Platinum-based adjuvant chemoradiotherapy versus adjuvant radiotherapy in patients with head and neck adenoid cystic carcinoma.

Platinum-based adjuvant chemoradiotherapy versus adjuvant radiotherapy in patients with head and neck adenoid cystic carcinoma.

Fuente:Journal of Cancer Research and Clinical Oncology

Extracto: In terms of reducing locoregional failures in HNACC patients, POCRT may potentially offer a more effective therapeutic approach than using PORT alone, although it also entails an augmented burden of treatment-related toxicity.

Claves:Adjuvant chemoradiotherapy, Head and neck adenoid cystic carcinoma, Intensity-modulated radiotherapy, Postoperative radiotherapy

Cita:J Cancer Res Clin Oncol 2024 Apr 16; 150 (4) : 195.

Autor/es:Qiu, Zichen (a)
Wu, Zheng (b)

institución:(a) Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Yuexiu District, Guanzhou, 510060, People's Republic of China.
(b) Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tong Zi Po Road, Changsha, 410013, People's Republic of China.

Conflicto:The authors have no relevant financial or non-financial interests to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s00432-024-05719-0

Tomato seed extract promotes health of the gut microbiota and demonstrates a potential new way to valorize tomato waste.

Tomato seed extract promotes health of the gut microbiota and demonstrates a potential new way to valorize tomato waste.

Fuente:Plos One

Extracto: These findings provide a novel application for TSE harvested from tomato pomace and demonstrate the potential to further valorize tomato waste products.

Cita:PLoS One 2024; 19 (4) : e0301381.

Autor/es:Firrman, Jenni (a)
Narrowe, Adrienne (b)

institución:(a) United States Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Dairy and Functional Foods Research Unit, Wyndmoor, Pennsylvania, United States of America.
(b) United States Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Dairy and Functional Foods Research Unit, Wyndmoor, Pennsylvania, United States of America.

Conflicto:No competing interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301381

Increased risk of chronic kidney disease and mortality in a cohort of people diagnosed with metabolic dysfunction associated steatotic liver disease with hepatic fibrosis.

Fuente:Plos One

Tipo de trabajo:Guía

Extracto: Liver fibrosis was an independent risk factor for CKD in this cohort of people living with MASLD. Furthermore, those with MASLD with liver fibrosis had higher risk for mortality and this risk was further elevated among those with co-morbid CKD. Given the increased risk of CKD, and consequent mortality risk, among people living with MASLD fibrosis, renal function screening should be considered within liver health surveillance programmes and guidelines.

Cita:PLoS One 2024; 19 (4) : e0299507.

Autor/es:Gurun, Marc (a)
Brennan, Paul (b)

institución:(a) Molecular and Clinical Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom.
(b) Molecular and Clinical Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299507

Could the mitotic count improve personalized prognosis in melanoma patients?

Fuente:Plos One

Extracto: The mitotic rate can be used to develop a personalized medicine approach in the treatment and follow-up monitoring of melanoma patients.

Cita:PLoS One 2024; 19 (4) : e0302309.

Autor/es:Buja, Alessandra (a)
Rugge, Massimo (b)

institución:(a) Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
(b) Veneto Tumor Registry, Azienda Zero, Padova, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0302309

Intra-abdominal hematomas and identifiable risk factors in patients receiving subcutaneous enoxaparin.

Fuente:Plos One

Tipo de trabajo:Caso clínico

Extracto: Patients at risk for an enoxaparin associated hematoma include female patients with a CrCl <60ml/min and/or BMI >30 kg/m2 receiving enoxaparin treatment dosing.

Cita:PLoS One 2024; 19 (4) : e0301906.

Autor/es:Lager, Stephanie (a)
Balakrishnan, Gautam (b)

institución:(a) Mosaic Life Care, Saint Joseph, MO, United States of America.
(b) Mosaic Life Care, Saint Joseph, MO, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301906

The causal relationship between genetically predicted blood metabolites and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization study.

Fuente:Plos One

Tipo de trabajo:Metanálisis

Extracto: Conclusively, hyperglycemia may confer a promoting effect on IPF, highlighting that attention should be paid to the relationship between diabetes and IPF, not solely to the diagnosis of diabetes. Additionally, urea, guanosine, and ADpSGEGDFXAEGGGVR also facilitate the development of IPF. This study may provide a reference for analyzing the potential mechanism of IPF and carry implications for the prevention and treatment of IPF.

