Understanding the potential role of whole genome sequencing (WGS) in managing patients with gonorrhoea

Understanding the potential role of whole genome sequencing (WGS) in managing patients with gonorrhoea

Fuente:The Journal of Infection

Tipo de trabajo:Revisión sistemática

Extracto: While there was some evidence of WGS use to provide individualised tuberculosis and gonorrhoea treatment, the eight identified studies contained few participants. Future research should focus on testing WGS intervention effectiveness and examining ethical considerations of STI WGS use.

Claves:Clinical decision-making, Clinical management, Gonorrhoea, Sexually transmitted infections, Systematic review, Tuberculosis, Whole genome sequencing

Cita:J Infect 2024 Jun; 88 (6) : 106168.

Autor/es:Osman, Roeann (a)
Dema, Emily (b)

institución:(a) Institute for Global Health, University College London (UCL), Mortimer Market Centre, London WC1E 6JB, United Kingdom; National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU) in Blood Borne and Sexually Transmitted Infections at University College London (UCL), London, United Kingdom. Electronic address: roeann.osman.20@ucl.ac.uk.
(b) Institute for Global Health, University College London (UCL), Mortimer Market Centre, London WC1E 6JB, United Kingdom.

Conflicto:Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1016/j.jinf.2024.106168

Advancing genomics to improve health equity.

Advancing genomics to improve health equity.

Fuente:Nature Genetics

Extracto: This Perspective describes these findings and examines health equity within the context of human genomics and genomic medicine.

Cita:Nat Genet 2024 May; 56 (5) : 752-757.

Autor/es:Madden, Ebony B (a)
Hindorff, Lucia A (b)

institución:(a) Office of the Director, National Human Genome Research Institute, Bethesda, MD, USA. ebony.madden@nih.gov.
(b) Office of the Director, National Human Genome Research Institute, Bethesda, MD, USA.

Conflicto:Competing Interest Statement: M.S. is a member of the Institutional Review Board for the All of Us Research Program. M.I. is a trustee of the Public Health Genomics (PHG) Foundation, member of the Scientific Advisory Board of Open Targets, and has research collaborations with AstraZeneca, Nightingale Health, and Pfizer (unrelated to the work of the manuscript). All other authors confirm... that there are no financial or non-financial interests that may bias the conclusions, implications, or opinions stated.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1038/s41588-024-01711-z

Increasing equity in science requires better ethics training: A course by trainees, for trainees.

Increasing equity in science requires better ethics training: A course by trainees, for trainees.

Fuente:Cell Genomics

Extracto: We conclude by arguing that if we are to work toward rectifying the inequities and injustices produced by our field, we must first learn to view our own research as impacting and being impacted by society.

Cita:Cell Genom 2024 May 8; 4 (5) : 100554.

Autor/es:Patel, Roshni A (a)
Ungar, Rachel A (b)

institución:(a) Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: rpatel7@stanford.edu.
(b) Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: raungar@stanford.edu.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1016/j.xgen.2024.100554

The Ethics of Electronic Tracking Devices in Dementia Care: An Interview Study with Developers.

The Ethics of Electronic Tracking Devices in Dementia Care: An Interview Study with Developers.

Fuente:Science and Engineering Ethics

Extracto: This leads to a perceived moral boundary between development and use, where some moral responsibility is shifted to end-users.

Claves:Dementia, Development, Ethics, Location-based technologies, Wandering

Cita:Sci Eng Ethics 2024 May 8; 30 (3) : 17.

Autor/es:Howes, Jared (a)
Denier, Yvonne (b)

institución:(a) Centre for Biomedical Ethics and Law, KU Leuven, Leuven, Belgium. Jaredmichael.Howes@kuleuven.be.
(b) Centre for Biomedical Ethics and Law, KU Leuven, Leuven, Belgium.

Conflicto:The authors declare they have no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1007/s11948-024-00478-0

The resistance patterns and molecular characteristics of ESBL/AmpC-producing Escherichia coli from captive panda ecosystem in China.

The resistance patterns and molecular characteristics of ESBL/AmpC-producing Escherichia coli from captive panda ecosystem in China.

Fuente:Ecotoxicology and Environmental Safety

Extracto: The interaction between giant pandas, surroundings and breeders contribute to development of resistant phenotypes and genotypes which might transfer across species or the surroundings easily; hence, strict monitoring based on a "One Health" approach is recommended.

Claves:AmpC, Commensal Escherichia coli, ESBL, Giant panda, Molecular typing, Resistance genes

Cita:Ecotoxicol Environ Saf 2024 Jun 15; 278 : 116395.

