TIMM17A overexpression in lung adenocarcinoma and its association with prognosis.

TIMM17A overexpression in lung adenocarcinoma and its association with prognosis.

Fuente:Scientific Reports

Extracto: The potential of TIMM17A as a biomarker and therapeutic target for LUAD presents a promising pathway for improving patient diagnosis and treatment strategies.

Claves:Biomarker, Lung adenocarcinoma, Prognosis, TIMM17A

Cita:Sci Rep 2024 Apr 17; 14 (1) : 8840.

Autor/es:Miao, Lili (a)
Wu, Dejun (b)

institución:(a) Department of Respiration, YiZheng People's Hospital, YiZheng, Jiangsu, China.
(b) Department of Respiration, YiZheng People's Hospital, YiZheng, Jiangsu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59526-1

Prognostic implication of 1-year decline in diffusing capacity in newly diagnosed idiopathic pulmonary fibrosis.

Fuente:Scientific Reports

Extracto: Therefore, serial monitoring of DLCO should be recommended because it may offer additional prognostic information compared with monitoring of FVC alone.

Claves:Disease progression, Idiopathic pulmonary fibrosis, Pulmonary diffusing capacity, Respiratory function test, Vital capacity

Cita:Sci Rep 2024 Apr 17; 14 (1) : 8857.

Autor/es:Lee, Hyeonsu (a)
Kim, So Yeon (b)

institución:(a) Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
(b) Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59649-5

Phase I/II clinical trial of efficacy and safety of EGCG oxygen nebulization inhalation in the treatment of COVID-19 pneumonia patients with cancer.

Phase I/II clinical trial of efficacy and safety of EGCG oxygen nebulization inhalation in the treatment of COVID-19 pneumonia patients with cancer.

Fuente:Bmc Cancer

Tipo de trabajo:Estudio abierto

Extracto: Aerosol inhalation of EGCG is well tolerated, and preliminary investigation in cancer population suggests that EGCG may be effective in COVID-19-induced pneumonia, which can promote the improvement of patients with moderate pneumonia or prevent them from developing into severe pneumonia. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05758571. Date of registration: 8 February 2023.

Claves:COVID-19 pneumonia, Cancer, Efficacy, Epigallocatechin-3-gallate, Safety

Cita:BMC Cancer 2024 Apr 17; 24 (1) : 486.

Autor/es:Yin, Xiaoyan (a)
Zhu, Wanqi (b)

institución:(a) Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jiyan Road 440, 250117, Jinan, Shandong, China.
(b) Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jiyan Road 440, 250117, Jinan, Shandong, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12885-024-12228-3

Application of propofol-remifentanil intravenous general anesthesia combined with regional block in pediatric ophthalmic surgery.

Application of propofol-remifentanil intravenous general anesthesia combined with regional block in pediatric ophthalmic surgery.

Fuente:Bmc Anesthesiology

Extracto: Propofol-remifentanil intravenous anesthesia combined with long-acting local anesthetic regional block anesthesia, combined with laryngeal mask ventilation technology without muscle relaxants, can be safely used in pediatric eye surgery to achieve rapid and smooth recovery from general anesthesia and better postoperative analgesia. This anesthesia scheme can improve the comfort and safety of children in perioperative period, and has a certain clinical popularization value.

Claves:Children, Ophthalmic surgery, Propofol, Regional block, Remifentanil

Cita:BMC Anesthesiol 2024 Apr 17; 24 (1) : 147.

Autor/es:Li, Ming-Ying (a)
Fei, Yu-Da (b)

institución:(a) Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 5 Jingyuan Street, Beijing, 100043, China.
(b) Department of Anesthesiology, Eye Hospital China Academy of Chinese Medical Sciences, Beijing, 100040, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12871-024-02531-8

Utility of bronchoscopically obtained frozen cytology pellets for next-generation sequencing.

Utility of bronchoscopically obtained frozen cytology pellets for next-generation sequencing.

