PPAR agonists as add-on treatment with metformin in management of type 2 diabetes

PPAR agonists as add-on treatment with metformin in management of type 2 diabetes

Fuente:Scientific Reports

Tipo de trabajo:Revisión sistemática

Extracto: CRD42023412603.

Claves:Gastrointestinal intolerance, Glycemic control, Insulin resistance, Lipids, Safety profile

Cita:Sci Rep 2024 Apr 16; 14 (1) : 8809.

Autor/es:Alnuaimi, Saif (a)
Reljic, Tea (b)

institución:(a) College of Medicine and Health Sciences, Khalifa University, PO Box 127788, Abu Dhabi, United Arab Emirates.
(b) Research Methodology and Biostatistics Core, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59390-z

Increased prevalence but decreased survival of nonviral hepatocellular carcinoma compared to viral hepatocellular carcinoma in recent ten years.

Fuente:Scientific Reports

Extracto: To detect nonviral HCC early, we should evaluate liver fibrosis in high-risk groups (including people with obesity or T2DM with NAFLD/NASH and alcoholic liver disease) and regular follow-up for those with liver fibrosis, regardless of cirrhosis.

Claves:Alcoholic liver disease, Non alcoholic fatty liver disease, Non-viral hepatocellular carcinoma, Type 2 diabetes mellitus, Viral hepatocellular carcinoma

Cita:Sci Rep 2024 Apr 20; 14 (1) : 9068.

Autor/es:Chen, Ting-Chun (a)
Hsiao, Shun-Wen (b)

institución:(a) Division of Endocrinology and Metabolism, Cheng Ching Hospital, Taichung, Taiwan.
(b) Division of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59668-2

The safety signal detection and analysis of monoclonal antibodies against SARS-CoV-2 based on real-world evidence - the suitable selectivity for different populations.

The safety signal detection and analysis of monoclonal antibodies against SARS-CoV-2 based on real-world evidence - the suitable selectivity for different populations.

Fuente:European Review For Medical and Pharmacological Sciences

Extracto: In summary, SOT may be unsuitable for allergic patients and may lead to abnormal test results. BEB showed the highest correlations with gastrointestinal and neuropsychiatric events. In addition, its infusion reactions should also be noted. TIX/CIL can lead to a variety of cardiovascular events.

Cita:Eur Rev Med Pharmacol Sci 2024 Apr; 28 (7) : 2943-2954.

Autor/es:Wang, Y (a)
Xu, X-W (b)

institución:Wang, Y (a)
Xu, X-W (b)

Formato:Informe impreso

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.26355/eurrev_202404_35925

Defining distal splenopancreatectomy by the mesopancreas.

Fuente:Langenbeck's Archives of Surgery

Extracto: While resection margin status was not affected by the MP status in dPDAC patients, the high MP infiltration rate, as well as improved survival in MP- dPDAC patients after R0CRM- resection, justify mesopancreatic excision during splenopancreatectomy. Larger scale studies are urgently needed to validate our results and to study the effect on neoadjuvant treatment in dPDAC patients.

Claves:CRM, Distal pancreatectomy, Ductal adenocarcinoma of the pancreas, Mesopancreatic excision, PDAC, Pancreatic cancer, Peripancreatic tissue, Survival outcome

Cita:Langenbecks Arch Surg 2024 Apr 16; 409 (1) : 127.

Autor/es:Safi, S-A (a)
Alexander, A (b)

institución:(a) Departments of Surgery (A), Heinrich-Heine-University and University Hospital Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
(b) Departments of Surgery (A), Heinrich-Heine-University and University Hospital Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s00423-024-03320-0

Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago.

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Sitio web:http://dx.doi.org/10.1186/s13017-024-00543-w

Impact of latent toxoplasmosis on pneumonic and non-pneumonic COVID-19 patients with estimation of relevant oxidative stress biomarkers.

Fuente:Folia Parasitologica

Extracto: gondii infection can be considered a strong indicator of the high risk of COVID-19.

Claves:C-reactive protein, SARS-CoV-2, Toxoplasma gondii, antioxidants, ferritin.

Cita:Folia Parasitol (Praha) 2024 Apr 4; 71

Autor/es:Hamdy, Doaa A (a)
Eid, Ragaey A (b)

institución:(a) Department of Medical Parasitology, College of Medicine, Beni-Suef University, Beni-Suef, Egypt.
(b) Department of Gastroenterology, Hepatology and infectious diseases (Tropical Medicine Department), College of Medicine, Beni-Suef University, Beni-Suef,Egypt.

Formato:Informe virtual

Idioma:Inglés

País de fuente:República Checa

Sitio web:http://dx.doi.org/10.14411/fp.2024.008

Surufatinib combined with transarterial embolization versus surufatinib monotherapy in patients with liver metastatic neuroendocrine tumors: Study protocol for a prospective, randomized, controlled trial.

Fuente:Cancer Medicine

Tipo de trabajo:Estudio abierto

Extracto: We expect this trial to propose a new and effective treatment strategy for liver metastatic NETs.

