DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer.

DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer.

Fuente:Clinical Epigenetics

Extracto: This study reveals a novel mechanism underpinning self-renewal and tumor growth of CSLC (cancer stem cell) in NSCLC and identifies potential therapeutic targets for NSCLC treatment.

Claves:Cancer stem cells, DNA Methyltransferase 1, Non-small cell lung cancer, SOS1, miR-152-3p

Cita:Clin Epigenetics 2024 Apr 15; 16 (1) : 55.

Autor/es:Yuan, Qing (a)
Wang, Rubo (b)

institución:(a) Department of Preclinical Medicine, Medical College, Hunan Normal University, Changsha, 410013, China.
(b) Key Laboratory of Study and Discover of Small Targeted Molecules of Hunan Province, Changsha, 410013, China.

Conflicto:The authors have declared that no competing interest exists.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1186/s13148-024-01663-5

Female genital mutilation: trends, economic burden of delay and basis for public health interventions.

Female genital mutilation: trends, economic burden of delay and basis for public health interventions.

Fuente:International Journal For Equity in Health

Extracto: Findings indicate that some countries show a declining trend over time while others not. It can be observed that there is heterogeneity and homogeneity in the FGM prevalence within and between countries which may indicate inequality that deserves further investigation. There is considerable economic burden due to delays in the implementation of interventions to reduce or eliminate FGM. These insights can help in the preparation of public health interventions.

Claves:Economic burden of delay, Economic burden of non-abandonment, Effective interventions, Female genital mutilation, Harmful practices, Sustainable development goals

Cita:Int J Equity Health 2024 Apr 15; 23 (1) : 73.

Autor/es:Cordova-Pozo, Kathya (a)
Abdalla, Hisham Hussein Imam (b)

institución:(a) Institute for Management Research, Radboud University, Nijmegen, The Netherlands.
(b) Department Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia, Egypt.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12939-024-02140-4

User-Centered Development of a Patient Decision Aid for Choice of Early Abortion Method: Multi-Cycle Mixed Methods Study.

User-Centered Development of a Patient Decision Aid for Choice of Early Abortion Method: Multi-Cycle Mixed Methods Study.

Fuente:Journal of Medical Internet Research

Extracto: We systematically designed the PtDA to address an unmet need to support informed, values-aligned decision-making about the method of abortion. The design process responded to a need identified by potential users and addressed unique sensitivities related to reproductive health decision-making.

Claves:Canada, abortion, evaluation, family planning, health equity, patient decision aid, qualitative, shared decision-making

Cita:J Med Internet Res 2024 Apr 16; 26 : e48793.

Autor/es:Wahl, Kate J (a)
Brooks, Melissa (b)

institución:(a) Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
(b) Department of Obstetrics and Gynecology, Dalhousie University, Halifax, NS, Canada.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:http://dx.doi.org/10.2196/48793

Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease.

Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease.

Fuente:Respiratory Research

Extracto: These results suggest a previously underappreciated role of host genetics in shaping the airway microbiome and provide fresh hypotheses for genetic-based host-microbiome interactions in COPD.

Claves:Airway microbiome, COPD, GWAS, Mendelian randomization, Microbiome-host genetic interaction

Cita:Respir Res 2024 Apr 16; 25 (1) : 165.

Autor/es:Gao, Jingyuan (a)
Yang, Yuqiong (b)

institución:(a) Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, Guangdong Province, China.
(b) State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12931-024-02805-2

The sedentary behavior reduction in pregnancy intervention (SPRING) pilot and feasibility randomized trial.

The sedentary behavior reduction in pregnancy intervention (SPRING) pilot and feasibility randomized trial.

Fuente:Bmc Pregnancy and Childbirth

Tipo de trabajo:Estudio clínico

Extracto: Further testing in a fully powered clinical trial is warranted.Trial registration NCT05093842 on clinicaltrials.gov.

Claves:Acceptability, Health coaching, Multi-level intervention, Thigh-worn accelerometer

Cita:BMC Pregnancy Childbirth 2024 Apr 11; 24 (1) : 261.

