Crónicas de autores

Nilo Ikuta *

Autor invitado por SIIC

O trabalho descreve os primeiros casos de vírus H1N1pdm09 resistentes a oseltamivir no Brasil.

H1N1 RESISTENTES A OSELTAMIVIR NO SUL DO BRASIL

Foram identificados dois mutantes resistentes ao inibidor NA, (H275Y e S247N). Este estudo revelou uma baixa prevalência (0,8%), sem propagação de vírus resistentes em todo Estado do Rio Grande do Sul.

*Nilo Ikuta
describe para SIIC los aspectos relevantes de su trabajo
OSELTAMIVIR-RESISTANT INFLUENZA A(H1N1)PDM09 VIRUS IN SOUTHERN BRAZIL
Memorias do Instituto Oswaldo Cruz,
108(3):392-394 May, 2013

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Universidade Luterana Do Brasil, Canoas, Brasil
Imprimir nota
Comprar este artículo
Otros artículos escogidos
Referencias bibliográficas
Hurt AC, Deng YM, Ernest J, Caldwell N, Leang L, Iannello P, et al. Oseltamivir-resistant influenza viruses circulating during the first year of the influenza A(H1N1) 2009 pandemic in the Asia-Pacific region, March 2009 to March 2010. Euro Surveill. 2011;16:24-31.
World Health Organization. Update on oseltamivir resistance in influenza A (H1N1) 2009 viruses. [cited 2011 Aug 24]. http://www.who.int/influenza/surveillance_
monitoring/updates/2011_08_26_weekly_web_update_oseltamivir_resistance.pdf
Kiso M, Shinya K, Shimojima M, Takano R, Takahashi K, Katsura H, et al. Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses. PLoS Pathog. 2010;6:1-7.
Renaud C, Kuypers J, Englund JA. Emerging oseltamivir resistance in seasonal and pandemic influenza A/H1N1. J Clin Virol. 2011;52:70-8.
Sheu T, Deyde V, Okomo-Adhiambo M, Garten R, Xu X, et al. Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008. Antimicrob Agents Chemother. 2008; 52:3284-92.
Gregianini TS, Dambrós BP, Tumioto GL, Seadi C, Baccin T, Ardenghi P, et al. Laboratory Diagnosis of Influenza in Rio Grande do Sul, from 2009 to 2011 [in Portuguese]. Bol Epidemiológico. 2011;13:13-16.
Deyde VM, Sheu TG, Trujillo AA, Okomo-Adhiambo M, Garten R, Klimov AI, et al. Detection of molecular markers of drug resistance in 2009 pandemic influenza A (H1N1) viruses by pyrosequencing. Antimicrob Agents Chemother. 2010;54:1102–10.
Hurt A, Holien J, Parker M, Kelso A, Barr I. Zanamivir-resistant influenza viruses with a novel neuraminidase mutation. Journal of Virology. 2009; 83:10366-10373.
Le QM, Wertheim HF, Tran ND, van Doorn HR, Nguyen TH, Horby P. A commu-nity cluster of oseltamivir-resistant cases of 2009 H1N1 influenza. New Engl J Med. 2010;362:86–7.
Ison MG, Mishin VP, Braciale TJ, Hayden FG, Gubareva LV. Comparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infection. J Infect Dis. 2006;193:765–772.
World Health Organization. Influenza A virus resistance to oseltamivir and other antiviral medicines. [cited 2009]. http://www.who.int/csr/disease/
influenza/2008- 9nhemisummaryreport/en/index.html.
Meijer A, Lackenby A, Hungnes O, Lina B, Werf van der S, Schweiger B, et al. Oseltamivir-resistant influenza virus A(H1N1), Europe, 2007-08 season. Emerg Infect Dis 2009;15:552-560.
Dharan NJ, Gubareva LV, Meyer JJ, Okomo-Adhiambo M, McClinton RC, Mar-shall SA, et al. Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States. JAMA 2009;301:1034–41.
Kawai N, Ikematsu H, Hirotsu N, Maeda T, Kawashima T, Tanaka O, et al. Clinical effectiveness of oseltamivir and zanamivir for treatment of influenza A virus subtype H1N1 with the H274Y mutation: a Japanese, multicenter study of the 2007-2008 and 2008-2009 influenza seasons. Clin Infect Dis. 2009;49:1828-35.
Ledesma J, Vicente D, Pozo F, Cilla G, Castro SP, Fernández JS, et al. The Spanish Influenza Surveillance System (SISS). Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain. J Clin Virol. 2011;51:205-208.


ua40317