Cita:PLoS One 2024; 19 (4) : e0300423.

Autor/es:Pan, Tingyu (a)
Bai, Le (b)

institución:(a) Department of Pulmonary and Critical Care Medicine, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
(b) Department of Pulmonary and Critical Care Medicine, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300423

Chest pain in pediatric patients in the emergency department- Presentation, risk factors and outcomes-A systematic review and meta-analysis.

Fuente:Plos One

Tipo de trabajo:Revisión sistemática

Extracto: The overwhelming majority of pediatric chest pain cases stem from benign origins. This comprehensive analysis found musculoskeletal pain as the predominant culprit behind chest discomfort in children. Scrutinizing our study cohort revealed that retrosternal chest pain stands as the unequivocal epicenter of this affliction. Thorough evaluation of pediatric patients manifesting with chest pain is paramount for the delivery of unparalleled care, especially in the context of potential cardiac risks in the emergency department.

Cita:PLoS One 2024; 19 (4) : e0294461.

Autor/es:Alsabri, Mohammed (a)
Elshanbary, Alaa Ahmed (b)

institución:(a) Department of Pediatrics/Emergency Pediatrics, Althawra Modern General Hospital, Sana'a, Yemen.
(b) Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0294461

Health information technology tools to accelerate gastrointestinal evaluation in patients with iron deficiency anaemia

Fuente:Bmj Open Quality

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: Providing PCPs with lists of patients with IDA and a pathway for expedited evaluation did not increase rates of completing endoscopic evaluation in the short term. TRIAL REGISTRATION NUMBER: NCT05365308.

Claves:Ambulatory care, Decision support, clinical, Healthcare quality improvement, Patient safety

Cita:BMJ Open Qual 2024 Apr 15; 13 (2)

Autor/es:Priyanath Gupta, Aparna (a)
Patel, Dharmesh (b)

institución:(a) Division of General Internal Medicine, Department of Medicine, Feinberg School of Medicine,Northwestern University, Chicago, Illinois, USA apriyan1@nm.org.
(b) Northwestern Medical Group Quality and Safety, Northwestern Memorial HealthCare Corp, Chicago, Illinois, USA.

Conflicto:Competing interests: The authors are solely responsible for the content and the decision to submit for publication. SDP receives unrelated research support from Omron Healthcare Co. Ltd. paid to Northwestern University and has received speaking honoraria from Omron Healthcare Co. Ltd. and the National Committee for Quality Assurance.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjoq-2023-002565

Real-world data evaluating Guy's rapid diagnostic clinic as an alternate pathway for patients with FIT levels below 10.

Real-world data evaluating Guy's rapid diagnostic clinic as an alternate pathway for patients with FIT levels below 10.

Fuente:Bmj Open

Extracto: This study demonstrates the effectiveness of RDCs as an alternate pathway for FIT <10 patients with ongoing clinical concerns. These results contribute to enhancing patient care and optimising resource allocation within the healthcare system.

Claves:EPIDEMIOLOGIC STUDIES, EPIDEMIOLOGY, Endoscopy

Cita:BMJ Open 2024 Apr 15; 14 (4) : e080285.

Autor/es:Monroy-Iglesias, Maria Jose (a)
Martin, Sabine (b)

institución:(a) Translational Oncology and Urology Research, King's College London, London, UK maria.j.monroy_iglesias@kcl.ac.uk.
(b) Medical Oncology, Guy's and St Thomas' Hospitals NHS Trust, London, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-080285

New treatment alternatives for primary and metastatic colorectal cancer by an integrated transcriptome and network analyses.

New treatment alternatives for primary and metastatic colorectal cancer by an integrated transcriptome and network analyses.

Fuente:Scientific Reports

Extracto: Network analysis suggests IL-29A induces the JAK/STAT pathway in a preventive manner.

Cita:Sci Rep 2024 Apr 16; 14 (1) : 8762.

Autor/es:Karaca, Caner (a)
Demir Karaman, Ezgi (b)

institución:(a) Department of Translational Oncology, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
(b) Department of Computer Engineering, Faculty of Engineering, Dokuz Eylul University, Izmir, Turkey.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59101-8

Barriers to the use of tests for early detection of colorectal cancer in Chile.

Fuente:Scientific Reports

Extracto: The results of this study provide valuable insights into factors influencing CRC screening, aiming to inform public health policies for expanding national coverage beyond diagnosis and treatment to encompass preventive measures.

