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Anubrata Ghosal
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In this current study, we have developed four antisense peptide-PNA conjugates by targeting two widely conserved bacterial genes, acpP and ftsZ. These molecules can completely inhibit the growth of several P. aeruginosa strains at 1-2 μM concentrations.

The article was published by
El artículo fue publicado por
Nucleic Acid Therapeutics
Volume / Volumen: 22
Number / Número: 5
First and last pages / Páginas inicial-final: 323-334
Year / Año: 2012
Month / Mes: october

Principal institution where the research took place
Institución principal de la investigación
The Panum Institute, University of Copenhagen, Copenhagen, Hovedstaden, Denmark

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

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9. Liam Good & Peter E. Nielsen (1998) Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA. Nat. Biotechnol., 16, 355–8.
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11. Jeon B,Z.Q. (2009) Sensitization of Campylobacter jejuni to fluoroquinolone and macrolide antibiotics by antisense inhibition of the CmeABC multidrug efflux transporter. J Antimicrob Chemother, 63, 946–8.
12. Nekhotiaeva N, Awasthi SK, Nielsen PE, and G.L. (2004) Inhibition of Staphylococcus aureus Gene Expression and Growth Using Antisense Peptide Nucleic Acids. Mol. Ther., 10, 652–9.
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14. Parthiban Rajasekaran, Jeffry C. Alexander, Mohamed N. Seleem, Neeta Jain, Nammalwar Sriranganathan, Alice R. Wattam, João C. Setubal,S.M.B. (2013) Peptide nucleic acids inhibit growth of Brucella suis in pure culture and in infected murine macrophages. Int. J. Antimicrob. Agents, 41, 358–362.
15. Ghosal,A. and Nielsen,P.E. (2012) Potent antibacterial antisense peptide-peptide nucleic acid conjugates against Pseudomonas aeruginosa. Nucleic Acid Ther., 22, 323–34.
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17. Ghosal,A., Vitali,A., Stach,J.E.M. and Nielsen,P.E. (2013) Role of SbmA in the uptake of peptide nucleic acid (PNA)-peptide conjugates in E. coli. ACS Chem. Biol., 8, 360–7.
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19. Patenge,N., Pappesch,R., Krawack,F., Walda,C., Mraheil,M.A., Jacob,A., Hain,T. and Kreikemeyer,B. (2013) Inhibition of Growth and Gene Expression by PNA-peptide Conjugates in Streptococcus pyogenes. Mol. Ther. Nucleic Acids, 2, e132.
20. Braasch,D. a, Nulf,C.J. and Corey,D.R. (2002) Synthesis and purification of peptide nucleic acids. Curr. Protoc. Nucleic Acid Chem., Chapter 4, Unit 4.11.
21. Ghosal,A. (2012) Novel antibacterial agents ( antibiotics ) based on RNA interference using Peptide Nucleic Acid ( PNA ). 10.1021/cb300434e.Appendix.

Other articles written by the author Anubrata Ghosal
Otros artículos de Anubrata Ghosal

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Anubrata Ghosal was invited by SIIC on
Anubrata Ghosal fue invitado por SIIC el
2013, january 25
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Genética Humana
Infectious Diseases
/ Infectología

and secondarily related to the following sections

y secundariamente con las siguientes secciones



Information about the full text
Acerca del trabajo completo

Potent Antibacterial Antisense Peptide-Peptide Nucleic Acid Conjugates Against Pseudomonas Aeuruginosa

Author / Autor
Anubrata Ghosal1

1 Dr., Massachusetts Institute Of Technology (mit), Boston, EE.UU., Postdoctoral Associate

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Nucleic Acid Therapeutics

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