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Nilo Ikuta *

Autor invitado por SIIC

O trabalho descreve os primeiros casos de vírus H1N1pdm09 resistentes a oseltamivir no Brasil.

H1N1 RESISTENTES A OSELTAMIVIR NO SUL DO BRASIL

Foram identificados dois mutantes resistentes ao inibidor NA, (H275Y e S247N). Este estudo revelou uma baixa prevalência (0,8%), sem propagação de vírus resistentes em todo Estado do Rio Grande do Sul.

*Nilo Ikuta
describe para SIIC los aspectos relevantes de su trabajo
OSELTAMIVIR-RESISTANT INFLUENZA A(H1N1)PDM09 VIRUS IN SOUTHERN BRAZIL
Memorias do Instituto Oswaldo Cruz,
108(3):392-394 May, 2013

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Universidade Luterana Do Brasil, Canoas, Brasil
Imprimir nota
Referencias bibliográficas
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World Health Organization. Update on oseltamivir resistance in influenza A (H1N1) 2009 viruses. [cited 2011 Aug 24]. http://www.who.int/influenza/surveillance_
monitoring/updates/2011_08_26_weekly_web_update_oseltamivir_resistance.pdf
Kiso M, Shinya K, Shimojima M, Takano R, Takahashi K, Katsura H, et al. Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses. PLoS Pathog. 2010;6:1-7.
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Kawai N, Ikematsu H, Hirotsu N, Maeda T, Kawashima T, Tanaka O, et al. Clinical effectiveness of oseltamivir and zanamivir for treatment of influenza A virus subtype H1N1 with the H274Y mutation: a Japanese, multicenter study of the 2007-2008 and 2008-2009 influenza seasons. Clin Infect Dis. 2009;49:1828-35.
Ledesma J, Vicente D, Pozo F, Cilla G, Castro SP, Fernández JS, et al. The Spanish Influenza Surveillance System (SISS). Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain. J Clin Virol. 2011;51:205-208.


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