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La creciente cantidad de artículos con Acceso Abierto (Open
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fundamentales. Para facilitarlo, profesionales biomédicos de SIIC
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Las citas de la sección TCA enlazan de manera legal, autorizada y
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SIIC creó, produjo y opera con exclusividad el software TCA para la
interpretación de los diversos campos documentales que integran la
estructura de un estudio: especialidad, modalidad del estudio,
fuente, fechas de publicación y selección, definición de la fuente,
limitaciones de consulta, resumen en castellano, etc.
Si bien la mayoría de los textos seleccionados corresponden a
artículos originales, revisiones y guías, los lectores también
encontrarán comentarios, entrevistas, notas periodísticas, cartas a
autores u otros textos precursores de debates o aclaratorios.
Sociedad Iberoamericana de Información Científica (SIIC) selects
complete quality-full texts which have been recently published in
renowned sources worldwide and are indexed by SIIC Data
Bases.
The increasing number of Open Access articles widens the reading offer
but, also, such myriad complicates the readers search of fundamental
articles. To facilitate this, SIIC biomedical professionals daily
consult a profuse amount of documents that will feed
Authorized Full Texts (TCA, Spanish acronym).
The citations of the AFT section link legally, authorized and free of
charge with the full texts published in the official web sites of
their corresponding sources.
SIIC created, produced and handles the AFT software that deciphers
the various documentary fields that form part of the structure of a
study: specialty, study style, source, publication and selection
dates, source definition, query limitations, summary in Spanish,
etc.
While most of the selected texts belong to original articles,
reviews, and guidelines, readers will also find commentaries,
interviews, journalistic reports, letters to authors or other texts
that may lead to discussions or clarifications.
Risk factors for enteral feeding intolerance in critically ill patients
Risk factors for enteral feeding intolerance in critically ill patients
Fuente:Bmc Gastroenterology
Tipo de trabajo:Revisión sistemática
Extracto:
According to the influencing factors, medical staff can pay
attention to the high-risk patients at ICU admission to reduce the risk of
feeding intolerance.
institución:(a) Interventional Surgery Center, The Second Hospital of Dalian Medical University, Dalian, Liaoning, 116000, China. (b) School of Nursing, Dalian Medical University, Dalian, Liaoning, 116000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Serratia marcescens and its role in Pink breast milk and upper GI bleeding in an infant
Serratia marcescens and its role in Pink breast milk and upper GI bleeding in an infant
Fuente:Bmc Infectious Diseases
Tipo de trabajo:Caso clínico
Extracto:
S.
marcescens should be considered a potential cause of gastrointestinal bleeding in
infants at risk. Although previously known to cause outbreaks in vulnerable
infants, pathogenicity in healthy infants is also possible. Maintaining strict
hygiene of feeding and breast milk pumping equipment is important to prevent
infections in infants.
Claves:Serratia marcescens, Infant, Pink breast milk, Upper Gastrointestinal bleeding
Cita:BMC Infect Dis 2025 Apr 8; 25 (1) : 482.
Autor/es:Osman, Rukhsar (a) Mbuki, Mayila (b)
institución:(a) Department of Paediatrics and Child Health, Aga Khan Hospital Tanzania, P.O. Box 2289, Dar Es Salaam, Tanzania. rukhsar.osman@scholar.aku.edu. (b) Department of Paediatrics and Child Health, Aga Khan University, P.O. Box 38129, Dar Es Salaam, Tanzania. rukhsar.osman@scholar.aku.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
CT manifestations of primary esophageal tuberculosis.
CT manifestations of primary esophageal tuberculosis.
Fuente:Bmc Infectious Diseases
Extracto:
This case
highlights the pivotal role of CT imaging in diagnosing primary esophageal
tuberculosis. The imaging modality's ability to delineate subtle mucosal
ulcerations and wall thickening provides a crucial diagnostic advantage,
facilitating accurate and timely diagnosis of this rare condition.
