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Chakrakodi Shastry
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

Identifying hepatotoxic effect of aripiprazole co-prescribed with carbamazepine and fluvoxamine

Aripiprazole given in combination with fluvoxamine, there was significant hepatotoxicity possibly due to inhibition of aripiprazole metabolizing enzyme CYP3A4. Similarly co-administration of carbamazepine, a CYP3A4 inducer may lead to significant decrease in plasma concentration of aripiprazole and potentially a loss in aripiprazole's clinical efficacy.

The article was published by
El artículo fue publicado por
Indian Journal of Pharmacology
Volume / Volumen: 45
Number / Número: 2
First and last pages / Páginas inicial-final: 121-125
Year / Año: 2013
Month / Mes: march

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
NGSM Institute of Pharmaceutical Sciences, Mangalore, Karnataka, India

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

Citrome L, Macher JP, Salazar DE, Mallikaardjun S, Boulton DW. Pharmacokinetics of aripiprazole and concomitant carbamacepine. J Clin Psychopharmacol 27(3):279-283, 2007.
Dumortier G, Cabaret W, Stamatiadis L. Hepatic tolerance of atypical antipsychotic drugs. Encephale 28(6):542-551, 2002.
Dumortier G, Cabaret W, Stamatiadis L. Hepatic tolerance of atypical antipsychotic drugs. Encephale 28(6):542-551, 2002.
Ghosh MN. Fundamentals of experimental pharmacology. 4th ed. Kolkata: Hilton and company; 2008. Pp. 178.
McLean EK, McLean AEM, Sutton PM. An improved method for producing cirrhosis of the liver in rats by stimulus administration of carbon tetrachloride and pentobarbitone. Brt J Exp Path 50:502-503, 1969.
Michalets EL. Update: clinically significant cytochrome P-450 drug interactions. Pharmacotherapy 18(1):84-112, 1998.
Olesen OV, Linnet K. Fluvoxamine-clozapine drug interaction: inhibition in vitro of five cytochrome P450 isoforms involved in clozapine metabolism. J Clin Psychopharmacol 20(1):35-42, 2000.
Sharif ZA. Pharmacokinetics, metabolism and drug-drug interactions of atypical antipsychotics in special populations. Primary Care Companion J Clin Psychiatry 5(6):22-25, 2003.

Other articles written by the author Chakrakodi Shastry
Otros artículos de Chakrakodi Shastry

Antivenom activity of ethanolic extract of Crescentia cujete fruit. Shastry C.S., Aswathanarayana B.J., Bhalodia Maulik. Int.J.Phytomed., 4(1), 2012. Effect of acute and chronic administration of the aqueous extract of Lawsonia inermis leaves on haloperidol induced catalepsy in albino mice. Shastry C.S., Kiran U.P., Aswathanarayana BJ. Res J Pharm Biol Che Sci 2012;3(3):1107-16. 012;5(4):2355-65 Evaluation of Antivenom Activity of Calotropis Gigantea Plant Extract Against Vipera Russelli Snake Venom. Nimmy Chacko*, Mohammed Ibrahim, Prerana Shetty and C.S. Shastry, IJPSR (2012), Vol. 3, Issue 07 pp.2272-79
Hepatportective Activity Of Elettaria Cardamomum Against Paracetamol Induced Hepatoprotective Activity. Nimmy Chacko*, Ambily Thomas, C S Shastry, Prerana Shetty,
Int J Pharm Pharm Sci, Vol 4, Issue 3, 611-613. Investigation of Investigation of pH dependant in situ gel forming solutions of imidazoline drug for ocular administration, Nisha G. Shetty*, Charyulu RN, Marina K, C. S Shastry, International Journal of Research in Pharmaceutical Sciences, 3(1), 120-126 2012, 1-7. Biochemical Studies on hepato and nephro protective effect of butter fly tree ( Bauhinia purpurea Linn. ) against acetaminophen induced toxicity. T. Sivanagi Reddy*, K.Prasanna Shama, P.Nirmala, C.S.Shastry. IJRAP 2012: 3(3). P.455-60.
Anticholesteremic and Antilipidemic activity of Stem bark extracts of Moringa oleifera in Diet induced hyperlipidemia model in rats. Chitresh Senecha*, Prasanna Shama K, Ullas Prakash D’Souza, CS. Shastry. Int J Pharm Chem Scis 2012;1(3):567-74.
Anti inflammatory and anti nociceptive evaluation of roots extracts of Bauhinia purpurea linn. Nirmala Jane Pais*, Ullas Prakash D Souza, Prasanna Shama K, Shastry CS. IJPCBS 2012;2(3):225-35. Comparative evaluation of diabetogenic and mutagenic potential of artificial sweeteners - aspartame, acesulfame-k and sucralose. Shastry C.S., Yatheesh C.K., Aswathanarayana B.J. NUJHS 2012;2(3):80-4.

SIIC System of Assisted Editing (SSEA)
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Chakrakodi Shastry was invited by SIIC on
Chakrakodi Shastry fue invitado por SIIC el
2013, august 29
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Farmacología
Pharmaceutical Medicine
/ Medicina Farmacéutica

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Primary Care
Atención Primaria


Mental Health
Salud Mental


Information about the full text
Acerca del trabajo completo

Effect of Combination of Aripiprazole With Carbamazepine and Fluvoxamine on Liver Functions in Experimental Animals

Author / Autor
Chakrakodi Shastry1

1 S, Ngsm Institute Of Pharmaceutical Sciences Paneer, Deralakatte, Mangalore-575018, Mangalore, India, Principal

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Indian Journal of Pharmacology

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