A causal analysis of the relationship between exposure to sunlight and colorectal cancer risk: A Mendelian randomization study.

Fuente:Medicine

Extracto: Randomized, controlled trials are needed to determine whether sunlight exposure protects against CRC.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e37991.

Autor/es:Lin, Yuan (a)
Wang, Shan-Juan (b)

institución:(a) Department of Gastroenterology, Jiading District Central Hospital Affiliated Shanghai University of Medicine &Health Sciences, Shanghai, China.
(b) Department of Gastroenterology, Jiading District Central Hospital Affiliated Shanghai University of Medicine &Health Sciences, Shanghai, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037991

Functional results after hiatal repair and gastropexy without fundoplication in patients with paraoesophageal hernia.

Fuente:Langenbeck's Archives of Surgery

Extracto: Gastropexy without fundoplication was performed by laparoscopy in most cases with acceptable complications rates. Two-thirds of patients reported symptoms resolution, and long-term quality-of-live associated to reflux symptoms is good. Although the rate of PEH recurrence requiring a new re-intervention remained increased (23%), it does not seem to affect long-term functional results.

Claves:Gastroesophageal reflux disease (GERD), Gastropexy, Hiatal Hernia, Paraoesophageal Hernia, Quality-of-life (QoL)

Cita:Langenbecks Arch Surg 2024 May 3; 409 (1) : 150.

Autor/es:Bomio-Pacciorini, Laura (a)
Gaspar-Figueiredo, Sérgio (b)

institución:(a) Department of Visceral Surgery, Faculty of Biology and Medicine UNIL, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
(b) Department of Visceral Surgery, Faculty of Biology and Medicine UNIL, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s00423-024-03340-w

Analyzing the expression and clinical significance of CENPE in gastric cancer.

Fuente:Bmc Medical Genomics

Extracto: According to our findings, CENPE is substantially expressed in GC and may perhaps contribute to its growth. CENPE might be a target for gastric cancer therapy and a predictor of a bad prognosis.

Claves:Bioinformatics, CENPE, Gastric cancer

Cita:BMC Med Genomics 2024 May 3; 17 (1) : 119.

Autor/es:Wang, Jing (a)
Li, Xiaofei (b)

institución:(a) Department of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China.
(b) Department of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12920-024-01887-7

Sleeve gastrectomy with duodenoileal bipartition using linear magnets: feasibility and safety at 1-year follow-up.

Fuente:Journal of Gastrointestinal Surgery Official Journal of The Society For Surgery of The Alimentary Tract

Extracto: Side-to-side MCA DI bipartition with SG in adults with class II to III obesity was feasible, safe, and efficient with good QoL at 1-year follow-up. Moreover, 19% of ingested food passed directly into the ileum.

Claves:Duodenoileal, Isotopic study of bipartition, Linear magnets, Magnetic compression anastomosis, Metabolic/bariatric surgery

Cita:J Gastrointest Surg 2024 May; 28 (5) : 640-650.

Autor/es:Cadière, Guy-Bernard (a)
Poras, Mathilde (b)

institución:(a) Division of Digestive Surgery, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium.
(b) Division of Digestive Surgery, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium. Electronic address: Mathilde.poras@stpierre-bru.be.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Países Bajos

Sitio web:http://dx.doi.org/10.1016/j.gassur.2024.02.001

Study of the potential role of CASPASE-10 mutations in the development of autoimmune lymphoproliferative syndrome.

Fuente:Cell Death & Disease

Extracto: In conclusion, this study challenges the notion that CASP10 variants contribute to the development of ALPS.

Cita:Cell Death Dis 2024 May 4; 15 (5) : 315.

Autor/es:Consonni, Filippo (a)
Moreno, Solange (b)

institución:(a) Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
(b) Centre of Excellence, Division of Paediatric Oncology/Haematology, Meyer Children's Hospital IRCCS, Florence, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41419-024-06679-6

Platinum-based adjuvant chemoradiotherapy versus adjuvant radiotherapy in patients with head and neck adenoid cystic carcinoma.

Platinum-based adjuvant chemoradiotherapy versus adjuvant radiotherapy in patients with head and neck adenoid cystic carcinoma.

Fuente:Journal of Cancer Research and Clinical Oncology

Extracto: In terms of reducing locoregional failures in HNACC patients, POCRT may potentially offer a more effective therapeutic approach than using PORT alone, although it also entails an augmented burden of treatment-related toxicity.

