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Osteostatin, a peptide for the future treatment of musculoskeletal diseases.
Osteostatin, a peptide for the future treatment of musculoskeletal diseases.
Fuente:Biochemical Pharmacology
Extracto:
Our aim with this work is to
review the Osteostatin main features, the knowledge of its mechanisms of action
as well as its possible use for the treatment of osteoporosis, bone regeneration
and fractures and against arthritis given its anti-inflammatory properties.
Claves:Aging, Bone anabolism, Fracture, Osteoporosis, Osteostatin, PTHrP
Cita:Biochem Pharmacol 2024 May; 223 : 116177.
Autor/es:Lozano, Daniel (a) Gortazar, Arancha R (b)
institución:(a) Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Hospital 12 de Octubre (i+12), Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain. (b) Grupo de Fisiopatología Ósea, Departamento de Ciencias Médicas Básicas, Instituto de Medicina Aplicada de la Universidad San Pablo-CEU, Facultad de Medicina, Universidad San Pablo CEU, CEU Universities, Urbanización Montepríncipe s/n, 28925 Madrid, Spain.
Conflicto:Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Cita:Biochem Biophys Res Commun 2024 May 28; 710 : 149860.
Autor/es:Kim, Soo-Ho (a) Park, Keun Ha (b)
institución:(a) Department of Dentistry, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon, 35015, Republic of Korea; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, 08826, Republic of Korea. (b) Department of Oral Microbiology and Immunology, College of Dentistry, Wonkwang University, Iksan, Jeonbuk, 54538, Republic of Korea.
Conflicto:Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Radiological manifestations and clinical findings of patients with oncologic and osteoporotic medication-related osteonecrosis of the jaw.
Radiological manifestations and clinical findings of patients with oncologic and osteoporotic medication-related osteonecrosis of the jaw.
Fuente:Scientific Reports
Extracto:
Radiological features such as sequestrum size on CT scan, and MCI values
on panoramic radiographs, may aid in differentiating MRONJ in osteoporotic and
oncologic patients.
Claves:Clinical assessment, Malignancy, Medication-related osteonecrosis of the jaw (MRONJ), Osteoporosis, Radiographic assessment
Cita:Sci Rep 2024 Apr 16; 14 (1) : 8744.
Autor/es:Shin, Jeong Won (a) Kim, Jo-Eun (b)
institución:(a) Department of Orthodontics, Institute of Oral Health Science, Ajou University School of Medicine, Suwon, Republic of Korea. (b) Department of Oral and Maxillofacial Radiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea. noel1st@snu.ac.kr.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Preoperative MRI-based endplate quality: a novel tool for predicting cage subsidence after anterior cervical spine surgery.
Preoperative MRI-based endplate quality: a novel tool for predicting cage subsidence after anterior cervical spine surgery.
Fuente:Journal of Orthopaedic Surgery and Research
Extracto:
The EBQ method presents
itself as a promising and efficient tool for surgeons to assess patients at risk
of cage subsidence and osteoporosis prior to cervical spine surgery, utilizing
readily accessible patient data.
Claves:Anterior cervical discectomy and fusion, Bone mineral density, Cage subsidence, Cervical spine, Endplate bone quality
Cita:J Orthop Surg Res 2024 Apr 16; 19 (1) : 245.
Autor/es:Tuo, Yuan (a) Lin, Kaiyuan (b)
institución:(a) Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, No. 76, Nanguo Road, Beilin District, Xi'an, 710054, Shaanxi, China. (b) Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, No. 76, Nanguo Road, Beilin District, Xi'an, 710054, Shaanxi, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Trends in pediatric prescription-opioid overdoses in U.S. emergency departments from 2008-2020: An epidemiologic study of pediatric opioid overdose ED visits.
Trends in pediatric prescription-opioid overdoses in U.S. emergency departments from 2008-2020: An epidemiologic study of pediatric opioid overdose ED visits.
Fuente:Plos One
Extracto:
Prescription-opioid overdose ED visits among U.S. children and
adolescents decreased over the past decade until 2019. However, there was a
substantial increase in ED visits from 2019 to 2020, suggesting the potential
impact due to the then-emerging COVID-19 pandemic. Findings suggest focusing on
young children and adolescents to reduce further prescription-opioid overdoses in
the United States.
Cita:PLoS One 2024; 19 (4) : e0299163.
Autor/es:Lu, Audrey (a) Armstrong, Megan (b)
institución:(a) The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Pediatric Trauma Research, Columbus, OH, United States of America. (b) The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Pediatric Trauma Research, Columbus, OH, United States of America.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Examination of medical student and physician attitudes towards suicide reveals need for required training.
