Antibiotic susceptibility patterns and trends of the gram-negative bacteria isolated from the patients in the emergency departments in China: results of SMART 2016-2019.

Antibiotic susceptibility patterns and trends of the gram-negative bacteria isolated from the patients in the emergency departments in China: results of SMART 2016-2019.

Fuente:Bmc Infectious Diseases

Tipo de trabajo:Guía

Extracto: Gram-negative bacteria collected from Chinese EDs exhibited high resistance to commonly used antibiotics. Susceptibilities were organ specific for different infection sites, knowledge which will be useful for guiding empirical therapies in the clinic.

Claves:Antibiogram, Antibiotic-Resistance, Carbapenem, Cephalosporin, OSWIA, SMART

Cita:BMC Infect Dis 2024 May 17; 24 (1) : 501.

Autor/es:Fu, Ying (a)
Zhao, Feng (b)

institución:(a) Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310016, Hangzhou, Zhejiang Province, China.
(b) Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, 310016, Hangzhou, Zhejiang Province, China.

Conflicto:Pengcheng Li is an employee of MSD China. All other authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12879-024-09294-0

Establishment and validation of a predictive model for tracheotomy in critically ill patients and analysis of the impact of different tracheotomy timing on patient prognosis.

Establishment and validation of a predictive model for tracheotomy in critically ill patients and analysis of the impact of different tracheotomy timing on patient prognosis.

Fuente:Bmc Anesthesiology

Extracto: The prediction model constructed and validated based on the MIMIC-IV database can accurately predict the outcome of tracheotomy in critically ill patients. Meanwhile, early tracheotomy in critically ill patients does not improve survival outcomes but has potential advantages in shortening the duration of hospitalization, IMV, and sedation.

Claves:Intensive care unit, Invasive mechanical ventilation, MIMIC-IV database, Predictive model, Timing of tracheotomy, Tracheotomy

Cita:BMC Anesthesiol 2024 May 17; 24 (1) : 175.

Autor/es:Chen, Xing-Hua (a)
Zhao, Jing-Jing (b)

institución:(a) Department of Intensive Care Unit, Hefei Hospital Affiliated to Anhui Medical University, The Second People's Hospital of Hefei, Hefei, Anhui, 230011, China.
(b) Department of Intensive Care Unit, Hefei Hospital Affiliated to Anhui Medical University, The Second People's Hospital of Hefei, Hefei, Anhui, 230011, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12871-024-02558-x

A prospective, open-label, randomized clinical trial to evaluate the efficacy and safety of remimazolam in patients undergoing EBUS-TBNA: REST trial design.

A prospective, open-label, randomized clinical trial to evaluate the efficacy and safety of remimazolam in patients undergoing EBUS-TBNA: REST trial design.

Fuente:Bmc Pulmonary Medicine

Extracto: Prospectively registered on 15 February 2024.

Claves:Endobronchial ultrasonography, Protocol, Pulmonary medicine, Remimazolam, Sedation

Cita:BMC Pulm Med 2024 May 17; 24 (1) : 243.

Autor/es:Seol, Hee Yun (a)
Hong, Kyung Soo (b)

institución:(a) Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
(b) Division of Pulmonary and Critical Care Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12890-024-03067-w

Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro.

Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro.

Fuente:Particle and Fibre Toxicology

Extracto: It also highlights that even in a healthy population these particles have the potential to induce this type II response and initiate an immune response following exposure to IAP.

Claves:Disease model, Healthy, In vitro, Indoor air pollution, Inhalation, Lung, Particulate matter

Cita:Part Fibre Toxicol 2024 May 17; 21 (1) : 25.

Autor/es:Meldrum, Kirsty (a)
Evans, Stephen J (b)

institución:(a) In Vitro Toxicology Group, Swansea University Medical School, Swansea University, Singleton Park Campus, Swansea, Wales, SA2 8PP, UK. kirsty.meldrum@swansea.ac.uk.
(b) In Vitro Toxicology Group, Swansea University Medical School, Swansea University, Singleton Park Campus, Swansea, Wales, SA2 8PP, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12989-024-00584-8

SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure.

SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure.

Fuente:Trials

Extracto: TRIAL STATUS: Currently enrolling.

Claves:Acute respiratory failure, CDP-choline, COVID-19, Citicoline, Hypoxemia, Influenza, Lung, SARS CoV-2

Cita:Trials 2024 May 18; 25 (1) : 328.