Claves:neuroendocrine tumors with liver metastasis, randomized controlled trial, surufatinib, transarterial embolization

Cita:Cancer Med 2024 Apr; 13 (8) : e7131.

Autor/es:Li, Ruizhen (a)
Li, Xiaofen (b)

institución:(a) Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
(b) Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1002/cam4.7131

Applicability of sodium butyrate preparations from a surgeon's and gastroenterologist's perspective.

Fuente:Polski Przeglad Chirurgiczny

Extracto: The following article discusses the possibilities of using microencapsulated sodium butyrate in the prevention and treatment of gastrointestinal diseases from the perspective of a gastroenterologist and gastrointestinal surgeon.

Claves:butyric acid, butyric suppositories, prehabilitation, sodium butyrate

Cita:Pol Przegl Chir 2024 Apr 30; 96 (2) : 68-73.

Autor/es:Pietrzak, Anna (a)
Banasiewicz, Tomasz (b)

institución:(a) 2nd Department of Gastroenterology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Gastroenterology, Bielanski Hospital in Warsaw, Poland.
(b) Chair and Department of General Surgery, Endocrine and Gastroenterological Oncology, Poznan University of Medical Sciences, Poznan, Poland.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Polonia

Sitio web:http://dx.doi.org/10.5604/01.3001.0054.4152

X-ray-guided self-expandable metal stent (SEMS) implantation in oesophageal malignancy as an alternative treatment.

Fuente:Polski Przeglad Chirurgiczny

Extracto: Two patients with ruptured thoracic aneurysm and thoracic stent graft implantation due to oesophageal haemorrhage, who were implanted with an oesophageal stent, died on postoperative days 4 and 14.</br> <b><br>Conclusions:</b> The modified intravascular X-ray-guided SEMS technique may be a palliative treatment for patients with unresectable oesophageal malignancies.</br>.

Claves:SEMS, oesophageal carcinoma, oesophageal haemorrhage, tracheoesophageal fistula

Cita:Pol Przegl Chir 2024 Apr 2; 96 (2) : 21-25.

Autor/es:Ziaja, Damian (a)
Sznapka, Mariola (b)

institución:(a) Department of Physiotherapy, Faculty of Health Sciences, Silesian Medical University in Katowice, Poland; Department of Vascular Surgery District Hospital in Sosnowiec, Poland.
(b) Department of Vascular Surgery District Hospital in Sosnowiec, Poland; Katowice Business University Faculty of Medicine, Poland.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Polonia

Sitio web:http://dx.doi.org/10.5604/01.3001.0054.0954

Deep learning methods in metagenomics

Fuente:Microbial Genomics

Tipo de trabajo:Revisión

Extracto: These methods aggregate contextualized data and pave the way for improved patient care and a better understanding of the microbiome's key role in our health.

Claves:binning, deep learning, disease prediction, embedding, metagenomics, microbiome, neural network

Cita:Microb Genom 2024 Apr; 10 (4)

Autor/es:Roy, Gaspar (a)
Prifti, Edi (b)

institución:(a) IRD, Sorbonne University, UMMISCO, 32 avenue Henry Varagnat, Bondy Cedex, France.
(b) IRD, Sorbonne University, UMMISCO, 32 avenue Henry Varagnat, Bondy Cedex, France.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1099/mgen.0.001231

Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides.

Fuente:Journal For Immunotherapy of Cancer

Extracto: The high frequency of germline homozygosity in EGA patients suggests reduced cancer immunosurveillance leading to an increased cancer risk. Therapeutic targeting of allelic imbalance of HLA-I molecules should be considered in EGA.

Claves:Antigen Presentation, Antigens, Computational Biology, Gastrointestinal Neoplasms, Tumor Escape

Cita:J Immunother Cancer 2024 Apr 17; 12 (4)

Autor/es:Garcia-Marquez, Maria Alejandra (a)
Thelen, Martin (b)

institución:(a) Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany maria.garcia-marquez@uk-koeln.de.
(b) Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/jitc-2023-007268

Efficacy of Linezolid in the management of pneumonic COVID-19 patients. Bioinformatics-based clinical study.

Fuente:Journal of Infection in Developing Countries

Tipo de trabajo:Guía

Extracto: Linazolid is considered an effective antiviral weapon against SARS-COV-2. It could be used in the management plan of pneumonic individuals due to SARS-COV-2 infection. We recommend using it to combat the current wave caused by Omicron EG-5 Variant.

Claves:Linazolid, SARS CoV-2, bioinformatics, pneumonia

Cita:J Infect Dev Ctries 2024 Mar 31; 18 (3) : 326-331.

Autor/es:Eid, Ragaey A (a)
Elgendy, Marwa O (b)

institución:(a) Department of Gastroenterology, Hepatology, and Infectious Diseases (Tropical Medicine Department), Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
(b) Department of Clinical Pharmacy, Beni-Suef University Hospitals, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Conflicto:No Conflict of Interest is declared

Formato:Informe virtual

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.3855/jidc.19205

Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application.

