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Parasite load as a marker of pathogenicity in Dientamoeba fragilis infections.
Parasite load as a marker of pathogenicity in Dientamoeba fragilis infections.
Fuente:Medicine
Extracto:
Any diagnostic approach for D fragilis should
incorporate or be complemented by quantitative information to accurately estimate
parasite load and enhance treatment decision-making.
Cita:Medicine (Baltimore) 2025 Mar 28; 104 (13) : e41963.
Autor/es:Burgaña Agoües, Ander (a) Abellana Sangra, Rosa (b)
institución:(a) Atenció Primària, Fundació Assitencial Mútua Terrassa, Terrassa. Spain. Fundació Docència i Recerca Mútua de Terrassa, Terrassa, Spain. (b) Departament Fonaments Clínics, Universitat de Barcelona, Barcelona, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
What is the optimal first-line treatment of autoimmune hepatitis? A systematic review with meta-analysis of randomised trials and comparative cohort studies.
What is the optimal first-line treatment of autoimmune hepatitis? A systematic review with meta-analysis of randomised trials and comparative cohort studies.
Fuente:Bmj Open Gastroenterology
Tipo de trabajo:Metanálisis
Extracto:
Mortality is lower in
pred-treated (vs untreated) patients, overall and in several subgroups, and in
those receiving pred+aza (vs pred). Higher initial pred doses confer no clear
benefit and cause more AEs. Bud (vs pred) achieves similar BR rates, with fewer
cosmetic AEs. MMF (vs aza) achieves similar BR rates, with fewer serious AEs.
institución:(a) Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK dermot.gleeson@nhs.net. (b) School of Medicine and Population Health, University of Sheffield, Sheffield School of, Sheffield, UK.
Conflicto:Competing interests: DG: Invited speaker (on PSC) Dr Falk sponsored symposium 2023; hospitality, no honorarium. Other authors: no interests declared.
A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases.
A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases.
Fuente:Nature Communications
Extracto:
In summary, our findings highlight
the genetic relationship between lung and gastrointestinal diseases, providing
insights into the genetic mechanisms underlying the development of lung
gastrointestinal comorbidities.
Cita:Nat Commun 2025 Mar 28; 16 (1) : 3032.
Autor/es:You, Dongfang (a) Wu, Yaqian (b)
institución:(a) Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China. (b) Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Autor/es:Triantafyllou, George (a) Zielinska, Nicol (b)
institución:(a) Department of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, 75 Mikras Asias str., Goudi, 11527, Athens, Greece. georgerose406@gmail.com. (b) Department of Clinical Anatomy, Masovian Academy in Płock, Plock, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Discrepancies in perceptions of well-being: comparing parental and pediatric PROMIS-patient-reported outcomes in Crohn's disease.
Discrepancies in perceptions of well-being: comparing parental and pediatric PROMIS-patient-reported outcomes in Crohn's disease.
Fuente:Journal of Patient-reported Outcomes
Extracto:
This study highlights the
importance of integrating patient and parental perspectives in the clinical
management of pediatric CD. The observed discrepancies in disease-related
perceptions, influenced by parental educational and professional background,
underscore the need for comprehensive assessments to ensure accurate,
patient-centered care. For broader generalization, further research should
explore these dynamics in newly diagnosed and hospitalized patients.
Autor/es:Azevedo, Sara (a) Oliveira, Maria Miguel (b)
institución:(a) Gastroenterology Unit, Pediatric Department, Unidade Local de Saúde Santa Maria, Avenida Egas Moniz, Lisbon, 1649-028, Portugal. saravazevedo@gmail.com. (b) Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. saravazevedo@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Surgery, Flevoziekenhuis, Almere, The Netherlands. l.munster@amsterdamumc.nl. (b) Department of Surgery, Amsterdam UMC (Location VUmc), De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. l.munster@amsterdamumc.nl.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Exploring blood immune cells in the protective effects of gut microbiota on rheumatic heart disease based on Mendelian randomization analysis.
Exploring blood immune cells in the protective effects of gut microbiota on rheumatic heart disease based on Mendelian randomization analysis.
Fuente:Scientific Reports
Extracto:
Similarly, the abundance of genus Ruminococcaceae UCG005 provides protection
against RHD-other by influencing CD4-CD8- T cell %T cell and CD4-CD8- T cell
%leukocyte.
institución:(a) The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China. (b) The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A comparison of three kinds of balloon dilatations for patients with benign esophageal strictures.
A comparison of three kinds of balloon dilatations for patients with benign esophageal strictures.
Fuente:Scientific Reports
Extracto:
The use of DCB seems
least preferable, as they are associated with more hospitalization cost and few
cases of clinical improvement.
