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The increasing number of Open Access articles widens the reading offer
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consult a profuse amount of documents that will feed
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SIIC created, produced and handles the AFT software that deciphers
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While most of the selected texts belong to original articles,
reviews, and guidelines, readers will also find commentaries,
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Colorectal disease the official journal of the Association of Coloproctology of Great Britain and Ireland
Selección SIIC: 4 Abril, 2025
Colorectal disease the official journal of the Association of Coloproctology of Great Britain and Ireland
A multicentre prospective single-arm clinical trial to evaluate the treatment outcomes of prophylactic laparoscopic lateral pelvic lymph node dissection for advanced lower rectal cancer.
A multicentre prospective single-arm clinical trial to evaluate the treatment outcomes of prophylactic laparoscopic lateral pelvic lymph node dissection for advanced lower rectal cancer.
Fuente:Colorectal Disease The Official Journal of The Association of Coloproctology of Great Britain and Ireland
Tipo de trabajo:Estudio multicéntrico
Extracto:
Prophylactic lateral pelvic lymph node
dissection can be safely performed with adequately quality-controlled
laparoscopic procedures.
institución:(a) Department of Gastroenterological Surgery, Osaka University, Osaka, Japan. (b) Department of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Liver international official journal of the International Association for the Study of the Liver
Selección SIIC: 4 Abril, 2025
Liver international official journal of the International Association for the Study of the Liver
Incidence and Predictors of Complications Following Percutaneous Liver Biopsy
Incidence and Predictors of Complications Following Percutaneous Liver Biopsy
Fuente:Liver International Official Journal of The International Association For The Study of The Liver
Tipo de trabajo:Estudio multicéntrico
Extracto:
Major complications following US-PLB
are few and strongly associated with early post-procedural pain. In the absence
of pain within the first hour, extended monitoring may be unnecessary, allowing
for earlier patient discharge.
institución:(a) Department of Biomedical Sciences, Humanitas University, Milan, Italy. (b) Division of Internal Medicine and Hepatology, Department of Gastroenterology, Humanitas Research Hospital IRCCS, Milan, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Small Bowel Strangulation under External Iliac Vessels after Robot-Assisted Prostatectomy.
Small Bowel Strangulation under External Iliac Vessels after Robot-Assisted Prostatectomy.
Fuente:Crsls Mis Case Reports From Sls
Extracto:
Internal herniation under external iliac vessels is
a rare and challenging condition. Operation can be performed well with both
laparotomy and laparoscopy. We suggest closing peritoneal defects during index
operation and strongly recommend defect closure after an episode of internal
herniation.
Claves:External iliac vessels, Laparoscopy, Robot-assisted prostatectomy, Small bowel strangulation
Cita:CRSLS 2025 Jan-Mar; 12 (1)
Autor/es:Jinno, Kazushi (a) Honore, Alfred (b)
institución:(a) Gastroenterologic Department, Haukeland University Hospital, Bergen, Norway. (Drs. Jinno and Øvrebø). (b) Urologic Department, Haukeland University Hospital, Bergen, Norway. (Dr. Honore).
Yakugaku zasshi Journal of the Pharmaceutical Society of Japan
Selección SIIC: 4 Abril, 2025
Yakugaku zasshi Journal of the Pharmaceutical Society of Japan
[Clinical Impact of Vonoprazan on the Use of Midazolam during Upper Gastrointestinal Endoscopy].
[Clinical Impact of Vonoprazan on the Use of Midazolam during Upper Gastrointestinal Endoscopy].
Fuente:Yakugaku Zasshi Journal of The Pharmaceutical Society of Japan
Extracto:
These results
suggest that the use of MDZ for sedation during upper gastrointestinal endoscopy
may have minimal clinical effects arising from drug interaction with VPZ.
Autor/es:Mujtaba, Ahmed (a) Ibrahim, Muhammad Suhail (b)
institución:(a) Department of Food Science and Technology, Faculty of Engineering Sciences and Technology, Hamdard University Islamabad Campus, Islamabad, Pakistan. (b) Institute of Food and Nutritional Sciences, PMAS-Arid Agriculture University, Rawalpindi, Pakistan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Tolerability, safety and feasibility of metformin combined with chemoradiotherapy in patients with locally advanced cervical cancer: A phase II, randomized study.
