PROBABLE ASOCIACIÓN DE LOS INHIBIDORES DE LA TIROSINA QUINASA CON LA PERSISTENCIA DE CLONES ABERRANTES CON CROMOSOMA FILADELFIA NEGATIVO

Se describe el caso de un paciente con leucemia mieloide crónica que, durante el tratamiento con inhibidores de la tirosina quinasa de primera y segunda generación, presenta múltiples clones con anomalías cromosómicas.
Autor
Adriana Zamecnikova
Columnista Experta de SIIC
Institución del autor
Kuwait Cancer Control Center, Shuwaikh, Kuwait

Palabras clave
leucemia mieloide crónica, imatinib, nilotinib, clones con cromosoma Filadelfia negativo, aplasia medular

Clasificación en siicsalud
Artículos originales > Expertos del Mundo >
página  http://www.siicsalud.com/dato/casiic.php/115090

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Primera edición
31 de agosto, 2011
Segunda edición, ampliada y corregida
7 de junio, 2021

Bibliografía del caso clínico
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Artículos publicados por el autor (selección)
Al- Bahar S, Zámecníkova A. Frequency and type of chromosomal abnormalities in childhood ALL patients in Kuwait: A six-year retrospective study. Med Princ Pract 19:176-181, 2010

Zamecnikova A . Targetting the BCR-ABL tyrosine kinase in chronic myeloid leukemia as a model of rational drug dsign in cancer. Expert Reviews of Hematology 3:45-56, 2010

Al-Bahar S, Zámecníkova A, Pandita R. A novel variant translocation t(6;8;21)(p21;q22;q22) leading to AML/ETO fusion in acute myeloid leukemia. Gulf Journal of Oncology. 5:56-59, 2008

Zámecníkova A, Al- Bahar S. Simultaneous occurrence of MLL and RARA rearrangements in a pediatric acute lymphoblastic leukemia patient. Pediatric Blood & Cancer 52:671-674, 2009



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