Postoperative care in hypospadias. Common practices and evidence available.

Fuente:Cirugia Pediatrica Organo Oficial de la Sociedad Espanola de Cirugia Pediatrica

Tipo de trabajo:Consenso

Extracto: In the absence of clear evidence for a specific care type, the patient's experience could be used to choose the best postoperative protocol on an individual basis.

Claves:Antibiotic prophylaxis, Hypospadias, Urinary catheters

Cita:Cir Pediatr 2024 Apr 1; 37 (2) : 79-83.

Autor/es:Fuentes Carretero, S (a)
Grande Moreillo, C (b)

institución:(a) Pediatric Surgery Unit. Hospital Universitari Mútua de Terrassa. Terrassa (Barcelona).
(b) Pediatric Surgery Unit. Hospital Universitari Mútua de Terrassa. Terrassa (Barcelona). Consorci Sanitari Alt Penedès i Garraf.

Formato:Informe virtual

Idioma:eng, spa

País de fuente:España

Sitio web:http://dx.doi.org/10.54847/cp.2024.02.17

Non-syndromic Hirschsprung's disease as a result of a RET gene variant.

Fuente:Cirugia Pediatrica Organo Oficial de la Sociedad Espanola de Cirugia Pediatrica

Tipo de trabajo:Caso clínico

Extracto: Mutations such as the RET gene variant highlight the importance of the genetic approach in understanding and managing HD.

Claves:Genetics, Hirschsprung’s disease, Proto-onco gene proteins c-ret

Cita:Cir Pediatr 2024 Apr 1; 37 (2) : 89-92.

Autor/es:Gietz, R (a)
Armando, R (b)

institución:(a) Pediatric General Surgery and Urology Department. Hospital Italiano de Buenos Aires. Buenos Aires, Argentina.
(b) Genetics Unit, Pediatrics Department. Hospital Italiano de Buenos Aires. Buenos Aires, Argentina.

Formato:Informe virtual

Idioma:eng, spa

País de fuente:España

Sitio web:http://dx.doi.org/10.54847/cp.2024.02.19

Purely robotic ileocystoplasty in children: why not? First case in Spain.

Fuente:Cirugia Pediatrica Organo Oficial de la Sociedad Espanola de Cirugia Pediatrica

Tipo de trabajo:Caso clínico

Extracto: We hope this case report will contribute to the divulgation and progressive introduction of robotic surgery in our daily lives.

Claves:Bladder augmentation, Ileocystoplasty, Neurogenic bladder, Robotic surgical procedures

Cita:Cir Pediatr 2024 Apr 1; 37 (2) : 93-98.

Autor/es:Ramos Rodríguez, P (a)
Rodríguez de Alarcón, J (b)

institución:(a) Pediatric Surgery Department. Hospital Clínico Universitario San Carlos. Madrid (Spain).
(b) Pediatric Surgery Department. Hospital Clínico Universitario San Carlos. Madrid (Spain)..

Formato:Informe virtual

Idioma:eng, spa

País de fuente:España

Sitio web:http://dx.doi.org/10.54847/cp.2024.02.20

Efficacy of an external cold and vibrating device in reducing discomfort during the administration of an inferior alveolar nerve block in children: A split-mouth randomised crossover study.

Efficacy of an external cold and vibrating device in reducing discomfort during the administration of an inferior alveolar nerve block in children: A split-mouth randomised crossover study.

Fuente:F1000research

Extracto: Conclusions: The "external cold and vibrating" device reduced discomfort during the administration of an IANB in children selected for the study.

Claves:Analgesia, Dental anaesthesia, Distraction, Local anaesthesia, Nerve block, Paediatric dentistry, Pain, Pain management

Cita:F1000Res 2023; 12 : 984.