Autor/es:Pannu, Sonal (a)
Exline, Matthew C (b)

institución:(a) Division of Pulmonary, Critical Care and Sleep Medicine of the Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
(b) Division of Pulmonary, Critical Care and Sleep Medicine of the Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.

Conflicto:I.C.D. is the sole inventor on a patent (US 10,874,684) covering use of citicoline as an ARDS therapeutic, which is assigned to the OSU Innovation Foundation. As such, there is the potential that both could profit from the trial should it result in out-licensing of the technology. However, Dr. Davis is not involved in patient enrollment or data analysis and... the OSU Innovation Foundation has played no role in developing or conducting the trial.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13063-024-08155-0

Molecular mechanism of radiation tolerance in lung adenocarcinoma cells using single-cell RNA sequencing.

Molecular mechanism of radiation tolerance in lung adenocarcinoma cells using single-cell RNA sequencing.

Fuente:Journal of Cellular and Molecular Medicine

Extracto: We identified two cellular subpopulations associated with radiotherapy tolerance, which may shed light on the molecular mechanisms of radiotherapy tolerance in LUAD and provide new clinical perspectives.

Claves:TP53, cell subpopulation, lung adenocarcinoma, radiotolerance, single‐cell RNA sequencing

Cita:J Cell Mol Med 2024 May; 28 (10) : e18378.

Autor/es:Chang, Feiyun (a)
Xi, Bozhou (b)

institución:(a) Department of Thoracic Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
(b) The Second Clinical Medical School, Shanxi Medical University, Taiyuan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/jcmm.18378

Diagnosis of Angioimmunoblastic T Cell Lymphoma After Receiving First Dose of Pfizer/BioNTech (BNT162b2) Vaccine

Diagnosis of Angioimmunoblastic T Cell Lymphoma After Receiving First Dose of Pfizer/BioNTech (BNT162b2) Vaccine

Fuente:Journal of Investigative Medicine High Impact Case Reports

Tipo de trabajo:Caso clínico

Extracto: Given the rarity of AITL and the heterogeneity of molecular findings, more studies are needed to establish such an association.

Claves:hematology oncology, immunology, pathology

Cita:J Investig Med High Impact Case Rep 2024 Jan-Dec; 12 : 23247096241231645.

Autor/es:Khatri, Jai Kumar (a)
Tahboub, Ihab (b)

institución:(a) Marshall University, Huntington, WV, USA.
(b) Marshall University, Huntington, WV, USA.

Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1177/23247096241231645

An exosomes-related lncRNA prognostic model correlates with the immune microenvironment and therapy response in lung adenocarcinoma.

An exosomes-related lncRNA prognostic model correlates with the immune microenvironment and therapy response in lung adenocarcinoma.

Fuente:Clinical and Experimental Medicine

Extracto: Our study pioneers an ER-lncRNA-related prognostic model for LUAD, proposing that ERS-based risk stratification could inform personalized treatment strategies to improve patient outcomes.

Claves:Exosome, Long non-coding RNA, Lung adenocarcinoma, Prognostic model, Tumor immune microenvironment

Cita:Clin Exp Med 2024 May 18; 24 (1) : 104.

Autor/es:Chu, Daifang (a)
Chen, Liulin (b)

institución:(a) Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Air Force Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China.
(b) Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Air Force Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China.

Conflicto:The authors have no relevant financial or non-financial interests to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.1007/s10238-024-01319-x

Nitrous oxide respiration in acidophilic methanotrophs.

Nitrous oxide respiration in acidophilic methanotrophs.

Fuente:Nature Communications

Extracto: Such metabolic capability enables these bacteria to simultaneously reduce the release of the key greenhouse gases CO(2), CH(4,) and N(2)O.

Cita:Nat Commun 2024 May 18; 15 (1) : 4226.

Autor/es:Awala, Samuel Imisi (a)
Gwak, Joo-Han (b)

institución:(a) Department of Biological Sciences and Biotechnology, Chungbuk National University, 1 Chungdae-ro, Seowon-Gu, Cheongju, 28644, Republic of Korea.
(b) Center for Ecology and Environmental Toxicology, Chungbuk National University, 1 Chungdae-Ro, Seowon-Gu, Cheongju, 28644, South Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48161-z

Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC.

Fuente:Nature Communications

Extracto: Overall, our findings implicate mitochondrial cysteine metabolism in the induction of ferroptosis and reveal a mechanism of mitochondrial resilience in response to nutrient stress.

Cita:Nat Commun 2024 May 18; 15 (1) : 4244.

