A prospective phase II clinical trial of total neoadjuvant therapy for locally advanced gastric cancer and gastroesophageal junction adenocarcinoma.

A prospective phase II clinical trial of total neoadjuvant therapy for locally advanced gastric cancer and gastroesophageal junction adenocarcinoma.

Fuente:Scientific Reports

Extracto: The total neoadjuvant therapy comprising NCRT followed by NCCT and surgery demonstrates a low severe adverse reactions and promising efficacy, which could be considered as a viable treatment for locally advanced GC or GEJ adenocarcinoma.Trial registration: Clinicaltrials.gov (registration number: NCT04062058); the full date of first trial registration was 20/08/2019.

Claves:Consolidation chemotherapy, Gastric cancer, Gastroesophageal junction cancer, Locally advanced, Neoadjuvant concurrent chemoradiotherapy

Cita:Sci Rep 2024 Mar 29; 14 (1) : 7522.

Autor/es:Shi, Jin-Ming (a)
Li, Ning (b)

institución:(a) Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
(b) Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58177-6

Abdominal abscess caused by Raoultella ornithinolytica secondary to postoperative gastric fistula

Abdominal abscess caused by Raoultella ornithinolytica secondary to postoperative gastric fistula

Fuente:Bmc Infectious Diseases

Tipo de trabajo:Revisión

Extracto: To the best of our knowledge, case of isolating R. ornithinolytica from a patient with non-viscerally abdominal abscess was extremely rare. We share a case of a woman with non-viscerally abdominal abscess secondary to postoperative gastric fistula, R. ornithinolytica was isolated from the patient's pus, and the pathogenic bacteria may originate from the gastrointestinal tract. Based on this case, We should be cautious that invasive treatment may greatly increase the probability of infection with this pathogenic bacterium.

Claves:Choledocholithotomy, Non-viscerally abdominal abscess, Postoperative gastric fistula, Raoultella ornithinolytica

Cita:BMC Infect Dis 2024 Mar 29; 24 (1) : 363.

Autor/es:Huang, Qiuxia (a)
Zhang, Jihong (b)

institución:(a) The Central Hospital of Shaoyang, Shaoyang, Hunan, China. 2374720832@qq.com.
(b) The Central Hospital of Shaoyang, Shaoyang, Hunan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12879-024-09234-y

Single-nucleotide polymorphism in CYP1A1, CYP1B1, CYP2B6, CYP2C8, and CYP2C9 genes and their association with gastrointestinal cancer: A hospital-based case-control study.

Single-nucleotide polymorphism in CYP1A1, CYP1B1, CYP2B6, CYP2C8, and CYP2C9 genes and their association with gastrointestinal cancer: A hospital-based case-control study.

Fuente:Journal of Cancer Research and Therapeutics

Extracto: The findings from this study supported that polymorphism of CYP2B6*5gene may be involved in the development of GI cancer. However, other SNPs of CYP1A, CYP1B, and CYP2C genes did not signify the risk for GI cancer in the studied population of rural Maharashtra.

Cita:J Cancer Res Ther 2024 Jan 1; 20 (1) : 216-223.

Autor/es:Patil, Madhavi N (a)
Datkhile, Kailas D (b)

institución:(a) Department of Molecular Biology and Genetics, Krishna Institute of Medical Sciences "Deemed to be University", Satara, Maharashtra, India.
(b) Department of Molecular Biology and Genetics, Krishna Institute of Medical Sciences "Deemed to be University", Satara, Maharashtra, India.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/jcrt.jcrt_294_22

Naples prognostic score may predict overall survival in metastatic pancreatic cancer.

Fuente:Journal of Cancer Research and Therapeutics

Extracto: NPS may be a useful prognostic marker for the prediction of OS in metastatic PC patients receiving systemic chemotherapy.

Cita:J Cancer Res Ther 2024 Jan 1; 20 (1) : 249-254.

Autor/es:Gulturk, Ilkay (a)
Yilmaz, Mesut (b)

institución:(a) Medical Oncology Department, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
(b) Medical Oncology Department, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/jcrt.jcrt_1392_22

Methylation study of tumor suppressor genes in human aberrant crypt foci, colorectal carcinomas, and normal colon.

Fuente:Journal of Cancer Research and Therapeutics

Extracto: Early epigenetic methylation of WIF1 gene is one of the mechanisms for ACF development in human colon.