Autor/es:Shu, Gang (a)
Gan, Ting (b)

institución:(a) College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
(b) College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Países Bajos

Sitio web:http://dx.doi.org/10.1016/j.ecoenv.2024.116395

An Anticipatory Approach to Ethico-Legal Implications of Future Neurotechnology.

An Anticipatory Approach to Ethico-Legal Implications of Future Neurotechnology.

Fuente:Science and Engineering Ethics

Extracto: Overall, this furnishes a mode of neurotechnology's emergence that can avoid crises of confidence in terms of ethico-legal issues, and promote policy responses balanced between knowledge, values, protected innovation potential, and regulatory safeguards.

Claves:Anticipation, Future, Law, Neurotechnology, Policy, Responsibility

Cita:Sci Eng Ethics 2024 May 15; 30 (3) : 18.

Autor/es:Anticipation, Future, Law, Neurotechnology, Policy, Responsibility

institución:Anticipation, Future, Law, Neurotechnology, Policy, Responsibility

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1007/s11948-024-00482-4

Mitigating animal methods bias to reduce animal use and improve biomedical translation.

Mitigating animal methods bias to reduce animal use and improve biomedical translation.

Fuente:Science Progress

Extracto: The COLAAB recently developed the first of several mitigation tools: the Author Guide for Addressing Animal Methods Bias in Publishing, which is described herein along with broader implications and future directions of this work.

Claves:Animal use alternatives, bias mitigation, disease models, peer review, publishing

Cita:Sci Prog 2024 Apr-Jun; 107 (2) : 368504241253693.

Autor/es:Kavanagh, Owen (a)
Krebs, Catharine E (b)

institución:(a) York St John University, York, UK. RINGGOLD: 41872
(b) Physicians Committee for Responsible Medicine, Washington, DC, USA. RINGGOLD: 8321

Conflicto:Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1177/00368504241253693

At the threshold of viability: to resuscitate or not to resuscitate - the perspectives of Israeli neonatologists.

At the threshold of viability: to resuscitate or not to resuscitate - the perspectives of Israeli neonatologists.

Fuente:Bmj Paediatrics Open

Tipo de trabajo:Guía

Extracto: Significant variation was observed among Israeli neonatologists regarding delivery room management of extremely premature infants born at 22-24 weeks gestation, usually with a notable emphasis on respecting parents' wishes. The current national guidelines do not fully encompass the wide range of approaches. The country's guidelines should reflect the existing range of opinions, possibly through a broad survey of caregivers before setting the guidelines and recommendations.

Claves:Ethics, Neonatology, Resuscitation

Cita:BMJ Paediatr Open 2024 May 15; 8 (1)

Autor/es:Sperling, Daniel (a)
Riskin, Arieh (b)

institución:(a) Cheryl Spencer Department of Nursing, University of Haifa, Haifa, Israel.
(b) Neonatology, Bnai Zion Medical Center, Haifa, Israel.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjpo-2024-002633

The pharmaceutical company-healthcare relationship: much ado about something.

The pharmaceutical company-healthcare relationship: much ado about something.

Fuente:Indian Journal of Medical Ethics

Extracto: Knowingly or unknowingly, they would end up serving the pharmaceutical companies' agenda to sell more drugs and drive up profits [2] .

Cita:Indian J Med Ethics 2024 Apr-Jun; IX (2) : 89-93.

Autor/es:Knowingly or unknowingly, they would end up serving the pharmaceutical companies' agenda to sell more drugs and drive up profits [2] .

institución:Knowingly or unknowingly, they would end up serving the pharmaceutical companies' agenda to sell more drugs and drive up profits [2] .

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.20529/IJME.2024.023

Publish and perish: New issues in publication ethics.

Fuente:Indian Journal of Medical Ethics

Extracto: There seems little point in undertaking research if we can no longer disseminate or, indeed, apply the wisdom gained from it.

Cita:Indian J Med Ethics 2024 Apr-Jun; IX (2) : 147-148.

Autor/es:There seems little point in undertaking research if we can no longer disseminate or, indeed, apply the wisdom gained from it.

institución:There seems little point in undertaking research if we can no longer disseminate or, indeed, apply the wisdom gained from it.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.20529/IJME.2024.017

Research on emerging infectious diseases: pros and cons of centralised government controls.

Fuente:Indian Journal of Medical Ethics

Extracto: In these challenging times, it is crucial to weigh the pros and cons of stringent administrative controls to ensure an effective and ethical approach to tackling emerging infectious diseases.

