High Frequencies of Genetic Variants in Patients with Atypical Femoral Fractures.

High Frequencies of Genetic Variants in Patients with Atypical Femoral Fractures.

Fuente:International Journal of Molecular Sciences

Extracto: Larger studies are needed to confirm the utility of gene set analysis in identifying patients at high risk of AFF during anti-resorptive therapy.

Claves:SNPs, atypical femur fractures, genetics

Cita:Int J Mol Sci 2024 Feb 15; 25 (4)

Autor/es:Del Real, Álvaro (a)
Cruz, Raquel (b)

institución:(a) Departamento de Medicina y Psiquiatría, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain.
(b) Grupo de Medicina Xenómica, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, Universidade de Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25042321

Statins-Their Role in Bone Tissue Metabolism and Local Applications with Different Carriers.

Fuente:International Journal of Molecular Sciences

Extracto: This paper outlines various carrier types, characterizing their structures and underscoring various statins' potential as local treatments for bone diseases.

Claves:bone tissue metabolism, local application, simvastatin, statin carriers, statins

Cita:Int J Mol Sci 2024 Feb 17; 25 (4)

Autor/es:Granat, Marcin Mateusz (a)
Eifler-Zydel, Joanna (b)

institución:(a) Department of Clinical and Experimental Pharmacology, Faculty of Medicine, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.
(b) Department of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25042378

Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus

Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus

Fuente:International Journal of Environmental Research and Public Health

Tipo de trabajo:Revisión

Extracto: Hydroxymethylation in the SOCS3-related region of blood DNA is promising to investigate for its mediation in the influences of environment on incident T2DM.

Claves:blood, human, hydroxymethylation, peripheral, twin, type 2 diabetes mellitus

Cita:Int J Environ Res Public Health 2024 Feb 4; 21 (2)

Autor/es:Luong, Ryan Anh Minh (a)
Guan, Weihua (b)

institución:(a) Doctoral Program of Osteopathic Medicine, College of Osteopathic Medicine, Des Moines University, West Des Moines, IA 50266, USA.
(b) Division of Biostatistics & Health Data Science, University of Minnesota School of Public Health, Minneapolis, MN 55414, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijerph21020177

Enhancing Behavioural Changes

Fuente:International Journal of Environmental Research and Public Health

Tipo de trabajo:Revisión

Extracto: Various concerns regarding the excessive use of APPs need to be addressed.

Claves:chronic disease, eHealth, physical exercise, telemedicine, weight control

Cita:Int J Environ Res Public Health 2024 Feb 16; 21 (2)

Autor/es:Di Martino, Giulia (a)
Della Valle, Carlo (b)

institución:(a) Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy.
(b) Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijerph21020233

Rosuvastatin as a Supplemental Treatment for the Clinical Symptoms of Nephropathia Epidemica: A Pilot Clinical Study.

Rosuvastatin as a Supplemental Treatment for the Clinical Symptoms of Nephropathia Epidemica: A Pilot Clinical Study.

Fuente:Viruses

Extracto: The data from our study provide evidence supporting the therapeutic potential of rosuvastatin in NE cases.

Claves:nephropathia epidemica, rosuvastatin, statins

Cita:Viruses 2024 Feb 17; 16 (2)

Autor/es:Shakirova, Venera (a)
Markelova, Maria (b)

institución:(a) Department of Infection Diseases, Kazan State Medical Academy, Kazan 420012, Russia.
(b) Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/v16020306

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.

Fuente:Communications Biology

Extracto: This mode of antigen delivery strengthens the evidence for post-ER ligand exchange pathways for MR1, which could represent an important avenue by which MR1 acquires antigens derived from endocytosed pathogens.

Cita:Commun Biol 2024 Feb 24; 7 (1) : 228.

Autor/es:Kulicke, Corinna A (a)
Swarbrick, Gwendolyn M (b)

institución:(a) Division of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.
(b) Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, 97239, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s42003-024-05912-4

CSF levels of Chitinase3like1 correlate with early response to cladribine in multiple sclerosis.

CSF levels of Chitinase3like1 correlate with early response to cladribine in multiple sclerosis.

