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Authors' Reports

Takeaki Nitto
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo


All-trans retinoic acid and arsenic trioxide are recently recognized as effective agents to treat acute promyelocytic leukemia. These two agents reduce leukemia cells followed by affecting the function of the PML-RAR alpha, an unusual molecule as a result of the t(15;17) chromosomal translocation.

The article was published by
El artículo fue publicado por
Journal of Pharmacological Sciences
Volume / Volumen: 126
Number / Número: 3
First and last pages / Páginas inicial-final: 179-185
Year / Año: 2014
Month / Mes: november

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Yokohama University of Pharmacy(横浜薬科大学), Yokohama, Kanagawa, Japan

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

1. Lallemand-Breitenbach V, Jeanne M, Benhenda S, Nasr R, Lei M, Peres L, et al. Arsenic degrades PML or PML-RAR-alpha; through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol 10:547-555, 2008.
2. Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, et al. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA 101:5328-5335, 2004.
3. Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 369:111-121, 2013.
4. Ablain J, Rice K, Soilihi H, de Reynies A, Minucci S, De Thé H. Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure. Nat Med 20:167-174, 2014.

Other articles written by the author Takeaki Nitto
Otros artículos de Takeaki Nitto

SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Takeaki Nitto was invited by SIIC on
Takeaki Nitto fue invitado por SIIC el
2015, august 6
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Farmacología
/ Hematología

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Pharmaceutical Medicine
Medicina Farmacéutica


Information about the full text
Acerca del trabajo completo

Molecular Mechanisms of the Antileukemia Activities of Retinoid and Arsenic

Author / Autor
Takeaki Nitto1

1 Ph. D., Yokohama University Of Pharmacy(横浜薬科大学), Yokohama, Japón, Professor

Access to the original source
Journal of Pharmacological Sciences

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