Claves:Benign esophageal strictures, Drug-coated balloon, Large balloon dilatation, Small balloon dilatation, Stents
Cita:Sci Rep 2025 Mar 29; 15 (1) : 10843.
Autor/es:Liu, Ping (a) Ren, Jianzhuang (b)
institución:(a) Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. (b) Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, No.1, East Jian She Road, Zhengzhou, 450052, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The predictive values of sarcopenia screening tools in preoperative elderly patients with colorectal cancer: applying the diagnostic criteria of EWGSOP2 and AWGS2019.
The predictive values of sarcopenia screening tools in preoperative elderly patients with colorectal cancer: applying the diagnostic criteria of EWGSOP2 and AWGS2019.
Fuente:Bmc Geriatrics
Extracto:
Among the five sarcopenia screening
tools, Ishii score chart and SARC-CalF had the largest overall diagnostic
accuracy for sarcopenia in preoperative elderly patients with CRC.
institución:(a) Department of Thyroid, Breast, and Gastrointestinal Surgery, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China. (b) Department of Thyroid, Breast, and Gastrointestinal Surgery, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between proton pump inhibitor use and migraine
Association between proton pump inhibitor use and migraine
Fuente:The Journal of Headache and Pain
Tipo de trabajo:Revisión sistemática
Extracto:
This review found no significant overall association
between PPI use and migraine. However, a significant association was observed in
males but not in females. Further research is needed to clarify this association
and explore the underlying causality mechanisms, and migraine subtypes,
particularly why the association appears more pronounced in males. CLINICAL TRIAL
NUMBER: Not applicable.
institución:(a) Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha University, Chennai, India. prakasini.satapathy@gmail.com. (b) Faculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia. prakasini.satapathy@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Lipopolysaccharide-binding protein (LBP): a prognostic biomarker for gastric cancer linked to immune infiltration.
Lipopolysaccharide-binding protein (LBP): a prognostic biomarker for gastric cancer linked to immune infiltration.
Fuente:Bmc Gastroenterology
Tipo de trabajo:Guía
Extracto:
LBP is intricately
linked to gastric cancer pathogenesis; it influences cell proliferation,
migration, and invasion, thereby representing a valuable prognostic and
diagnostic biomarker. This study not only highlights the potential of LBP as a
therapeutic target but also provides the groundwork for future investigations
into its mechanistic pathways in gastric cancer. CLINICAL TRIAL NUMBER: Not
applicable. I would like to clarify that our research does not fall under
clinical studies and therefore does not involve ethical concerns related to human
or animal subjects. The cells used in this study are established cell lines
purchased from a certified biotechnology company. All experimental procedures
comply with standard research protocols and guidelines for cell line studies.
Claves:Bioinformatics analysis, Biomarker, Gastric cancer, Lipopolysaccharide-binding protein
Cita:BMC Gastroenterol 2025 Mar 28; 25 (1) : 205.
Autor/es:Lv, Hao (a) Lv, Mei (b)
institución:(a) Department of Gastroenterology Medicine (Endoscopy Center), China-Japan, Union Hospital of Jilin University, Changchun, Jilin, 130033, PR China. (b) Department of Gastroenterology, University of Health and Rehabilitation Sciences Affiliated, Qingdao Municipal Hospital Jiaozhou Road 1#, Qingdao, 266071, PR China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Hemoglobin as a mediator between air pollution and growth outcomes in children under 60 months: the moderating role of nutritional supplementation.
Hemoglobin as a mediator between air pollution and growth outcomes in children under 60 months: the moderating role of nutritional supplementation.
Fuente:Bmc Public Health
Tipo de trabajo:Guía
Extracto:
Postnatal exposure to air pollution (PM(2.5), PM(10), SO(2), CO) increases the
risk of stunting, particularly during the critical developmental window of 6-23
months of age. This effect is partially mediated by hemoglobin levels, and YYB
can moderate this relationship. These findings highlight the importance of
prolonged nutritional interventions in mitigating the adverse effects of air
pollution on child growth and development, with significant implications for
public health policies targeting air quality and child nutrition in
high-pollution regions.
Cita:BMC Public Health 2025 Mar 28; 25 (1) : 1187.
Autor/es:Jin, Xingyi (a) Wu, Di (b)
institución:(a) Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, China. (b) Department of Gynaecology and Obstetrics, Zhongda Hospital, Southeast University, Nanjing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) School of Chemistry and Chemical Engineering, Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Medical School, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China. (b) Wuxi People's Hospital, Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Wuxi, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between sedentary behavior, depressive symptoms, and the risk of all-cause and cause-specific mortality among U.S. cancer survivors.
Association between sedentary behavior, depressive symptoms, and the risk of all-cause and cause-specific mortality among U.S. cancer survivors.