Claves:Barriers to colon cancer screening, Cancer prevention, Chile, Colonoscopies, Colorectal cancer

Cita:Sci Rep 2024 Apr 17; 14 (1) : 8817.

Autor/es:Alfaro, Gabriela (a)
Berger, Zoltan (b)

institución:(a) Industrial Engineering Department, University of Chile, Beauchef 851, Santiago, Chile.
(b) Department of Medicine, Gastroenterology Section, Hospital Clínico de La Universidad de Chile, Santiago, Chile.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58920-z

Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology.

Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology.

Fuente:Bmc Infectious Diseases

Extracto: Screening for toxoplasmosis among H. pylori-infected patients is recommended as it is considered a potential risk factor for gastric inflammation severity. H. pylori gastric inflammation may be heightened by Toxoplasma coinfection.

Claves:Cag A, Helicobacter pylori, Toxoplasma, Vac As1, Histopathological features, Humans

Cita:BMC Infect Dis 2024 Apr 16; 24 (1) : 408.

Autor/es:Gouda, Marwa A (a)
Saied, Sara A (b)

institución:(a) Clinical and Molecular Parasitology Department, National Liver Institute, Menoufia University, Shibin Elkom, Menoufia, Egypt.
(b) Clinical Pathology Department, National Liver Institute, Menoufia University, Shibin Elkom, Menoufia, Egypt. sarasaied@liver.menofia.edu.eg.

Conflicto:This study's research, writing, and publication were all done without any actual or prospective conflicts of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12879-024-09270-8

The role of piRNAs in predicting and prognosing in cancer

The role of piRNAs in predicting and prognosing in cancer

Fuente:Bmc Cancer

Tipo de trabajo:Revisión sistemática

Extracto: Our findings suggest that various piRNAs may play a role in cancer survival outcomes and that piRNA-823 in particular holds promise as a prognostic biomarker for multiple human cancers. IMPLICATIONS FOR CANCER SURVIVORS: Our systematic review and meta-analysis of piRNA-823 has important implications for cancer survivors. Our findings suggest that piRNA-823 can be used as a prognostic biomarker for predicting cancer recurrence and survival rates. This information can help clinicians develop personalized treatment plans for cancer survivors, which can improve their quality of life and reduce the risk of recurrence.

Claves:Cancer, Meta-analysis, Prognosis, Survival, Systematic review, piRNA

Cita:BMC Cancer 2024 Apr 16; 24 (1) : 484.

Autor/es:Taghizadeh, Mohammad (a)
Jafari-Koshki, Tohid (b)

institución:(a) Department of Molecular Medicine, Faculty of Advanced Medical School, Tabriz University of Medical Sciences, Tabriz, 5166614756, Iran.
(b) Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, 5166616471, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12885-024-12180-2

Efficacy of salvage surgery versus re-irradiation for isolated regional lymph node recurrence in patients with nasopharyngeal carcinoma.

Fuente:Bmc Cancer

Tipo de trabajo:Revisión

Extracto: For NPC patients with isolated regional lymph node recurrence after initial radiotherapy, those who underwent surgery had survival prognosis similar to those who underwent re-radiotherapy with or without chemotherapy. A prospective study is needed to validate these findings.

Claves:Lymph node dissection, Nasopharyngeal carcinoma, Re-irradiation, Recurrence, Regional lymph nodes

Cita:BMC Cancer 2024 Apr 16; 24 (1) : 483.

Autor/es:Chen, Yuebing (a)
Huang, Yiping (b)

institución:(a) Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
(b) Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12885-024-12259-w

Comparison of three frailty scales for prediction of prolonged postoperative ileus following major abdominal surgery in elderly patients

Comparison of three frailty scales for prediction of prolonged postoperative ileus following major abdominal surgery in elderly patients

Fuente:Bmc Surgery

Tipo de trabajo:Estudio de cohortes

Extracto: Elderly patients diagnosed as frail on the mFI-5 or GFI are at an increased risk of PPOI after major abdominal surgery. However, neither mFI-5 nor GFI can accurately identify individuals who will develop PPOI. TRIAL REGISTRATION: This study was registered in Chinese Clinical Trial Registry (No. ChiCTR2200058178). The date of first registration, 31/03/2022, https://www.chictr.org.cn/ .

Claves:Elderly patients, Frailty, Major abdominal surgery, Prediction, Prolonged postoperative ileus

Cita:BMC Surg 2024 Apr 16; 24 (1) : 115.