institución:(a) Department of Radiology, Hospital of Traditional Chinese Medicine in Qijiang District, Chongqing Municipality, 401420, China. (b) Department of Spleen and Stomach Diseases, Hospital of Traditional Chinese Medicine in Qijiang District, Chongqing Municipality, 401420, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Efficacy and safety of PPAR agonists in primary biliary cholangitis
Efficacy and safety of PPAR agonists in primary biliary cholangitis
Fuente:Bmc Gastroenterology
Tipo de trabajo:Revisión sistemática
Extracto:
The current study demonstrates that combining UDCA and PPAR agonists effectively
reduces ALP, GGT, and Bilirubin levels, crucial markers for effective therapy in
PBC patients.
institución:(a) School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. (b) Digestive Diseases Research Institute (DDRI), Tehran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Adjuvant TRastuzumab deruxtecan plus fluoropyrimidine versus standard chemotherapy in HER2-positive gastric or gastroesophageal cancer patients with persistence of minimal residual disease in liquid biopsy after pre-operative chemotherapy and radical surgery
Adjuvant TRastuzumab deruxtecan plus fluoropyrimidine versus standard chemotherapy in HER2-positive gastric or gastroesophageal cancer patients with persistence of minimal residual disease in liquid biopsy after pre-operative chemotherapy and radical surgery
Fuente:Bmc Cancer
Tipo de trabajo:Estudio multicéntrico
Extracto:
TRIAL REGISTRATION: TRINITY is registered at
ClinicalTrials.gov (NCT06253650).
institución:(a) Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy. (b) Medical Oncology 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Conflicto:Declarations. Ethics approval and consent to participate: The study was registered on 02/02/2024 at Clinicaltrials.gov (NCT06253650) and it is currently ongoing. The trial was submitted to CTIS and approved by the Ethics Committee “CET Comitato Etico Lombardia 4”. The study will be performed in accordance with ethical principles that have their origin in the Declaration of Helsinki and are consistent...
tent with ICH/Good Clinical Practice, applicable regulatory requirements and the Company policy on Bioethics and Human Biological Samples. The Informed Consent Form will incorporate (or, in some cases, be accompanied by a separate document incorporating) wording that complies with relevant data protection and privacy legislation. The names of patients will not be recorded; a sequential identification number will be attributed to each patient registered in the trial. This number will identify the patient and must be included on all eCRF. To avoid identification errors, patients’ initials (maximum of 2 letters) and date of birth will also be reported on the eCRF. Investigators will guarantee that all persons involved in this study will respect the confidentiality of any information concerning the trial subject. All parties involved in this clinical trial will maintain strict confidentiality to assure that neither the person nor the family privacy of the patient participating in the trial is violated. Appropriate measures shall be taken to avoid the access of non-authorized persons to the trial data by assuring that only the principal investigator and its delegates will have the authorization to access trial data thanks to protected programs and strict organization flows. The investigator will guarantee to have a process in place to ensure that the site staff or service providers delegated by the investigator/institution can identify the occurrence of a (potential) serious breach and this will be promptly reported. The processing of the personal data of patients taking part in the trial, and regarding data concerning consent, shall comply with local law on the privacy (D.Lg. 30 giugno 2003, n. 196, Codice in materia di protezione dei dati personali) and with the European Directive on the privacy of data, namely General Data Protection Regulation, EU regulation 2016/679 of 27 April 2016). The patient can withdraw consent whenever he/she wants and further data will not be collected, even if the already collected data will be used for the study’s analyses. Consent for publication: Not applicable. Competing interests: FB received personal honoraria as invited speaker from Eli-Lilly, MSD, EISAI, Bristol Myers Squibb, AstraZeneca, Pierre Fabre; participation in advisory board for Servier, AAA Novartis. LF reports personal honoraria as invited speaker from Incyte, Bristol Myers Squibb, Lilly, AstraZeneca; research funding (to Institution) from MSD, Bristol Myers Squibb, AstraZeneca, Incyte, BeiGene, Astellas, Daiichi Sankyo, Roche; participation in advisory board for MSD, AstraZeneca, Incyte, Taiho, Servier, Daiichi Sankyo, Lilly, BeiGene and Astellas. AP reports personal fees for advisory boards from Takeda, GlaxoSmithKline, Daiichi Sankyo; research grant (institutional) from