Effectiveness of the ALT/AST ratio for predicting insulin resistance in a Korean population

Effectiveness of the ALT/AST ratio for predicting insulin resistance in a Korean population

Fuente:Plos One

Tipo de trabajo:Estudio de cohortes

Extracto: A simple, precise marker that represents the ALT/AST ratio could be a practical method to screen for insulin resistance in the general population, regardless of diabetes mellitus, alcohol intake, and sex.

Cita:PLoS One 2024; 19 (5) : e0303333.

Autor/es:Han, Seul Ki (a)
Seo, Myung Jae (b)

institución:(a) Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
(b) Regeneration Medicine Research Center, Yonsei University Wonju College of Medicine, Wonju, Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303333

Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia.

Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia.

Fuente:Scientific Reports

Extracto: Potential gene-to-gene interaction and their association with clinical phenotype in women with FMS should be further investigated in future studies including large sample sizes.

Claves:Fibromyalgia, Pain genes, Single nucleotide polymorphism

Cita:Sci Rep 2024 May 17; 14 (1) : 11273.

Autor/es:Fernández-de-Las-Peñas, César (a)
Ambite-Quesada, Silvia (b)

institución:(a) Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos, Av. de Atenas S/N, 28922, Alcorcón, Madrid, Spain. cesar.fernandez@urjc.es.
(b) Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, SMI, Aalborg University, Aalborg, Denmark. cesar.fernandez@urjc.es.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-62240-7

The association between dietary vitamin B1 intake and constipation: a population-based study.

The association between dietary vitamin B1 intake and constipation: a population-based study.

Fuente:Bmc Gastroenterology

Extracto: This research uncovered an inverse correlation between the consumption of vitamin B1 in the diet and the occurrence of chronic constipation. One potential explanation for this phenomenon is that the consumption of vitamin B1 in one's diet is linked to the softening of stools and an augmented occurrence of colonic peristalsis. Additional extensive prospective research is required to thoroughly examine the significance of thiamine in long-term constipation.

Claves:Constipation, Cross-sectional study, National Health and Nutrition Examination Survey, Vitamin B1

Cita:BMC Gastroenterol 2024 May 17; 24 (1) : 171.

Autor/es:Du, Wenyi (a)
Lu, Lingchen (b)

institución:(a) The Affiliated Stomatological Hospital of Soochow University, Suzhou Stomatological Hospital, Suzhou, Jiangsu, China.
(b) Department of General Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Wuxi, Jiangsu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12876-024-03255-2

Characterization of the gut microbiota in polycystic ovary syndrome with dyslipidemia.

Characterization of the gut microbiota in polycystic ovary syndrome with dyslipidemia.

Fuente:Bmc Microbiology

Extracto: The gut microbiota characterizations in patients with PCOS.D differ from those in patients with PCOS and controls, and those might also be related to clinical parameters. This may have the potential to become an alternative therapy to regulate the clinical lipid levels of patients with PCOS in the future.

Claves:Dyslipidemia, Gut microbiota, Polycystic ovary syndrome

Cita:BMC Microbiol 2024 May 17; 24 (1) : 169.

Autor/es:Yang, Tianjin (a)
Li, Guanjian (b)

institución:(a) Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
(b) Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12866-024-03329-x

Analysis of causes and prognostic impact of tube occlusion during hyperthermic intraperitoneal chemotherapy for appendiceal pseudomyxoma peritonei.

Analysis of causes and prognostic impact of tube occlusion during hyperthermic intraperitoneal chemotherapy for appendiceal pseudomyxoma peritonei.

Fuente:World Journal of Surgical Oncology

Extracto: Tubing blockages are a common occurrence during HIPEC treatment, leading to prolonged postoperative gastrointestinal functional recovery time. When patients are elderly and have concomitant hypertension and diabetes, along with a histological type of low-grade mucinous tumor, the risk of tube occlusion increases. However, this study did not find a significant correlation between tubing blockage and the incidence of postoperative complications or overall patient survival.

Claves:Complication, Gastrointestinal function, HIPEC, Tube occlusion

Cita:World J Surg Oncol 2024 May 21; 22 (1) : 134.

Autor/es:Liu, Qi (a)
Jiao, Jie (b)

institución:(a) School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.
(b) Department of Gastrointestinal Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12957-024-03412-7

Metabolic dysfunction-associated steatotic liver disease: Navigating terminological evolution, diagnostic frontiers and therapeutic horizon-an editorial exploration.

Metabolic dysfunction-associated steatotic liver disease: Navigating terminological evolution, diagnostic frontiers and therapeutic horizon-an editorial exploration.

Fuente:World Journal of Gastroenterology

Extracto: There is a strong need to emphasize the importance of collaborative efforts in understanding, diagnosing, and managing MASLD to improve physicians' approaches and patient outcomes.