Autor/es:H, Ananthu (a)
Rao, Ashwin (b)

institución:(a) Department of Pediatric and Preventive Dentistry, NITTE (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka, India.
(b) Department of Pediatric and Preventive Dentistry, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Conflicto:No competing interests were disclosed.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.12688/f1000research.138340.1

COVID-19 vaccination and the risk of autoimmune diseases: a Mendelian randomization study.

COVID-19 vaccination and the risk of autoimmune diseases: a Mendelian randomization study.

Fuente:Frontiers in Public Health

Extracto: Our study provided potential evidence for the impact of COVID-19 vaccination on the risk of MS and UC occurrence, but it lacks sufficient robustness, which could provide a new idea for public health policy.

Claves:COVID-19, COVID-19 vaccination, Mendelian randomization study, autoimmune diseases, immunity, multiple sclerosis, ulcerative colitis, vaccination

Cita:Front Public Health 2024; 12 : 1322140.

Autor/es:Shan, Jiayi (a)
Hu, Xiaoyun (b)

institución:(a) The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
(b) Department of Pediatrics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2024.1322140

MICA-specific nanobodies for diagnosis and immunotherapy of MICA(+) tumors.

MICA-specific nanobodies for diagnosis and immunotherapy of MICA(+) tumors.

Fuente:Frontiers in Immunology

Extracto: The nanobody-DM1 conjugate selectively kills MICA positive tumor cells in vitro.

Claves:MICA, NKG2D, NKG2D ligands, VHHs, cancer, immuno-oncology, nanobodies, nanobody drug conjugate

Cita:Front Immunol 2024; 15 : 1368586.

Autor/es:Verhaar, Elisha R (a)
Knoflook, Anouk (b)

institución:(a) Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
(b) Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, Netherlands.

Conflicto:Author KW serves on the scientific advisory boards of DEM BioPharma, Solu Therapeutics, D2M Biotherapeutics and Nextechinvest. He is a co-founder of Immunitas Therapeutics and receives sponsored research funding from Novartis and Fate Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict... of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1368586

T-cell count and T-cell telomere length in patients with severe COVID-19.

Fuente:Frontiers in Immunology

Extracto: Shortened T-cell telomeres may be a risk factor for COVID-19-associated T-cell lymphopenia.

Claves:COVID-19, SARS-CoV-2, T-lymphocytes, aging, lymphopenia, sex, telomere

Cita:Front Immunol 2024; 15 : 1356638.

Autor/es:Kraft, Bryan D (a)
Verhulst, Simon (b)

institución:(a) Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC, United States.
(b) Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, Netherlands.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1356638

The Subjective Interpretation of the Medical Evidence.

The Subjective Interpretation of the Medical Evidence.

Fuente:Jama Health Forum

Cita:JAMA Health Forum 2024 Mar 1; 5 (3) : e240213.

Autor/es:Bauchner, Howard (a)
Ioannidis, John P A (b)

institución:(a) Department of Pediatrics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
(b) Visiting Scholars & Researchers Programme, National University of Singapore, Singapore.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamahealthforum.2024.0213

Developing and Testing the Usability of a Novel Child Abuse Clinical Decision Support System: Mixed Methods Study.

Developing and Testing the Usability of a Novel Child Abuse Clinical Decision Support System: Mixed Methods Study.

Fuente:Journal of Medical Internet Research

Extracto: With its user-centered design and evidence-based content, the CA-CDS can aid providers in the real-time recognition and evaluation of infant physical abuse and has the potential to reduce the number of missed cases.

Claves:CDS, child, child abuse, children, clinical decision support, clinical decision support system, natural language processing, pediatrics, physical abuse, usability

Cita:J Med Internet Res 2024 Mar 29; 26 : e51058.

Autor/es:Thomas, Amy (a)
Asnes, Andrea (b)

institución:(a) Department of Pediatrics, Yale University School of Medicine, New Haven, CT, United States.
(b) Department of Pediatrics, Yale University School of Medicine, New Haven, CT, United States.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:http://dx.doi.org/10.2196/51058

Proceedings of the 6th Asia Dengue Summit, June 2023.