Amgen and GlaxoSmithKline. Travel grants from Amgen, Merck Serono, Astrazeneca FP reports personal fees from Amgen, Merck-Serono, MSD, Bayer, Astellas, Takeda, Servier, GlaxoSmithKline, Pierre-Fabre, Ipsen, J&J; and research grant (institutional) from Lilly, BMS, AstraZeneca, Incyte, Amgen, and Agenus. AR reports honoraria for speaker bureau or participation at advisory boards from Servier and MSD. LF reports personal honoraria as invited speaker from Incyte, Bristol Myers Squibb, Lilly, AstraZeneca; research funding (to Institution) from MSD, Bristol Myers Squibb, AstraZeneca, Incyte, BeiGene, Astellas, Daiichi Sankyo, Roche; participation in advisory board for MSD, AstraZeneca, Incyte, Taiho, Servier, Daiichi Sankyo, Lilly, BeiGene and Astellas. AP reports personal fees for advisory boards from Takeda, GlaxoSmithKline, Daiichi Sankyo; research grant (institutional) from Amgen and GlaxoSmithKline. Travel grants from Amgen, Merck Serono, Astrazeneca. FP reports personal fees from Amgen, Merck-Serono, MSD, Bayer, Astellas, Takeda, Servier, GlaxoSmithKline, Pierre-Fabre, Ipsen, J&J; and research grant (institutional) from Lilly, BMS, AstraZeneca, Incyte, Amgen, and Agenus. AR reports honoraria for speaker bureau or participation at advisory boards from Servier and MSD.
The transhiatal tunnel valvuloplasty technique following laparoscopic proximal gastrectomy: the single-center experience in a retrospective cohort.
The transhiatal tunnel valvuloplasty technique following laparoscopic proximal gastrectomy: the single-center experience in a retrospective cohort.
Fuente:World Journal of Surgical Oncology
Tipo de trabajo:Revisión
Extracto:
Transhiatal tunnel valvuloplasty is a simple and reliable
anti-reflux method following laparoscopic proximal gastric surgery. The further
verification of the esophageal function is warranted.
institución:(a) Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 PanjiayuanNanli, Chaoyang District, Beijing, 100021, China. (b) Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 PanjiayuanNanli, Chaoyang District, Beijing, 100021, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Real-world safety and efficacy of neoadjuvant docetaxel, cisplatin, and 5-fluorouracil therapy for locally advanced esophageal squamous cell carcinoma.
Real-world safety and efficacy of neoadjuvant docetaxel, cisplatin, and 5-fluorouracil therapy for locally advanced esophageal squamous cell carcinoma.
Fuente:Bmc Cancer
Tipo de trabajo:Estudio de cohortes
Extracto:
Neoadjuvant DCF was effective and well-tolerated
in real-world ESCC patients. Primary TRG grade 1a or pCR showed a favorable
DFS/RFS, while positive ypN and GPS were independent risk factors for worse
DFS/RFS.
institución:(a) Department of Gastroenterological Chemotherapy, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. (b) Department of Gastroenterological Chemotherapy, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Undifferentiated autoinflammatory disease in adults: a prospective study in 61 patients.
Undifferentiated autoinflammatory disease in adults: a prospective study in 61 patients.
Fuente:Orphanet Journal of Rare Diseases
Extracto:
This study is the first to describe the clinical
and genetic features of a cohort of Chinese adult patients with uSAID. Patients
with pulmonary manifestations may be more prone to developing complex phenotypes,
while those with atypical phenotypes have a high rate of spontaneous remission,
indicating a favorable prognosis.
institución:(a) Department of Rare Diseases, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College; State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, Beijing, 100730, China. (b) Department of Rheumatology and Clinical Immunology, PUMCH; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100730, China.
Conflicto:Declarations. Ethics approval and consent to participate: Ethical no: ZS-3272. Approved by the Institutional Review Board of Peking Union Medical College Hospital (PUMCH). Informed consent was obtained from all individual participants included in the study. Consent for publication: Informed consent was obtained from all subjects. Competing Interests: The authors have no relevant financial or non-financial interests to disclose.
Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study.
Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study.
Fuente:Bmc Psychiatry
Tipo de trabajo:Metanálisis
Extracto:
Our findings
provide potential biomarkers for predicting and preventing PTSD, as well as
possible therapeutic targets for that. However, further research is needed to
confirm the clear mechanism.
institución:(a) Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China. (b) Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The diagnostic value of combined pulmonary function test and exhaled nitric oxide monitoring in cough variant asthma with or without gastroesophageal reflux disease: a retrospective study.