Tolerability, safety and feasibility of metformin combined with chemoradiotherapy in patients with locally advanced cervical cancer: A phase II, randomized study.
Fuente:Acta Oncologica (stockholm, Sweden)
Tipo de trabajo:Estudio abierto
Extracto:
Serial sampling of MRI and tumor biopsies for hypoxia biomarker assessment is
feasible.
Cita:Acta Oncol 2025 Mar 19; 64 : 439-447.
Autor/es:Skipar, Kjersti (a) Hompland, Tord (b)
institución:(a) Department of Oncology, Telemark Hospital Trust, Skien, Norway; Department of Radiation Biology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. kjeski@sthf.no. (b) Department of Radiation Biology, Oslo University Hospital, Oslo, Norway.
Analysis of the effectiveness and safety of lenvatinib/bevacizumab combined with PD-1/PD-L1 inhibitors and GEMOX in the first-line treatment of advanced biliary tract carcinoma.
Analysis of the effectiveness and safety of lenvatinib/bevacizumab combined with PD-1/PD-L1 inhibitors and GEMOX in the first-line treatment of advanced biliary tract carcinoma.
Fuente:Clinical and Experimental Medicine
Extracto:
Lenvatinib/bevacizumab
combined with programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1)
inhibitors and gemcitabine/oxaliplatin (GEMOX) represent an effective and
tolerable regimen for advanced BTC in a multicenter retrospective real-world
study.
institución:(a) Department of Gastroenterology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China. (b) Department of Gastroenterology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Key parameters and sensitivity analysis of lower limb muscle strength in young men with different gait patterns.
Key parameters and sensitivity analysis of lower limb muscle strength in young men with different gait patterns.
Fuente:Plos One
Extracto:
(1) Left semitendinosus,
right semitendinosus, right biceps femoris, and left gastrocnemius can be used as
the main muscles for gait recognition. (2) The left semitendinosus principal
component V, the right biceps femoris principal component III, and the left
gastrocnemius medial principal component IV are sensitive indicators for gait
stage classification.
Cita:PLoS One 2025; 20 (3) : e0318693.
Autor/es:Wang, Yifei (a) Sun, Jianbo (b)
institución:(a) College of Sports Sciences, Qufu Normal University, Jining, China. (b) Exercise and Sports Science Programme, School of Health Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Remedial colon hydrotherapy device enema as a salvage strategy for inadequate bowel preparation for colonoscopy
Remedial colon hydrotherapy device enema as a salvage strategy for inadequate bowel preparation for colonoscopy
Fuente:Plos One
Tipo de trabajo:Estudio de cohortes
Extracto:
The colon
hydrotherapy device enema is an effective, efficient, and well-tolerated method
for bowel cleansing, demonstrating a low incidence of adverse events. It is
recommended as an effective and safe remedial therapy for patients with
inadequate bowel preparation prior to colonoscopy.
Cita:PLoS One 2025; 20 (3) : e0319493.
Autor/es:Zhang, Dongxuan (a) Zhao, Chunxia (b)
institución:(a) Department of Gastroenterology, Beijing Changping Hospital of Traditional Chinese Medicine, Beijing, China. (b) Department of Neurology, Aerospace Center Hospital, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Understanding climate-sensitive diseases in Bangladesh using systematic review and government data repository.
Understanding climate-sensitive diseases in Bangladesh using systematic review and government data repository.
Fuente:Plos One
Tipo de trabajo:Revisión sistemática
Extracto:
The findings underscore the urgent need to tackle data challenges in
understanding climate-sensitive diseases in Bangladesh. Policies and programs are
required to prioritize the digitalization of the healthcare system and implement
a unique patient identification number to facilitate accurate tracking and
analysis of health data. Climate Change, including rising temperature and extreme
weather events like cyclone and floods, poses a significant global health threat
[1]. The World Health Organization estimates climate change already causes at
least 150,000 deaths annually at the global level, and that number is projected
to double by 2030. Beside these other impact of climate change are far-reaching,
leading to forced displacement, malnutrition and increased incidence of diseases
such as dengue, diarrhea, and pneumonia [2]. Additionally, climate change has
established links to mental health issues, like anxiety and depression [3]. The
effects are particularly severe in Low- and Middle-Income Countries (LMICs) due
to limited resources and inadequate infrastructure for coping with erratic
weather and disasters [4]. We undertook a comprehensive mixed-method study,
incorporating a systematic review of existing studies conducted in Bangladesh,
along with an analysis of government data repository. A detailed description of
each component is presented below.
