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Authors' Reports

Tomáš Fait
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

Prospective clinical study in menopausal women
The estradiol metered-dose transdermal spray in clinical practice

The metered-dose transdermal spray with 1,53 mg estradiol was given to symptomatic menopausal women for 24 weeks. There was a statistically significant drop (p < 0.001) in menopause rating scale (MRS) values. The average MRS values improved by 66.2% between the first and the third visit.

The article was published by
El artículo fue publicado por
Climacteric
Volume / Volumen: 21
Number / Número: 6
First and last pages / Páginas inicial-final: 549-553
Year / Año: 2018
Month / Mes: december


This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.
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Principal institution where the research took place
Institución principal de la investigación
ČMAS ČLS JEP, Praha 2, Czecchia, Czech Republic


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Authors' Report

Crónica del Autor
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Estudio Clínico Prospectivo en Mujeres Posmenopáusicas
Solución para pulverización transdérmica de estradiol en dosis medida en la práctica diaria

Se indicó solución para pulverización transdérmica en dosis medida con 1.53 mg de estradiol en mujeres menopáusicas sintomáticas durante 24 semanas. Se registró una disminución significativa de los puntajes en la escala de menopausia (menopause rating scale [MRS], p < 0.001). Los valores promedio en la MRS mejoraron en un 66.2% entre la primera y la tercera visitas.
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Crónica del Autor

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Bibliographic references
Referencias bibliográficas

Ibrahim SA: Spray-on transdermal drug delivery systems. Expert Opin Drug Delivery 2015, 12(2): 195-205 Derzko C., Sergerie M., Siliman G. et al. Comparative efficacy and safety of oestradiol transdermal preparations for the treatment of vasomotor symptoms in postmenopausal women: an indirect comparison meta-analysis. Menopause 2016, 23(3):294-303
Morton TL., Gattermeir DJ., Petersen CA. et al.: Steady state pharmacokinetics following application of a novel transdermal oestradiol spray in healthy postmenopausal women. J Clin Pharmacol 2009, 49(9): 1037-46
Acher D.: Menopausal hot flashes are treated effectively by a transdermal, low dose oestradiol spray. Nature Review Endocrinology 2009, 5: 18-9
Buster JE., Koltun WD., Pascual ML. et al.: Low-dose oestradiol spray to treat vasomotor symptoms: a randomize controlled trial. Obstet Gynecol 2008, 111(6): 1343-51

Other articles written by the author Tomáš Fait
Otros artículos de Tomáš Fait

Fait T., Vrablik M., Cibula D. et al.: Oral but not Transdermal Estrogen Replacement Therapy Reduced Level of Tissue Factor Pathway Inhibitor: Cross-over Designed Study. Neuro Endocrinol Lett 2006, 27(5): 557-61 Fait T., Vrablík M., Zizka Z., Kostirova M.: Changes in Haemostatic Variables Induced by Estrogen Replacement Therapy: Comparison of Transdermal and Oral Methods of Administration in Cross-over Designed Study, Gynecol Obstet Invest 2008, 65(1): 47-51 Fait T.: Combined Hormone Contraceptive Choice Experience in Czech Republic. Central European Journal of Medicine 2011, 6(5): 582-7 ISSN: 1644-3640 IF 0,312 Fait T., Vrablik M.: Coronary heart disease and hormone replacement therapy - from primary and secondary prevention to the window of opportunity. Neuro Endocrinol Lett 2012, 33, Suppl. 2: 17-21 ISSN 0172-780X IF 1,296 Fait T., Sailer M., Regidor PA.: Prospective observational study to evaluate the efficacy and safety of the pollen extract Sérélys® in the management of women with menopausal symptoms. Gynecol Endocrinol 2019, 35(4): 360-3 Fait T., Buryak D., Cîrstoiu M., Luczai E., Janczura R.: Needs and preferences of women users of oral contraceptives in selected countries in Central and Eastern Europe. Drugs in Context 2018, 7: 2125ID Fait T.: Hormone replacement therapy: latest developments and clinical practice. Drugs in Context 2019, 8: 212551




SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Tomáš Fait was invited by SIIC on
Tomáš Fait fue invitado por SIIC el
2019, december 16
  The authors' report was accepted on
La crónica del autor fue aprobada el
2020, april 21
The authors' report was accepted on
La crónica del autor fue aprobada el
2020, april 21
Published in siicsalud
Publicado en siicsalud
2020, july 20





The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

 
Endocrinology and Metabolism
/ Endocrinología y Metabolismo
 
Gynaecology and Obstetrics
/ Obstetricia y Ginecología
 

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Geriatrics
Geriatría

Public Health
Salud Pública

Climacteric and Menopause
Climaterio y Menopausia

Family Planning
Planificación Familiar

Pharmacology
Farmacología

Clinical Pharmacology
Farmacología Clínica

Mental Health
Salud Mental

Information about the full text
Acerca del trabajo completo


The use of estradiol metered-dose transdermal spray in clinical practice


Author / Autor
Tomáš Fait1

1 Assoc. Prof., Md., Phd., Gynecologicko-porodnická Klinika 2. Lf Uk A Fn Motol, Prague, República Checa, Doctor


Access to the original source
Climacteric

Article URL:
/ URL del artículo:
http://www.imsociety.org/about_the_journal.php

URL of Abstract:
/ URL del abstract:

URL of Abstract page in Medline:
/ URL del abstract en Medline:
https://www.ncbi.nlm.nih.gov/pubmed/30296172

URL of Abstract page in Scielo:
/ URL del abstract en Scielo:

URL of Abstract page in Scopus:
/ URL del abstract en Scopus:

URL of Abstract page in Embase:
/ URL del abstract en Embase:

Other data bases:
/ Otras bases de datos:

siic DB:
/ siic DB:
http://www.siicsalud.com/main/distriprinrel.php
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