Claves:Diagnostics, Metabolic dysfunction-associated steatotic liver disease, Pathophysiology of metabolic dysfunction-associated steatotic liver disease, Therapeutic innovations, Therapy of metabolic dysfunction-associated steatotic liver disease

Cita:World J Gastroenterol 2024 May 14; 30 (18) : 2387-2390.

Autor/es:Boldys, Aleksandra (a)
Buldak, Lukasz (b)

institución:(a) Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of Silesia, Katowice 40-752, Poland.
(b) Department of Internal Medicine and Clinical Pharmacology, School of Medicine in Katowice, Medical University of Silesia, Katowice 40-752, Poland. lbuldak@gmail.com.

Conflicto:Conflict-of-interest statement: The authors have nothing to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.3748/wjg.v30.i18.2387

Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics.

Fuente:Journal of Experimental & Clinical Cancer Research Cr

Extracto: Our model demonstrated ultrasensitivity of plasma cfDNA fragementomics in detecting biliopancreatic cancers, fulfilling the unmet accuracy of widely-used serum biomarker CA19-9, and provided an affordable way for accurate noninvasive biliopancreatic cancer screening in clinical practice.

Claves:Biliopancreatic cancer, Cell-free DNA, Fragmentomics, Low-coverage whole-genome sequencing

Cita:J Exp Clin Cancer Res 2024 May 15; 43 (1) : 145.

Autor/es:Shi, Xiaohan (a)
Guo, Shiwei (b)

institución:(a) Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Navy Military Medical University, 168 Changhai Road, Shanghai, 200433, China.
(b) Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Navy Military Medical University, 168 Changhai Road, Shanghai, 200433, China.

Conflicto:All authors affiliated with 3D Medicines Inc. are current or former employees. No potential conflicts of interest were disclosed by the other authors.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13046-024-03067-y

Value of integrated pulmonary index monitoring for the detection of adverse respiratory events in patients undergoing sedation for gastrointestinal system endoscopy.

Fuente:Jpma. The Journal of The Pakistan Medical Association

Extracto: Capnographic monitoring, especially the follow-up integrated pulmonary index score, was found to be valuable and reliable in terms of finding both time and accuracy of the risk factor in the diagnosis of respiratory events.

Claves:Endoscopy, Hypoxia, Index monitoring, Pulmonary

Cita:J Pak Med Assoc 2024 Apr; 74 (4) : 641-646.

Autor/es:Celik, Hale Kefeli (a)
Doganay, Zahide (b)

institución:(a) Department of Anaesthesiology and Reanimation, Samsun Research and Education Hospital, Samsun.
(b) Department of Anaesthesiology and Reanimation, Kastamonu University, Kastamonu.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Pakistán

Sitio web:http://dx.doi.org/10.47391/JPMA.8597

Telangiectasias, recurrent epistaxis and a strong family history-a case of Osler- Weber-Rendu Syndrome in Pakistan.

Fuente:Jpma. The Journal of The Pakistan Medical Association

Extracto: Informed consent was taken from the patient prior to the writing of the manuscript.

Claves:Recurrent epistaxis, Telangiectasias, Arteriovenous malformations, Autosomal dominant, Hereditary haemorrhagic telangiectasia.

Cita:J Pak Med Assoc 2024 Apr; 74 (4) : 800-803.

Autor/es:Arif Siddiqui, Muhammad Mustafa (a)
Hafeez, Tayyaba (b)

institución:(a) Department of Medicine, Hameed Latif Teaching Hospital.
(b) Department of Nephrology, Bahria Town International Hospital.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Pakistán

Sitio web:http://dx.doi.org/10.47391/JPMA.9577

Detection of Vancomycin Resistant Genes in Intrinsically Antibiotic Resistant Bacteria from the Gut Microbiota of Indonesian Individuals.

Fuente:Iranian Journal of Medical Sciences

Extracto: The presence of multiple vancomycin resistance genes in intrinsically resistant Gram-negative bacterial strains demonstrated the importance of the gut microbiota as a reservoir and hub for the horizontal transfer of antibiotic resistant genes.

Claves:Antibiotics, Gastrointestinal microbiome, Health-risk, Indonesia, Vancomycin resistance

Cita:Iran J Med Sci 2024 May; 49 (5) : 302-312.