Claves:Adjuvant chemoradiotherapy, Head and neck adenoid cystic carcinoma, Intensity-modulated radiotherapy, Postoperative radiotherapy

Cita:J Cancer Res Clin Oncol 2024 Apr 16; 150 (4) : 195.

Autor/es:Qiu, Zichen (a)
Wu, Zheng (b)

institución:(a) Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Yuexiu District, Guanzhou, 510060, People's Republic of China.
(b) Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tong Zi Po Road, Changsha, 410013, People's Republic of China.

Conflicto:The authors have no relevant financial or non-financial interests to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s00432-024-05719-0

Tomato seed extract promotes health of the gut microbiota and demonstrates a potential new way to valorize tomato waste.

Tomato seed extract promotes health of the gut microbiota and demonstrates a potential new way to valorize tomato waste.

Fuente:Plos One

Extracto: These findings provide a novel application for TSE harvested from tomato pomace and demonstrate the potential to further valorize tomato waste products.

Cita:PLoS One 2024; 19 (4) : e0301381.

Autor/es:Firrman, Jenni (a)
Narrowe, Adrienne (b)

institución:(a) United States Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Dairy and Functional Foods Research Unit, Wyndmoor, Pennsylvania, United States of America.
(b) United States Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Dairy and Functional Foods Research Unit, Wyndmoor, Pennsylvania, United States of America.

Conflicto:No competing interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301381

Increased risk of chronic kidney disease and mortality in a cohort of people diagnosed with metabolic dysfunction associated steatotic liver disease with hepatic fibrosis.

Fuente:Plos One

Tipo de trabajo:Guía

Extracto: Liver fibrosis was an independent risk factor for CKD in this cohort of people living with MASLD. Furthermore, those with MASLD with liver fibrosis had higher risk for mortality and this risk was further elevated among those with co-morbid CKD. Given the increased risk of CKD, and consequent mortality risk, among people living with MASLD fibrosis, renal function screening should be considered within liver health surveillance programmes and guidelines.

Cita:PLoS One 2024; 19 (4) : e0299507.

Autor/es:Gurun, Marc (a)
Brennan, Paul (b)

institución:(a) Molecular and Clinical Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom.
(b) Molecular and Clinical Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299507

Could the mitotic count improve personalized prognosis in melanoma patients?

Fuente:Plos One

Extracto: The mitotic rate can be used to develop a personalized medicine approach in the treatment and follow-up monitoring of melanoma patients.

Cita:PLoS One 2024; 19 (4) : e0302309.

Autor/es:Buja, Alessandra (a)
Rugge, Massimo (b)

institución:(a) Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
(b) Veneto Tumor Registry, Azienda Zero, Padova, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0302309

Intra-abdominal hematomas and identifiable risk factors in patients receiving subcutaneous enoxaparin.

Fuente:Plos One

Tipo de trabajo:Caso clínico

Extracto: Patients at risk for an enoxaparin associated hematoma include female patients with a CrCl <60ml/min and/or BMI >30 kg/m2 receiving enoxaparin treatment dosing.

Cita:PLoS One 2024; 19 (4) : e0301906.

Autor/es:Lager, Stephanie (a)
Balakrishnan, Gautam (b)

institución:(a) Mosaic Life Care, Saint Joseph, MO, United States of America.
(b) Mosaic Life Care, Saint Joseph, MO, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301906

The causal relationship between genetically predicted blood metabolites and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization study.

Fuente:Plos One

Tipo de trabajo:Metanálisis

Extracto: Conclusively, hyperglycemia may confer a promoting effect on IPF, highlighting that attention should be paid to the relationship between diabetes and IPF, not solely to the diagnosis of diabetes. Additionally, urea, guanosine, and ADpSGEGDFXAEGGGVR also facilitate the development of IPF. This study may provide a reference for analyzing the potential mechanism of IPF and carry implications for the prevention and treatment of IPF.

Cita:PLoS One 2024; 19 (4) : e0300423.

Autor/es:Pan, Tingyu (a)
Bai, Le (b)

institución:(a) Department of Pulmonary and Critical Care Medicine, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
(b) Department of Pulmonary and Critical Care Medicine, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300423

Chest pain in pediatric patients in the emergency department- Presentation, risk factors and outcomes-A systematic review and meta-analysis.