Autor/es:Ward, Nathan P (a)
Yoon, Sang Jun (b)

institución:(a) Department of Metabolism & Physiology, Moffitt Cancer Center, Tampa, FL, USA. nathan.ward@moffitt.org.
(b) Department of Metabolism & Physiology, Moffitt Cancer Center, Tampa, FL, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48695-2

Social network analysis of a decade-long collaborative innovation network between hospitals and the biomedical industry in China.

Social network analysis of a decade-long collaborative innovation network between hospitals and the biomedical industry in China.

Fuente:Scientific Reports

Extracto: Policy support and economic investments, strategic collaborative help, and resource and partnership optimization, especially for small players and in less-developed and northwest regions, should be encouraged to enhance collaborative innovation between hospitals and the biomedical industry in China and other similar countries or regions.

Claves:Biomedicine, Collaborative innovation, Hospital, Industry, Network, Social network analysis

Cita:Sci Rep 2024 May 18; 14 (1) : 11374.

Autor/es:Liu, Xiang (a)
Chen, Hong (b)

institución:(a) Affiliated Xihu Hospital, Hangzhou Medical College, Hangzhou, 310000, China.
(b) Department of Respiratory Disease, The 903Rd Hospital of PLA, Hangzhou, 310000, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-62082-3

Efficacy of non-pharmacological interventions for individuals with amyotrophic lateral sclerosis

Fuente:Scientific Reports

Tipo de trabajo:Revisión sistemática

Extracto: The current study findings support a multimodal intervention strategy with an emphasis on EI for slowing disease progression in patients with ALS.

Claves:Amyotrophic lateral sclerosis, Network meta-analysis, Non-pharmacological intervention

Cita:Sci Rep 2024 May 18; 14 (1) : 11365.

Autor/es:Li, Zhao (a)
Kang, Hyunsik (b)

institución:(a) College of Sport Science, Sungkyunkwan University, 2066 Seoburo, Jangan-gu, Suwon, Republic of Korea.
(b) College of Sport Science, Sungkyunkwan University, 2066 Seoburo, Jangan-gu, Suwon, Republic of Korea. hkang@skku.edu.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-62213-w

The effect of deep and awake extubation on emergence agitation after nasal surgery: a randomized controlled trial.

The effect of deep and awake extubation on emergence agitation after nasal surgery: a randomized controlled trial.

Fuente:Bmc Anesthesiology

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: Extubation under deep anesthesia can significantly reduce emergence agitation after nasal surgery under general anesthesia without increasing the incidence of adverse events. TRIAL REGISTRATION: Registered in Clinicaltrials.gov (NCT04844333) on 14/04/2021.

Claves:Emergence agitation, Extubation, Nasal surgery

Cita:BMC Anesthesiol 2024 May 18; 24 (1) : 177.

Autor/es:Suo, Lulu (a)
Lu, Lu (b)

institución:(a) Department of Anaesthesiology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No.639 Zhizaoju Road, Shanghai, 200125, China.
(b) Department of Anaesthesiology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No.639 Zhizaoju Road, Shanghai, 200125, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12871-024-02565-y

Comparative microbiome analysis in cystic fibrosis and non-cystic fibrosis bronchiectasis.

Comparative microbiome analysis in cystic fibrosis and non-cystic fibrosis bronchiectasis.

Fuente:Respiratory Research

Extracto: Bronchiectasis is associated with reduced microbial diversity and a shift in microbial and resistome composition compared to healthy subjects. Despite some similarities, CF and NCFB present significant differences in microbiome composition and antimicrobial resistance profiles, suggesting the need for customized management strategies for each disease.

Claves:Bronchiectasis, Cystic fibrosis, Microbiome, Non-cystic fibrosis, Resistome

Cita:Respir Res 2024 May 18; 25 (1) : 211.

Autor/es:Motta, Heryk (a)
Reuwsaat, Júlia Catarina Vieira (b)

institución:(a) Laboratório de Biologia Molecular de Patógenos, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
(b) Laboratório de Biologia Molecular de Patógenos, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12931-024-02835-w

Ciclesonide Inhibits SARS-CoV-2 Papain-Like Protease in Vitro.

Ciclesonide Inhibits SARS-CoV-2 Papain-Like Protease in Vitro.

Fuente:Biological & Pharmaceutical Bulletin

Extracto: These findings provide insights into the development of PLpro inhibitors.

Claves:ciclesonide, coronavirus disease 2019 (COVID-19), papain-like protease (PLpro), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Cita:Biol Pharm Bull 2024; 47 (5) : 965-966.