Examination of medical student and physician attitudes towards suicide reveals need for required training.
Fuente:Frontiers in Public Health
Extracto:
In summary, primary care providers are recognized as a top area where
improvements can prevent suicides; providing proper suicide prevention training
can effectively improve attitudes and quality of care for suicidal patients.
Claves:awareness, medical education, medical student, physician, residency education, suicide attitudes, suicide prevention
Cita:Front Public Health 2024; 12 : 1331208.
Autor/es:Schulz, Paulyna (a) Zapata, Isain (b)
institución:(a) Rocky Vista University College of Osteopathic Medicine, Englewood, CO, United States. (b) Department of Biomedical Sciences, Rocky Vista University College of Osteopathic Medicine, Englewood, CO, United States.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Exploring the impact of pathogenic microbiome in orthopedic diseases: machine learning and deep learning approaches.
Exploring the impact of pathogenic microbiome in orthopedic diseases: machine learning and deep learning approaches.
Fuente:Frontiers in Cellular and Infection Microbiology
Extracto:
The importance of ML and DL in detecting, categorizing, and
forecasting harmful microorganisms in orthopedic infectious illnesses is reviewed
in this work.
institución:(a) Department of Joint and Sports Medicine, Zaozhuang Municipal Hospital, Affiliated to Jining Medical University, Zaozhuang, China. (b) Department of Joint and Sports Medicine, Zaozhuang Municipal Hospital, Affiliated to Jining Medical University, Zaozhuang, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Incidence of Total Knee Arthroplasty After Arthroscopic Surgery for Knee Osteoarthritis
Incidence of Total Knee Arthroplasty After Arthroscopic Surgery for Knee Osteoarthritis
Fuente:Jama Network Open
Tipo de trabajo:Estudio clínico aleatorizado
Extracto:
AND RELEVANCE: In this secondary
analysis of a randomized clinical trial of arthroscopic surgery for patients with
OA of the knee, a statistically significant association with delaying or
hastening TKA was not identified. Approximately 80% of patients did not undergo
TKA within 10 years of nonoperative management with or without additional knee
arthroscopic surgery. TRIAL REGISTRATION: ClinicalTrials.gov Identifier:
NCT00158431.
Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e246578.
Autor/es:Birmingham, Trevor B (a) Primeau, Codie A (b)
institución:(a) Fowler Kennedy Sport Medicine Clinic, University of Western Ontario, London, Canada. (b) School of Physical Therapy, Faculty of Health Sciences, University of Western Ontario, London, Canada.
Three-year follow-up of a novel orthopedic ward fracture liaison services (OWFLS) model.
Three-year follow-up of a novel orthopedic ward fracture liaison services (OWFLS) model.
Fuente:The Journal of International Medical Research
Tipo de trabajo:Estudio de cohortes
Extracto:
OWFLS improved
the detection rate of bone metabolism indicators, treatment rate, and patient
adherence and reduced recurrence of bone pain. OWFLS may be suitable for settings
lacking human resources.
Cita:J Int Med Res 2024 Apr; 52 (4) : 3000605241245280.
Autor/es:Cai, Xiongxiong (a) Ying, Yijian (b)
institución:(a) Department of Orthopaedics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. RINGGOLD: 117881 (b) Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
Conflicto:Declaration of conflicting interestThe authors declare that there is no conflict of interest.
Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study.
Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study.
Fuente:Scientific Reports
Extracto:
Our results support HGS
as a useful indicator of a variety of clinical characteristics; however, its
utility varies by age and sex.
Cita:Sci Rep 2024 Apr 18; 14 (1) : 8937.
Autor/es:Taylor, Kenneth A (a) Carroll, Megan K (b)
institución:(a) Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA. kenneth.taylor@duke.edu. (b) Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA. kenneth.taylor@duke.edu.
Conflicto:KAT and APG have no competing interests to declare. MKC and SS are employees of Verily Life Sciences.
The association of FRAX with predictors of falls in the assessment of postmenopausal osteoporosis in Turkey: the fracture study of Turkey (FRACT study).
The association of FRAX with predictors of falls in the assessment of postmenopausal osteoporosis in Turkey: the fracture study of Turkey (FRACT study).
Fuente:Archives of Osteoporosis
Extracto:
Assessment of fall risk predictors should be one of
the major pillars in the physical evaluation of osteoporotic patients in the FLS
setting. FRAX is a useful tool to determine the fracture risk of patients with
both static and dynamic balance impairments. Combining balance assessment with
FRAX may be an important step to optimize osteoporosis risk assessment.