Fuente:Plos One

Tipo de trabajo:Revisión sistemática

Extracto: The overwhelming majority of pediatric chest pain cases stem from benign origins. This comprehensive analysis found musculoskeletal pain as the predominant culprit behind chest discomfort in children. Scrutinizing our study cohort revealed that retrosternal chest pain stands as the unequivocal epicenter of this affliction. Thorough evaluation of pediatric patients manifesting with chest pain is paramount for the delivery of unparalleled care, especially in the context of potential cardiac risks in the emergency department.

Cita:PLoS One 2024; 19 (4) : e0294461.

Autor/es:Alsabri, Mohammed (a)
Elshanbary, Alaa Ahmed (b)

institución:(a) Department of Pediatrics/Emergency Pediatrics, Althawra Modern General Hospital, Sana'a, Yemen.
(b) Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0294461

Health information technology tools to accelerate gastrointestinal evaluation in patients with iron deficiency anaemia

Fuente:Bmj Open Quality

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: Providing PCPs with lists of patients with IDA and a pathway for expedited evaluation did not increase rates of completing endoscopic evaluation in the short term. TRIAL REGISTRATION NUMBER: NCT05365308.

Claves:Ambulatory care, Decision support, clinical, Healthcare quality improvement, Patient safety

Cita:BMJ Open Qual 2024 Apr 15; 13 (2)

Autor/es:Priyanath Gupta, Aparna (a)
Patel, Dharmesh (b)

institución:(a) Division of General Internal Medicine, Department of Medicine, Feinberg School of Medicine,Northwestern University, Chicago, Illinois, USA apriyan1@nm.org.
(b) Northwestern Medical Group Quality and Safety, Northwestern Memorial HealthCare Corp, Chicago, Illinois, USA.

Conflicto:Competing interests: The authors are solely responsible for the content and the decision to submit for publication. SDP receives unrelated research support from Omron Healthcare Co. Ltd. paid to Northwestern University and has received speaking honoraria from Omron Healthcare Co. Ltd. and the National Committee for Quality Assurance.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjoq-2023-002565

Real-world data evaluating Guy's rapid diagnostic clinic as an alternate pathway for patients with FIT levels below 10.

Real-world data evaluating Guy's rapid diagnostic clinic as an alternate pathway for patients with FIT levels below 10.

Fuente:Bmj Open

Extracto: This study demonstrates the effectiveness of RDCs as an alternate pathway for FIT <10 patients with ongoing clinical concerns. These results contribute to enhancing patient care and optimising resource allocation within the healthcare system.

Claves:EPIDEMIOLOGIC STUDIES, EPIDEMIOLOGY, Endoscopy

Cita:BMJ Open 2024 Apr 15; 14 (4) : e080285.

Autor/es:Monroy-Iglesias, Maria Jose (a)
Martin, Sabine (b)

institución:(a) Translational Oncology and Urology Research, King's College London, London, UK maria.j.monroy_iglesias@kcl.ac.uk.
(b) Medical Oncology, Guy's and St Thomas' Hospitals NHS Trust, London, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-080285

New treatment alternatives for primary and metastatic colorectal cancer by an integrated transcriptome and network analyses.

New treatment alternatives for primary and metastatic colorectal cancer by an integrated transcriptome and network analyses.

Fuente:Scientific Reports

Extracto: Network analysis suggests IL-29A induces the JAK/STAT pathway in a preventive manner.

Cita:Sci Rep 2024 Apr 16; 14 (1) : 8762.

Autor/es:Karaca, Caner (a)
Demir Karaman, Ezgi (b)

institución:(a) Department of Translational Oncology, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
(b) Department of Computer Engineering, Faculty of Engineering, Dokuz Eylul University, Izmir, Turkey.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59101-8

Barriers to the use of tests for early detection of colorectal cancer in Chile.

Fuente:Scientific Reports

Extracto: The results of this study provide valuable insights into factors influencing CRC screening, aiming to inform public health policies for expanding national coverage beyond diagnosis and treatment to encompass preventive measures.

Claves:Barriers to colon cancer screening, Cancer prevention, Chile, Colonoscopies, Colorectal cancer

Cita:Sci Rep 2024 Apr 17; 14 (1) : 8817.

