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EVALUACION DE NUEVOS AGENTES PARA EL CANCER DE PANCREAS

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EVALUACION DE NUEVOS AGENTES PARA EL CANCER DE PANCREAS

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La gemcitabina se mantiene como el patrón de referencia en el tratamiento del cáncer de páncreas exocrino avanzado. Los nuevos agentes citotóxicos solos o en combinación con gemcitabina pueden mejorar el control del tumor y, posiblemente, aumentar la supervivencia.
evans9.jpg Autor:
T. R. Jeffry Evans
Columnista Experto de SIIC

Institución:
Centre of Oncology and Applied Pharmacology University of Glasgow Cancer Research UK Beatson Laboratories Glasgow, UK

Artículos publicados por T. R. Jeffry Evans
Recepción del artículo
8 de Septiembre, 2004 		Aprobación
20 de Septiembre, 2004
Primera edición
1 de Agosto, 2005 		Segunda edición, ampliada y corregida
7 de Junio, 2021

EVALUACION DE NUEVOS AGENTES PARA EL CANCER DE PANCREAS

Resumen
El carcinoma del páncreas exocrino es la cuarta causa más frecuente de muerte por cáncer en el Reino Unido. La mayor parte de los casos se presentan como una enfermedad inoperable con un promedio de supervivencia de solamente unos pocos meses en pacientes con enfermedad metastásica. En la actualidad la gemcitabina es el tratamiento de elección en los pacientes con enfermedad avanzada. En esta revisión se remarca la necesidad de desarrollar nuevas estrategias terapéuticas que mejoren la supervivencia en esta patología y se discute la combinación de aquellos regímenes quimioterapéuticos evaluados previamente. El camino más promisorio para los estadios avanzados de la enfermedad parece ser el diseño de nuevos agentes terapéuticos que se obtengan de la profundización del conocimiento de la biología del cáncer pancreático.

Palabras clave
Páncreas, gemcitabina, quimioterapia, terapias moleculares


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EVALUATION OF NOVEL AGENTS IN PANCREATIC CANCER

Abstract
Carcinoma of the exocrine pancreas is the fourth commonest cause of cancer deaths in the UK. Most cases present with inoperable disease with a median survival of only a few months in patients with metastatic disease. Currently single-agent gemcitabine is the treatment of choice in patients with advanced disease. This review highlights the challenges in developing therapeutic strategies to improve survival in this disease and discusses the various combination chemotherapy regimens that have been evaluated. Exploiting our understanding of the biology of pancreatic cancer to design novel agents seems to hold the greatest promise in advanced disease.

Key words
Pancreas, gemcitabine, chemotherapy, molecular therapies


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Especialidades
Principal: Oncología
Relacionadas: Farmacología, Gastroenterología, Medicina Farmacéutica, Medicina Interna



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Evans, TRJ
Patrocinio y reconocimiento:
Agradecimiento: El autor desea expresar su agradacimiento a Fiona Conway –secretaria asistente– por su ayuda en la preparación de este manuscrito.
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