Fuente:Bmc Cancer

Extracto: Our study showed that frozen cytology pellets may have equivalent diagnostic value to frozen tissue for NGS analyses. Bronchial cytology specimens are usually used only for cytology, but NGS analysis is possible if enough cells are collected to create pellet specimens. In particular, the frozen cytology pellets obtained by endobronchial ultrasound-guided transbronchial needle aspiration yielded sufficient amounts of DNA. TRIAL REGISTRATION: This was registered with the University Medical Hospital Information Network in Japan (UMINCTR registration no. UMIN000052050).

Claves:Cytology, Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), Lung cancer, Next-generation sequencing (NGS), Pellet specimen

Cita:BMC Cancer 2024 Apr 17; 24 (1) : 489.

Autor/es:Mimura, Chihiro (a)
Takamiya, Rei (b)

institución:(a) Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe-City, Hyogo, 650-0017, Japan.
(b) Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe-City, Hyogo, 650-0017, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12885-024-12250-5

Burden of antimicrobial prescribing in primary care attributable to sore throat

Burden of antimicrobial prescribing in primary care attributable to sore throat

Fuente:Bmc Primary Care

Tipo de trabajo:Estudio de cohortes

Extracto: Frequency of antibiotic prescribing for sore throat is high and broad, despite Australian Therapeutic guideline recommendations. Multiple, sustained interventions to reduce prescribing, including availability of effective S. pyogenes vaccines that could reduce the incidence of streptococcal pharyngitis, could obviate the need to prescribe antibiotics and support ongoing efforts to promote antimicrobial stewardship.

Claves:Streptococcus pyogenes, Antimicrobial prescribing, Primary care, Sore throat, URTI

Cita:BMC Prim Care 2024 Apr 17; 25 (1) : 117.

Autor/es:Carville, Kylie S (a)
Meagher, Niamh (b)

institución:(a) Doherty Epidemiology, Victorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
(b) Department of Infectious Diseases, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12875-024-02371-y

Respiratory carriage of hypervirulent Klebsiella pneumoniae by indigenous populations of Malaysia.

Respiratory carriage of hypervirulent Klebsiella pneumoniae by indigenous populations of Malaysia.

Fuente:Bmc Genomics

Extracto: A proportion were hypervirulent (hvKp) however antibiotic resistance was low.

Claves:Klebsiella pneumoniae, Antimicrobial resistance, ESBL, Hypervirulent, Malaysia

Cita:BMC Genomics 2024 Apr 17; 25 (1) : 381.

Autor/es:Das, Souradeep (a)
Pandey, Anish K (b)

institución:(a) Faculty of Medicine, Institute for Life Sciences, University of Southampton, Southampton, UK.
(b) Faculty of Medicine, Institute for Life Sciences, University of Southampton, Southampton, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12864-024-10276-4

Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency.

Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency.

Fuente:Bmc Pulmonary Medicine

Tipo de trabajo:Estudio de cohortes

Extracto: Cardiac AD is associated with impaired pulmonary vascular volume and ventilatory efficiency. This suggests that lung blood perfusion abnormalities may occur in these patients. Further confirmation is required in a large population-based cohort.

Claves:Abnormal heart rate response, Cardiac autonomic dysfunction, Chronic obstructive pulmonary disease, Pulmonary vascular volume, Ventilation efficiency

Cita:BMC Pulm Med 2024 Apr 17; 24 (1) : 183.

Autor/es:Shi, Minghui (a)
Qumu, Shiwei (b)

institución:(a) National Center for Respiratory Diseases, No. 2 East Yinghua Road, Chaoyang District, 100029, Beijing, China.
(b) Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, No. 2 East Yinghua Road, Chaoyang District, 100029, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12890-024-03003-y

Correlation Between HIF1-A Expression and Airway Remodeling in COPD.

Correlation Between HIF1-A Expression and Airway Remodeling in COPD.

Fuente:International Journal of Chronic Obstructive Pulmonary Disease

Extracto: The findings suggest a correlation between increased HIF-1α expression and COPD airway remodelling. This study provides novel evidence that HIF-1α may be a potential biomarker for airway remodelling in COPD patients.

Claves:airway remodelling, chronic obstructive pulmonary disease, hypoxia-inducible factor 1-α, matrix metalloproteinase 9

Cita:Int J Chron Obstruct Pulmon Dis 2024; 19 : 921-931.

