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Shared and Unique Genetic Links between Neuroticism and Gastrointestinal Tract Diseases.
Shared and Unique Genetic Links between Neuroticism and Gastrointestinal Tract Diseases.
Fuente:Depression and Anxiety
Extracto:
Our findings document the genetic links between neuroticism and
six GIT diseases, highlighting the genetic overlaps and heterogeneity between
neuroticism and psychiatric disorders in the context of gastrointestinal
disorders. Both the shared and unique pleiotropic loci identified between
neuroticism and different GIT diseases could facilitate mechanistic
understandings and may stimulate further translational implications.
Cita:Depress Anxiety 2024; 2024 : 5515448.
Autor/es:Tian, Ye (a) Zi, Jing (b)
institución:(a) Department of Occupational and Environmental Health, Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. (b) Department of Occupational and Environmental Health, Healthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Alpha-1 antitrypsin deficiency-associated liver disease: From understudied disorder to the poster child of genetic medicine.
Alpha-1 antitrypsin deficiency-associated liver disease: From understudied disorder to the poster child of genetic medicine.
Fuente:Hepatology Communications
Extracto:
In summary, AATD
represents a systemic disorder increasingly seen in the hepatologic routine and
requiring thorough interdisciplinary care, since the currently ongoing clinical
trials often address only one of the organs it affects.
institución:(a) Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Health Care Provider of the European Reference Network on Rare Liver Disorders (ERN RARE LIVER), Aachen, Germany. (b) Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Health Care Provider of the European Reference Network on Rare Liver Disorders (ERN RARE LIVER), Aachen, Germany.
Conflicto:Malin Fromme received consulting fees from Takeda Pharmaceuticals and honoraria from CSL Behring, Grifols Inc., and Takeda Pharmaceuticals. Paul Ellis has received consulting fees from Takeda Pharmaceuticals and Ipsem and honoraria from Chiesi, AstraZeneca, and GSK. Pavel reports receiving grants and honoraria from Arrowhead Pharmaceuticals, CSL Behring, Grifols Inc., consulting fees or honoraria from Alnylam Pharmaceuticals, Arrowhead Pharmaceuticals, BioMarin Pharmaceutical,...
Dicerna Pharmaceuticals, GSK, Intellia Pharmaceuticals, Takeda Pharmaceuticals, Novo Nordisk, and Ono Pharmaceuticals, participating in leadership or fiduciary roles in Alpha1-Deutschland, Alpha1 Global, and material transfer support for Vertex Pharmaceuticals and Dicerna Pharmaceuticals. All others have no conflict of interest to disclose.
A nationwide study of primary biliary cholangitis prevalence, geographic distribution, and health care providers.
A nationwide study of primary biliary cholangitis prevalence, geographic distribution, and health care providers.
Fuente:Hepatology Communications
Extracto:
This is the most comprehensive and
contemporary estimation of PBC prevalence in the United States to date. The
pockets of high prevalence of PBC located in some rural areas highlight the need
to better evaluate PBC risk factors and potential barriers in access to
specialist care once patients are diagnosed. Greater awareness of PBC and its
management are needed.
institución:(a) Schiff Center for Liver Diseases, University of Miami, Miami, Florida, USA. (b) Division of Digestive Health and Liver Diseases, University of Miami, Miami, Florida, USA.
Conflicto:Cynthia Levy: Institutional research grants from Calliditas, CymaBay, Escient, Gilead, GSK, Intercept, Ipsen, Kowa, Mirum, Target RWE, and Zydus; consulting fees from Calliditas, CymaBay, Gilead, GSK, Intercept, Ipsen, Kowa, Mirum, and Target RWE. Joanna P. MacEwan and Alina Levine: Employees of Genesis Research Group. Radhika Nair, and Leona Bessonova: Employees of Intercept. Darren Wheeler: Former employee of Intercept. Aparna Goel:...