The diagnostic value of combined pulmonary function test and exhaled nitric oxide monitoring in cough variant asthma with or without gastroesophageal reflux disease: a retrospective study.
Fuente:Bmc Pulmonary Medicine
Tipo de trabajo:Estudio clínico
Extracto:
Combining FeNO with small
airway function tests, especially MMEF, can improve the diagnostic accuracy of
CVA, while FeNO and FeNO + MMEF performed similar diagnostic accuracy in patients
with GERD. CLINICAL TRIAL NUMBER: Not applicable.
Claves:Asthma diagnosis, Cough variant asthma, Fractional exhaled nitric oxide, Gastroesophageal reflux disease, Pulmonary function test
Cita:BMC Pulm Med 2025 Apr 8; 25 (1) : 161.
Autor/es:Li, Sen (a) Xu, Siyao (b)
institución:(a) Department of Respiratory and Critical Care Medicine, HanZhong Central Hospital, Hanzhong, 723000, China. (b) Department of Respiratory and Critical Care Medicine, HanZhong Central Hospital, Hanzhong, 723000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identification of Diagnostic Biomarkers for Colorectal Polyps Based on Noninvasive Urinary Metabolite Screening and Construction of a Nomogram.
Identification of Diagnostic Biomarkers for Colorectal Polyps Based on Noninvasive Urinary Metabolite Screening and Construction of a Nomogram.
Fuente:Cancer Medicine
Extracto:
This study
successfully identified seven urinary metabolites as potential noninvasive
biomarkers for CRP. The constructed diagnostic nomogram, based on these
metabolites, offers high predictive accuracy and clinical applicability,
providing a promising tool for the early detection of CRP.
institución:(a) Department of Gastroenterology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, Nanchang, Jiangxi, China. (b) Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma: A Phase II Study.
Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma: A Phase II Study.
Fuente:Cancer Medicine
Tipo de trabajo:Estudio abierto
Extracto:
IC with
trifluridine/tipiracil and oxaliplatin followed by CRT did not improve pCR rate
in resectable EGAC compared to pCR from previous reports with CRT alone. We found
a correlation between ctDNA clearance and improved survival, which merits further
investigation. CLINICAL TRIAL INFORMATION: NCT04097028.
institución:(a) Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA. (b) Miami Cancer Institute, Baptist Health South Florida, Miami, Florida, USA.
Prediction model of gastrointestinal tumor malignancy based on coagulation indicators such as TEG and neural networks.
Prediction model of gastrointestinal tumor malignancy based on coagulation indicators such as TEG and neural networks.
Fuente:Frontiers in Immunology
Extracto:
This study found that the R
and MA values are independent predictive factors for the malignancy of
gastrointestinal tumors. Compared to other coagulation indicators, the TEG five
items have better discrimination ability regarding tumor malignancy. The RFCBC
model created in this study outperforms other commonly used binary classification
methods in predicting the malignancy of gastrointestinal tumors, providing a new
model construction method and feasible approach for future coagulation index
prediction of gastrointestinal tumor malignancy.
institución:(a) Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. (b) School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China.
Conflicto:Author XL was employed by the company Hefei Da’an Medical Laboratory Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol.
Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol.
Fuente:Elife
Extracto:
Thus, targeting the
DNAJB12/14-HSC70/SGTA axis is a promising strategy to inhibit ERCYS and impair
cancer cell fitness.
Claves:DNAJB12, ER stress, ERCYS, UPR, cancer biology, cell biology, chaperones, none, reflux
Cita:Elife 2025 Apr 9; 14
Autor/es:Dabsan, Salam (a) Zur, Gali (b)
institución:(a) Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. (b) Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Conflicto:SD, GZ, NA, SS, IG, AG, AI No competing interests declared
institución:(a) Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. (b) NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Conflicto:Competing interests: PR has options in Synairgen plc. BC is an employee of Synairgen Research Ltd and has options in Synairgen plc. SA and SD are employees of Synairgen Research Ltd and have options and shares in Synairgen plc. SS has received fees for advisory services/speaker fees from Astra Zeneca, Chiesi, GSK, Areteia therapeutics, CSL Behring, Medscape. KJS reports grants...
