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Hepatic encephalopathy as an indication or contraindication to liver transplant?
Hepatic encephalopathy as an indication or contraindication to liver transplant?
Fuente:Metabolic Brain Disease
Extracto:
In the future, objective measures of HE severity
should be included in the MELD score to enhance the fairness and efficacy of
transplant listings, ensuring those with cirrhosis complicated by HE receive
timely and appropriate treatment.
Autor/es:Lauridsen, Mette Munk (a) Bajaj, Jasmohan S (b)
institución:(a) Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA. (b) Department of Gastroenterology, University Hospital of South Denmark, Finsensgade 35, Esbjerg, 6700, Denmark.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
The aim of
this Cytoimaging Correlation Series is to demonstrate the multidisciplinary
involvement in the diagnosis of pancreatic pathology and to highlight main
findings in the most common entities found in everyday practice.
institución:(a) Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA. (b) Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Study protocol: Fecal Microbiota Transplant combined with Atezolizumab/Bevacizumab in Patients with Hepatocellular Carcinoma who failed to achieve or maintain objective response to Atezolizumab/Bevacizumab - the FAB-HCC pilot study.
Study protocol: Fecal Microbiota Transplant combined with Atezolizumab/Bevacizumab in Patients with Hepatocellular Carcinoma who failed to achieve or maintain objective response to Atezolizumab/Bevacizumab - the FAB-HCC pilot study.
institución:(a) Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria. (b) Division of Gastroenterology and Hepatology, Department of Medicine III, Vienna Liver Cancer Study Group, Medical University of Vienna, Vienna, Austria.
Conflicto:I have read the journal's policy and the authors of this manuscript have the following competing interests: KP has nothing to disclose. AF received travel support from Takeda and Amgen, he received speaker honoraria from AbbVie. BS received travel support from AbbVie, AstraZeneca, Gilead and Ipsen, speaker honoraria from Eisai as well as grant support from AstraZeneca and Eisai. LB...
received speaker honoraria from Chiesi and Gilead. LP has nothing to disclose. AKL has nothing to disclose. AKR has nothing to disclose. KL has nothing to disclose. KR has nothing to disclose. KZ has nothing to disclose. MT received speaker honoraria from Albireo, BMS, Falk Foundation, Gilead, Intercept, Madrigal and MSD; he has advised for Abbvie, Albireo, BiomX, Boehringer Ingelheim, Falk Pharma GmbH, Genfit, Gilead, Hightde, Intercept, Ipsen, Jannsen, MSD, Novartis, Phenex, Pliant, Rectify Regulus, Siemens and Shire. He further received travel grants from Abbvie, Falk, Gilead Intercept and Jannsen and research grants from Albireo, Almylam, Cymabay, Falk, Gilead, Intercept, MSD, Takeda and Ultragenyx. He is also co-inventor of patents on the medical use of NorUDCA filed by the Medical Universities of Graz and Vienna. DT served as a speaker and/or consultant and/or advisory board member for Siemens, Roche, Sanova, Bristol-Myers Squibb and received travel support from Bayer and Siemens. CG holds Roche shares. MP received speaker honoraria from AstraZeneca, Bayer, BMS, Eisai, Ipsen, Lilly, MSD, and Roche; he is a consultant/advisory board member for AstraZeneca, Bayer, BMS, Eisai, Ipsen, Lilly, MSD, and Roche; he received grants from AstraZeneca, Bayer, BMS, Eisai, and Roche; he received travel support from Bayer, BMS, Ipsen, and Roche.
Prevalence and factors associated with Helicobacter Pylori infection among patients with dyspeptic symptoms in Tanzania: Experience from temeke regional referral hospital in Dar Es Salaam.
Prevalence and factors associated with Helicobacter Pylori infection among patients with dyspeptic symptoms in Tanzania: Experience from temeke regional referral hospital in Dar Es Salaam.
Fuente:Plos One
Extracto:
Preventive measures and eradication of Helicobacter pylori
infection should be considered worthy by public health authorities. More studies
have to be emphasized to check the relationship between sex and Helicobacter
pylori infection.
institución:(a) School of Public Health and Social Sciences, Muhimbili University of Health and Allied Science, Dar es Salaam, Tanzania. (b) Jakaya Kikwete Cardiac Institute, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Exploring the role of audit and feedback cycle in primary healthcare quality improvement.
Exploring the role of audit and feedback cycle in primary healthcare quality improvement.