Fuente:Frontiers in Immunology

Extracto: CSF Chitinase 3 like1 might provide prognostic information for predicting disease activity in the first years after initiation of cladribine. The drug's effect on chronic macrophage and microglia activation deserves further evaluation.

Claves:biomarkers, chemokines, cladribine, cytokines, disease activity, relapsing multiple sclerosis

Cita:Front Immunol 2024; 15 : 1343892.

Autor/es:Marastoni, Damiano (a)
Foschi, Matteo (b)

institución:(a) Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
(b) Neurology Unit, Department of Neuroscience, Multiple Sclerosis Center, S. Maria delle Croci Hospital, AUSL, Romagna, Ravenna, Italy.

Conflicto:DM received honoraria for research or speaking and funds for travel from Biogen Idec, Roche, Sanofi-Genzyme, Novartis. MC received honoraria for research or speaking and funds for travel from Roche, Sanofi-Genzyme, Merck Serono S.p.a Italy, Biogen Idec, Teva and Novartis. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could... be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1343892

The effect of the whole-process care model of the medical union on the improvement of kinesiophobia and bone mineral density in patients with osteoporosis.

The effect of the whole-process care model of the medical union on the improvement of kinesiophobia and bone mineral density in patients with osteoporosis.

Fuente:Journal of Orthopaedic Surgery and Research

Extracto: The whole-process care model of the medical association is used for osteoporosis patients, which might reduce the risk of kinesiophobia and improve the bone density of the lumbar spine and total hip in patients. But further promotion and improvement of relevant support systems are needed to achieve comprehensive promotion and maximize clinical benefits in this field.

Claves:Bone density, Full care, Medical association, Osteoporosis, Phobia

Cita:J Orthop Surg Res 2024 Feb 27; 19 (1) : 154.

Autor/es:Qian, Xiaoli (a)
Cao, Xiaodong (b)

institución:(a) Department of Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, China.
(b) Department of Nursing, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13018-024-04616-z

In Vitro Assessment of Cortisol Release Inhibition, Bioaccessibility and Bioavailability of a Chemically Characterized Scutellaria lateriflora L. Hydroethanolic Extract.

Fuente:Molecules (basel, Switzerland)

Extracto: In vivo studies and clinical trials remain necessary to draw a conclusion on the efficacy and tolerability of this plant extract.

Claves:Scutellaria lateriflora L., bioaccessibility, bioavailability, cortisol, osteoporosis, stress

Cita:Molecules 2024 Jan 25; 29 (3)

Autor/es:Buccato, Daniele Giuseppe (a)
Ullah, Hammad (b)

institución:(a) Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.
(b) Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/molecules29030586

The Extraction, Determination, and Bioactivity of Curcumenol

Fuente:Molecules (basel, Switzerland)

Tipo de trabajo:Revisión

Extracto: This review of curcumenol provides a theoretical basis for further research and clinical applications.

Claves:Curcuma wenyujin, TCM, biological activity, curcumenol

Cita:Molecules 2024 Jan 30; 29 (3)

Autor/es:Li, Jie (a)
Sun, Yitian (b)

institución:(a) State Key Laboratory of Quality Research in Chinese Medicines, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
(b) College of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/molecules29030656

Bergaptol, a Major Furocoumarin in Citrus: Pharmacological Properties and Toxicity.

Fuente:Molecules (basel, Switzerland)

Extracto: Further in vivo and clinical studies are warranted to identify the safe and effective doses of bergaptol for its multimodal application.

Claves:bergaptol, citrus, furanocoumarin, pharmacologic actions, toxicity

Cita:Molecules 2024 Feb 4; 29 (3)

Autor/es:Phucharoenrak, Pakkapong (a)
Trachootham, Dunyaporn (b)

institución:(a) Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand.
(b) Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/molecules29030713

Non-Athletic Cohorts Enrolled in Longitudinal Whole-Body Electromyostimulation Trials-An Evidence Map.

Fuente:Sensors (basel, Switzerland)

Extracto: In summary, the evidence gaps in WB-EMS research were particular evident for cohorts with diseases of the nervous and cerebrovascular system.

