PEPTIDE NUCLEIC ACID HOLDS THE PROMISE OF NOVEL ANTIBIOTICS

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Anubrata Ghosal
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PEPTIDE NUCLEIC ACID HOLDS THE PROMISE OF NOVEL ANTIBIOTICS

In this current study, we have developed four antisense peptide-PNA conjugates by targeting two widely conserved bacterial genes, acpP and ftsZ. These molecules can completely inhibit the growth of several P. aeruginosa strains at 1-2 μM concentrations.

The article was published by
El artículo fue publicado por

Nucleic Acid Therapeutics
Volume / Volumen: 22
Number / Número: 5
First and last pages / Páginas inicial-final: 323-334
Year / Año: 2012
Month / Mes: october

Principal institution where the research took place
Institución principal de la investigación
The Panum Institute, University of Copenhagen, Copenhagen, Hovedstaden, Denmark

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Bibliographic references
Referencias bibliográficas

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15. Ghosal,A. and Nielsen,P.E. (2012) Potent antibacterial antisense peptide-peptide nucleic acid conjugates against Pseudomonas aeruginosa. Nucleic Acid Ther., 22, 323–34.
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20. Braasch,D. a, Nulf,C.J. and Corey,D.R. (2002) Synthesis and purification of peptide nucleic acids. Curr. Protoc. Nucleic Acid Chem., Chapter 4, Unit 4.11.
21. Ghosal,A. (2012) Novel antibacterial agents ( antibiotics ) based on RNA interference using Peptide Nucleic Acid ( PNA ). 10.1021/cb300434e.Appendix.

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The authors' report was accepted on La crónica del autor fue aprobada el 2021, march 9	Published in siicsalud Publicado en siicsalud 2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

Genetics
/ Genética Humana

Infectious Diseases
/ Infectología

and secondarily related to the following sections
y secundariamente con las siguientes secciones

Biochemistry
Bioquímica

Inmunology
Inmunología

Information about the full text
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Potent Antibacterial Antisense Peptide-Peptide Nucleic Acid Conjugates Against Pseudomonas Aeuruginosa

Author / Autor
Anubrata Ghosal¹

1 Dr., Massachusetts Institute Of Technology (mit), Boston, EE.UU., Postdoctoral Associate

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Nucleic Acid Therapeutics

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