Claves:Balance, FRAX, Fall risk predictors, Postmenopausal osteoporosis
Cita:Arch Osteoporos 2024 Apr 20; 19 (1) : 29.
Autor/es:Tuzun, Sansin (a) Akarirmak, Ulku (b)
institución:(a) Department of Physical Medicine and Rehabilitation, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Fatih, Istanbul, Turkey. sansin.tuzun@iuc.edu.tr. (b) Department of Physical Medicine and Rehabilitation, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Fatih, Istanbul, Turkey.
Protocol for a magnetic resonance imaging study of participants in the fever RCT: Does fever control prevent brain injury in malaria?
Protocol for a magnetic resonance imaging study of participants in the fever RCT: Does fever control prevent brain injury in malaria?
Fuente:Plos One
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
It may
also help elucidate the underlying mechanism(s) of neuroprotection and expand
upon FEVER RCT safety assessments.
Cita:PLoS One 2024; 19 (4) : e0294823.
Autor/es:Chilombe, Moses B (a) Seydel, Karl B (b)
institución:(a) Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi. (b) Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.
Conflicto:Moses Chilombe has no disclosures. Karl B. Seydel has received funding from the US NIH. Colleen Hammond has no disclosures. Suzanna Mwanza has not disclosures. Archana Patel -has received funding from the US NIH. Frank Lungu has no disclosures. Somwe wa Somwe has no disclosures. Sam Kampondeni has no disclosures. Michael J. Potchen has received funding. from the US NIH...
and is a paid medical legal consultant on work unrelated to the research presented here. Gretchen L. Birbeck has received funding from the US NIH and is a paid consultant for BlueSpark Technologies.
Percutaneous kyphoplasty through unilateral puncture on the convex side for the treatment of painful osteoporotic vertebral compression fracture with scoliosis.
Percutaneous kyphoplasty through unilateral puncture on the convex side for the treatment of painful osteoporotic vertebral compression fracture with scoliosis.
Fuente:Bmc Musculoskeletal Disorders
Extracto:
Combining with the
proper assessment of the pre-injured life status of patients, PKP surgery using
unilateral puncture on the convex side for the treatment of P-OVCF with scoliosis
can achieve safe, excellent clinical, and radiographic outcomes.
institución:(a) Department of Clinical skills center, Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, Sichuan, China. (b) Department of Orthopedics Surgery, Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, Sichuan, China. Jasewangspine@swmu.edu.cn.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Development of a program theory for osteoporosis patient education in Denmark: a qualitative study based on realist evaluation.
Development of a program theory for osteoporosis patient education in Denmark: a qualitative study based on realist evaluation.
Fuente:Bmc Geriatrics
Tipo de trabajo:Revisión sistemática
Extracto:
We developed a program theory and examined how and why osteoporosis
patient education is likely to be effective. Understanding these prerequisites is
important for future implementation and evaluation of osteoporosis patient
education.
Claves:Mechanism of change, Osteoporosis, Patient education, Program theory
Cita:BMC Geriatr 2024 Apr 16; 24 (1) : 346.
Autor/es:Rubæk, Mette (a) Broholm-Jørgensen, Marie (b)
institución:(a) National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. (b) National Research Center for Bone Health, Zealand University Hospital, Køge, Denmark.
Conflicto:Mette Friberg Hitz has received grants from Orkla Care, Denmark, UCB, Ellab Fond, and Amgen and received personal payment in relation to lectures and advisory board meetings. All other authors have no competing interests.
Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2.
Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2.
Fuente:Frontiers in Endocrinology
Extracto:
Bone
manifestations are prevalent, heterogeneous, and silent in CGL1 and CGL2.
Osteolytic lesions are the most common, followed by osteosclerosis and
pseudo-osteopoikilosis. Bone mass is high in most cases. There was no pain
complaint related to bone lesions. Thus, systematic assessment of bone
manifestations in CGL is essential. Studies are needed to better understand its
pathogenesis and clinical consequences.
Claves:Berardinelli-Seip syndrome, bone, bone cyst, bone mineral density, lipodystrophy
Autor/es:Freire, Erika Bastos Lima (a) Brasil d'Alva, Catarina (b)
institución:(a) Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Fortaleza, Brazil. (b) Clinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará/EBSERH, Fortaleza, CE, Brazil.