Fuente:Bmc Cancer
Extracto:
Our study highlighted the importance of considering both
sedentary behavior and mental health in making effective long-term follow-up
recommendations for cancer survivors.
institución:(a) Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China. (b) Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Colorectal cancer at the anastomotic site following childhood surgery for hirschsprung disease
Colorectal cancer at the anastomotic site following childhood surgery for hirschsprung disease
Fuente:World Journal of Surgical Oncology
Tipo de trabajo:Caso clínico
Extracto:
This case
highlights the need for awareness of potential colorectal cancer development in
patients with a history of Hirschsprung disease and emphasizes the importance of
individualized management and close surveillance strategies.
Claves:Case report, Duhamel procedure, Hirschsprung disease, Intersphincteric resection, Rectal cancer
institución:(a) Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany. Matthias.mehdorn@medizin.uni-leipzig.de. (b) Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.
Conflicto:Declarations. Ethics approval and consent to participate: Written informed consent was given by the patient for the publication of this case report. The consent form is available from the corresponding author upon reasonable request. Competing interests: None of the authors has any conflict of interest to declare in relation to the presented manuscript.
A scoring model based on the pleural effusion adenosine deaminase-to-serum C-reactive protein ratio for differentiating tuberculous pleural effusion from non-tuberculous benign pleural effusion.
A scoring model based on the pleural effusion adenosine deaminase-to-serum C-reactive protein ratio for differentiating tuberculous pleural effusion from non-tuberculous benign pleural effusion.
Fuente:Bmc Pulmonary Medicine
Extracto:
The pADA/sCRP ratio exhibited improved
diagnostic performance compared to pADA alone. The novel scoring system based on
a nomogram demonstrated good diagnostic efficacy in differentiating TPE from
non-TB BPE.
institución:(a) Departments of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. (b) Departments of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Impact of negative lymph node removal on survival in esophageal cancer
Impact of negative lymph node removal on survival in esophageal cancer
Fuente:Bmc Surgery
Tipo de trabajo:Revisión sistemática
Extracto:
The high number of NLNs removed (≥ 19) during
surgery was associated with improved survival after surgery, especially in
patients with adenocarcinoma. Removing ≥ 19 NLNs significantly improves survival
in EC patients, particularly those with adenocarcinoma. This threshold should be
incorporated into surgical guidelines.
Claves:Esophageal cancer, Esophagostomy, Five- survival rate, Lymph node, Surgery
institución:(a) Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. (b) Faculty of Medical Sciences, Fasa University of Medical Sciences, Fasa, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of vitamin D and platelet-to-lymphocyte ratio in treatment escalation risk for newly diagnosed Crohn's disease adults.
Association of vitamin D and platelet-to-lymphocyte ratio in treatment escalation risk for newly diagnosed Crohn's disease adults.
Fuente:Nutrition Journal
Extracto:
This study underscores a significant interplay
between VD levels and PLR in influencing treatment outcomes in CD. VDD
exacerbates the risk of treatment escalation primarily in individuals with
heightened PLR levels, highlighting the combined impact of vitamin D status and
inflammation on disease progression of CD.
Claves:Crohn’s disease, Inflammation biomarkers, Interplay, Platelet-to-lymphocyte ratio, Treatment escalation, Vitamin D status
Cita:Nutr J 2025 Mar 28; 24 (1) : 49.
Autor/es:Wang, Kan (a) Zhu, Shichen (b)
institución:(a) Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China. (b) Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058, Zhejiang Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Safety analysis of self-administered enzyme replacement therapy using data from the Fabry Outcome and Gaucher Outcome Surveys.
Safety analysis of self-administered enzyme replacement therapy using data from the Fabry Outcome and Gaucher Outcome Surveys.
Fuente:Orphanet Journal of Rare Diseases
Extracto:
These findings suggest that
self-administration of agalsidase alfa or velaglucerase alfa infusions are not
associated with additional safety risks compared with HCP-supported infusions and
are a suitable option for qualifying patients. Further research is warranted to
support these findings and to explore further the long-term safety and efficacy
of ERT self-administration. FOS trial registration: ClinicalTrials.gov,
NCT03289065. Registered 01 April 2001,
https://clinicaltrials.gov/study/NCT03289065 . GOS trial registration:
ClinicalTrials.gov, NCT03291223. Registered 27 July 2010, https://classic.
CLINICALTRIALS: gov/ct2/show/NCT03291223 .
Autor/es:Revel-Vilk, Shoshana (a) Ramaswami, Uma (b)
institución:(a) Gaucher Unit and Pediatric Hematology/Oncology Unit, The Eisenberg R&D Authority, Shaare Zedek Medical Center, Jerusalem, Israel. (b) Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Conflicto:Declarations. Ethics approval and consent to participate: FOS and GOS registries have been approved by the ethics institutional review boards of participating centers and are conducted in compliance with relevant global and local regulations and best practices, Good Pharmacoepidemiological Practice, Good Research for Comparative Effectiveness principles, and the relevant principles of the International Conference on Harmonisation Good Clinical Practice guidelines...