Autor/es:Luqman, Arif (a)
Saising, Jongkon (b)

institución:(a) Department of Biology, Institute Teknologi Sepuluh Nopember, Surabaya, Indonesia.
(b) Institute for Molecular Infection Biology (IMIB), Julius Maximilians University of Wuerzburg, Wuerzburg, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Irán

Sitio web:http://dx.doi.org/10.30476/IJMS.2023.98767.3087

Safety of RNA-Dependent RNA Polymerase Inhibitors, Molnupiravir and VV116, for Oral Treatment of COVID-19

Fuente:Iranian Journal of Medical Sciences

Tipo de trabajo:Metanálisis

Extracto: The RdRp inhibitors molnupiravir and VV116 are safe for oral treatment of COVID-19. Further evidence is necessary that RdRp inhibitors have a higher safety profile than Paxlovid.

Claves:COVID-19, GS-621763, Molnupiravir, Nirmatrelvir and ritonavir drug combination, RNA-dependent RNA polymerase

Cita:Iran J Med Sci 2024 May; 49 (5) : 275-285.

Autor/es:Zheng, Zequn (a)
Zhou, Jiaozhi (b)

institución:(a) Ningbo Institute of Innovation for Combined Medicine and Engineering, Ningbo Medical Center Lihuili Hospital, Ningbo University, No. 378 Dongqing Road, Yinzhou District, Ningbo.
(b) Department of Cardiology, Shantou University Medical College, Shantou University, Shantou, 515000, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Irán

Sitio web:http://dx.doi.org/10.30476/IJMS.2024.99837.3196

A Comparison of the Effect of Kegel Exercises and Conventional Therapy versus Conventional Therapy Alone in the Treatment of Functional Constipation in Children

Fuente:Iranian Journal of Medical Sciences

Tipo de trabajo:Estudio clínico aleatorizado

Extracto: Kegel exercise was an effective adjunctive treatment for pediatric functional constipation.Trial Registration Number: IRCT20230424057984N1.

Claves:Child, Constipation, Exercise therapy, Kegel exercises

Cita:Iran J Med Sci 2024 May; 49 (5) : 286-293.

Autor/es:Ansari Chaharsoghi, Narges (a)
Davoodi, Marzieh (b)

institución:(a) Department of Pediatrics, School of Medicine, Namazi Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
(b) Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Conflicto:Mohammad Hadi Imanieh and Naeimehossadat Asmarian, as the Editorial Board Members, were not involved in any stage of handling this manuscript. A team of independent experts was formed by the Editorial Board to review the article without their knowledge.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Irán

Sitio web:http://dx.doi.org/10.30476/IJMS.2023.98539.3055

The optimal threshold of PD-L1 combined positive score to predict the benefit of PD-1 antibody plus chemotherapy for patients with HER2-negative gastric adenocarcinoma

Fuente:Cancer Immunology, Immunotherapy Cii

Tipo de trabajo:Metanálisis

Extracto: The benefit derived from ICIs plus chemotherapy is similar between Asian and global GEAC patients. However, those with a PD-L1 CPS < 5 or CPS < 10 may not have significant benefits from ICIs therapy. Therefore, it is advisable to routinely assess PD-L1 expression in GEAC patients considered for ICIs treatment.

Claves:Combined positive score, Cutoff value, Gastric cancer, Immune checkpoint inhibitors, Meta-analysis

Cita:Cancer Immunol Immunother 2024 May 16; 73 (7) : 132.

Autor/es:Li, Ji-Bin (a)
Lai, Ming-Yu (b)

institución:(a) Department of Clinical Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
(b) Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s00262-024-03726-1

A Comprehensive Review on Ulcer and Their Treatment.

Fuente:Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology

Extracto: This review article underscores the importance of a multidisciplinary approach in the management of ulcers to improve patient outcomes and quality of life.

Claves:H.pylori, Infection, Peptic ulcer, Sore, Stomach

Cita:Zhongguo Ying Yong Sheng Li Xue Za Zhi 2023 Dec 21; 39 : e20230006.

Autor/es:RaviKKumar, V R (a)
Rathi, Sanjesh (b)

institución:(a) Professor and Head, Dept. of Pharmacognosy, The Erode College of Pharmacy, Perundurai Main Road, Veppampalayam, Erode-638112, Tamilnadu, India.
(b) Professor & Principal, School of Pharmacy, Rai University, Ahmedabad, Gujarat, India.

Formato:Informe virtual

Idioma:Inglés

País de fuente:China

Sitio web:http://dx.doi.org/10.62958/j.cjap.2023.006

A retrieval-augmented chatbot based on GPT-4 provides appropriate differential diagnosis in gastrointestinal radiology: a proof of concept study.

Fuente:European Radiology Experimental

Extracto: The GIA-CB not only provided an accurate diagnosis for gastrointestinal pathologies, but also direct access to source documents, providing insight into the decision-making process, a step towards trustworthy and explainable AI. Integrating context-specific data into AI models can support evidence-based clinical decision-making. RELEVANCE STATEMENT: A context-aware GPT-4 chatbot demonstrates high accuracy in providing differential diagnoses based on imaging descriptions, surpassing the generic GPT-4. It provided formulated rationale and source excerpts supporting the diagnoses, thus enhancing trustworthy decision-support. KEY POINTS: • Knowledge retrieval enhances differential diagnoses in a gastrointestinal imaging-aware chatbot (GIA-CB). • GIA-CB outperformed the generic counterpart, providing formulated rationale and source excerpts. • GIA-CB has the potential to pave the way for AI-assisted decision support systems.