Fuente:Bmj Open Quality
Extracto:
The A&F
cycle is a viable intervention for enhancing clinical practices in PHC settings.
The findings highlight the potential of A&F to drive quality improvements in
healthcare delivery to resource-limited settings in Karachi. Further longitudinal
studies are recommended to assess the sustainability of these practice
enhancements and to explore the role of contextual factors in the effectiveness
of A&F interventions.
Claves:Audit and feedback, GENERAL PRACTICE, Healthcare quality improvement, PRIMARY CARE, Quality improvement
Cita:BMJ Open Qual 2025 Apr 15; 13 (Suppl 1)
Autor/es:Omair, Wajiha (a) Jawaid, Mohammad Bilal (b)
institución:(a) Medical Affairs Department, SINA Health Education and Welfare Trust, Karachi, Pakistan wajihanaved3@gmail.com. (b) Medical Affairs Department, SINA Health Education and Welfare Trust, Karachi, Pakistan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for stage III melanoma: outcomes and the impact of the microbiome from the NeoACTIVATE trial.
Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for stage III melanoma: outcomes and the impact of the microbiome from the NeoACTIVATE trial.
Fuente:Journal For Immunotherapy of Cancer
Extracto:
Neoadjuvant treatment with cobimetinib and
atezolizumab±vemurafenib was associated with a low rate of distant metastasis in
patients with high-risk stage III melanoma. Freedom from early distant metastasis
was highly associated with taxonomic differences in gut microbiome structure and
with functional pathway alterations known to modulate T cell immunity.
Identification of predictive biomarkers will permit optimization of neoadjuvant
therapy regimens for individual patients. TRIAL REGISTRATION NUMBER: NCT03554083.
Claves:Immune Checkpoint Inhibitor, Immunotherapy, Neoadjuvant, Skin Cancer, Surgery
Cita:J Immunother Cancer 2025 Apr 15; 13 (4)
Autor/es:Block, Matthew S (a) Nelson, Garth D (b)
institución:(a) Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA. (b) Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Conflicto:Competing interests: MSB: Research support—Alkermes, Bristol-Myers Squibb, Genentech, Merck, nFerence, Perspective Therapeutics, Pharmacyclics, Regeneron, Sorrento, TILT Biotherapeutics, and Transgene; Consultant/Scientific Advisory Board—Perspective Therapeutics, Sorrento Therapeutics, TILT Biotherapeutics; RRM: Research support—Glaxo SmithKline and Bristol-Myers Squibb; LAK: Consultant/Scientific Advisory Board—Immunocore; SNM: Research support—Bristol-Myers Squibb; Royalties—Sorrento Therapeutics and Journey Therapeutics; AD: Research support—Syntrix Pharmaceuticals, Novartis, Merck, AnHearth Therapeutics, Sorrento Therapeutics, Guardant, Philogen, AstraZeneca;...
, AstraZeneca; Consultant/Scientific Advisory Board—TP Therapeutics, Guardant Health, AnHeart Therapeutics, Chromacode; Honoraria—Intellisphere; MAP: Research support—Intuitive Surgical; DLP: Consultant/Scientific Advisory Board—In Situ Biologics; TJH: Research support—Genentech and SkylineDX BV.
The association between dietary live microbe intake and risk of chronic kidney disease among US adults: a cross-sectional survey from NHANES (2001-2018).
The association between dietary live microbe intake and risk of chronic kidney disease among US adults: a cross-sectional survey from NHANES (2001-2018).
Fuente:Renal Failure
Extracto:
High dietary intake of live
microorganisms is associated with a lower risk of CKD, highlighting the potential
role of gut microbiota modulation in CKD prevention.
Claves:Chronic kidney disease, NHANES, dietary live microbe, population-based study
Cita:Ren Fail 2025 Dec; 47 (1) : 2488236.
Autor/es:Liu, Xingzi (a) Shen, Yang (b)
institución:(a) Department of Nephrology, Beijing-Chaoyang Hospital, Capital Medical University, Beijing, China. (b) Department of Nephrology, Beijing-Chaoyang Hospital, Capital Medical University, Beijing, China.
Conflicto:No potential conflict of interest was reported by the author(s).