from AstraZeneca and Epiendo and speakers’ honoraria from AstraZeneca. TWC has received research grants from BioFire diagnostics, Biomerieux, QIAGEN, Sense Biodetection and Inflammatix. He has received speaker fees, honoraria and travel re-imbursement from BioFire diagnostics, BioMerieux, QIAGEN, Cepheid and Janssen. He has received consultancy fees from BioMerieux, QIAGEN, Cepheid, Roche, Janssen and Synairgen and has been a member of advisory boards for Cepheid, Roche, Roche diagnostics, Janssen, GSK, Shiongi, Sanofi and Seqirus. He is a member of an independent data monitoring committee for a trial sponsored by Roche. He owns shares in Synairgen plc. TW has received grants and fees from AstraZeneca, Bergenbio, Boehringer Ingelheim, Chiesi, GSK, Janssen, Olam, MMH, Synairgen, Union Chimique Belge and Valneva.
institución:(a) Department of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden. (b) Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Characterising the volume and variation of multiple urgent suspected cancer referrals in England, April 2013-March 2018
Characterising the volume and variation of multiple urgent suspected cancer referrals in England, April 2013-March 2018
Fuente:Bmj Open
Tipo de trabajo:Estudio de cohortes
Extracto:
Multiple USC referrals increased in the study
period, particularly within a year of the first referral. Common referral
pairings suggest opportunities for pathway reorganisation where common
non-specific symptoms result in multiple USC referrals.
Claves:Epidemiology, ONCOLOGY, Primary Care
Cita:BMJ Open 2025 Apr 8; 15 (4) : e097180.
Autor/es:Roberts, Kirstin (a) Cooper, Nicola (b)
institución:(a) National Disease Registration Service, NHS England, Leeds, UK. (b) Cancer Research UK, London, UK.
Conflicto:Competing interests: BDN is the co-director of the National Institute of Health Research (NIHR) Policy Research Unit on Cancer Awareness, Screening and Early Diagnosis (PR-PRU-NIHR206132), and received individual funding from Cancer Research UK (CRUK) and the NIHR during the conduct of this study. TR also received funding from CRUK and NIHR during the conduct of this study. The views expressed...
are those of the authors and not necessarily those of the NIHR, CRUK or the Department of Health and Social Care.
eHealth interventions and patients with metabolic dysfunction-associated steatotic liver disease
eHealth interventions and patients with metabolic dysfunction-associated steatotic liver disease
Fuente:Bmj Open Gastroenterology
Tipo de trabajo:Revisión sistemática
Extracto:
The utilisation of
eHealth interventions showed significant improvements in outcomes related to AST,
ALT, abdominal circumference, weight loss and BMI. However, future studies with
larger sample sizes and longer follow-ups are warranted to assess the
sustainability of these outcomes.
Claves:META-ANALYSIS, Mobile Applications, NONALCOHOLIC STEATOHEPATITIS, Non-alcoholic Fatty Liver Disease, OBESITY
Cita:BMJ Open Gastroenterol 2025 Apr 9; 12 (1)
Autor/es:Zafar, Yousuf (a) Sohail, Muhammad Umer (b)
institución:(a) Department of Medicine, University of Mississippi University Hospital, Jackson, Mississippi, USA. (b) Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Real-world evaluation of an intravenous iron service for the treatment of iron deficiency with or without anemia.
Real-world evaluation of an intravenous iron service for the treatment of iron deficiency with or without anemia.
Fuente:Scientific Reports
Extracto:
Patients remained anemic after > 65% of courses,
demonstrating the need to optimize dosing based on iron need.
Cita:Sci Rep 2025 Apr 9; 15 (1) : 12093.
Autor/es:Fijn, Roel (a) Ablij, Hans C (b)
institución:(a) Department of Clinical Pharmacy, Alrijne Healthcare Group, Leiden, The Netherlands. r.fijn@nwz.nl. (b) Department of Hospital Pharmacy, Northwest Hospital Group, Wilhelminalaan 12, 1815 JD, Alkmaar, The Netherlands. r.fijn@nwz.nl.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Pediatrics, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. (b) AMILI Pte Ltd, Singapore, 118261, Singapore.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