Claves:Artificial intelligence, Diagnosis (differential), Gastrointestinal diseases, Knowledge acquisition (computer), Zero-shot learning

Cita:Eur Radiol Exp 2024 May 17; 8 (1) : 60.

Autor/es:Rau, Stephan (a)
Rau, Alexander (b)

institución:(a) Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, 79106, Freiburg Im Breisgau, Germany. stephan.rau@uniklinik-freiburg.de.
(b) Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, 79106, Freiburg Im Breisgau, Germany.

Conflicto:The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors report unrelated financial disclosures for the preceding 12 months: AR received grants from Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg. All declared interests are independent of the submitted work.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s41747-024-00457-x

Autochthonous and imported giardiasis cases: An analysis of two decades of national surveillance data, Germany, 2002 to 2021.

Fuente:Euro Surveillance Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin

Extracto: Dietary, behavioural and environmental risk factors need to be further investigated to enhance infection prevention measures for autochthonous giardiasis.

Claves:Giardiasis, epidemiology, imported disease, surveillance

Cita:Euro Surveill 2024 May; 29 (20)

Autor/es:Hommes, Franziska (a)
Dörre, Achim (b)

institución:(a) Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
(b) Postgraduate Training for Applied Epidemiology (PAE), Robert Koch Institute, Berlin, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Suecia

Sitio web:http://dx.doi.org/10.2807/1560-7917.ES.2024.29.20.2300509

Network pharmacology and molecular docking technology for exploring the effect and mechanism of high-dose vitamin c on ferroptosis of tumor cells

Fuente:Medicine

Tipo de trabajo:Revisión

Extracto: Our study provides a reference for further clinical studies on HVC antitumor therapy.

Cita:Medicine (Baltimore) 2024 May 17; 103 (20) : e38189.

Autor/es:Qu, Jinxiu (a)
Lu, Shuai (b)

institución:(a) Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
(b) Center of Metabolism and Nutrition of Cancer, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000038189

Effects of preoperative inhaled budesonide combined with intravenous dexamethasone on postoperative sore throat in patients who underwent thyroidectomy: A randomized controlled trial.

Fuente:Medicine

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: Preoperative inhaled budesonide combined with intravenous dexamethasone reduced the incidence and severity of POST at 6, 12, and 24 hours after extubation compared with intravenous dexamethasone alone in patients who underwent thyroidectomy. Additionally, this combination decreased the incidence of postoperative coughing at 24 hours.

Cita:Medicine (Baltimore) 2024 May 17; 103 (20) : e38235.

Autor/es:Chen, Ping-Ping (a)
Zhang, Xing (b)

institución:(a) Department of Gastrointestinal Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China.
(b) Department of Thyroid and Breast Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China.

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000038235

Distinct characteristics of distant metastasis in early-onset gastric cancer patients compared to late-onset patients: An observational study.

Fuente:Medicine

Extracto: Our findings suggest that early-onset serves as a protective factor against liver metastasis in GC, while it poses a risk for distant metastasis, likely influenced by the increased prevalence of diffuse-type GC in early-onset patients.

Cita:Medicine (Baltimore) 2024 May 17; 103 (20) : e38098.

Autor/es:Wu, Feng (a)
Wu, Shuang (b)

institución:(a) Department of Gastroenterology, Jingdezhen Second People's Hospital, Jingdezhen City, Jiangxi Province, China.
(b) Department of Gastroenterology, Jingdezhen Second People's Hospital, Jingdezhen City, Jiangxi Province, China.

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000038098

Exploration of the molecular linkage between endometriosis and Crohn disease by bioinformatics methods.

Fuente:Medicine

Extracto: Our findings firstly revealed the linkage between EMT and CD, including inflammation, angiogenesis, immune regulation, and cell behaviors, which may lead to the risk of CD in EMT. FGF9, FZD7, IGFBP5, KDR, and NAMPT may closely relate to the linkage.

Cita:Medicine (Baltimore) 2024 May 17; 103 (20) : e38097.

Autor/es:Zhou, Weijie (a)
Su, Peizhu (b)

institución:(a) Department of Gastroenterology, The Six Affiliated Hospital of South China University of Technology, Foshan City, Guangdong Province, China.
(b) Department of Gastroenterology, The First People's Hospital of Foshan, Foshan City, Guangdong Province, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000038097