Fuente:Cell Communication and Signaling Ccs

Extracto: Emphasis is placed on the considerable potential of manipulating gut microbiota within clinical settings for managing mCRC.

Claves:Colorectal cancer, Gut microbiota, Metastasis, “seed and soil” hypothesis

Cita:Cell Commun Signal 2024 Apr 18; 22 (1) : 232.

Autor/es:Fan, Shiying (a)
Zhou, Lujia (b)

institución:(a) Clinical Medical College, Yangzhou University, 225000, Yangzhou, P. R. China.
(b) Clinical Medical College, Yangzhou University, 225000, Yangzhou, P. R. China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12964-024-01615-9

Effects of bone marrow mesenchymal stem cell-conditioned medium on the proliferation and migration of liposarcoma cells.

Fuente:Folia Histochemica Et Cytobiologica

Extracto: These findings provide new insights into the impact of BMSC-CM on liposarcoma and suggest its possible involvement in liposarcoma cell growth.

Claves:YAP1 silencing, conditioned medium, human BMSC, liposarcoma, migration, proliferation

Cita:Folia Histochem Cytobiol 2024; 62 (1) : 50-60.

Autor/es:Chen, Hua (a)
Sha, Na (b)

institución:(a) Department of Emergency, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, China. chenhua88@163.com.
(b) Department of Emergency, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Polonia

Sitio web:http://dx.doi.org/10.5603/fhc.98379

Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer.

Fuente:Science Advances

Extracto: This study suggests distinct putative causal pathways between adiposity subtypes and CRC.

Cita:Sci Adv 2024 Apr 19; 10 (16) : eadj1987.

Autor/es:Peruchet-Noray, Laia (a)
Sedlmeier, Anja M (b)

institución:(a) International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366 Lyon CEDEX 07, France.
(b) Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1126/sciadv.adj1987

Endoscopic submucosal dissection for the treatment of a large inflammatory fibroid polyp in the gastric antrum prolapsing into the duodenum

Fuente:Medicine

Tipo de trabajo:Caso clínico

Extracto: LESSONS: While IFPs have traditionally been managed surgically, ESD demonstrates promising treatment outcomes, avoiding the need for surgical distal gastrectomy, and emerges as a safe and effective treatment option.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37877.

Autor/es:Wang, Xiaoyun (a)
Ma, Ru (b)

institución:(a) Department of Gastroenterology, The First People's Hospital of Shizuishan, Affiliated to Ningxia Medical University, Shizuishan, China.
(b) Department of Gastroenterology, The First People's Hospital of Shizuishan, Affiliated to Ningxia Medical University, Shizuishan, China.

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037877

Exploring the pathogenesis of chronic atrophic gastritis with atherosclerosis via microarray data analysis.

Fuente:Medicine

Extracto: Such joint pathways and hub genes provide new insights for further studies.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37798.

Autor/es:Men, Xiaoxiao (a)
Shi, Xiuju (b)

institución:(a) Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
(b) Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037798

A comprehensive review on the hepatotoxicity of herbs used in the Indian (Ayush) systems of alternative medicine.

Fuente:Medicine

Extracto: This review also aims to provide adequate knowledge regarding herbalism in traditional practices, pertinent for medical doctors to diagnose, treat, and prevent avoidable liver disease burdens within communities, and improve public health and education.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37903.

Autor/es:Philips, Cyriac Abby (a)
Theruvath, Arif Hussain (b)

institución:(a) Clinical and Translational Hepatology, The Liver Institute, Center of Excellence in Gastrointestinal Sciences, Rajagiri Hospital, Aluva, India.
(b) Department of Clinical Research, Division of Complementary and Alternative Medicine and the Liver, The Liver Institute, Center of Excellence in Gastrointestinal Sciences, Rajagiri Hospital, Aluva, India.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037903

Successful treatment of gastric cancer 10 years after heart transplantation

Fuente:Medicine

Tipo de trabajo:Caso clínico

Extracto: This case underscores the potential risk of malignancy from immunosuppressive agents in transplant recipients. The successful management of this complex scenario underscores the indispensable role of an MDT approach in treating such unique and challenging cases.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37841.

Autor/es:Zhao, Lin (a)
Wang, Ye (b)

institución:Zhao, Lin (a)
Wang, Ye (b)

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037841

Over-the-scope clip as a rescue treatment for massive bleeding due to Dieulafoy lesion at the colorectal anastomosis

Fuente:Medicine

Tipo de trabajo:Caso clínico

Extracto: LESSONS: As far as we know, there is no reported case of lower gastrointestinal bleeding caused by Dieulafoy lesion at the colorectal anastomosis, OTSC is a safe and effective rescue treatment for Dieulafoy lesions.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37871.

Autor/es:Han, Ping (a)
Li, Demin (b)

institución:Han, Ping (a)
Li, Demin (b)

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037871