Autor/es:Gibbs, Bethany Barone (a)
Kozai, Andrea C (b)

institución:(a) Department of Epidemiology and Biostatistics, West Virginia University School of Public Health, PO Box 9190, 64 Medical Center Drive, Morgantown, WV, 26506, USA. bethany.gibbs@hsc.wvu.edu.
(b) Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12884-024-06474-3

Analysis of the Expression of LSF Transcription Factor in the Regulation of Transcription and TSG101 during the Neoplastic Transformation of Endometrial Cells.

Analysis of the Expression of LSF Transcription Factor in the Regulation of Transcription and TSG101 during the Neoplastic Transformation of Endometrial Cells.

Fuente:Cells

Extracto: These markers might be used as diagnostic and prognostic markers-however, there is a lack of a correlation between them.

Claves:LSF transcription factor, TSG101, carcinogenesis, endometrial cancer

Cita:Cells 2024 Mar 26; 13 (7)

Autor/es:Ziemiński, Rafał (a)
Stupak, Aleksandra (b)

institución:(a) Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland.
(b) Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/cells13070580

The Cellular Respiration of Endometrial Biopsies from Patients with Various Forms of Endometriosis.

The Cellular Respiration of Endometrial Biopsies from Patients with Various Forms of Endometriosis.

Fuente:International Journal of Molecular Sciences

Extracto: These data allow us to suggest that the therapeutic strategies of endometriosis based on modulation energy metabolism should take lesion localization into account.

Claves:OXPHOS, adenomyosis, endometriosis, glycolysis, macrolides

Cita:Int J Mol Sci 2024 Mar 26; 25 (7)

Autor/es:Toniyan, Konstantin A (a)
Malkov, Artyom A (b)

institución:(a) Cell Biophysics Laboratory, State Scientific Center of the Russian Federation Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia.
(b) Gynecology Department, FGBU KB1 (Volynskaya) UDP RF, 121352 Moscow, Russia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073680

Phytotherapy of Vulvovaginal Candidiasis

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: There is research currently undergoing aimed at comparing classical pharmacotherapy and herbal therapy in the treatment of vaginal candidiasis for the purpose of increasing medical competence and knowledge for the care of the health and long-term comfort of gynecological patients.

Claves:Allium jesdianum, Anethum graveolens, Cannabis savita subs, Curcuma longa, Fridericia chica, VVC, flavonoids, phytotherapy

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Picheta, Natalia (a)
Piekarz, Julia (b)

institución:(a) Student's Scientific Association at the I Chair and Department of Gynaecological Oncology and Gynaecology, Medical University of Lublin, Staszica 16 Str., 20-081 Lublin, Poland.
(b) Student's Scientific Association at the I Chair and Department of Gynaecological Oncology and Gynaecology, Medical University of Lublin, Staszica 16 Str., 20-081 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073796

Comparison of pregnancy outcomes among patients of different ages who underwent frozen-thawed high-quality single blastocyst transfer.

Comparison of pregnancy outcomes among patients of different ages who underwent frozen-thawed high-quality single blastocyst transfer.

Fuente:Bmc Pregnancy and Childbirth

Extracto: Frozen-thawed high-quality single blastocyst transfer produces the same satisfactory pregnancy outcomes for women aged 35-37 years as younger patients. Future prospective randomized controlled studies with larger populations are needed to verify the feasibility and safety of this method.

Claves:Advanced maternal age (AMA), Assisted reproductive technology (ART), Frozen-thawed embryo transfer (FET), Pregnancy outcomes, Single blastocyst transfer (SBT)

Cita:BMC Pregnancy Childbirth 2024 Apr 15; 24 (1) : 276.

Autor/es:Chen, Haoying (a)
Wu, Shenghao (b)

institución:(a) Department of Reproductive Center, Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
(b) Department of Reproductive Center, Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12884-024-06451-w

The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial.

The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial.

Fuente:Journal of Ovarian Research

Extracto: Preliminary results from this study indicate that pre-treatment with resveratrol may improve ovarian sensitivity to exogenous FSH, which in turn may decrease the risk of hypo-response to OS in advanced reproductive age women.