Inflammatory myofibroblastic tumors of the colon in pediatrics
Inflammatory myofibroblastic tumors of the colon in pediatrics
Fuente:International Journal of Colorectal Disease
Tipo de trabajo:Revisión sistemática
Extracto:
Colorectal IMTs in children present diagnostic and therapeutic challenges. While
complete surgical resection remains the gold standard treatment, emerging
therapies such as ALK inhibitors and NSAIDs warrant further investigation. The
potential for late recurrence mandates long term follow-up.
institución:(a) Department of Surgery, Faculty of Medicine, Tanta University, Tanta, Egypt. ismaelelhalaby@gmail.com. (b) Kenanah Children's Medical Center, Tanta, Egypt. ismaelelhalaby@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Supportive Care Needs and Related Interventions in Patients with Pancreatic Cancer and Their Informal Caregivers
Supportive Care Needs and Related Interventions in Patients with Pancreatic Cancer and Their Informal Caregivers
Fuente:Journal of Gastrointestinal Cancer
Tipo de trabajo:Revisión
Extracto:
Patients with pancreatic cancer and their
informal caregivers experienced a spectrum of supportive care needs, particularly
informational needs. Intervention strategies have been developed to address their
supportive care needs, but only a few studies demonstrated statistically
significant improvements in outcomes. These findings advance our understanding of
the supportive care needs and related interventions for patients with pancreatic
cancer and/or their informal caregivers, providing a foundation for future
research and targeted interventions to better address these needs.
Cita:J Gastrointest Cancer 2025 Apr 16; 56 (1) : 98.
Autor/es:Fu, Liang (a) Kim, Su Hyun (b)
institución:(a) School of Nursing, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, 78229, USA. (b) College of Nursing, Research Institute of Nursing Science, Kyungpook National University, Daegu, 41944, Republic of Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study.
The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study.
Fuente:Scientific Reports
Extracto:
Future studies should aim to elucidate the specific metabolites
involved and their roles in ocular health, potentially offering new avenues for
treatment.
A nomogram for prognostic prediction and for therapeutic decision making of elderly HCC patients.
A nomogram for prognostic prediction and for therapeutic decision making of elderly HCC patients.
Fuente:Bmc Gastroenterology
Extracto:
The nomogram
established based on demographic characteristics and other clinical parameters
can be used as an effective tool to predict the prognosis of elderly HCC
patients, and its good prediction efficiency can realize the individualized
treatment plan formulation and follow-up management of elderly HCC patients.
institución:(a) Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. (b) Department of Gastroenterology, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of ultrasound signs of sarcopenia with serum ferritin levels and hepatic indices like NFS and FIB-4 in NAFLD patients.
Association of ultrasound signs of sarcopenia with serum ferritin levels and hepatic indices like NFS and FIB-4 in NAFLD patients.
Fuente:Bmc Gastroenterology
Extracto:
This research's
results reflect the correlation between serum ferritin and sarcopenia; however,
it cannot conclude a cause-and-effect relationship between these variables.
institución:(a) Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. (b) Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. hamzehzadehsina.shz@yahoo.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Development and verification of a radiomics model to forecast Ki67 index and prognosis in advanced gastric tubular adenocarcinoma.
Development and verification of a radiomics model to forecast Ki67 index and prognosis in advanced gastric tubular adenocarcinoma.
Fuente:Bmc Gastroenterology
Extracto:
The
radiomics model accurately predicts the Ki67 index and correlates with prognosis
in advanced gastric tubular adenocarcinoma, offering valuable insights for
clinical decision-making and personalized treatment strategies.
institución:(a) Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, Hubei, China. (b) Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The current landscape of gastric cancer and gastroesophageal junction cancer diagnosis and treatment in China: a comprehensive nationwide cohort analysis.
The current landscape of gastric cancer and gastroesophageal junction cancer diagnosis and treatment in China: a comprehensive nationwide cohort analysis.
Fuente:Journal of Hematology & Oncology
Tipo de trabajo:Guía
Extracto:
These findings offer critical insights into the
current state of gastric cancer treatment in China and can inform future
initiatives to improve therapeutic outcomes for patients with gastric cancer.
Claves:Gastric cancer, Immunotherapy, Stage at diagnosis, Survival, Treatment regimen
Cita:J Hematol Oncol 2025 Apr 15; 18 (1) : 42.
Autor/es:Chen, Yang (a) Jia, Keren (b)
institución:(a) Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing, 100142, China. Yang_chen@bjcancer.org. (b) Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Whole genome-based surveillance for human adenovirus-related diseases in Kobe City, Japan, 2018-2022.