(ICH E6), as appropriate for an observational registry. All participants provided written informed consent. Consent for publication: Not applicable. Competing interests: SRV received grant/research support, honoraria, and advisory fees from Pfizer, Sanofi/Genzyme and Takeda. UR received honoraria for lectures and advisory boards from Amicus, Sanofi and Takeda; research grants from Amicus, Intrabio and Takeda. GPM received honoraria as a speaker and/or consultancy from Amicus, Chiesi, Lucane, and Takeda and unrestricted grants for research of Rare Diseases at VHIR from Sanofi and Takeda. DH received honoraria for speaking and advisory boards from Amicus, Chiesi, Freeline, Idorsia, Sangamo, Sanofi and Takeda. KN reports honoraria from Amicus Therapeutics, Sanofi Genzyme, and Takeda; and is a member of the FOS Steering Committee. RR reports honoraria, speaker fees, and consulting fees from Amicus Therapeutics, CSL Behring, Gador, Sanofi Genzyme, Novartis, and Takeda; and is a member of the FOS Steering Committee. RG received research grants, investigator fees, speaker/consultancy honoraria, and travel support to attend scientific meetings from Allievex, Amicus, Avrobio, Asafaros, BioMarin, Chiesi, Cyclo, DASA, Idorsia, Inventiva, Janssen, JCR, Lysogene, Novartis, Paradigm, PassageBio, Pfizer, Protalix, PTC, RegenxBio, Sanofi, Sigilon, Sobi,Takeda and Ultragenyx. OGA has received grant support from 4DMT, Chiesi, Idorsia, Protalix, Sangamo, and Sanofi for clinical research trials and from Sanofi and Takeda for other investigator-initiated studies; consulting fees from Chiesi, Sanofi, Takeda, and Uniqure; honoraria for speaker bureaus from Sanofi and Takeda and participates on the Advisory Board on Fabry Disease for Chiese and Sanofi. MI received support for the SZMC Gaucher Unit from Sanofi/Genzyme for participation in the ICGG Registry, from Takeda for the GOS Registry, and Pfizer for TALIAS; the Unit also receives research grants from Centogene, Pfizer, Sanofi/Genzyme and Takeda. AG was an employee of Takeda and stockholder in Takeda at the time of study start. MS has received honoraria and travel support from Alexion, Bi-938 oMarin, CHIESI, Orchard, Regenexbio, Sanofi, Takeda, and Ultragenyx. JB is an employee of Takeda and holds stock options in Takeda.
A full response chain surge capacity test of a small rural hospital, prehospital resources and collaborating organisations.
A full response chain surge capacity test of a small rural hospital, prehospital resources and collaborating organisations.
Fuente:Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Extracto:
The simulation system
provided detailed data to determine surge capacity and capacity-limiting factors
in the mass casualty incidents response at a rural hospital and performed as a
training tool for staff. Methods to improve pre-test simulation system knowledge
should be examined. Broad inclusion of cooperating organisations was found
beneficial.
Claves:Hospital preparedness, Major incident, Mass casualty incident, Mass casualty incident simulation, Surge capacity, Surge capacity test
Cita:Scand J Trauma Resusc Emerg Med 2025 Mar 28; 33 (1) : 55.
institución:(a) Regional Trauma Centre, Haukeland University Hospital, Bergen, Norway. kristina.stolen.ugelvik@helse-bergen.no. (b) University of Bergen, Bergen, Norway. kristina.stolen.ugelvik@helse-bergen.no.
Conflicto:Declarations. Ethics and consent: Participation in the “Vossa-test” and the following web-based survey was voluntary. As neither patients nor real persons were involved as subjects for medical examination or treatment, a request for ethics approval according to the Health Research Act of 2008 was not applicable. The project was performed according to the requirements in the Personal Data Act of...
t of 2017. The project is registered in E-protocol within Helse-Bergen Health Trust (registration number 3478–3478). As a health service research project, Guidelines for Research Ethics in the Social Sciences and the Humanities (Revised version 2023) were adhered to at all phases of the project and development of this article. Consent for publication: Participation in the post-test web-based survey was voluntary. A cover letter followed to link to the survey. In the cover letter the participants are informed that the data will be used in scientific publication as well as in the internal evaluation report provided to VH. Competing interests: The co-author K. Lennquist Montán has copyright to the MACSIM® system and C. Montán is Secretary General for the International Association for Promotion of Education and Training in Major Incidents and Disasters (MRMID) which owns the MRMI courses. MRMI is a non-profit international organisation. No conflict of interest for the other authors.
