The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.

The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.

Fuente:Frontiers in Immunology

Extracto: Taken together, IL-35 gene variation might contribute to a protective role on the susceptibility to PTB, and IL-27 and IL-35 gene polymorphisms were associated with several clinical manifestations of patients with PTB.

Claves:IL-27, IL-35, infectious diseases, pulmonary tuberculosis, single-nucleotide polymorphisms

Cita:Front Immunol 2024; 15 : 1267624.

Autor/es:Gao, Lei (a)
Xiong, Yan-Jun (b)

institución:(a) Anhui Geriatric Institute, Department of Geriatric Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
(b) Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1267624

A machine learning model for the early diagnosis of bloodstream infection in patients admitted to the pediatric intensive care unit.

A machine learning model for the early diagnosis of bloodstream infection in patients admitted to the pediatric intensive care unit.

Fuente:Plos One

Extracto: Our model might help the medical team in clinical-decision making by creating an alert in the electronic medical record, which may allow early antimicrobial initiation and better outcomes.

Cita:PLoS One 2024; 19 (5) : e0299884.

Autor/es:Liporaci, Felipe (a)
Carlotti, Danilo (b)

institución:(a) Department of Pediatrics, Division of Pediatric Critical Care Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
(b) Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299884

Assessment of Illness Severity in Adults Hospitalized With Acute Respiratory Tract Infection due to Influenza, Respiratory Syncytial Virus, or Human Metapneumovirus.

Assessment of Illness Severity in Adults Hospitalized With Acute Respiratory Tract Infection due to Influenza, Respiratory Syncytial Virus, or Human Metapneumovirus.

Fuente:Influenza and Other Respiratory Viruses

Extracto: These findings support the use of PROs (e.g., the RiiQ™) correlating with clinician assessments to gauge patient well-being and aid patient management by accurately assessing respiratory illness severity due to RSV, hMPV, or influenza.

Claves:HARTI, RSV, hMPV, hospitalization, human metapneumovirus, influenza, patient‐reported outcomes, respiratory syncytial virus

Cita:Influenza Other Respir Viruses 2024 May; 18 (5) : e13275.

Autor/es:Falsey, Ann R (a)
Walsh, Edward E (b)

institución:(a) Department of Medicine, University of Rochester, Rochester, New York, USA.
(b) Department of Medicine, University of Rochester, Rochester, New York, USA.

Conflicto:ARF has received research grants from Janssen, Merck Sharp & Dohme, Pfizer, BioFire Diagnostics, Moderna, Vax Co., and CyanVac; consulting fees from Sanofi Pasteur, ADMA Biologics, and Arrowhead; and personal fees for serving on a Data Safety Monitoring Board for Novavax. EEW received grants from Merck, Janssen, and Pfizer and was a paid member of the Data Safety and Monitoring... Board for GSK. SLH received advisory board consulting fees from Janssen Pharmaceuticals. YV is an employee of Janssen Research & Development. MS is a shareholder of Johnson & Johnson and former employee of Janssen Research & Development. EKHC is an employee of Janssen Global Services, LLC, and is a shareholder of Johnson & Johnson. GI is a shareholder of Johnson & Johnson and a former employee of Janssen Global Medical Affairs Infectious Diseases & Vaccines.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/irv.13275

Lack of racial and ethnic disparities in mortality in minority patients hospitalised with COVID-19 in a mid-Atlantic healthcare system.

Lack of racial and ethnic disparities in mortality in minority patients hospitalised with COVID-19 in a mid-Atlantic healthcare system.

Fuente:Bmj Open Respiratory Research

Extracto: However, there continues to remain a need for efforts to address the significant pre-existing race and ethnicity inequities highlighted by the COVID-19 pandemic to be better prepared for future public health emergencies.

Claves:COVID-19, Critical Care, Respiratory Infection, Viral infection

Cita:BMJ Open Respir Res 2024 May 1; 11 (1)

Autor/es:Galiatsatos, Panagis (a)
Garibaldi, Brian (b)

institución:(a) Johns Hopkins Medicine, Baltimore, Maryland, USA.
(b) Johns Hopkins Medicine, Baltimore, Maryland, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjresp-2024-002310

The Role of Human Mobility Flow in the Region-to-Region Spread of Respiratory Syncytial Virus Infection among Infants: An Infographic Analysis.