Whole genome-based surveillance for human adenovirus-related diseases in Kobe City, Japan, 2018-2022.
Fuente:Bmc Research Notes
Extracto:
Whole-genome
analysis of HAdV is an important approach not only for understanding local
epidemics, but also for monitoring the emergence of recombinant genotypes.
Claves:Genotyping, Human adenovirus, Japan, Surveillance, Whole genome sequence
institución:(a) Department of Infectious Diseases, Kobe Institute of Health, 4-6-5 Minatojima-nakamachi, Chuo-ku, Kobe, Hyogo, 650-0046, Japan. yoshihiko0218tanimoto@gmail.com. (b) Institute for Life and Medical Sciences, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. yoshihiko0218tanimoto@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Long-term trends in the clinical management and outcomes of patients with gastroesophageal cancer in Norway.
Long-term trends in the clinical management and outcomes of patients with gastroesophageal cancer in Norway.
Fuente:Acta Oncologica (stockholm, Sweden)
Extracto:
Future studies are required to identify optimum treatment strategies for
gastroesophageal cancer subtypes.
Cita:Acta Oncol 2025 Apr 15; 64 : 540-549.
Autor/es:Kolstad, Alexander (a) Emanuel, Gabrielle (b)
institución:(a) Department of Gastrointestinal Surgery, University Hospital of North Norway, Tromsø, Norway; Institute of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. (b) Bristol Myers Squibb, Uxbridge, United Kingdom.
Extracto:
When
unexplained bowel obstruction occurs during ICI therapy, antineuronal antibody
testing should be performed to exclude GIPO, as early identification and
intervention can reduce mortality.
institución:(a) Department of Respiratory and Critical Care Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan, China. (b) Department of Respiratory and Critical Care Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Exclusive breastfeeding is associated with the gut microbiome maturation in infants according to delivery mode.
Exclusive breastfeeding is associated with the gut microbiome maturation in infants according to delivery mode.
Fuente:Gut Microbes
Extracto:
Moreover, EBF
influences the microbiome maturation in early life, toward a microbiome age more
similar to the chronological infant's age.
Claves:Early-life gut microbiome, exclusive breastfeeding, microbiome functional pathways
Cita:Gut Microbes 2025 Dec; 17 (1) : 2493900.
Autor/es:Naspolini, Nathalia F (a) Schüroff, Paulo A (b)
institución:(a) Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil. (b) School of Arts, Sciences and Humanity, University of Sao Paulo, Sao Paulo, Brazil.
Feasibility, Acceptability, and Effectiveness of a Smartphone App to Increase Pretransplant Vaccine Rates: Usability Study.
Feasibility, Acceptability, and Effectiveness of a Smartphone App to Increase Pretransplant Vaccine Rates: Usability Study.
Fuente:Jmir Formative Research
Tipo de trabajo:Revisión
Extracto:
The overwhelming majority
of children whose parents and providers used the Immunize PediatricTransplant app
were up to date on vaccines at the time of transplant. The majority of app users
felt the app was feasible and acceptable. In future iterations of the app and
subsequent clinical trials, we will explore whether application programming
interfaces might be used to extract vaccine data from the electronic medical
record. If implemented broadly, this app has the potential to improve
pretransplant vaccine rates, resulting in fewer posttransplant infections and
improved posttransplant outcomes.
Claves:beta test, children, immunizations, mHealth, mobile app, mobile health, transplantation, vaccines
Cita:JMIR Form Res 2025 Apr 15; 9 : e68855.
Autor/es:Feldman, Amy G (a) Beaty, Brenda L (b)
institución:(a) Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado, 13123 E 16th Ave, Aurora, CO, 80045, United States, 1 720-777-5354. (b) Digestive Health Institute, Children's Hospital Colorado, Aurora, CO, United States.
Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity.
Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity.
Fuente:Elife
Extracto:
Our functional classifications
are a resource to aid the interpretation of CDKN2A variants and have important
implications for the application of variant interpretation guidelines,
particularly the use of in silico models for clinical variant interpretation.
institución:(a) Department of Pathology, the Johns Hopkins University School of Medicine, Baltimore, United States. (b) Division of Integrated Genomics, Translational Genomics Research Institute, Phoenix, United States.
Conflicto:HK, KL, NR No competing interests declared, CT Receives royalties from Exact Science; is a founder of C2T, a scientific advisor for PrognomiQ, and a consultant for Bayer