Autor/es:Kiba, Yuka (a)
Tanikawa, Takashi (b)

institución:(a) School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University.
(b) School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Japón

Sitio web:http://dx.doi.org/10.1248/bpb.b24-00038

Computational Estimation of Residues Involving Resistance to the SARS-CoV-2 Main Protease Inhibitor Ensitrelvir Based on Virtual Alanine Scan of the Active Site.

Fuente:Biological & Pharmaceutical Bulletin

Extracto: These findings suggest that our research approach can predict mutations that incite drug resistance.

Claves:coronavirus disease 2019 (COVID-19), drug resistance, main protease, molecular dynamics simulation, severe acute respiratory syndrome 2, virtual alanine scan

Cita:Biol Pharm Bull 2024; 47 (5) : 967-977.

Autor/es:Mizuno, Ayato (a)
Nakayoshi, Tomoki (b)

institución:(a) Faculty of Pharmacy, Meijo University.
(b) Faculty of Pharmacy, Meijo University.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Japón

Sitio web:http://dx.doi.org/10.1248/bpb.b24-00031

Monitoring COPD patients: systemic and bronchial eosinophilic inflammation in a 2-year follow-up.

Monitoring COPD patients: systemic and bronchial eosinophilic inflammation in a 2-year follow-up.

Fuente:Bmc Pulmonary Medicine

Extracto: Blood and sputum eosinophils remained stable during the 2 year follow-up and were not associated with worsened symptoms or exacerbations. Almost 30% of mild/moderate COPD patients in bronchodilator therapy at enrollment, received ICS for worsened symptoms in a 2 year-follow-up and only FEV(1)/FVC at T0 seems to predict this addition. History of ischemic heart disease seems to be associated with a progressive increase of blood eosinophils.

Claves:Blood, COPD, Eosinophils, Inhaled corticosteroids, Sputum

Cita:BMC Pulm Med 2024 May 19; 24 (1) : 247.

Autor/es:Pignatti, Patrizia (a)
Visca, Dina (b)

institución:(a) Allergy and Immunology Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Via S.Maugeri 10, Pavia, 27100, Italy. patrizia.pignatti@icsmaugeri.it.
(b) Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12890-024-03062-1

Identifying excessive length of antibiotic treatment duration for hospital-acquired infections: a semi-automated approach to support antimicrobial stewardship.

Fuente:Antimicrobial Resistance and Infection Control

Extracto: Semi-automatic data extraction can yield reliable information about the indication and LOT in treatment courses of hospitalized patients, for both HAI and CAI. This can provide stewardship programs with a surveillance tool for all in-hospital treated infections, which can be used to achieve stewardship goals.

Cita:Antimicrob Resist Infect Control 2024 May 20; 13 (1) : 52.

Autor/es:Kuijpers, Suzanne M E (a)
van Haeringen, Koen J (b)

institución:(a) Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
(b) Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13756-024-01406-4

Reliability, Validity, Modification and Expansion of the Chinese Version of the Disease-Specific Anxiety Questionnaire for Chronic Obstructive Pulmonary Disease.

Reliability, Validity, Modification and Expansion of the Chinese Version of the Disease-Specific Anxiety Questionnaire for Chronic Obstructive Pulmonary Disease.

Fuente:International Journal of Chronic Obstructive Pulmonary Disease

Extracto: The CAF-R-CN had satisfactory reliability and validity and can be used to identify and assess anxiety in COPD patients with a Chinese cultural background.

Claves:Chinese translation, assessment, chronic respiratory disease, fear, scale, specificity

Cita:Int J Chron Obstruct Pulmon Dis 2024; 19 : 1047-1060.

Autor/es:Miao, XiaoLang (a)
Han, Yanxia (b)

institución:(a) Department of Respiratory Medicine, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
(b) Department of Respiratory Medicine, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Nueva Zelanda

Sitio web:http://dx.doi.org/10.2147/COPD.S455171

Rapid respiratory microbiological point-of-care-testing and antibiotic prescribing in primary care

Rapid respiratory microbiological point-of-care-testing and antibiotic prescribing in primary care

Fuente:Plos One

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: TRIAL REGISTRATION: ISRCTN16039192, prospectively registered on 08/11/2022.

Cita:PLoS One 2024; 19 (5) : e0302302.

Autor/es:Abbs, Samantha Elizabeth (a)
Armstrong-Buisseret, Lindsay (b)

institución:(a) Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
(b) Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0302302