The Role of Human Mobility Flow in the Region-to-Region Spread of Respiratory Syncytial Virus Infection among Infants: An Infographic Analysis.

Fuente:Biological & Pharmaceutical Bulletin

Extracto: While social implementation of infection control measures has successfully suppressed the droplet-mediated respiratory infections, such as influenza, but not the airborne infections, it was suggested that the aerosol transmission and adult asymptomatic carrier were involved in the transmission of RSV akin to COVID-19.

Claves:human mobility flow, infection control measures, region-to-region spread, respiratory syncytial virus (RSV), social implementation, transmission mode

Cita:Biol Pharm Bull 2024; 47 (5) : 924-929.

Autor/es:Sasaki, Hide (a)
Seoka, Ryo (b)

institución:(a) Department of Microbiology and Infection Control, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University.
(b) Department of Microbiology and Infection Control, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Japón

Sitio web:http://dx.doi.org/10.1248/bpb.b23-00767

An eco-friendly and cost-effective HPTLC method for quantification of COVID-19 antiviral drug and co-administered medications in spiked human plasma.

An eco-friendly and cost-effective HPTLC method for quantification of COVID-19 antiviral drug and co-administered medications in spiked human plasma.

Fuente:Scientific Reports

Tipo de trabajo:Guía

Extracto: The method's greenness was assessed using Analytical Eco-scale, GAPI, and AGREE metrics.

Claves:COVID-19 antiviral, Remdesivir, Spiked human plasma, TLC, The method’s greenness

Cita:Sci Rep 2024 May 1; 14 (1) : 10025.

Autor/es:Ghozzy, Ekram A (a)
El-Enany, Nahed M (b)

institución:(a) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 35712, Egypt.
(b) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-56923-4

Characteristics and outcomes of patients admitted to intensive care units in Uganda

Fuente:Scientific Reports

Tipo de trabajo:Estudio multicéntrico

Extracto: It not only adds to the global body of knowledge on ICU care in resource-limited settings but also serves as a foundation for future research and policy initiatives aimed at optimizing ICU care in Sub-Saharan Africa.

Claves:Intensive care unit, Low-income country, Mortality, Patient characteristics, Risk factors

Cita:Sci Rep 2024 Apr 30; 14 (1) : 9963.

Autor/es:Atumanya, Patience (a)
Agaba, Peter K (b)

institución:(a) Uganda Cancer Institute, Kampala, Uganda.
(b) Makerere University, Kampala, Uganda.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59031-5

The effects of real-time waveform analysis software on patient ventilator synchronization during pressure support ventilation: a randomized crossover physiological study.

The effects of real-time waveform analysis software on patient ventilator synchronization during pressure support ventilation: a randomized crossover physiological study.

Fuente:Bmc Pulmonary Medicine

Tipo de trabajo:Estudio clínico

Extracto: IntelliSync + software reduced inspiratory trigger delay time compared to the conventional flow trigger system during PSV mode. However, no significant improvements in cycle delay time and other physiological variables were observed with IntelliSync + software. TRIAL REGISTRATION: This study was registered in the Thai Clinical Trial Registry (TCTR20200528003; date of registration 28/05/2020).

Claves:Asynchrony, Esophageal pressure, Patient-ventilator interaction, Pressure support ventilation

Cita:BMC Pulm Med 2024 May 1; 24 (1) : 212.

Autor/es:Nakornnoi, Barnpot (a)
Tscheikuna, Jamsak (b)

institución:(a) Division of Respiratory Diseases and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
(b) Division of Respiratory Diseases and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12890-024-03039-0

Towards a better diagnosis of mouth breathing: validity and reliability of a protocol for assessing the awake breathing pattern in preschool children.

Towards a better diagnosis of mouth breathing: validity and reliability of a protocol for assessing the awake breathing pattern in preschool children.

Fuente:Codas

Tipo de trabajo:Consenso

Extracto: The reference tool based on CO2 data was used in children for the first time and was found to be reliable. The ABPA is a suitable tool for SLPs to confirm the diagnosis of mouth breathing in preschool children if more sensitive screening tools, like parental questionnaires, are used beforehand.

Cita:Codas 2024; 36 (3) : e20220330.

Autor/es:Warnier, Morgane (a)
Piron, Léonor (b)

institución:(a) Department of Speech-Language Pathology, Research Unit for a life-Course Perspective on Health and Education, University of Liège, Liège, Belgium.
(b) Department of Speech-Language Pathology, Research Unit for a life-Course Perspective on Health and Education, University of Liège, Liège, Belgium.

Conflicto:Conflict of interests: nothing to declare.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Brasil

Sitio web:http://dx.doi.org/10.1590/2317-1782/20242022330en

The prone position in COVID-19 impacts the thickness of peripapillary retinal nerve fiber layers and macular ganglion cell layers.

The prone position in COVID-19 impacts the thickness of peripapillary retinal nerve fiber layers and macular ganglion cell layers.

Fuente:Plos One

Extracto: Consequently, there is no increase in COVID-19 patients' morbidity burden.

Cita:PLoS One 2024; 19 (5) : e0300621.

Autor/es:Chirapapaisan, Niphon (a)
Eiamsamarng, Akarawit (b)

institución:(a) Faculty of Medicine Siriraj Hospital, Department of Ophthalmology, Mahidol University, Bangkok, Thailand.
(b) Faculty of Medicine Siriraj Hospital, Department of Ophthalmology, Mahidol University, Bangkok, Thailand.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300621

Effects of mechanical insufflation-exsufflation on ventilator-free days in intensive care unit subjects with sputum retention; a randomized clinical trial.

Fuente:Plos One

Tipo de trabajo:Estudio abierto

Extracto: In ventilated subjects in the ICU with high sputum retention, the use of MI-E did not significantly increase the number of ventilator-free days over that with conventional care.

Cita:PLoS One 2024; 19 (5) : e0302239.

Autor/es:Kubota, Shota (a)
Hashimoto, Hideki (b)

institución:(a) Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Ibaraki, Japan.
(b) Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Ibaraki, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0302239

Impact of COVID-19 on asthma management in general practice: A qualitative study.

Fuente:Australian Journal of General Practice

Tipo de trabajo:Guía

Extracto: These lessons can be used to re-evaluate how we deliver asthma care and inform future models of care as we transition towards a 'post-COVID' landscape.

Cita:Aust J Gen Pract 2024 May; 53 (5) : 327-331.

Autor/es:Ling, Louisa (a)
Bosnic-Anticevich, Sinthia (b)

institución:(a) MBBS, FRACGP, DCH, Academic Registrar and Lecturer, The University of Notre Dame Australia School of Medicine Sydney Campus, School of Medicine, Darlinghurst, NSW; General Practitioner, Sydney, NSW.
(b) BPharm (Hons), PhD, Professor and Team Leader, Quality Use of Respiratory Medicines Use Group, Woolcock Institute, University of Sydney, Sydney Local Health District, NSW.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Australia

Sitio web:http://dx.doi.org/10.31128/AJGP-06-22-6466

Unravelling the health and economic burden of interstitial lung diseases in adults in Australia.

Fuente:Australian Journal of General Practice

Tipo de trabajo:Revisión

Extracto: Early diagnosis and referral to tertiary care is crucial for favourable outcomes, and general practitioners are considerably important to this as the first interface to identify patients at risk and detect early symptoms of ILDs.

Cita:Aust J Gen Pract 2024 May; 53 (5) : 333-336.

Autor/es:Cox, Ingrid A (a)
de Graaff, Barbara (b)

institución:(a) MD, Grad Cert (Economics), MSc, PhD, Postdoctoral Research Fellow, Menzies Institute for Medical Research, University of Tasmania, Hobart, Tas; Researcher, NHMRC Centre of Research Excellence for Pulmonary Fibrosis, Sydney, NSW.
(b) PhD, Senior Research Fellow, Menzies Institute for Medical Research, University of@Tasmania, Hobart, Tas.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Australia

Sitio web:http://dx.doi.org/10.31128/AJGP-02-23-6713

Impact of patient support programmes among patients with severe asthma treated with biological therapies

Impact of patient support programmes among patients with severe asthma treated with biological therapies

Fuente:Bmj Open Respiratory Research

Tipo de trabajo:Revisión

Extracto: PSPs contribute to positive clinical outcomes in patients with severe asthma on biological treatment. Future analyses will benefit from thorough descriptions of PSP services, and study designs that allow direct comparisons of patient outcomes with and without a PSP.