Cita:PLoS One 2025; 20 (3) : e0313031.
Autor/es:Kabir, Md Iqbal (a) Hossain, Dewan Mashrur (b)
institución:(a) Climate Change and Health Promotion Unit (CCHPU), Health Services Division, Ministry of Health and Family Welfare (MoHFW), Dhaka, Bangladesh. (b) Department of Disaster Science and Climate Resilience, University of Dhaka, Dhaka, Bangladesh.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Vibrational exercise for Crohn's to observe response (VECTOR): Protocol for a randomized controlled trial.
Vibrational exercise for Crohn's to observe response (VECTOR): Protocol for a randomized controlled trial.
Fuente:Plos One
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
Ethical approval was granted by the Nottingham
Research Ethics Committee (REC: 24/EM/0106) and the study has been registered
prospectively as a clinical trial (NTC06211400).
Cita:PLoS One 2025; 20 (3) : e0319685.
Autor/es:Sinclair, Jonathan (a) Brooks-Warburton, Johanne (b)
institución:(a) Research Centre for Applied Sport, Physical Activity and Performance, School of Sport and Health Sciences, Faculty of Allied Health and Wellbeing, University of Central Lancashire, Preston, Lancashire, United Kingdom. (b) Centre for Research in Psychology and Sports, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Hertfordshire, United Kingdom.
Conflicto:I have read the journal's policy and the authors of this manuscript have the following competing interests: this project is fully funded by an award from Crohn's and Colitis Foundation - award number 1167823. The funder has no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Reducing hepatitis C diagnostic disparities with a fully automated deep learning-enabled microfluidic system for HCV antigen detection.
Reducing hepatitis C diagnostic disparities with a fully automated deep learning-enabled microfluidic system for HCV antigen detection.
Fuente:Science Advances
Extracto:
With an overall accuracy of 94.59%, this cost-effective,
portable device has the potential to reduce HCV-related health disparities,
particularly among AI/AN populations, improving accessibility and equity in care.
Cita:Sci Adv 2025 Mar 21; 11 (12) : eadt3803.
Autor/es:Chen, Hui (a) Gao, Yuxin (b)
institución:(a) Division of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA. (b) Division of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA.
Autor/es:Monberg, Tine J (a) Pakola, Santeri A (b)
institución:(a) National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, 2730 Herlev, Denmark. (b) Cancer Gene Therapy Group, Translational Immunology Research Progam, University of Helsinki, Helsinki, Finland.
Conflicto:Declaration of interests T.J.M. has been a co-investigator in a trial from TILT Biotherapeutics. E.E. has received personal payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Novartis, Merck, Bristol Myers Squibb, and Pierre Fabre. She has received support for attending meetings and/or travel from Pierre Fabre and Merck. M.D. is an advisor of Achilles...
Therapeutics and expert group member of Guidepoint LLC and AlphaSights. R.L.E. received institutional drug funding from BMS to investigator-initiated trial. T.H.B. has received personal honoraria for lectures from Bristol Myers Squibb. C.K. is an employee and shareholder at TILT Biotherapeutics. J.M.S. is an employee and stocks/share holder at TILT Biotherapeutics. He received a research grant from TILT Biotherapeutics. He is a co-inventor of patent applications for TILT Biotherapeutics. He received personal payment for consultancy for TILT Biotherapeutics. J.H.A.C. is an employee and shareholder at TILT Biotherapeutics. L.H. is an employee and option holder at TILT Biotherapeutics. D.C.A.Q. is an employee and shareholder at TILT Biotherapeutics. R.H. is an employee at TILT Biotherapeutics. S.S. is an employee and option holder at TILT Biotherapeutics. V.C.-C. is an employee and shareholder at TILT Biotherapeutics. A.H. is a shareholder in Circio Holding ASA and an employee and shareholder at TILT Biotherapeutics Oy. I.M.S. has received personal payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, advisory board, or educational events from Bristol Myers Squibb, Instil Bio, Mendus, MSD, Novartis, Sanofi, and Takeda. She has stocks/shares in IO Biotech. She has received research grants from Adaptimmune, Asgard Therapeutics, Enara Bio, IO Biotech, Lytix Biopharma, and TILT Biotherapeutics. She has been principal investigator in trials from BMS, Immunocore, Lytix Biopharma, MSD, Novartis, Roche, and TILT Biotherapeutics. The TILT technology is patented by the company TILT Biotherapeutics.