Claves:body composition, cohorts, diseases, electromyostimulation, function, longitudinal studies, whole-body electrostimulation

Cita:Sensors (Basel) 2024 Feb 2; 24 (3)

Autor/es:Beier, Miriam (a)
Schoene, Daniel (b)

institución:(a) Institute of Radiology, University Hospital Erlangen, 91054 Erlangen, Germany.
(b) Institute of Radiology, University Hospital Erlangen, 91054 Erlangen, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/s24030972

[Prescription of osteoporosis drugs and secondary fracture prevention still at low levels and with large regional variation].

Fuente:Lakartidningen

Extracto: Our results show that medical treatment with osteoporosis drugs is still at low levels, covering approximately 5 percent of the population aged 70 or older, with clear differences between regions.

Cita:Lakartidningen 2024 Jan 30; 121

Autor/es:Modig, Karin (a)
Meyer, Anna (b)

institución:(a) **** med dr enheten för epidemiologi, Institutet för miljömedicin, Karo-linska institutet.
(b) leg sjukgymnast, med dr, enheten för epidemiologi, Institutet för miljö-medicin, Karolinska institutet.

Formato:Informe virtual

Idioma:swe

País de fuente:Suecia

Sitio web:

Alignment of substance use community benefit prioritization and service lines in US hospitals: a cross-sectional study.

Fuente:Addiction Science & Clinical Practice

Extracto: The availability of service offerings is related both to a hospital's prioritization of substance use and to its size, indicating that these factors are likely inter-related regarding a hospital's sense of its ability to address substance use as a community need. Policymakers should consider why a hospital may not prioritize a need that is prevalent within their community; e.g., whether the organization believes it lacks resources to take such steps. This study also highlights the value of the assessment and implementation strategy process as a way for hospitals to engage with community needs.

Claves:Community benefit, Hospitals, Substance use

Cita:Addict Sci Clin Pract 2024 Feb 13; 19 (1) : 11.

Autor/es:Cronin, Cory E (a)
Kubacki, Luke (b)

institución:(a) College of Health Sciences and Professions, Ohio University, Athens, OH, 45701, USA. croninc@ohio.edu.
(b) Appalachian Institute to Advance Health Equity Science, Ohio University, Athens, OH, 45701, USA. croninc@ohio.edu.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13722-024-00442-0

Effects of metabolic syndrome on bone mineral density in postmenopausal Turkish women.

Fuente:African Health Sciences

Extracto: Our findings support that MetS is associated with increased BMD at the femoral neck and spine in postmenopausal women. A significant positive association was observed among the MetS components, especially with abdominal obesity, and also a weak positive association with serum triglycerides, and systolic and diastolic blood pressure.

Claves:Postmenopausal women, bone mineral density, metabolic syndrome, osteoporosis

Cita:Afr Health Sci 2023 Sep; 23 (3) : 99-108.

Autor/es:Bahtiyarca, Zeynep T (a)
Serçe, Azize (b)

institución:(a) Department of Physical Medicine and Rehabilitation, University of Health Science, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
(b) Department of Algology, Ankara Training and Research Hospital, Ankara, Turkey.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Uganda

Sitio web:http://dx.doi.org/10.4314/ahs.v23i3.13

Finite element study on three osteotomy methods for treating thoracolumbar osteoporotic fracture vertebral collapse complicated with neurological dysfunction.

Fuente:Medicine

Extracto: The relatively simple modified osteotomy has certain advantages in stress and displacement. In contrast, the stability of BDBO group was poor, especially in the lumbar intervertebral disc and lumbar body. For this type of osteotomy patients, it is recommended to avoid postoperative flexion so as not to increase the load.

Cita:Medicine (Baltimore) 2024 Feb 16; 103 (7) : e36987.

Autor/es:Long, Zhisheng (a)
Zhou, Jingyu (b)

institución:(a) Department of Orthopedics, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
(b) Medical College, Nanchang University, Nanchang, Jiangxi, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000036987

The association between type 2 diabetes mellitus/prediabetes status and femoral neck bone mineral density in old adults.