Consulting/advisory boards for Gilead, Intercept, Ipsen, and Mirum. Robert G. Gish: Grant/research support from Gilead; consultant and/or advisor for Abbott, AbbVie, Altimmune, Antios, Arrowhead, Dynavax, Eiger, Eisai, Enyo, Genentech, Genlantis, Gerson Lehrman Group, Gilead, Helios, HepaTx, HepQuant, Intercept, Janssen, Merck, Pfizer, Topography Health, and Venatorx; current activity with scientific or clinical advisory boards for AbbVie, Dynavax, Genlantis, Gilead, Helios, HepaTx, HepQuant, Intercept, Janssen, Pfizer, and Prodigy; current clinical trials alliance with Topography Health; chair of clinical advisory board for Prodigy; advisory consultant (diagnostic companies) for Fujifilm/Wako, Perspectum, Quest, and Sonic Incytes; data safety monitoring board for CymaBay, Durect, and Takeda; speakers’ bureau for activities focused on hepatitis B, C, and D virus, and liver cancer, specifically epidemiology, diagnosis, and treatment. In addition, there were program presentations on vaccination for hepatitis B virus and the management of complications of cirrhosis; speaker’s contract for promotional talks for AbbVie, BMS, Eisai, Genentech, Gilead, and Intercept; minor stock shareholder (liver space noted only) for CoCrystal and RiboScience; stock options with AngioCrine, Eiger, Genlantis, HepaTx, and HepQuant. Alan Bonder: Consulting for Chemomab, CymaBay, Genfit, and Guidepoint; research grants from Chemomab, CymaBay, Gilead, GSK, Intercept, and Mirium; medical monitor for Pfizer. Keri-Ann Buchanan-Peart has no conflicts to report.
The global prevalence and impact of steatotic liver disease and viral infections
The global prevalence and impact of steatotic liver disease and viral infections
Fuente:Hepatology Communications
Tipo de trabajo:Revisión sistemática
Extracto:
SLD is highly prevalent in viral-infected populations, and the
reciprocal interactions between SLD and viral diseases exacerbate both
conditions, leading to poorer patient outcomes in general.
institución:(a) Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. (b) Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Conflicto:Ming-Hua Zheng has received honoraria for lectures from AstraZeneca, Hisky Medical Technologies, and Novo Nordisk consulting fees from Boehringer Ingelheim. Harry L. A. Janssen has received grants from Gilead Sciences, GlaxoSmithKline, Janssen, Roche, Vir Biotechnology Inc. Prof. Dr. Harry L. A. Janssen is consultant for Aligos, Gilead Sciences, GlaxoSmithKline, Grifols, Roche, Vir Biotechnology Inc., Precision Biosciences. Robert J. de Knegt...
is consultant for Bracco. Robert J. de Knegt has received honoraria for consulting or speaking from AbbVie, Echosens, Gilead, Schallware, and grants from Echosens, Gilead, GSK, Inventiva, Janssen-Cilag. Bettina E. Hansen consults, is on the speakers’ bureau, and received grants from Ipsen. She consults and is on the speaker’s bureau for Advanz. She consults and received grants from Mirum and Gilead. She consults for Intercept. She advises Pilant. The remaining authors have no conflicts to report.
institución:(a) Vanderbilt University School of Medicine, Nashville, TN, USA. kaitlyn.l.mi@vanderbilt.edu. (b) Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Incidence of Pancreas and Colorectal Adenocarcinoma in the US.
Incidence of Pancreas and Colorectal Adenocarcinoma in the US.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: The findings of this cohort study suggest that the incidence of
pancreatic adenocarcinoma has increased among all age groups, whereas that of
colorectal adenocarcinoma has increased among younger age groups. Clinicians
should be aware of this trend when evaluating younger patients with relevant
symptoms.
Cita:JAMA Netw Open 2025 Apr 1; 8 (4) : e254682.
Autor/es:Bussetty, Arvind (a) Shen, Jing (b)
institución:(a) Department of Medicine, Rutgers University School of Medicine, New Brunswick, New Jersey. (b) Division of Gastroenterology, Rutgers University School of Medicine, New Brunswick, New Jersey.
Conflicto:Conflict of Interest Disclosures: Dr Benias reported receiving personal fees from Boston Scientific and Micro-Tech outside the submitted work. Dr Trindade reported receiving personal fees from Exact Science, Lucid Diagnostics, and Boston Scientific outside the submitted work. No other disclosures were reported.
Effect of comfort-oriented intervention combined with medical sponge positioning cushion on treatment compliance and psychological status of patients undergoing side-lying enema operation: A retrospective study.
Effect of comfort-oriented intervention combined with medical sponge positioning cushion on treatment compliance and psychological status of patients undergoing side-lying enema operation: A retrospective study.
Fuente:Medicine
Extracto:
Comfort-oriented intervention combined
with medical sponge positioning cushion can improve treatment compliance of
patients undergoing side-lying enema operation, promote patients to face enema
with a positive attitude, prolong drug retention time, and improve satisfaction.
Hepatic progenitor cell activation and ductular reaction in metabolic dysfunction-associated steatotic liver disease (MASLD): Indicators for disease activity and the degree of fibrosis: The pilot study.
Hepatic progenitor cell activation and ductular reaction in metabolic dysfunction-associated steatotic liver disease (MASLD): Indicators for disease activity and the degree of fibrosis: The pilot study.