Cita:J Cancer Res Ther 2024 Jan 1; 20 (1) : 268-274.

Autor/es:Sarangi, Jayati (a)
Das, Prasenjit (b)

institución:(a) Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
(b) Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/jcrt.jcrt_1573_22

Clinicopathological and prognostic significance of VEGF, PDGF-B, and HER2/neu expression in gallbladder cancer.

Fuente:Journal of Cancer Research and Therapeutics

Extracto: Overexpression of VEGF, PDGF-B, and HER2/neu might be possible prognostic biomarkers in GBC. Poor survival of VEGF and HER2/neu positive cases indicates the possibilities of using their blockers as therapeutic agents.

Cita:J Cancer Res Ther 2024 Jan 1; 20 (1) : 349-357.

Autor/es:Shukla, Pooja (a)
Mishra, Kumudesh (b)

institución:(a) Department of Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX, USA.
(b) Department of Neurology, Faculty of Medicine, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/jcrt.jcrt_1473_22

Comparison of clinical outcomes of robotic-assisted and video-assisted esophagectomy for esophageal cancer.

Fuente:Journal of Cancer Research and Therapeutics

Extracto: Robotic procedures can be safely performed in esophageal cancers with complication rates and oncological radicality similar to those of other minimally invasive techniques.

Cita:J Cancer Res Ther 2024 Jan 1; 20 (1) : 410-416.

Autor/es:Yüksel, Sercan (a)
Topal, Uğur (b)

institución:(a) Department of General Surgery, Başakşehir Çam and Sakura City Hospital, Başakşehir, Istanbul, Turkey.
(b) Department of Surgical Oncology, Başakşehir Çam and Sakura City Hospital, Başakşehir, Istanbul, Turkey.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/jcrt.jcrt_2518_22

Extranodal follicular dendritic cell sarcoma presenting as colonic mass: A diagnostic and therapeutic challenge.

Fuente:Journal of Cancer Research and Therapeutics

Extracto: Herein we report, two cases of extranodal FDCS of colon with the aim of contributing to the management of this uncommon entity.

Cita:J Cancer Res Ther 2024 Jan 1; 20 (1) : 450-453.

Autor/es:Pasricha, Sunil (a)
Durga, Garima (b)

institución:(a) Department of Pathology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India.
(b) Department of Pathology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/jcrt.jcrt_1534_22

Redefining clinical practice through spatial profiling: a revolution in tissue analysis.

Fuente:Annals of The Royal College of Surgeons of England

Extracto: In this paper, we discuss the recent evolution of spatial biology, and its potential for improving our tissue level understanding and treatment of disease, to help advance precision and effectiveness in healthcare interventions.

Claves:image analysis, immunohistochemistry, multiplexed imaging, spatial biology, spatial transcriptomics

Cita:Ann R Coll Surg Engl 2024 Apr; 106 (4) : 305-312.

Autor/es:Mulholland, E J (a)
Leedham, S J (b)

institución:(a) Centre for Human Genetics, University of Oxford, UK.
(b) Centre for Human Genetics, University of Oxford, UK.

Conflicto:SJL has received grant income from UCB Pharma. All other authors declare no competing interests.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1308/rcsann.2023.0091

Clinical Analysis and in Vitro Correlation of BCRP-Mediated Drug-Drug Interaction in the Gastrointestinal Tract.

Clinical Analysis and in Vitro Correlation of BCRP-Mediated Drug-Drug Interaction in the Gastrointestinal Tract.

Fuente:Biological & Pharmaceutical Bulletin

Extracto: Therefore, it is suggested that the in vitro study using Caco-2 cells could be used to quantitatively estimate BCRP-mediated DDI with ROS in the gastrointestinal tract.

Claves:Caco-2, absorption rate constant (ka), breast cancer resistance protein, cell to medium ratio, drug–drug interaction, rosuvastatin

Cita:Biol Pharm Bull 2024; 47 (4) : 750-757.

Autor/es:Perera, Liyanage Manosika Buddhini (a)
Okazaki, Kenzo (b)

institución:(a) Laboratory of Biopharmaceutics, Department of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare.
(b) Laboratory of Biopharmaceutics, Department of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Japón

Sitio web:http://dx.doi.org/10.1248/bpb.b23-00786

U-Shaped Association between Serum Chloride Levels and In-Hospital Mortality in Patients with Congestive Heart Failure in Intensive Care Units.