Proceedings of the 6th Asia Dengue Summit, June 2023.

Fuente:Plos Neglected Tropical Diseases

Extracto: With more than 51 speakers and 451 delegates from over 24 countries, 10 symposiums, and 2 full days, the 6th ADS highlighted the growing threat of dengue and its antigenic evolution, flagged the urgent need to overcome vaccine hesitancy and misinformation crisis, and focused on dengue control policies, newer diagnostics, therapeutics and vaccines, travel-associated dengue, and strategies to improve community involvement.

Cita:PLoS Negl Trop Dis 2024 Mar; 18 (3) : e0012060.

Autor/es:Srisawat, Nattachai (a)
Gubler, Duane J (b)

institución:(a) Tropical Medicine Cluster, Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Thailand.
(b) Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pntd.0012060

Comparison of raw accelerometry data from ActiGraph, Apple Watch, Garmin, and Fitbit using a mechanical shaker table.

Comparison of raw accelerometry data from ActiGraph, Apple Watch, Garmin, and Fitbit using a mechanical shaker table.

Fuente:Plos One

Extracto: Future studies could explore device-agnostic and harmonization methods for estimating physical activity using the raw accelerometry signals from the consumer wearables studied herein.

Cita:PLoS One 2024; 19 (3) : e0286898.

Autor/es:White, James W 3rd (a)
Finnegan, Olivia L (b)

institución:(a) Department of Exercise Science, University of South Carolina, Columbia, SC, United States of America.
(b) Department of Exercise Science, University of South Carolina, Columbia, SC, United States of America.

Conflicto:I have read the journal’s policy and the authors of this manuscript have the following competing interests: Unrelated to this work Dr. Weaver and Dr. Armstrong report board membership and ownership shares in Trackster LLC. Unrelated to this work Dr. de Zambotti reports grants from Noctrix Health and Verily Life Science LLC (Alphabet Inc.), and is a co-founder and Chief... ef Scientific Officer at Lisa Health Inc. and has ownership of shares in Lisa Health.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0286898

Secondary bone marrow graft loss after third-party virus-specific T cell infusion

Secondary bone marrow graft loss after third-party virus-specific T cell infusion

Fuente:Nature Communications

Tipo de trabajo:Caso clínico

Extracto: This case thus demonstrates a rare but serious side effect of VST therapy.

Cita:Nat Commun 2024 Mar 29; 15 (1) : 2749.

Autor/es:Keller, Michael D (a)
Schattgen, Stefan A (b)

institución:(a) Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, USA.
(b) Division of Allergy and Immunology, Children's National Hospital, Washington, DC, USA.

Conflicto:CMB is on the scientific advisory boards for Catamaran Bio and Mana Therapeutics with stock and/or ownership, is on the Board of Directors for Caballeta Bio with stock options and has stock in Neximmune and Repertoire Immune Medicines and serves on the DSMB of SOBI. MAP is on Advisory boards—Novartis, Gentibio, Bluebird, Vertex, Medexus, Equillium; and Study Support—Adaptive, Miltenyi. PJH... PJH is a Co-founder and Board of Directors: Mana Therapeutics; and Scientific Advisory Board: Cellevolve, Cellenkos, Capsida, MicrofluidX, Discovery Life Sciences. MDK is an author for Elsevier (Uptodate), and has received research funding from Chiesi Pharmaceuticals. SC is on SAB/ Honoraria from SOBI, honoraria from Pharming P.G.T. has consulted and/or received honoraria and travel support from Illumina, Johnson and Johnson, and 10X Genomics. P.G.T. serves on the Scientific Advisory Board of Immunoscape and Cytoagents. The remaining authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-47056-3

Identification and validation of a metabolism-related gene signature for predicting the prognosis of paediatric medulloblastoma.

Identification and validation of a metabolism-related gene signature for predicting the prognosis of paediatric medulloblastoma.