Fuente:Medicine
Extracto:
As pathologists, we might integrate
the degree of HPCs and the grade of DR in our pathology reports as these findings
might contribute to the disease progression risk categorization of the patients.
institución:(a) Department of Pathology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey. (b) Department of Pathology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Conflicto:The authors have no funding and conflicts of interest to disclose.
institución:(a) Department of General Medicine, The Jikei University School of Medicine, Daisan Hospital, Komae-si, Tokyo, Japan. (b) Department of General Medicine, The Jikei University School of Medicine, Daisan Hospital, Komae-si, Tokyo, Japan.
Conflicto:The authors have no funding and conflicts of interest to disclose.
Exploring the intricate relationship between peptic ulcers and immunohematological responses
Exploring the intricate relationship between peptic ulcers and immunohematological responses
Fuente:Medicine
Tipo de trabajo:Revisión
Extracto:
Ultimately, unraveling the intricate relationship between peptic
ulcers and immunohematological responses holds significant promise in advancing
the understanding and management of this prevalent gastrointestinal disorder.
institución:(a) Department of Biomedical and Laboratory Science, Africa University, Mutare, Zimbabwe. (b) School of Nursing Science, Kampala International University, Kampala, Uganda.
Conflicto:The authors have no funding and conflicts of interest to disclose.
Intestinal perforation in recurrent cervical cancer following bevacizumab and pembrolizumab therapy
Intestinal perforation in recurrent cervical cancer following bevacizumab and pembrolizumab therapy
Fuente:Medicine
Tipo de trabajo:Caso clínico
Extracto:
In the clinical process of combined medication, more attention
should be paid to adverse reactions, early identification of severe adverse
reactions, and active management.
Pre-Surgical Education and Discharge Planning for Head and Neck Cancer: A Qualitative Study of Patient and Caregiver Perspectives.
Pre-Surgical Education and Discharge Planning for Head and Neck Cancer: A Qualitative Study of Patient and Caregiver Perspectives.
Fuente:Cancer Control Journal of The Moffitt Cancer Center
Extracto:
ConclusionParticipants identified gaps in
pre-surgical education and discharge planning and provided recommendations to
improve HNC surgical care.
Claves:caregiver education, discharge planning, head and neck cancer, patient education, pre-surgery education, surgical oncology
Cita:Cancer Control 2025 Jan-Dec; 32 : 10732748251331979.
Autor/es:Basta, Ameer (a) Mikhael, Marian (b)
institución:(a) Morsani College of Medicine, University of South Florida, Tampa, FL, USA. RINGGOLD: 33697 (b) Morsani College of Medicine, University of South Florida, Tampa, FL, USA. RINGGOLD: 33697
Conflicto:Conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
institución:(a) Department of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil. (b) Department of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil. Electronic address: franciscotustumi@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The supramolecular polymer-related signature predicts prognosis and indicates immune microenvironment infiltration in gastric cancer.
The supramolecular polymer-related signature predicts prognosis and indicates immune microenvironment infiltration in gastric cancer.
Fuente:Clinics (sao Paulo, Brazil)
Tipo de trabajo:Consenso
Extracto:
This
study constructed a prognostic risk signature based on SPRGs in gastric cancer,
which is closely related to clinical pathological features, drug sensitivity, and
immune landscape, providing new insights for personalized treatment.
Clinical and immunological differences between primary and autoimmune-associated neuromyelitis optica spectrum disorders: a retrospective study.
Clinical and immunological differences between primary and autoimmune-associated neuromyelitis optica spectrum disorders: a retrospective study.
Fuente:Lupus Science & Medicine
Extracto:
Despite various treatments, no significant
differences were found in relapse rates or sequelae severity, highlighting the
need for personalised management strategies.
Claves:Autoimmune Diseases, Lupus Erythematosus, Systemic, Outcome Assessment, Health Care, Risk Factors
Cita:Lupus Sci Med 2025 Apr 14; 12 (1)
Autor/es:Tsai, Hung-Cheng (a) Sun, Yi-Syuan (b)
institución:(a) Division of Allergy, Immunology and Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan. (b) Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University Taipei Campus, Taipei, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Metagenomic source tracking after microbiota transplant therapy.
Metagenomic source tracking after microbiota transplant therapy.
Fuente:Gut Microbes
Extracto:
MAGEnTa is a powerful tool to
study community and strain engraftment dynamics in the development of MTT-based
treatments that can be integrated into frameworks for functional and taxonomic
analysis.
