone mineral density.
Relationship between DXA measured systemic bone mineral density and subchondral bone cysts in postmenopausal female patients with knee osteoarthritis: a cross-sectional study Osteoarthritis cysts and bone mineral density.
Fuente:Bmc Musculoskeletal Disorders
Extracto:
Development of TF OA high-grade SBCs may be linked to systemic bone mass as
represented by trabecular bone-rich lumbar vertebrae. The relationship might
point to the importance of bone stiffness as an acting factor in knee OA possibly
with mechanical energy transfer to the joint.
Claves:Bone mineral density, Osteoarthritis, Subchondral bone cyst, Vitamin D
Cita:BMC Musculoskelet Disord 2024 Jan 11; 25 (1) : 50.
institución:(a) Department of Physical Medicine and Rehabilitation, Bolu Abant Izzet Baysal University, Karacasu, Bolu, Turkey. sbtonuk@gmail.com. (b) Department of Physical Medicine and Rehabilitation, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Megaprosthetic replacement in complex distal humerus fractures in elderly patients: a case series.
Megaprosthetic replacement in complex distal humerus fractures in elderly patients: a case series.
Fuente:Journal of Orthopaedic Surgery and Research
Tipo de trabajo:Revisión
Extracto:
The indication for
this type of treatment must be selected and narrowed down, as it is a salvage
procedure, and any failure would cause even more complex situations. Short
operating times and early mobilization of the elbow are the advantages of this
technique.
Risk of low bone mineral density in patients with haemophilia
Risk of low bone mineral density in patients with haemophilia
Fuente:Journal of Orthopaedic Surgery and Research
Tipo de trabajo:Revisión sistemática
Extracto:
Haemophilia was associated with an increased
risk of low BMD. However, the risk of low BMD did not increase significantly in
developed countries. And BMD was reduced in PWH, regardless of age, region, or
economic ability. For PWH, our concerns should extend beyond bleeding and
osteoarthritis to encompass BMD starting at a young age.
institución:(a) Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China. (b) Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Assessment of osteopontin as an early nephrotoxicity indicator in human renal proximal tubule cells and its application in evaluating lanthanum-induced nephrotoxicity.
Assessment of osteopontin as an early nephrotoxicity indicator in human renal proximal tubule cells and its application in evaluating lanthanum-induced nephrotoxicity.
Fuente:Ecotoxicology and Environmental Safety
Extracto:
The
findings indicated that lanthanum possesses nephrotoxic properties; however, the
degree of nephrotoxicity was relatively low, consistent with the outcomes of in
vivo experiments.
Claves:HK-2, IPSCs, In vitro cell model, Lanthanum, Nephrotoxicity, Osteopontin
Cita:Ecotoxicol Environ Saf 2024 Feb; 271 : 115928.
Autor/es:Chen, Yingsi (a) Xu, Feifei (b)
institución:(a) Food Safety and Health Research Center, NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, PR China. (b) Food Safety and Health Research Center, NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, PR China.
Conflicto:Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Extracto:
For studies
that provided detailed data on medical decision-making algorithms, bootstrapped
datasets were generated from source data to perform comprehensive machine
learning analysis on these algorithms and their constituent steps, which revealed
a novel and thorough evaluation of medical diagnostic algorithms.
Cita:Sci Rep 2024 Jan 12; 14 (1) : 1181.
Autor/es:He, Shuhan (a) Chong, Paul (b)
institución:(a) Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. she@mgh.harvard.edu. (b) Campbell University School of Osteopathic Medicine, Lillington, NC, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators.
Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators.
Fuente:Molecular Cancer
Extracto:
This article consolidates the significance and prospects of CXCL9:SPP1 as a novel
indicator for tumor development and prognosis, while also proposing future
research directions and addressing potential challenges in this promising field.
institución:(a) Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China. (b) Department of Clinical Medicine, Hangzhou City University, Hangzhou, Zhejiang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Associations of urinary non-persistent endocrine disrupting chemical biomarkers with early-to-mid pregnancy plasma sex-steroid and thyroid hormones.
Associations of urinary non-persistent endocrine disrupting chemical biomarkers with early-to-mid pregnancy plasma sex-steroid and thyroid hormones.
Fuente:Environment International
Extracto:
Some biomarkers were
associated with early-to-mid pregnancy hormones. There were some sex-specific and
non-linear associations. Future studies could consider how these findings relate
to pregnancy/birth outcomes.
institución:(a) Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, United States; College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, United States; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, United States. (b) Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, United States; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, United States.
Conflicto:Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Channel-Boosted and Transfer Learning Convolutional Neural Network-Based Osteoporosis Detection from CT Scan, Dual X-Ray, and X-Ray Images.
Channel-Boosted and Transfer Learning Convolutional Neural Network-Based Osteoporosis Detection from CT Scan, Dual X-Ray, and X-Ray Images.
Fuente:Journal of Healthcare Engineering
Extracto:
All 3
modules work together to improve the performance of the proposed approach,
CBTCNNOD, in terms of accuracy by 10.38%, 10.16%, 7.86%, and 14.32%; precision by
11.09%, 9.08%, 10.01%, and 16.51%; sensitivity by 9.77%, 10.74%, 6.20%, and
12.78%; and specificity by 11.01%, 9.52%, 9.5%, and 15.84%, while requiring less
processing time of 33.52%, 17.79%, 23.34%, and 10.86%, when compared to the
existing techniques of RCETA, BMCOFA, BACBCT, and XSFCV, respectively.
Cita:J Healthc Eng 2024; 2024 : 3733705.
Autor/es:Dhanagopal, R (a) Menaka, R (b)
institución:(a) Centre for System Design, Chennai Institute of Technology, Chennai, Tamil Nadu, India. (b) Centre for System Design, Chennai Institute of Technology, Chennai, Tamil Nadu, India.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación