Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo.

Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo.

Fuente:Embo Reports

Extracto: In this review, we discuss several examples of TEs expressed during embryo development, their potential for co-option in genome regulation and the evolutionary pressures on TEs and on our genomes.

Claves:Genome Evolution, Genome Regulation, Preimplantation Development, Transposable Elements

Cita:EMBO Rep 2024 Apr; 25 (4) : 1721-1733.

Autor/es:Oomen, Marlies E (a)
Torres-Padilla, Maria-Elena (b)

institución:(a) Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, München, Germany.
(b) Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, München, Germany. torres-padilla@helmholtz-muenchen.de.

Conflicto:METP is member of the ethics advisory panel of MERCK. The other authors declare no conflict of interest. METP is a member of the Advisory Editorial Board of EMBO reports. This has no bearing on the editorial consideration of this article for publication.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s44319-024-00118-5

Assessment of transparency indicators in space medicine.

Assessment of transparency indicators in space medicine.

Fuente:Plos One

Extracto: Enhancing transparency in space medicine research is imperative for safeguarding its scientific rigor and reproducibility.

Cita:PLoS One 2024; 19 (4) : e0300701.

Autor/es:Bellomo, Rosa Katia (a)
Zavalis, Emmanuel A (b)

institución:(a) Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, United States of America.
(b) Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300701

Incidence of hypopituitarism in adults undergoing radiotherapy for neck and head cancer

Incidence of hypopituitarism in adults undergoing radiotherapy for neck and head cancer

Fuente:Bmj Open

Tipo de trabajo:Revisión sistemática

Extracto: PROSPERO REGISTRATION NUMBER: CRD42021235163.

Claves:Head & neck tumours, Pituitary disorders, RADIOTHERAPY

Cita:BMJ Open 2024 Apr 3; 14 (4) : e078595.

Autor/es:Barros-Sevillano, Shamir (a)
Cabanillas-Lazo, Miguel (b)

institución:(a) Facultad de Ciencias de la Salud, Escuela de Medicina, Universidad César Vallejo, Trujillo, Peru Shamir.bs17@gmail.com.
(b) Sociedad Científica de Estudiantes de Medicina de la Universidad César Vallejo, Trujillo, Peru.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-078595

Self-identified rurality in a nationally representative population in the US.

Self-identified rurality in a nationally representative population in the US.

Fuente:Rural and Remote Health

Extracto: Reclassification of RUCA 2-3 as rural represents a more patient-centric definition of rurality.

Claves:RUCA, US, population, survey, patient-centric

Cita:Rural Remote Health 2024 Jan; 24 (1) : 8483.

Autor/es:Krutsinger, Dustin C (a)
Yadav, Kuldeep N (b)

institución:(a) Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
(b) Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Australia

Sitio web:http://dx.doi.org/10.22605/RRH8483

Developer perspectives on the ethics of AI-driven neural implants: a qualitative study.

Developer perspectives on the ethics of AI-driven neural implants: a qualitative study.

Fuente:Scientific Reports

Tipo de trabajo:Estudio clínico

Extracto: We discuss strategies to mitigate these challenges.

Claves:Amyotrophic lateral sclerosis, Blindness, Deafness, Ethics, Locked-in-syndrome, Neuromodulation

Cita:Sci Rep 2024 Apr 3; 14 (1) : 7880.

Autor/es:van Stuijvenberg, Odile C (a)
Broekman, Marike L D (b)

institución:(a) Department of Bioethics and Health Humanities, Julius Center, University Medical Center Utrecht, Utrecht University, 3508 GA, Utrecht, The Netherlands. o.c.vanstuijvenberg-2@umcutrecht.nl.
(b) Department of Neurosurgery, Haaglanden Medical Center, 2512 VA, The Hague, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58535-4

"It is very hard to just accept this" - a qualitative study of palliative care teams' ethical reasoning when patients do not want information.

"It is very hard to just accept this" - a qualitative study of palliative care teams' ethical reasoning when patients do not want information.

Fuente:Bmc Palliative Care

Extracto: In their work with dying patients, palliative care staff meet many autonomy challenges. When faced with a choice to withhold information as per a patient's wishes, or to provide information with the patient's best interest in mind, staff find it hard to balance competing values. Staff also find it hard to balance their own interests against a purely professional stance. The overall strategy seems to be to look for caring ways to impart the information.

Claves:Autonomy, Beneficence, Health care staff, Informed consent, Palliative care, Qualitative research

Cita:BMC Palliat Care 2024 Apr 5; 23 (1) : 91.

Autor/es:Autonomy, Beneficence, Health care staff, Informed consent, Palliative care, Qualitative research

institución:(a) Centre for Research Ethics and Bioethics (CRB), Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. joar.bjork@crb.uu.se.
(b) Department of Research and Development, Region Kronoberg, Växjö, Sweden. joar.bjork@crb.uu.se.

Conflicto:The author declares no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12904-024-01412-8

Ethical use of artificial intelligence to prevent sudden cardiac death: an interview study of patient perspectives.

Ethical use of artificial intelligence to prevent sudden cardiac death: an interview study of patient perspectives.

Fuente:Bmc Medical Ethics

Tipo de trabajo:Guía

Extracto: The 'human touch' patients exclusively ascribe to human medical practitioners extends beyond sympathy and kindness, and has clinical relevance in medical decision-making. Because this cannot be replaced by AI, we suggest that normative research into the 'right to a human doctor' is needed. Furthermore, policies on patient-centered AI integration in clinical practice should encompass the ethics of everyday practice rather than only principle-based ethics. We suggest that an empirical ethics approach grounded in ethnographic research is exceptionally well-suited to pave the way forward.

Claves:Artificial intelligence, Ethics, Implantable cardioverter defibrillator, PROFID, Patient values, Personalized medicine, Sudden cardiac death

Cita:BMC Med Ethics 2024 Apr 4; 25 (1) : 42.

Autor/es:Maris, Menno T (a)
Koçar, Ayca (b)

institución:(a) Department of Ethics, Law and Humanities, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. m.t.maris@amsterdamumc.nl.
(b) Institute for Healthcare Management and Health Sciences, University of Bayreuth, Bayreuth, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12910-024-01042-y

Letermovir prophylaxis for cytomegalovirus in lung-transplant recipients

Letermovir prophylaxis for cytomegalovirus in lung-transplant recipients

Fuente:Clinical and Experimental Medicine

Tipo de trabajo:Revisión

Extracto: However, careful consideration is important in judiciously integrating letermovir into the treatment protocol.

Claves:Cytomegalovirus, Letermovir, Lung transplant, Off-label use, Prophylaxis

Cita:Clin Exp Med 2024 Apr 5; 24 (1) : 68.

Autor/es:Hirama, Takashi (a)
Shundo, Yuki (b)

institución:(a) Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan. takashi.hirama.b5@tohoku.ac.jp.
(b) Division of Organ Transplantation, Tohoku University Hospital, Sendai, Miyagi, Japan. takashi.hirama.b5@tohoku.ac.jp.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.1007/s10238-024-01330-2

What are the bottlenecks to health data sharing in Switzerland? An interview study.

What are the bottlenecks to health data sharing in Switzerland? An interview study.

Fuente:Swiss Medical Weekly

Tipo de trabajo:Estudio clínico

Extracto: Facilitating a data access culture in Switzerland may require legal clarifications, further education about the process and resources to support data sharing, and further investment in sustainable infrastructureby funders and institutions.

Cita:Swiss Med Wkly 2024 Jan 22; 154 : 3538.

Autor/es:Ormond, Kelly E (a)
Bavamian, Sabine (b)

institución:(a) D-HEST, Health Ethics and Policy Lab, ETH-Zurich, Zurich, Switzerland.
(b) Swiss Biobanking Platform, Epalinges, Switzerland.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.57187/s.3538

Developing a questionnaire to evaluate an automated audit & feedback intervention: a Rand-modified Delphi method.

Developing a questionnaire to evaluate an automated audit & feedback intervention: a Rand-modified Delphi method.

Fuente:Bmc Health Services Research

Tipo de trabajo:Consenso

Extracto: A questionnaire consisting of 30 questions was drawn up for the assessment and improvement of automated A&F systems, based on CP-FIT and REFLECT-52 theory and approved by experts. Next steps will be piloting and implementation of the questionnaire.

Claves:Audit and feedback, Delphi method, Medical audit, Process evaluation, Quality of health care, Questionnaire

Cita:BMC Health Serv Res 2024 Apr 5; 24 (1) : 433.

Autor/es:Van den Wyngaert, Ine (a)
Van Pottelbergh, Gijs (b)

institución:(a) Academic Centre for General Practice, Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium. ine.vandenwyngaert@kuleuven.be.
(b) Academic Centre for General Practice, Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12913-024-10915-2

Advancing kidney xenotransplantation with anesthesia and surgery - bridging preclinical and clinical frontiers challenges and prospects.

Advancing kidney xenotransplantation with anesthesia and surgery - bridging preclinical and clinical frontiers challenges and prospects.

Fuente:Frontiers in Immunology

Extracto: Addressing these challenges through rigorous research and collective collaboration will be the key, not only to navigate the ethical, medical, and logistical complexities of introducing kidney xenotransplantation into mainstream clinical practice, but also itself marks a new era in organ transplantation.

Claves:anesthesia, genetically modified pigs, immunological compatibility, immunotherapy, organ rejection, surgical techniques, xenogeneic kidney transplantation

Cita:Front Immunol 2024; 15 : 1386382.

Autor/es:Zhang, Xiaojian (a)
Wang, Hailian (b)

institución:(a) Central of Reproductive Medicine, Department of Obstetrics and Gynecology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
(b) Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1386382

Physical therapy interventions for people experiencing homelessness to improve pain and self-perceived health status.

Physical therapy interventions for people experiencing homelessness to improve pain and self-perceived health status.

Fuente:Bmc Public Health

Extracto: This study demonstrates the potentially negative impact of untreated pain on the self-perceived health of homeless individuals with musculoskeletal disorders that should be targeted for consideration. The findings suggest that a paradigm shift in pain management, including a physical therapy service in shelters, is needed to address the rehabilitation demands of these individuals in a real-life context. This study was approved by the Aragon Ethics Committee (PI19/438) and performed according to the Transparent Reporting of Evaluations with Nonrandomized Designs (TREND) statement.

Claves:Homelessness, Musculoskeletal disorders, Pain, People experiencing homelessness, Physical therapy, Self-perceived health, Self-rated health

Cita:BMC Public Health 2024 Apr 9; 24 (1) : 993.

Autor/es:Jiménez-Sánchez, Carolina (a)
la Cruz, Natalia Brandín-de (b)

institución:(a) Department of Physical Therapy, Faculty of Health Sciences, Universidad San Jorge, Villanueva de Gállego, Zaragoza, Spain.
(b) IIS Aragón, Zaragoza, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-024-18453-6

Embracing ChatGPT for Medical Education: Exploring Its Impact on Doctors and Medical Students.

Embracing ChatGPT for Medical Education: Exploring Its Impact on Doctors and Medical Students.

Fuente:Jmir Medical Education

Extracto: By emphasizing ethical considerations and human-centric approaches, ChatGPT's potential can be fully harnessed in medical education, benefiting both students and patients alike.

Claves:AI, ChatGPT, artificial intelligence, doctors, medical education, medical students

Cita:JMIR Med Educ 2024 Apr 10; 10 : e52483.

Autor/es:Wu, Yijun (a)
Zheng, Yue (b)

institución:(a) Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
(b) Laboratory of Clinical Cell Therapy, West China Hospital, Sichuan University, Chengdu, China.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:http://dx.doi.org/10.2196/52483

A systematic scoping review of group reflection in medical education.

A systematic scoping review of group reflection in medical education.

Fuente:Bmc Medical Education

Tipo de trabajo:Revisión

Extracto: Scaffolded by current approaches to individual reflections and theories and inculcated with nuanced adaptations from other medical practices, this SSR in SEBA suggests that structured group reflections may fill current gaps in training. However, design and assessment of the evidence-based structuring of group reflections proposed here must be the focus of future study.

Claves:Group reflections, Medical education, Postgraduate medical education, Professional identity formation, Reflection, Undergraduate medical education

Cita:BMC Med Educ 2024 Apr 10; 24 (1) : 398.

Autor/es:Phua, Gillian Li Gek (a)
Owyong, Jasmine Lerk Juan (b)

institución:(a) Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 11, Singapore, Singapore.
(b) Division of Supportive and Palliative Care, National Cancer Centre Singapore, Singapore, Singapore.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12909-024-05203-w

User Information Sharing and Hospital Website Privacy Policies.

User Information Sharing and Hospital Website Privacy Policies.

Fuente:Jama Network Open

Extracto: AND RELEVANCE: In this cross-sectional study of hospital website privacy policies, a substantial number of hospital websites did not present users with adequate information about the privacy implications of website use, either because they lacked a privacy policy or had a privacy policy that contained limited content about third-party recipients of user information.

Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e245861.

Autor/es:McCoy, Matthew S (a)
Wu, Angela (b)

institución:(a) Department of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia.
(b) Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia.

Conflicto:Conflict of Interest Disclosures: Dr McCoy reported being an unpaid member of the University of Pennsylvania’s Data Ethics Working Group, which was funded, in part, by a gift from Deloitte to the University of Pennsylvania. Dr Friedman reported receiving grants from the National Institute on Aging outside the submitted work. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.5861

Conflicts of Interest Among Cardiology Clinical Practice Guideline Authors in Japan.

Conflicts of Interest Among Cardiology Clinical Practice Guideline Authors in Japan.

Fuente:Journal of The American Heart Association

Tipo de trabajo:Guía de práctica clínica

Extracto: The study elucidated that there were considerable financial relationships between pharmaceutical companies and cardiology CPG authors in Japan. This finding deviates from international conflict of interest management policies, suggesting the need for more stringent conflict of interest management strategies by the Japanese Circulation Society to ensure the development of trustworthy and evidence-based CPGs.

Claves:cardiology, clinical practice guideline, conflict of interest, health policy, medical ethics

Cita:J Am Heart Assoc 2024 Apr 16; 13 (8) : e034506.

Autor/es:Murayama, Anju (a)
Aizawa, Megumi (b)

institución:(a) Tohoku University School of Medicine Sendai Miyagi Japan.
(b) Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai New York NY USA.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1161/JAHA.124.034506

Temporal and geographical variations in diagnostic imaging in Norway.

Temporal and geographical variations in diagnostic imaging in Norway.

Fuente:Bmc Health Services Research

Extracto: As the population in Norway is homogeneous it is difficult to attribute the variations to socio-economic or demographic factors. Unwarranted and supply-sensitive variations are challenging for healthcare systems where equal access and justice traditionally are core values.

Claves:CT, Efficiency, Imaging, MRI, Quality, Radiograph, Safety, Ultrasound, Variation

Cita:BMC Health Serv Res 2024 Apr 12; 24 (1) : 463.

Autor/es:Hofmann, Bjørn Morten (a)
Brandsaeter, Ingrid Øfsti (b)

institución:(a) Department of Health Sciences Gjøvik, Norwegian University of Science and Technology (NTNU), NTNU Gjøvik, PO Box 191, 2802, Gjøvik, Norway. bjoern.hofmann@ntnu.no.
(b) Centre for Medical Ethics, University of Oslo, PO Box 1130, 0318, Blindern, Oslo, Norway. bjoern.hofmann@ntnu.no.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12913-024-10869-5

Genetic Researchers' Use of and Interest in Research With Diverse Ancestral Groups.

Genetic Researchers' Use of and Interest in Research With Diverse Ancestral Groups.

Fuente:Jama Network Open

Extracto: AND RELEVANCE: In this survey study of US genetic researchers, respondents reported existing databases only provide adequate ancestral samples for European populations, despite their interest in other ancestral populations. These findings suggest there are specific gaps in access to and composition of genetic databases, highlighting the urgent need to boost diversity in research samples to improve inclusivity in genetic research practices.

Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e246805.

Autor/es:Jaffe, Kaitlyn (a)
Greene, Amanda K (b)

institución:(a) Department of Health Promotion and Policy, University of Massachusetts, Amherst.
(b) Center for Bioethics and Social Sciences in Medicine, University of Michigan Medical School, Ann Arbor.

Conflicto:Conflict of Interest Disclosures: Dr McGuire reported receiving personal fees from Geisinger Research, Morgridge Institute for Research, Danaher, Greenwall Foundation Board, and Nature Genomics outside the submitted work. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.6805

Technology and the Situationist Challenge to Virtue Ethics.

Fuente:Science and Engineering Ethics

Extracto: By paying careful attention to these contextual factors, we can design systems that promote human flourishing.

Claves:Emerging technology, Situationist challenge, well-being

Cita:Sci Eng Ethics 2024 Mar 27; 30 (2) : 10.

Autor/es:Emerging technology, Situationist challenge, well-being

institución:(a) Department of Philosophy, University of Edinburgh, Edinburgh, UK. fabiotollon@gmail.com.
(b) Department of Philosophy, Unit for the Ethics of Technology, Center for Applied Ethics, Stellenbosch University, Stellenbosch, South Africa. fabiotollon@gmail.com.

Conflicto:The author declares no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1007/s11948-024-00474-4

The critical need to accelerate cerebral palsy research with consumer engagement, global networks, and adaptive designs.

Fuente:Journal of Pediatric Rehabilitation Medicine

Tipo de trabajo:Estudio clínico

Extracto: This paper underscores the urgency of transforming CP research methodologies for quicker translation of novel treatments into clinical practice to improve quality of life for those with CP.

Claves:Cerebral palsy (CP), adaptive designs, clinical trials, consumer engagement, global research networks

Cita:J Pediatr Rehabil Med 2024; 17 (1) : 9-17.

Autor/es:Thomas, Sruthi P (a)
Novak, Iona (b)

institución:(a) H. Ben Taub Department of Physical Medicine and Rehabilitation and Departments of Neurosurgery and Pediatrics, Baylor College of Medicine, Houston, TX, USA.
(b) Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Conflicto:Sruthi P. Thomas – employed by Baylor College of Medicine. Iona Novak – employed by The University of Sydney. Anina Ritterband-Rosenbaum – employed by the Elsass Foundation, Denmark. Karin Lind – employed by the University of Sydney. Annabel Webb – employed by Cerebral Palsy Alliance, Australia. Paul Gross – none. Maria McNamara – employed by Cerebral Palsy Alliance, Australia.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Países Bajos

Sitio web:http://dx.doi.org/10.3233/PRM-240014