Cita:Indian J Med Ethics 2024 Apr-Jun; IX (2) : 169-170.

Autor/es:In these challenging times, it is crucial to weigh the pros and cons of stringent administrative controls to ensure an effective and ethical approach to tackling emerging infectious diseases.

institución:In these challenging times, it is crucial to weigh the pros and cons of stringent administrative controls to ensure an effective and ethical approach to tackling emerging infectious diseases.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.20529/IJME.2024.016

The impact of Covid-19 pandemic on the research portfolio and approval turnaround time at the Kenya Medical Research Institute.

Fuente:Indian Journal of Medical Ethics

Tipo de trabajo:Revisión

Extracto: The research portfolio was minimally affected by the pandemic. The adoption of email submission, and faster-than-usual processing and review protocols during the pandemic reduced the approval turnaround time.

Cita:Indian J Med Ethics 2024 Apr-Jun; IX (2) : 109-114.

Autor/es:Kebenei, Enock Kipchirchir (a)
Cheruiyot, Daisy (b)

institución:(a) Scientific and Ethics Review Unit, Kenya Medical Research Institute, PO Box 54840-00200, Nairobi, KENYA.
(b) Scientific and Ethics Review Unit, Kenya Medical Research Institute, PO Box 54840-00200, Nairobi, KENYA.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.20529/IJME.2024.013

A quantitative analysis of publication trends in Iranian medical ethics and a comparison with EMRO countries.

Fuente:Indian Journal of Medical Ethics

Tipo de trabajo:Revisión

Extracto: The results of this study show that the trend of publication of EMRO countries, especially Iranian publications, is insufficient to respond to national demands in medical ethics. A concept map has been presented to determine research needs in medical ethics. Focusing on national and regional research potentials could synergistically affect medical ethics progress in the EMRO region.

Cita:Indian J Med Ethics 2024 Apr-Jun; IX (2) : 94-100.

Autor/es:Noroozi, Mahshad (a)
Salari, Pooneh (b)

institución:(a) Assistant Professor, Department of Medical Ethics, School of Medicine, Iran University of Medical Sciences, Tehran, IRAN.
(b) Professor, Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, IRAN.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.20529/IJME.2024.008

COMMENTARY: Public health ethics and the Kerala Public Health Act, 2023.

Fuente:Indian Journal of Medical Ethics

Extracto: Principles such as autonomy, privacy/confidentiality, transparency, accountability, rule of law, least harm etc have not even been given token consideration, making this law a potential tool of abuse, particularly against already vulnerable communities.

Cita:Indian J Med Ethics 2024 Apr-Jun; IX (2) : 154-158.

Autor/es:Principles such as autonomy, privacy/confidentiality, transparency, accountability, rule of law, least harm etc have not even been given token consideration, making this law a potential tool of abuse, particularly against already vulnerable communities.

institución:Principles such as autonomy, privacy/confidentiality, transparency, accountability, rule of law, least harm etc have not even been given token consideration, making this law a potential tool of abuse, particularly against already vulnerable communities.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.20529/IJME.2024.007

Lessons learnt from daily oral PrEP delivery to inform national planning for PrEP ring introduction for women in low-income and middle-income countries: a qualitative inquiry of international stakeholders.

Lessons learnt from daily oral PrEP delivery to inform national planning for PrEP ring introduction for women in low-income and middle-income countries: a qualitative inquiry of international stakeholders.

Fuente:Bmj Global Health

Extracto: Lessons learnt from stakeholder participants suggest standardised and modular processes can improve efficiencies in LA-PrEP planning and implementation. Tiered communication strategies addressing product efficacy and effectiveness will improve clients' and providers' efficacy in making informed decisions. Integration is important for LA-PrEP delivery, but data on empirical integration approaches and frameworks is minimal: further research in this discipline is needed.

Claves:HIV, Health policy, Health services research, Prevention strategies, Public Health

Cita:BMJ Glob Health 2024 May 7; 9 (5)

Autor/es:Heck, Craig J (a)
Dam, Anita (b)

institución:(a) Columbia University Mailman School of Public Health, New York, New York, USA cjh2204@cumc.columbia.edu.
(b) Columbia University Irving Medical Center, New York, New York, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjgh-2023-014709

Cardiac organoids do not warrant additional moral scrutiny.

Cardiac organoids do not warrant additional moral scrutiny.