Autor/es:Alfaro, Gabriela (a)
Berger, Zoltan (b)

institución:(a) Industrial Engineering Department, University of Chile, Beauchef 851, Santiago, Chile.
(b) Department of Medicine, Gastroenterology Section, Hospital Clínico de La Universidad de Chile, Santiago, Chile.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58920-z

Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology.

Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology.

Fuente:Bmc Infectious Diseases

Extracto: Screening for toxoplasmosis among H. pylori-infected patients is recommended as it is considered a potential risk factor for gastric inflammation severity. H. pylori gastric inflammation may be heightened by Toxoplasma coinfection.

Claves:Cag A, Helicobacter pylori, Toxoplasma, Vac As1, Histopathological features, Humans

Cita:BMC Infect Dis 2024 Apr 16; 24 (1) : 408.

Autor/es:Gouda, Marwa A (a)
Saied, Sara A (b)

institución:(a) Clinical and Molecular Parasitology Department, National Liver Institute, Menoufia University, Shibin Elkom, Menoufia, Egypt.
(b) Clinical Pathology Department, National Liver Institute, Menoufia University, Shibin Elkom, Menoufia, Egypt. sarasaied@liver.menofia.edu.eg.

Conflicto:This study's research, writing, and publication were all done without any actual or prospective conflicts of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12879-024-09270-8

The role of piRNAs in predicting and prognosing in cancer

The role of piRNAs in predicting and prognosing in cancer

Fuente:Bmc Cancer

Tipo de trabajo:Revisión sistemática

Extracto: Our findings suggest that various piRNAs may play a role in cancer survival outcomes and that piRNA-823 in particular holds promise as a prognostic biomarker for multiple human cancers. IMPLICATIONS FOR CANCER SURVIVORS: Our systematic review and meta-analysis of piRNA-823 has important implications for cancer survivors. Our findings suggest that piRNA-823 can be used as a prognostic biomarker for predicting cancer recurrence and survival rates. This information can help clinicians develop personalized treatment plans for cancer survivors, which can improve their quality of life and reduce the risk of recurrence.

Claves:Cancer, Meta-analysis, Prognosis, Survival, Systematic review, piRNA

Cita:BMC Cancer 2024 Apr 16; 24 (1) : 484.

Autor/es:Taghizadeh, Mohammad (a)
Jafari-Koshki, Tohid (b)

institución:(a) Department of Molecular Medicine, Faculty of Advanced Medical School, Tabriz University of Medical Sciences, Tabriz, 5166614756, Iran.
(b) Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, 5166616471, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12885-024-12180-2

Efficacy of salvage surgery versus re-irradiation for isolated regional lymph node recurrence in patients with nasopharyngeal carcinoma.

Fuente:Bmc Cancer

Tipo de trabajo:Revisión

Extracto: For NPC patients with isolated regional lymph node recurrence after initial radiotherapy, those who underwent surgery had survival prognosis similar to those who underwent re-radiotherapy with or without chemotherapy. A prospective study is needed to validate these findings.

Claves:Lymph node dissection, Nasopharyngeal carcinoma, Re-irradiation, Recurrence, Regional lymph nodes

Cita:BMC Cancer 2024 Apr 16; 24 (1) : 483.

Autor/es:Chen, Yuebing (a)
Huang, Yiping (b)

institución:(a) Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
(b) Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12885-024-12259-w

Comparison of three frailty scales for prediction of prolonged postoperative ileus following major abdominal surgery in elderly patients

Comparison of three frailty scales for prediction of prolonged postoperative ileus following major abdominal surgery in elderly patients

Fuente:Bmc Surgery

Tipo de trabajo:Estudio de cohortes

Extracto: Elderly patients diagnosed as frail on the mFI-5 or GFI are at an increased risk of PPOI after major abdominal surgery. However, neither mFI-5 nor GFI can accurately identify individuals who will develop PPOI. TRIAL REGISTRATION: This study was registered in Chinese Clinical Trial Registry (No. ChiCTR2200058178). The date of first registration, 31/03/2022, https://www.chictr.org.cn/ .

Claves:Elderly patients, Frailty, Major abdominal surgery, Prediction, Prolonged postoperative ileus

Cita:BMC Surg 2024 Apr 16; 24 (1) : 115.

Autor/es:Xiong, Xianwei (a)
Zhang, Ting (b)

institución:(a) Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing, 400016, China.
(b) Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing, 400016, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12893-024-02391-6