Claves:Asthma

Cita:BMJ Open Respir Res 2024 May 2; 11 (1)

Autor/es:Rabe, Adrian P J (a)
Loke, Wei J (b)

institución:(a) AstraZeneca UK Limited, Cambridge, UK submissions@pshta.com.
(b) Imperial College London, London, London, UK.

Conflicto:Competing interests: DK and TM are employees of AstraZeneca; APJR and VHS were employees of AstraZeneca at the time the study was conducted; LO is an employee of Cytel contracted by AstraZeneca; MGM, ZL and SH are employees of Cytel who was contracted by AstraZeneca for support in conducting this study; WJL is an external consultant at Wei Medical Consultancy... and a medical doctor affiliated with Royal Free NHS Trust; LGH has received grant funding, participated in advisory boards and given lectures at meetings supported by Amgen, AstraZeneca, Boehringer Ingelheim, Chiesi, Circassia, Hoffmann la Roche, GlaxoSmithKline, Novartis, Theravance, Evelo Biosciences, Sanofi and Teva; he has received grants from MedImmune, Novartis UK, Roche/Genentech and GlaxoSmithKline, Amgen, Genentech/Hoffman la Roche, AstraZeneca, MedImmune, GlaxoSmithKline, Aerocrine and Vitalograph; he has received sponsorship for attending international scientific meetings from AstraZeneca, Boehringer Ingelheim, Chiesi, GSK and Napp Pharmaceuticals; he has also taken part in asthma clinical trials sponsored by AstraZeneca, Boehringer Ingelheim, Hoffmann la Roche and GlaxoSmithKline for which his institution received remuneration; he is the Academic Lead for the Medical Research Council Stratified Medicine UK Consortium in Severe Asthma which involves industrial partnerships with a number of pharmaceutical companies including Amgen, AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Hoffmann la Roche and Janssen.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjresp-2023-001799

Single and multiple breath nitrogen washout compared with the methacholine test in patients with suspected asthma and normal spirometry.

Fuente:Bmj Open Respiratory Research

Extracto: Both MCT and N(2) washout tests are frequently pathological in patients with suspicion of asthma with normal spirometry. The weak association and lack of concordance across the tests highlight that they reflect different but not interchangeable pathological pathways of the disease.

Claves:Asthma, Asthma Mechanisms, Exhaled Airway Markers, Respiratory Measurement

Cita:BMJ Open Respir Res 2024 May 2; 11 (1)

Autor/es:Siebeneichler, Aline Stalder (a)
Schumann, Desiree M (b)

institución:(a) Clinic of Pneumology, University Hospital Basel, Basel, Switzerland.
(b) Clinic of Pneumology, University Hospital Basel, Basel, Switzerland.

Conflicto:Competing interests: DS (second author) is currently employed at Tillotts Pharma AG, however, during the period of the study was an employee of the University Hospital of Basel. AMD has received a grant from University Hospital Basel, PL has a grant/contract to Vertex and OM Pharma. DS (last author) reports grants from Astra-Zeneca AG, Curetis AG, BostonScientific, Novartis AG, GSK... AG, Roche AG, Zambon, Pfizer, Schwabe Pharma AG, Vifor AG. Other authors have no conflict of interest to declare.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjresp-2023-001919

Determinants of multidrug-resistant tuberculosis among adults undergoing treatment for tuberculosis in Tigray Region, Ethiopia: a case-control study.

Fuente:Bmj Open Respiratory Research

Extracto: Rural residence, HIV, relapses, return after lost follow-up and treatment failure were the identified determinant factors of multidrug-resistance tuberculosis.