Influencing factors and prediction algorithms to estimate public preference for painless medical procedures in China: a national cross-sectional study.
Influencing factors and prediction algorithms to estimate public preference for painless medical procedures in China: a national cross-sectional study.
Fuente:Bmj Open
Extracto:
The Chinese public has a good level of acceptance
of comfortable medical care, although there are still many obstacles to its
popularisation and promotion. Our prediction model could be used to screen the
population for targeted popularisation work to expand the implementation of this
approach.
institución:(a) Department of Anesthesiology, Peking University Third Hospital, Beijing, China. (b) Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Predictors of blood pressure control among patients with hypertension: a cross-sectional study in a Nigerian tertiary health facility.
Predictors of blood pressure control among patients with hypertension: a cross-sectional study in a Nigerian tertiary health facility.
Fuente:Bmj Open
Extracto:
Addressing
prevalent risk factors like sedentary lifestyle and dietary habits, as well as
structural initiatives like accessibility to health insurance, presents
opportunities for targeted interventions to enhance well-being and improve
outcomes that will strengthen public health, clinical practice and research.
Claves:Blood Pressure, Hypertension, Patients
Cita:BMJ Open 2025 Mar 18; 15 (3) : e091010.
Autor/es:Ukpeh, Ido Edem (a) Akpan, Margaret Inemesit (b)
institución:(a) Cardiology Unit, Department of Internal Medicine, University of Calabar Teaching Hospital, Calabar, Cross River, Nigeria. (b) Faculty of Clinical Sciences, Department of Internal Medicine, University of Calabar Teaching Hospital, Calabar, Cross River, Nigeria.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study.
Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study.
Fuente:Signal Transduction and Targeted Therapy
Extracto:
Thus, KN026 plus KN04 exhibits promising efficacy
and acceptable safety profiles in HER2-positive nonbreast cancer, as does the
1st-line treatment for GC.
institución:(a) Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Early Drug Development Center, Peking University Cancer Hospital and Institute, Beijing, China. (b) State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
Conflicto:Competing interests: T.X. and F.K. were employees of Jiangsu Alphamab Biopharmaceuticals Co., Ltd. Other authors declared that they had no personal relationships and known competing financial interests that could have appeared to influence the work reported in this paper.
Predicting coronavirus disease 2019 severity using explainable artificial intelligence techniques.
Predicting coronavirus disease 2019 severity using explainable artificial intelligence techniques.
Fuente:Scientific Reports
Extracto:
Simple and well-structured
predictive models were established, which may aid in patient management and the
selection of therapeutic interventions.
institución:(a) Division of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. (b) Division of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. bachibachi472000@z6.keio.jp.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) China-Japan Union Hospital of Jilin University, Changchun, 130000, Jilin, People's Republic of China. (b) China-Japan Union Hospital of Jilin University, Changchun, 130000, Jilin, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Stroma and lymphocytes identified by deep learning are independent predictors for survival in pancreatic cancer.
Stroma and lymphocytes identified by deep learning are independent predictors for survival in pancreatic cancer.
Fuente:Scientific Reports
Extracto:
These
findings underscore the potential of SIP and LIP as prognostic biomarkers for
PDAC and highlight the utility of DL as a tool for PDAC biomarkers detecting on
WSIs.
institución:(a) Department of Surgery and Transplantation, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. tanxiuxiang2017@outlook.com. (b) Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China. tanxiuxiang2017@outlook.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between gestational diabetes mellitus and offspring health: a two-sample mendelian randomization study.
Association between gestational diabetes mellitus and offspring health: a two-sample mendelian randomization study.
Fuente:Bmc Pregnancy and Childbirth
Extracto:
The findings of this study provide genetic evidence
supporting an association between GDM and higher risk of offspring diseases. This
supports classification of GDM as risk factors for short- and long-term offspring
health.
Cita:BMC Pregnancy Childbirth 2025 Mar 19; 25 (1) : 321.
Autor/es:Yan, Mi (a) Chen, Zhengdong (b)
institución:(a) Department of Pediatrics, Daping Hospital, Army Medical University, Chongqing, 400042, China. (b) Department of Pediatrics, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