Fuente:Scientific Reports

Extracto: This study could aid in identifying metabolic targets for MB as well as optimizing risk stratification systems and individual treatment plans for MB patients via the use of a metabolism-related gene prognostic risk score signature.

Claves:Medulloblastoma, Metabolic-related genes, Migration and invasion, Ornithine decarboxylase

Cita:Sci Rep 2024 Mar 30; 14 (1) : 7540.

Autor/es:Su, Jun (a)
Xie, Qin (b)

institución:(a) Department of Neurosurgery, The Affiliated Children's Hospital Of Xiangya School of Medicine, Central South University (Hunan children's hospital), No. 86 Ziyuan Road, Changsha, 410007, Hunan, China.
(b) Department of Neurosurgery, Xiangya Hospital, Central South University, No. 86 Xiangya Road, Changsha, 410008, Hunan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-57549-2

Validation of clinical simulation scenarios for the teaching of soft skills in child-centered care.

Validation of clinical simulation scenarios for the teaching of soft skills in child-centered care.

Fuente:Bmc Medical Education

Extracto: We are investigating whether this training leads to better patient outcomes in real clinical settings.

Claves:Child health, Clinical competence, Education, Medical, Simulation training, Students, Undergraduate, Validation study

Cita:BMC Med Educ 2024 Mar 29; 24 (1) : 355.

Autor/es:de Araújo Baptista, Vivianne Izabelle (a)
Braga, Liliane Pereira (b)

institución:(a) Multicampi School of Medical Sciences of Rio Grande Do Norte, Federal University of Rio Grande Do Norte, Rio Grande Do Norte, Caicó, Brazil. vivianne.baptista@ufrn.br.
(b) Graduate Program in Child and Adolescent Health, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. vivianne.baptista@ufrn.br.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12909-024-05284-7

Patients' evaluation of aftercare following hospitalization for COVID-19: satisfaction and unmet needs.

Patients' evaluation of aftercare following hospitalization for COVID-19: satisfaction and unmet needs.

Fuente:Respiratory Research

Tipo de trabajo:Estudio de cohortes

Extracto: Despite the forced quick development of COVID-19 aftercare, patients were generally satisfied. Follow-up by healthcare professionals and information provision is important to meet patients' aftercare needs.

Claves:Aftercare, COVID-19, Healthcare services, Implementation, Long COVID, Patient satisfaction, Unmet needs

Cita:Respir Res 2024 Mar 29; 25 (1) : 145.

Autor/es:Berentschot, Julia C (a)
de Ridder, Willemijn A (b)

institución:(a) Department of Respiratory Medicine, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. j.berentschot@erasmusmc.nl.
(b) Department of Rehabilitation Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Conflicto:All authors have no competing interests related to this work.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12931-024-02748-8

Comparative dosimetric, setup margin, and treatment time analysis between ring gantry and C-Arm linear accelerators for VMAT-based craniospinal irradiation plans.

Comparative dosimetric, setup margin, and treatment time analysis between ring gantry and C-Arm linear accelerators for VMAT-based craniospinal irradiation plans.

Fuente:Journal of Cancer Research and Therapeutics

Extracto: Even though the majority of the delivery parameters such as gantry speed, dose rate, beam characteristic (flatten or unflatten), MLC width, and speed between the ring gantry HAL and C-arm NTx linear accelerators were distinctly different, they offered no or minimal difference in the dose distribution and in the setup margin. HAL gives a faster treatment time delivery, which could be crucial for some selective cases such as patients receiving treatment under general anesthesia.

Cita:J Cancer Res Ther 2024 Jan 1; 20 (1) : 224-231.

Autor/es:Biswal, Subhra S (a)
Sarkar, Biplab (b)

institución:(a) Department of Radiation Oncology, Apolo Multispeciality Hospitals, Kolkata, West Bengal.
(b) Depertment of Physics, GLA University, Mathura, Uttar Pradesh, India.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/jcrt.jcrt_1091_22

Biodosimetric analysis of head and neck cancer patients undergoing radiotherapy by dicentric chromosome aberration assay.

