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Danilo Roman-Campos
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 describe para SIIC los aspectos relevantes de su artículo


ALVOS TERAPÊUTICOS CONTRA A DISFUNÇÃO CARDIACA NA DOENÇA DE CHAGAS

Chagas disease, which is caused by the parasite Trypanosoma cruzi, is an important cause of heart failure. We investigated modifications in the cellular electrophysiological and calcium-handling characteristics of an infected mouse heart during the chronic phase of the disease. The patch-clamp technique was used to record action potentials (APs) and L-type Ca2+ and transient outward K+ currents. [Ca2+]i changes were determined using confocal microscopy. Infected ventricular cells showed prolonged APs, reduced transient outward K+ and L-type Ca2+ currents and reduced Ca2+ release from the sarcoplasmic reticulum. Thus, the chronic phase of Chagas disease is characterised by cardiomyocyte dysfunction, which could lead to heart failure.

The article was published by
 El artículo fue publicado por
Memorias do Instituto Oswaldo Cruz
 Volume / Volumen: 108
 Number / Número: 2
 First and last pages / Páginas inicial-final: 243-245
 Year / Año: 2013
 Month / Mes: april

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
 Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC. icopagok.gif



Principal institution where the research took place
Institución principal de la investigación
, BH-MG, Brasil


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Authors' Report
Crónica del Autor
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Bibliographic references
Referencias bibliográficas

 Novel insights into the development of chagasic cardiomyopathy: Role of PI3Kinase/NO axis.

Roman-Campos D, Sales-Junior P, Duarte HL, Gomes ER, Lara A, Campos P, Rocha NN, Resende RR, Ferreira A, Guatimosim S, Gazzinelli RT, Ropert C, Cruz JS.

Int J Cardiol. 2012 Sep 29. doi:pii: S0167-5273(12)01126-6

 Other articles written by the author Danilo Roman-Campos
Otros artículos de Danilo Roman-Campos

A novel channelopathy in pulmonary arterial hypertension.

Roman-Campos D, Ma L,Austin ED, Eyries M, Sampson KS, Soubrier F, Germain M, Trégouët DA, Borczuk A, Rosenzweig EB, Girerd B, Montani D, Humbert M, Loyd JE, Kass RS, Chung WK.

N Engl J Med. 2013 Jul 25;369(4):351-61;

Cardiomyocyte dysfunction during the chronic phase of Chagas disease.

Roman-Campos D, Sales-Júnior P, Duarte HL, Gomes ER, Guatimosim S, Ropert C, Gazzinelli RT, Cruz JS.

Mem Inst Oswaldo Cruz. 2013 Apr;108(2):243-5.

Novel insights into the development of chagasic cardiomyopathy: Role of PI3Kinase/NO axis.

Roman-Campos D, Sales-Junior P, Duarte HL, Gomes ER, Lara A, Campos P, Rocha NN, Resende RR, Ferreira A, Guatimosim S, Gazzinelli RT, Ropert C, Cruz JS.

Int J Cardiol. 2012 Sep 29. doi:pii: S0167-5273(12)01126-6;


Changes in cellular contractility and cytokines profile during Trypanosoma cruzi infection in mice.

Roman-Campos D, Duarte HL, Sales PA Jr, Natali AJ, Ropert C, Gazzinelli RT, Cruz JS.

Basic Res Cardiol. 2009 May;104(3):238-46;


Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease.

Esper L, Roman-Campos D, Lara A, Brant F, Castro LL, Barroso A, Araujo RR, Vieira LQ, Mukherjee S, Gomes ER, Rocha NN, Ramos IP, Lisanti MP, Campos CF, Arantes RM, Guatimosim S, Weiss LM, Cruz JS, Tanowitz HB, Teixeira MM, Machado FS.

Am J Pathol. 2012 Jul;181(1):130-40


Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway.

Cunha TM, Roman-Campos D, Lotufo CM, Duarte HL, Souza GR, Verri WA Jr, Funez MI, Dias QM, Schivo IR, Domingues AC, Sachs D, Chiavegatto S, Teixeira MM, Hothersall JS, Cruz JS, Cunha FQ, Ferreira SH.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4442-7.


SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)
Danilo Roman-Campos was invited by SIIC on
Danilo Roman-Campos fue invitado por SIIC el
2013, july 22 		  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9 		Published in siicsalud
Publicado en siicsalud
2021, june 7




The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud
 
Cardiology
/ Cardiología 		 
Pharmacology
/ Farmacología
 		 

and secondarily related to the following sections
y secundariamente con las siguientes secciones

Infectious Diseases
Infectología
Inmunology
Inmunología
Information about the full text
Acerca del trabajo completo


Cardiomyocyte Dysfunction During the Chronic Phase of Chagas Disease


Author / Autor
Danilo Roman-Campos1

1 Researcher, Faculdade de Medicina de Ribeirão Preto, Av Bandeirantes 3900, Ribeirão Preto, Brasil, Postdoctoral Researcher


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 Memorias do Instituto Oswaldo Cruz
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http://memorias.ioc.fiocruz.br/
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http://www.siicsalud.com/main/distriprinrel.php
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