Fuente:Bmc Medical Ethics

Extracto: Despite the heartbeat's moral significance in organ procurement and abortion discussions, we argue that this significance should not translate into moral implications for cardiac organoids.

Claves:Abortion, Ethics, Heartbeat, Moral intuitions, Moral status, Organ donation, Organoids

Cita:BMC Med Ethics 2024 May 21; 25 (1) : 61.

Autor/es:Simons, Jannieke N (a)
van der Graaf, Rieke (b)

institución:(a) Department of Bioethics and Health Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. j.n.simons-6@umcutrecht.nl.
(b) Department of Bioethics and Health Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12910-024-01064-6

Instrument fracture in periodontal therapy

Instrument fracture in periodontal therapy

Fuente:Bmc Oral Health

Tipo de trabajo:Caso clínico

Extracto: This case underscores the importance of truthful communication, the proper use of instruments, equipment maintenance in dentistry, and the significance of ongoing professional development to enhance treatment safety, proficiency, and ethical standards in dental care.

Claves:Ethics, Instrument replacement, Management, Periodontal instrument fractures, Retrieval, Sickle scaler, Treatment protocol

Cita:BMC Oral Health 2024 May 21; 24 (1) : 585.

Autor/es:Yaqoob, Hassan (a)
Sadiq, Ali (b)

institución:(a) Dental Section, Department of Surgery, The Aga Khan University, Karachi, Pakistan. hassan.yaqoob@aku.edu.
(b) Dental Section, Department of Surgery, The Aga Khan University, Karachi, Pakistan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12903-024-04349-9

Barriers to diverse clinical trial participation in Duchenne muscular dystrophy: Engaging Hispanic/Latina caregivers and health professionals.

Barriers to diverse clinical trial participation in Duchenne muscular dystrophy: Engaging Hispanic/Latina caregivers and health professionals.

Fuente:Orphanet Journal of Rare Diseases

Tipo de trabajo:Guía

Extracto: Numerous barriers hinder participation in Duchenne clinical trials for Hispanic/Latino families and other populations experiencing health disparities. Addressing these barriers necessitates interventions across multiple stages of the clinical trial enrollment process. Recommendations to enhance participation opportunities include developing clinical trial decision support tools, translating prominent clinical trials educational resources such as ClinicalTrials.gov, fostering trusting family-provider relationships, engaging families in clinical trial design, and establishing ethical guidelines for pre-screening potentially non-compliant patients.

Claves:Clinical trial as topic, Diversity, equity and inclusion, Duchenne muscular dystrophy

Cita:Orphanet J Rare Dis 2024 May 21; 19 (1) : 207.

Autor/es:Crossnohere, Norah L (a)
Campoamor, Nicola B (b)

institución:(a) Division of General Internal Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA. Norah.crossnohere@osumc.edu.
(b) Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH, USA.

Conflicto:NA, EC, ED, AH are employees of Parent Project Muscular Dystrophy (PPMD). NLC received funding from PPMD. Other authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03209-7

Introducing a machine learning algorithm for delirium prediction-the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead).

Introducing a machine learning algorithm for delirium prediction-the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead).

Fuente:Age and Ageing

Tipo de trabajo:Revisión

Extracto: We present a clinically useful and explainable ML model for POD prediction. The model will be deployed in the Supporting SURgery with GEriatric Co-Management and AI project.

Claves:delirium prediction, explainable artificial intelligence (AI), machine learning, older people, post-operative delirium, support vector machine

Cita:Age Ageing 2024 May 1; 53 (5)

Autor/es:Benovic, Samuel (a)
Ajlani, Anna H (b)

institución:(a) Institute of Geriatric Research, Ulm University Medical Center, Ulm, Germany.
(b) Agaplesion Bethesda Clinic Ulm, Ulm, Germany.

Conflicto:None.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1093/ageing/afae101

'Experiencing one thing and saying another'-Ecological Momentary Assessment (EMA) of nursing students' competence and challenge during clinical placements compared with retrospective interviews.

'Experiencing one thing and saying another'-Ecological Momentary Assessment (EMA) of nursing students' competence and challenge during clinical placements compared with retrospective interviews.

Fuente:Plos One

Extracto: Momentary assessment thus enabled capturing data about clinical activities which may be overlooked by retrospective methods.

Cita:PLoS One 2024; 19 (5) : e0302866.

Autor/es:Karlgren, Klas (a)
Andersson Franko, Mikael (b)

institución:(a) Department Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.
(b) Department of Research, Education, Development and Innovation, Södersjukhuset, Stockholm, Sweden.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0302866