Claves:FOI, FORT, FSH, Hypo-response, Ovarian sensitivity, POSEIDON

Cita:J Ovarian Res 2024 Apr 15; 17 (1) : 81.

Autor/es:Conforti, A (a)
Iorio, G G (b)

institución:(a) Department of Neuroscience, Reproductive Science and Odontostomatology, School of Medicine, University of Naples "Federico II, Naples, Italy, Via Sergio Pansini, 5, 80131.
(b) Department of Neuroscience, Reproductive Science and Odontostomatology, School of Medicine, University of Naples "Federico II, Naples, Italy, Via Sergio Pansini, 5, 80131. giuseppeg.iorio94@gmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13048-024-01391-7

Low-dose aspirin for the prevention of preterm birth in nulliparous women

Low-dose aspirin for the prevention of preterm birth in nulliparous women

Fuente:Bmc Pregnancy and Childbirth

Tipo de trabajo:Revisión sistemática

Extracto: Low-dose aspirin might reduce the risk of preterm birth at less than 34 weeks of gestation in nulliparous women. The use of low-dose aspirin in nulliparous women increased the risk of postpartum hemorrhage and might increase the risk of placental abruption and cesarean section.

Claves:Aspirin, Preterm birth, Systematic review, meta-analysis

Cita:BMC Pregnancy Childbirth 2024 Apr 11; 24 (1) : 260.

Autor/es:Yan, Xin (a)
Zheng, Wei (b)

institución:(a) Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, No.251, Yaojiayuan Road, Chaoyang District, Beijing, 100026, China.
(b) Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, No.251, Yaojiayuan Road, Chaoyang District, Beijing, 100026, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12884-024-06413-2

Genetic analysis of 37 cases with primary periodic paralysis in Chinese patients.

Genetic analysis of 37 cases with primary periodic paralysis in Chinese patients.

Fuente:Orphanet Journal of Rare Diseases

Extracto: Our results suggest that SCN4A alleles are the main cause in our cohort, with the remainder caused by CACNA1S alleles, which are the predominant cause in Europe and the United States. Additionally, this study identified 3 novel SCN4A and 2 novel CACNA1S variants, broadening the mutation spectrum of genes associated with PPP.

Claves:CACNA1S and SCN4A genes, Hypokalemic periodic paralysis, Minigene, Panel and WES, Primary periodic paralysis

Cita:Orphanet J Rare Dis 2024 Apr 12; 19 (1) : 160.

Autor/es:Zhao, Xuechao (a)
Ning, Haofeng (b)

institución:(a) The Genetics and Prenatal Diagnosis Center, The Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Jianshe Rd, Erqi District, 450052, Zhengzhou, Henan, China.
(b) Obstetrics and Gynaecology, The Seventh Affiliated Hospital, Sun Yat-Sen University, No 628 Zhenyuan Road Guangming District, 518107, Shenzhen, PR China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03170-5

MicroRNA Associations with Preterm Labor-A Systematic Review.

MicroRNA Associations with Preterm Labor-A Systematic Review.

Fuente:International Journal of Molecular Sciences

Extracto: In conclusion, this comprehensive analysis lays the foundation for subsequent research, intervention strategies and improved outcomes in the realm of preterm labor.

Claves:MicroRNA expression, pregnancy, preterm labor

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Kondracka, Adrianna (a)
Stupak, Aleksandra (b)

institución:(a) Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.
(b) Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073755

Substance P Concentration in Gestational Diabetes and Excessive Gestational Weight Gain and Its Impact on Neonatal Anthropometry.

Fuente:International Journal of Molecular Sciences

Extracto: To our knowledge, it is the first study assessing substance P concentration in GDM and EGWG patients.

Claves:excessive gestational weight gain, fetal programming, gestational diabetes mellitus, substance P

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Niebrzydowska-Tatus, Magdalena (a)
Pełech, Aleksandra (b)

institución:(a) Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.
(b) Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073759

TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study.

Fuente:International Journal of Molecular Sciences

Extracto: The presence of at least one minor T allele was associated with a higher risk of fetal macrosomia.