Claves:Bacterial Infection, Infection Control, Opportunist lung infections, Patient Outcome Assessment, Pulmonary Disease, Chronic Obstructive, Rare lung diseases, Respiratory Infection, Tuberculosis

Cita:BMJ Open Respir Res 2024 May 2; 11 (1)

Autor/es:Zereabruk, Kidane (a)
Kahsay, Tensay (b)

institución:(a) Adult health Nursing, Aksum University College of Health Science and Medicine, Axum, Ethiopia zereabrukkidane@gmail.com.
(b) Nursing, Mekelle University College of Health Sciences, Mekelle, Tigray, Ethiopia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjresp-2023-001999

Singing for lung health in COPD

Fuente:Bmj Open Respiratory Research

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: A 12-week online SLH programme can improve the physical component of quality of life for people with COPD, but the overall effect is relatively modest compared with the impact seen in research using face-to-face group sessions. Further work on the content, duration and dose of online interventions may be useful. TRIAL REGISTRATION NUMBER: NCT04034212.

Claves:Complementary Medicine, Emphysema, Exercise, Pulmonary Rehabilitation, Respiratory Muscles

Cita:BMJ Open Respir Res 2024 May 2; 11 (1)

Autor/es:Philip, Keir E J (a)
Buttery, Sara C (b)

institución:(a) National Heart and Lung Institute, Imperial College London, London, UK k.philip@imperial.ac.uk.
(b) Respiratory Medicine, Royal Brompton and Harefield Hospitals, London, UK.

Conflicto:Competing interests: EJ is a SLH session leader, and ALe and PC train SLH session leaders. However, these authors were not involved in data collection or analysis.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjresp-2024-002365

Loss and gain of ceftazidime-avibactam susceptibility in a non-carbapenemase-producing K1-ST23 hypervirulent Klebsiella pneumoniae.

Loss and gain of ceftazidime-avibactam susceptibility in a non-carbapenemase-producing K1-ST23 hypervirulent Klebsiella pneumoniae.

Fuente:Virulence

Extracto: In summary, we reported the rare ceftazidime-avibactam resistance in a non-carbapenemase-producing hvKp strain. Resistance plasmid carrying bla(CTX-M-71) and mutated OmpK36 had a synergetic effect on the resistance.

Claves:CTX-M-71, Hypervirulent Klebsiella pneumoniae, OmpK36, ceftazidime-avibactam resistance, non-carbapenemase-producing strain

Cita:Virulence 2024 Dec; 15 (1) : 2348251.

Autor/es:Zhao, Jiankang (a)
Pu, Danni (b)

institución:(a) National Center for Respiratory Medicine, Beijing, China.
(b) State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China.

Conflicto:No potential conflict of interest was reported by the author(s).

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1080/21505594.2024.2348251

Atmosphere particulate matter and respiratory diseases during COVID-19 in Korea.

Atmosphere particulate matter and respiratory diseases during COVID-19 in Korea.

Fuente:Scientific Reports

Extracto: Our study may provide evidence that implementing NPIs and reducing PM(10) and PM(2.5) exposure during the COVID-19 pandemic has contributed to reducing hospital admissions for environment-based respiratory diseases.

Cita:Sci Rep 2024 May 2; 14 (1) : 10074.

Autor/es:Hong, Ji Young (a)
Bang, Taemo (b)

institución:(a) Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University Medical Center, Chuncheon-si, Gangwon-do, 24253, Republic of Korea.
(b) AI Product Team, Gmarket, Seoul, Republic of Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59643-x

On the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation.

Fuente:Scientific Reports

Extracto: The mechanisms of wogonin on AML-M5 treatment may be associated with inhibiting cell proliferation and regulating the cell cycle via the PI3K/AKT signaling pathway.

Cita:Sci Rep 2024 May 2; 14 (1) : 10114.

Autor/es:Wang, Xixi (a)
Wang, Yanfei (b)

institución:(a) Center for Clinical Medicine Research, The First People's Hospital of Yunnan Province (Affiliated Hospital of Kunming University of Science and Technology), Kunming, 650032, China.
(b) Medical school, Kunming University of Science and Technology, Kunming, 650032, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-60859-0