Conflicto:RMMJ has received grant support and has served as an advisor and/or a consultant to Amryt Pharma, PTC Therapeutics and NovoNordisk. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Changes in acromegaly comorbidities, treatment, and outcome over three decades
Changes in acromegaly comorbidities, treatment, and outcome over three decades
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Estudio de cohortes
Extracto:
Modern medical
treatment regimens of acromegaly as well as increased awareness and improved
diagnostics for its comorbidities have led to better disease control, fewer
patients with severe hypopituitarism, and declining mortality in the Danish
cohort of acromegaly patients. The risk of cancer did not increase over the study
period.
Claves:acromegaly, acromegaly and cancer, acromegaly comorbidities, acromegaly treatment, cancer endocrinology, pituitary adenomas
Autor/es:Rosendal, Christian (a) Arlien-Søborg, Mai Christiansen (b)
institución:(a) Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark. (b) Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Primary stability in locking plate fixation for proximal humeral fractures may be increased by using an additional nail osteosynthesis in combination with locking plate osteosynthesis-A biomechanical comparison.
Primary stability in locking plate fixation for proximal humeral fractures may be increased by using an additional nail osteosynthesis in combination with locking plate osteosynthesis-A biomechanical comparison.
Fuente:Clinical Biomechanics (bristol, Avon)
Extracto:
This combined approach may offer advantages as a treatment for complex proximal
humeral fractures in osteoporotic bone, and specific implants should be developed
to ensure optimal treatment.
Autor/es:Schöbel, Tobias (a) Gemkow, Maximilian (b)
institución:(a) Department of Orthopedic, Trauma, and Plastic Surgery, University of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany. Electronic address: tobias.schoebel@medizin.uni-leipzig.de. (b) Department of Orthopedic, Trauma, and Plastic Surgery, University of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany. Electronic address: maximilian.gemkow@medizin.uni-leipzig.de.
Conflicto:Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Tobias Schoebel reports financial support was provided by German Arthrosis Aid. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this...
paper.
Journal of the American Medical Informatics Association JAMIA
Selección SIIC: 25 Abril, 2024
Journal of the American Medical Informatics Association JAMIA
Genetically guided precision medicine clinical decision support tools
Genetically guided precision medicine clinical decision support tools
Fuente:Journal of The American Medical Informatics Association Jamia
Tipo de trabajo:Revisión sistemática
Extracto:
We recommend that
future research on CDS system implementation for genetically GPM should focus on
implementing more CDS systems, utilization of standards-based approaches,
user-centered design, exploration of alternative forms of CDS interventions, and
use of formal frameworks to systematically evaluate genetic CDS systems and their
effects on patient care.
Claves:clinical decision support systems, electronic health record, genetics, genomics, personalized medicine
Cita:J Am Med Inform Assoc 2024 Apr 19; 31 (5) : 1183-1194.
Autor/es:Johnson, Darren (a) Del Fiol, Guilherme (b)
institución:(a) Department of Genomic Health, Geisinger Health Systems, Danville, PA 17822, United States. (b) Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, United States.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Autor/es:Sircar, Krishnan (a) Weber, Maximilian (b)
institución:(a) Department of Orthopedic and Trauma Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener-Strasse 62, 50937 Cologne, Germany. Electronic address: krishnan.sircar@uk-koeln.de. (b) Department of Orthopedic and Trauma Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener-Strasse 62, 50937 Cologne, Germany.
Conflicto:Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Medical science monitor international medical journal of experimental and clinical research
Selección SIIC: 25 Abril, 2024
Medical science monitor international medical journal of experimental and clinical research
Injury-Admission Time is an Independent Risk Factor for Deep Vein Thrombosis in Older Patients with Osteoporotic Hip Fracture.
Injury-Admission Time is an Independent Risk Factor for Deep Vein Thrombosis in Older Patients with Osteoporotic Hip Fracture.
Fuente:Medical Science Monitor International Medical Journal of Experimental and Clinical Research
Extracto:
Our results suggest that screening for deep vein thrombosis should be
routinely performed for patients with osteoporotic hip fractures, particularly
for those with injury-admission time ≥21 h.
Cita:Med Sci Monit 2024 Apr 14; 30 : e943587.
Autor/es:Cui, Xiuli (a) Liu, Qingjun (b)
institución:(a) Department of Osteo-Internal Medicine, Tianjin Hospital (Tianjin University Tianjin Hospital), Tianjin, China (mainland). (b) Department of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China (mainland).
Conflicto:Los autores declaran no tener conflictos de interés con la investigación