Claves:TCF7L2 gene, fetal macrosomia, gestational diabetes mellitus, rs7903146 (C/T) polymorphism

Cita:Int J Mol Sci 2024 Apr 4; 25 (7)

Autor/es:Cruciat, Gheorghe (a)
Florian, Andreea Roxana (b)

institución:(a) Mother and Child Department, Obstetrics and Gynecology I, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, Romania.
(b) Mother and Child Department, Obstetrics and Gynecology I, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, Romania.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074039

Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy.

Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy.

Fuente:Nutrients

Extracto: Dietary inflammatory potential was associated with a reduction in the consumption of vitamins and minerals and predicted gut microbiota metabolic dysregulation.

Claves:diet, dietary inflammatory index, food frequency questionnaire, galactose, gut microbiota, inflammation, pregnancy

Cita:Nutrients 2024 Mar 24; 16 (7)

Autor/es:Alvernaz, Suzanne A (a)
Wenzel, Elizabeth S (b)

institución:(a) Department of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USA.
(b) Department of Psychology, University of Illinois, Chicago, IL 60607, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070935

Food Cravings and Obesity in Women with Polycystic Ovary Syndrome: Pathophysiological and Therapeutic Considerations.

Fuente:Nutrients

Extracto: Cognitive-behavioral intervention seems to be the mainstay of treatment, while the role of medical agents, such as GLP-1 analogs and naltrexone/bupropion, has emerged.

Claves:binge eating, food cravings, food disorders, obesity, polycystic ovary syndrome

Cita:Nutrients 2024 Apr 3; 16 (7)

Autor/es:Stefanaki, Katerina (a)
Karagiannakis, Dimitrios S (b)

institución:(a) Endocrine Unit and Diabetes Center, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
(b) Academic Department of Gastroenterology, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16071049

Early prediction of gestational diabetes mellitus using maternal demographic and clinical risk factors.

Early prediction of gestational diabetes mellitus using maternal demographic and clinical risk factors.

Fuente:Bmc Research Notes

Extracto: While the performance markedly decreased to an AUC of 0.69 when testing the MMC-based model on the external nuMoM2b test data, close to the performance trained and tested on the nuMoM2b dataset only (AUC = 0.70).

Claves:Clinical risk factors, Early prediction, Gestational diabetes mellitus, Maternal demographics, Model validation

Cita:BMC Res Notes 2024 Apr 15; 17 (1) : 105.

Autor/es:Wu, Yanqi (a)
Hamelmann, Paul (b)

institución:(a) Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
(b) Philips Research, Eindhoven, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13104-024-06758-z

Circadian Gene Variants: Effects in Overweight and Obese Pregnant Women.

Circadian Gene Variants: Effects in Overweight and Obese Pregnant Women.

Fuente:International Journal of Molecular Sciences

Extracto: These data suggest a potential role of the polymorphisms in clock systems and in fat taste perception in both susceptibility to overweight/obesity and influencing the related metabolic traits in pregnant women.

Claves:BMAL1, CD36, CLOCK, GDM, Mediterranean diet, obesity, pregnancy

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Franzago, Marica (a)
Borrelli, Paola (b)

institución:(a) Department of Medicine and Aging, School of Medicine, and Health Sciences, "G. D'Annunzio" University, Via dei Vestini, Chieti-Pescara, 66100 Chieti, Italy.
(b) Center for Advanced Studies and Technology (CAST), "G. D'Annunzio" University, Chieti-Pescara, 66100 Chieti, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073838

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health.

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health.

Fuente:Nutrients

Tipo de trabajo:Revisión

Extracto: This review stands as the first to offer such a detailed examination of minerals in the context of the menstrual cycle, aiming to elevate the understanding of their critical role in female fertility and reproductive health.

Claves:endometrial health, fertility, menstrual cycle, minerals, ovulation

Cita:Nutrients 2024 Mar 29; 16 (7)

Autor/es:Kapper, Celine (a)
Oppelt, Peter (b)

institución:(a) Experimental Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria.
(b) Experimental Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16071008