Autor/es:Xiong, Xianwei (a)
Zhang, Ting (b)

institución:(a) Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing, 400016, China.
(b) Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing, 400016, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12893-024-02391-6

Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices

Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices

Fuente:Trials

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: ISRCTN reference number: ISRCTN10324656. Registered on April 24 2019.

Cita:Trials 2024 Apr 16; 25 (1) : 265.

Autor/es:Patel, Vishal C (a)
McPhail, Mark J (b)

institución:(a) Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK. vishal.patel@nhs.net.
(b) Institute of Liver Studies, Faculty of Life Sciences and Medicine, School of Immunology and Microbial Sciences, King's College London, London, UK. vishal.patel@nhs.net.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13063-024-08063-3

Sex-related differences in outcome of thoracic aortic surgery.

Sex-related differences in outcome of thoracic aortic surgery.

Fuente:Journal of Cardiothoracic Surgery

Tipo de trabajo:Guía

Extracto: The outcome after TAA surgery was less favorable in women with significantly increased overall mortality. It highlights the need to focus on implementing personalized surgery strategies and gender-specific guidelines in treating female patients following TAA surgery.

Claves:Gender, Mortality, Risk factors, Thoracic aortic aneurysms, Thoracic aortic surgery

Cita:J Cardiothorac Surg 2024 Apr 16; 19 (1) : 226.

Autor/es:Jiang, Hongxue (a)
Xu, Hongjie (b)

institución:(a) Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
(b) Department of Cardiovascular Surgery, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200168, China.

Conflicto:On behalf of all authors, I declare that there is no conflict of interest to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13019-024-02735-6

Gut microbiota-host lipid crosstalk in Alzheimer's disease: implications for disease progression and therapeutics.

Gut microbiota-host lipid crosstalk in Alzheimer's disease: implications for disease progression and therapeutics.

Fuente:Molecular Neurodegeneration

Extracto: This review highlights the current understanding of how gut microbiota disrupts lipid metabolism and discusses the implications of these discoveries in guiding strategies for the prevention or treatment of Alzheimer's disease based on existing data.

Claves:APOE, Alzheimer’s disease, Cholesterol, Exercise, Gut microbiota, LPS, Lifestyle, Lipid metabolism, Neuroinflammation, Probiotics, SCFAs

Cita:Mol Neurodegener 2024 Apr 16; 19 (1) : 35.

Autor/es:Luo, Ya-Xi (a)
Yang, Ling-Ling (b)

institución:(a) Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
(b) Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13024-024-00720-0

Factors promoting and hindering resilience in youth with inflammatory bowel disease: A descriptive qualitative study.

Factors promoting and hindering resilience in youth with inflammatory bowel disease: A descriptive qualitative study.

Fuente:Nursing Open

Extracto: Health care professionals need to develop greater awareness of factors, stemming from both the individual and the outside world, that hinder or promote resilience in order to aid young patients with IBD. Building targeted nursing measures to excavate the internal positive quality of patients, provide external support and promote the development of resilience.

Claves:inflammatory bowel disease, nursing, qualitative study, resilience, youth

Cita:Nurs Open 2024 Apr; 11 (4) : e2150.

Autor/es:You, Lili (a)
Wang, Siyao (b)

institución:(a) Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China.
(b) Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China.

Conflicto:All authors have no financial or other relationships to report.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1002/nop2.2150

A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live Bifidobacterium longum CECT 7347 (ES1) and heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome.

A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live Bifidobacterium longum CECT 7347 (ES1) and heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome.

Fuente:Gut Microbes

Extracto: These results are both statistically significant and clinically meaningful, representing, to the best of the authors' knowledge, the first positive results observed for either a probiotic or postbiotic from the same strain, in this particular population.

Claves:Gut microbiome, IBS-D, IBS-SSS, QoL, abdominal pain, postbiotic, probiotic

Cita:Gut Microbes 2024 Jan-Dec; 16 (1) : 2338322.

Autor/es:Srivastava, S (a)
Basak, U (b)

institución:(a) Clinical Development & Science Communications, Vedic Lifesciences Pvt Ltd, Mumbai, India.
(b) Clinical Development & Science Communications, Vedic Lifesciences Pvt Ltd, Mumbai, India.

Conflicto:This study was funded by ADM. RD, MN and VV are all employees of ADM but were not involved in the study conduct, data management or statistical analysis.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1080/19490976.2024.2338322