Fuente:Journal of Cancer Research and Therapeutics

Extracto: There is a dose-dependent increase in the yield of DCs in lymphocytes of HNC patients undergoing RT with subsequent fractions. Cisplatin-based chemoradiation is the superior method of treatment intensification radio-biologically proven by higher DC yield.

Cita:J Cancer Res Ther 2024 Jan 1; 20 (1) : 321-326.

Autor/es:Agarwal, Nayan (a)
Rathi, Arun K (b)

institución:(a) Department of Radiation Oncology, Maulana Azad Medical College, New Delhi, India.
(b) Department of Radiation Oncology, Maulana Azad Medical College, New Delhi, India.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/jcrt.jcrt_2058_22

Serum total oxidant and anti-oxidant status in children with cancer.

Fuente:Journal of Cancer Research and Therapeutics

Extracto: It has been revealed for the first time that the serum total anti-oxidant level was high in children undergoing chemotherapy and the survivor group as well. Moreover, the oxidative stress index was low in children with cancer. Longitudinal prospective studies are needed to reveal the alterations in oxidant status among children with cancer.

Cita:J Cancer Res Ther 2024 Jan 1; 20 (1) : 369-374.

Autor/es:Yilmaz, Yasin (a)
Dincaslan, Handan (b)

institución:Yilmaz, Yasin (a)
Dincaslan, Handan (b)

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/jcrt.jcrt_1948_22

FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA.

FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA.

Fuente:Nature Communications

Extracto: We validate the performance with 80 pairs of deep and shallow-coverage whole-genome sequencing and whole-genome bisulfite sequencing data.

Cita:Nat Commun 2024 Mar 30; 15 (1) : 2790.

Autor/es:Liu, Yaping (a)
Reed, Sarah C (b)

institución:(a) Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. lyping1986@gmail.com.
(b) Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, 60611, USA. lyping1986@gmail.com.

Conflicto:Y.L., V.A.A. and M.K. have an approved patent covered FinaleMe (“Methods for genome characterization”, US Patent US11788135B2, date of patent, Oct 17, 2023, filed by MIT and Broad Institute of MIT and Harvard). Y.L. owns stocks from Freenome Inc. V.A.A., G.H. and S.F. are inventors on an approved patent covered ichorCNA (US20190078232A1, “Methods for genome characterization”, date of patent, Mar... ent, Mar 14, 2019, filed by Harvard College, Dana Farber Cancer Institute Inc, Broad Institute of MIT and Harvard) on methods for estimating tumor fraction in cfDNA. VAA is a co-inventor on a patent application covering MAESTRO (US 2023/0203568, “Minor allele enrichment sequencing through recognition oligonucleotides”, pending, filed by Broad Institute of MIT and Harvard), which has been licensed to Exact Sciences, receives sponsored research funding from Exact Sciences, and is a cofounder and advisor to Amplifyer. The remaining authors declare no competing interests. H.Z is currently an employee at Regeneron Pharmaceuticals Inc. and contributed to this article as an employee of Cincinnati Children’s Hospital Medical Center, and the views expressed do not necessarily represent the views of Regeneron Pharmaceuticals Inc.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-47196-6

Supervised representation learning based on various levels of pediatric radiographic views for transfer learning.

Supervised representation learning based on various levels of pediatric radiographic views for transfer learning.

Fuente:Scientific Reports

Extracto: Additionally, visual analyses confirmed that the Model-PedXnets were more focused on meaningful regions of interest.

Claves:Bone age assessment, Deep learning, Fracture classification, Pediatric radiographs, Representation learning, Transfer learning

Cita:Sci Rep 2024 Mar 30; 14 (1) : 7551.

Autor/es:Kyung, Sunggu (a)
Jang, Miso (b)

institución:(a) Department of Biomedical Engineering, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea.
(b) Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58163-y