U-Shaped Association between Serum Chloride Levels and In-Hospital Mortality in Patients with Congestive Heart Failure in Intensive Care Units.

Fuente:International Heart Journal

Extracto: Stratified analyses demonstrated the robustness of this correlation.The relationship between serum chloride levels and in-hospital mortality in patients with heart failure was U-shaped, with an inflection point of 105.017 mmol/L.

Claves:Blood chloride, Generalized additive model, MIMIC, Subgroup analysis

Cita:Int Heart J 2024; 65 (2) : 237-245.

Autor/es:Zhang, Kai (a)
Han, Yu (b)

institución:(a) The Second Hospital of Jilin University.
(b) Department of Ophthalmology, The First Hospital of Jilin University.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Japón

Sitio web:http://dx.doi.org/10.1536/ihj.23-331

Intravenous metoclopramide for increasing endoscopic mucosal visualization in patients with acute upper gastrointestinal bleeding: a multicenter, randomized, double-blind, controlled trial.

Intravenous metoclopramide for increasing endoscopic mucosal visualization in patients with acute upper gastrointestinal bleeding: a multicenter, randomized, double-blind, controlled trial.

Fuente:Scientific Reports

Tipo de trabajo:Estudio clínico

Extracto: Pre-endoscopic intravenous metoclopramide improved the quality of EMV in variceal etiologies of UGIH, which was especially prominent in those who had signs of active bleeding based on nasogastric tube assessment.Trial Registration: Trial was registered in Clinical Trials: TCTR 20210708004 (08/07/2021).

Claves:Acute upper gastrointestinal hemorrhage, Endoscopic mucosal visualization, Length of hospital stay, Metoclopramide, Modified Avgerinos Score

Cita:Sci Rep 2024 Mar 31; 14 (1) : 7598.

Autor/es:Manupeeraphant, Paveeyada (a)
Wanichagool, Dhanusorn (b)

institución:(a) Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, 681 Samsen Road, Dusit District, Bangkok, 10300, Thailand.
(b) Division of Gastroenterology, Phra Nakhon Si Ayutthaya Hospital, Ayutthaya, Thailand.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-57913-2

CAF-associated genes putatively representing distinct prognosis by in silico landscape of stromal components of colon cancer.

CAF-associated genes putatively representing distinct prognosis by in silico landscape of stromal components of colon cancer.

Fuente:Plos One

Extracto: Our current in silico analysis of the micro-dissected stromal gene signatures with prognostic relevance clarified comprehensive understanding of clinical features of the TME and provides deep insights of the landscape.

Cita:PLoS One 2024; 19 (4) : e0299827.

Autor/es:Okuno, Kota (a)
Ikemura, Kyonosuke (b)

institución:(a) Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan.
(b) Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299827

Association of per- and polyfluoroalkyl substances with constipation: The National Health and Nutrition Examination Survey (2005-2010).

Fuente:Plos One

Extracto: The findings of this study provide evidence of a significant inverse correlation between serum concentrations of PFAS, particularly PFOA and PFHxS, and constipation.

Cita:PLoS One 2024; 19 (4) : e0301129.

Autor/es:Zhao, Yifan (a)
Pu, Ke (b)

institución:(a) The First Clinical Medical College, Lanzhou University, Lanzhou, China.
(b) Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301129

Targeting the gut microbiota to enhance the antitumor efficacy and attenuate the toxicity of CAR-T cell therapy: a new hope?

Targeting the gut microbiota to enhance the antitumor efficacy and attenuate the toxicity of CAR-T cell therapy: a new hope?

Fuente:Frontiers in Immunology

Extracto: Above all, we highlight potential strategies and challenges in harnessing the gut microbiota as a predictor and modifier of CAR-T cell therapy efficacy while attenuating toxicity.

Claves:CAR-T cell therapy, antitumor efficacy, gut microbiota, immunotherapy, toxicity

Cita:Front Immunol 2024; 15 : 1362133.

Autor/es:Zhang, Peng-Fei (a)
Xie, Dan (b)

institución:(a) Gastric Cancer Center, Division of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
(b) Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1362133

Rapid identification of inflammatory arthritis and associated adverse events following immune checkpoint therapy: a machine learning approach.

Fuente:Frontiers in Immunology

Extracto: Patients with ICI-IA were significantly more likely to also develop cutaneous, endocrine, and gastrointestinal irAEs during their clinical course compared to ICI therapy patients without ICI-IA.