Fuente:Journal of Orthopaedic Surgery (hong Kong)

Extracto: The association between a positive T2DM/prediabetes status and femoral neck BMD differed by sex among older individuals, with the association being further modulated by BMI. For women with a BMI of 25-29.9 kg/m(2) or ≥30 kg/m(2), T2DM was associated with a significantly higher femoral neck BMD, compared to the non-diabetes group.

Claves:bone health, national health and nutrition examination survey, old adults, type 2 diabetes mellitus

Cita:J Orthop Surg (Hong Kong) 2024 Jan-Apr; 32 (1) : 10225536241233472.

Autor/es:Wang, Bo (a)
Shi, Chenhao (b)

institución:(a) Department of Osteoporosis Care and Control, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, China.
(b) The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China. RINGGOLD: 70571

Conflicto:Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1177/10225536241233472

[Role of NLRP3 inflammasomes in musculoskeletal disorders].

Fuente:Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology

Extracto: This review provides a summary of the activation pathway and mechanism of NLRP3 inflammasomes, and analyzes the role in musculoskeletal disorders such as sarcopenia, osteoporosis and arthritis, with the aim to facilitate the treatment of musculoskeletal disorders.

Claves:NLRP3 inflammasomes, bone, joint, musculoskeletal system, skeletal muscle

Cita:Sheng Wu Gong Cheng Xue Bao 2024 Feb 25; 40 (2) : 337-349.

Autor/es:Ding, Kaizhi (a)
Gong, Yanchun (b)

institución:(a) School of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi, China.
(b) School of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi, China.

Formato:Informe impreso

Idioma:chi

País de fuente:China

Sitio web:http://dx.doi.org/10.13345/j.cjb.230378

A Healed Intertrochanteric Femur Fracture, Shoulder, and Rib Fractures in an Ancient Nubian Female: An Osteoarchaeological Perspective.

Fuente:Thescientificworldjournal

Extracto: It is likely that this individual's high socioeconomic status allowed for intensive nursing care which likely decreased the morality risk.

Cita:ScientificWorldJournal 2024; 2024 : 8339694.

Autor/es:Loder, Randall T (a)
Buzon, Michele R (b)

institución:(a) Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
(b) Department of Anthropology, Purdue University, West Lafayette, IN, USA.

Conflicto:RTL is a member of the editorial board for the Journal of Pediatric Orthopaedics and the Journal of Children's Orthopaedics. He receives royalties from publishers of book chapters not related to the subject of this manuscript. MRB is a board member and officer of the American Sudanese Archaeological Research Center and an editorial board member of the Journal of the... American Research Center in Egypt and the Brepols Publisher book series Nubia: Studies in Archaeology and History of Northeast Africa. She receives honoraria for lectures. KES has no activities or affiliations to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1155/2024/8339694

Deep Learning and Machine Learning Algorithms for Retinal Image Analysis in Neurodegenerative Disease

Fuente:Translational Vision Science & Technology

Tipo de trabajo:Revisión sistemática

Extracto: The use of bilateral and multimodal imaging together with metadata seems to improve model performance, thus multimodal bilateral image datasets with patient metadata are needed. We identified several deep learning tools that have been useful in this context including feature extraction algorithms specifically for retinal images, retinal image preprocessing techniques, transfer learning, feature fusion, and attention mapping. Importantly, we also consider the limitations common to these models in real-world clinical applications. TRANSLATIONAL RELEVANCE: This systematic review evaluates the deep learning models and retinal features relevant in the evaluation of retinal images of patients with neurodegenerative disease.

Cita:Transl Vis Sci Technol 2024 Feb 1; 13 (2) : 16.

Autor/es:Bahr, Tyler (a)
Vu, Truong A (b)

institución:(a) Mayo Clinic, Department of Ophthalmology, Rochester, MN, USA.
(b) University of the Incarnate Word, School of Osteopathic Medicine, San Antonio, TX, USA.

Conflicto:Disclosure: T. Bahr, None; T.A. Vu, None; J.J. Tuttle, None; R. Iezzi, None

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1167/tvst.13.2.16