Autor/es:Hoops, Susan L (a) Moutsoglou, Daphne (b)
institución:(a) Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA. (b) Biotechnology Institute, University of Minnesota, Minneapolis, MN, USA.
Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology.
Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology.
Fuente:Nature Communications
Extracto:
Thus, we identify
associations between gut microbial tryptophan metabolites, ASD symptoms, and
brain activity in humans, particularly in brain regions associated with
interoceptive processing.
Cita:Nat Commun 2025 Apr 14; 16 (1) : 3465.
Autor/es:Aziz-Zadeh, Lisa (a) Ringold, Sofronia M (b)
institución:(a) Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA. lazizzad@usc.edu. (b) Brain and Creativity Institute, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA. lazizzad@usc.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
CAR T-cell therapy response varies by extranodal disease site in large B-cell lymphoma.
CAR T-cell therapy response varies by extranodal disease site in large B-cell lymphoma.
Fuente:Blood Cancer Journal
Extracto:
Risk of
site-specific relapse or progression was not evaluable for CNS/orbital/cranial
sinuses, adrenal/genitourinary, hepatobiliary/pancreas, and spleen due to
insufficient number of events.
Cita:Blood Cancer J 2025 Apr 14; 15 (1) : 64.
Autor/es:Luna, Alejandro (a) Devlin, Sean M (b)
institución:(a) Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. (b) Bone Marrow Transplantation Unit. Hematology Service. Hospital Universitario Ramon y Cajal, Madrid, Spain.
Conflicto:Competing interests: AL reports research funding from Gilead. KR: Kite/Gilead: Research Funding, Consultancy, Honoraria and travel support; Novartis: Honoraria; BMS/Celgene: Consultancy, Honoraria; Pierre-Fabre: travel support. MAP reports honoraria from Adicet, Allogene, Caribou Biosciences, Celgene, Bristol-Myers Squibb, Equilium, Exevir, ImmPACT Bio, Incyte, Karyopharm, Kite/Gilead, Merck, Miltenyi Biotec, MorphoSys, Nektar Therapeutics, Novartis, Omeros, OrcaBio, Sanofi, Syncopation, Takeda, VectivBio AG, and Vor Biopharma....
He serves on DSMBs for Cidara Therapeutics and Sellas Life Sciences, and the scientific advisory board of NexImmune. He has ownership interests in NexImmune, Omeros and OrcaBio. He has received institutional research support for clinical trials from Allogene, Incyte, Kite/Gilead, Miltenyi Biotec, Nektar Therapeutics, and Novartis. RS: Received speaker honorarium from Incyte and Sanofi. GS Consultancy: AbbVie, BeiGene, BMS, Debiopharm, Epizyme, Genentech/Roche, Genmab, Innate Pharma, Incyte, Ipsen, Janssen, Kite/Gilead, Merck, Modex, Molecular Partners, Nurix, Orna Therapeutics, Pfizer, Treeline. Research funding: AbbVie, Genentech, Genmab, Janssen, Ipsen, and Nurix. MS served as a paid consultant for McKinsey & Company, Angiocrine Bioscience, Inc., and Omeros Corporation; received research funding from Angiocrine Bioscience, Inc., Omeros Corporation, Amgen Inc., Bristol Myers Squibb, and Sanofi; served on ad hoc advisory boards for Kite – A Gilead Company, and Miltenyi Biotec; and received honoraria from i3Health, Medscape, CancerNetwork, and IDEOlogy. The rest of co-authors declare no COIs.
Development and validation of survival prediction tools in early and late onset colorectal cancer patients.
Development and validation of survival prediction tools in early and late onset colorectal cancer patients.
Fuente:Scientific Reports
Extracto:
This study successfully developed online
calculators using machine learning algorithms to predict 1- to 8-year survival
probabilities for EOCRC and LOCRC patients under various treatment strategies.
institución:(a) Department of Gastroenterology, University-Town Hospital of Chongqing Medical University, Chongqing, 401331, China. (b) Department of Gastroenterology, Chongqing Hospital of Jiangsu Province Hospital, The People's Hospital of Qijiang District, Chongqing, 401420, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Non-epinephrine monotherapy matches combination therapy in high-risk PUB patients.
Non-epinephrine monotherapy matches combination therapy in high-risk PUB patients.
Fuente:Scientific Reports
Extracto:
However, for PUB patients with
visible blood vessel (FIIa) ulcers, combined therapy has higher hemostatic
efficacy than non-epinephrine injection monotherapy.
institución:(a) Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. (b) Department of Gastroenterology, South China Hospital, Medical School, Shenzhen University, Shenzhen, 518116, P. R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