Claves:big data, electronic health records, immune checkpoint inhibitor-induced inflammatory arthritis, immune checkpoint inhibitors, immune-related adverse events, machine learning

Cita:Front Immunol 2024; 15 : 1331959.

Autor/es:Tran, Steven D (a)
Lin, Jean (b)

institución:(a) Center for Health Information Partnerships, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
(b) Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

Conflicto:TLW receives unrelated research funding from Gilead Sciences. AK is a strategic advisor for Datavant, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.​

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1331959

Intestinal microbiota and biliary system diseases.

Intestinal microbiota and biliary system diseases.

Fuente:Frontiers in Cellular and Infection Microbiology

Tipo de trabajo:Revisión

Extracto: We hope to provide biomarkers forearly diagnosis of biliary system diseases and provide new directions for the mechanism of intestinal microbiota in biliary diseases.

Claves:biliary tract cancer, gallstones, microbial community, primary biliary cholangitis, primary sclerosing cholangitis

Cita:Front Cell Infect Microbiol 2024; 14 : 1362933.

Autor/es:Wang, Hua (a)
Gong, Junfeng (b)

institución:(a) Department of Health, The Chinese People's Armed Police Forces Anhui Provincial Corps Hospital, Hefei, China.
(b) Department of General Surgery, The Chinese People's Armed Police Forces Anhui Provincial Corps Hospital, Hefei, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fcimb.2024.1362933

The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis.

Fuente:Frontiers in Cellular and Infection Microbiology

Extracto: This investigation represents the inaugural identification of indicative data supporting either beneficial or detrimental causal relationships between gut microbiota and the risk of BTC, as determined through the utilization of MR methodologies. These outcomes could hold significance for the formulation of individualized therapeutic strategies aimed at BTC prevention and survival enhancement.

Claves:biliary tract cancer, comprehensive bidirectional mendelian randomization, genome-wide association study, gut microbiota, probiotics

Cita:Front Cell Infect Microbiol 2024; 14 : 1308742.

Autor/es:Wang, Kui (a)
Wang, Suijian (b)

institución:(a) Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
(b) Department of Gastroenterology, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fcimb.2024.1308742

A multicenter clinical epidemiology of pediatric pneumococcal meningitis in China: results from the Chinese Pediatric Bacterial Meningitis Surveillance (CPBMS) 2019-2020.

Fuente:Frontiers in Cellular and Infection Microbiology

Extracto: Pediatric PM is more common in children aged 3 months to < 3 years old. Intracranial complications mostly occur in children < 1 year of age with fever being the most common clinical manifestations and subdural effusion and (or) empyema and hydrocephalus being the most common complications, respectively. CSF non-culture methods can facilitate improving the detection rate of pathogenic bacteria. More than 10% of PM children had adverse outcomes. S. pneumoniae strains are susceptible to vancomycin, linezolid, ertapenem, levofloxacin, moxifloxacin, rifampicin, and chloramphenicol.

Claves:S. pneumoniae, epidemiology, meningitis, multicenter study, pediatric

Cita:Front Cell Infect Microbiol 2024; 14 : 1353433.

Autor/es:Wang, Caiyun (a)
Xu, Hongmei (b)

institución:(a) Department of Infectious Disease, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, Zhejiang, China.
(b) Department of Infectious Disease, Children's Hospital of Chongqing Medical University, Chongqing, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fcimb.2024.1353433

Targeted multispectral filter array design for the optimization of endoscopic cancer detection in the gastrointestinal tract.

Targeted multispectral filter array design for the optimization of endoscopic cancer detection in the gastrointestinal tract.

Fuente:Journal of Biomedical Optics

Tipo de trabajo:Estudio clínico

Extracto: The ability to retain good classification accuracies with a reduced number of spectral bands could enable the future deployment of multispectral imaging in an endoscopic chip-on-tip configuration using simplified MSFA hardware. Further studies using an expanded clinical dataset are needed to confirm these findings.

Claves:colon cancer, colonoscopy, endoscopy, esophageal cancer, multispectral filter array, multispectral imaging

Cita:J Biomed Opt 2024 Mar; 29 (3) : 036005.

Autor/es:Taylor-Williams, Michaela (a)
Tao, Ran (b)

institución:(a) University of Cambridge, Department of Physics, Cavendish Laboratory, Cambridge, United Kingdom.
(b) University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1117/1.JBO.29.3.036005