Autor/es:Tan, Lingfang (a)
Yang, Xuefeng (b)

institución:(a) The Nanhua Affiliated Hospital, Department of Respiratory Physicians, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
(b) The Nanhua Affiliated Hospital, Department of General Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Nueva Zelanda

Sitio web:http://dx.doi.org/10.2147/COPD.S447256

Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients.

Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients.

Fuente:Frontiers in Cellular and Infection Microbiology

Extracto: Our study highlights the diagnostic potential of CRP, ESR, PCT, LDH, and CER for IPA in COPD patients. CRP and LDH can also initially predict the need for assisted ventilation, while CRP can initially estimate the length of hospitalization. This study represents the first report of the potential of CER for diagnosing IPA, suggesting its significance for further research.

Claves:C-reactive protein, ceruloplasmin, chronic obstructive pulmonary disease, erythrocyte sedimentation rate, invasive pulmonary aspergillosis, lactate dehydrogenase, procalcitonin

Cita:Front Cell Infect Microbiol 2024; 14 : 1294971.

Autor/es:Long, Zhiwei (a)
Li, Xiaotong (b)

institución:(a) State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, Guangzhou, China.
(b) State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, Guangzhou, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fcimb.2024.1294971

Respiratory Syncytial Virus Hospital-Based Burden of Disease in Children Younger Than 5 Years, 2015-2022.

Respiratory Syncytial Virus Hospital-Based Burden of Disease in Children Younger Than 5 Years, 2015-2022.

Fuente:Jama Network Open

Extracto: AND RELEVANCE: Hospitalizations for RSV and bronchiolitis demonstrated atypical seasonality in 2021 and 2022, with an overall increase in RSV encounters. Postpandemic RSV hospitalization increased for all ages, but especially among older children, whereas bronchiolitis hospitalization was decreased or unchanged compared with earlier seasons. These findings suggest some of the observed increase in RSV hospital use may be due to increased testing.

Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e247125.

Autor/es:Suss, Robert J (a)
Simões, Eric A F (b)

institución:(a) Department of Pediatric Infectious Diseases, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora.
(b) Department of Pediatric Infectious Diseases, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.7125

Health care utilisation of asylum seekers and refugees in the South-West of Germany.

Health care utilisation of asylum seekers and refugees in the South-West of Germany.

Fuente:Plos One

Tipo de trabajo:Estudio de cohortes

Extracto: Though seasonal variation and referral practices must be considered, a high rate of revisits to the ICF were recorded. While visits to the LED decreased after the implementation of the ICF, visits returned to the pre-ICF levels during the routine running of the ICF. The results show that AS&R require reliable access to health care, yet the needs of specific groups of migrants may be different, especially those with language barriers, minority groups or those from certain regions. As such, care should be migrant sensitive and adapt to the changing needs of the population. Though more research is required to better understand the differing needs of migrants, this study may help to inform guidelines surrounding migrant sensitive standards of care in Germany.

Cita:PLoS One 2024; 19 (4) : e0299886.

Autor/es:Bockey, Annabelle J (a)
Braun, Cornelia (b)

institución:(a) Department of Medicine II, Division of Infectious Diseases, Medical Centre-University Hospital Freiburg, Faculty of Medicine, Freiburg, Germany.
(b) PhD Programme "Epidemiology" Braunschweig-Hannover, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299886

Chronic obstructive pulmonary disease as a risk factor for sarcopenia

Fuente:Plos One

Tipo de trabajo:Revisión sistemática

Extracto: Nursing researchers should pay more attention to the symptomatic management of COPD and encourage patients to participate in daily activities in the early stages of the disease.

Cita:PLoS One 2024; 19 (4) : e0300730.

Autor/es:Yu, Zhenjie (a)
He, Jingchun (b)

institución:(a) School of Nursing, Tianjin Medical University, Tianjin, China.
(b) Department of Respiratory and Critical Care Medicine, Tianjin No. 4 Central Hospital, Tianjin, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300730

Pneumococcal vaccination and primary care presentations for acute respiratory tract infection and antibiotic prescribing in older adults.

Fuente:Plos One

Extracto: PPV23 vaccination in older adults may result in a small reduction in the incidence of total ARI presentations in primary care. However, the effect is small and residual confounding cannot be excluded.

Cita:PLoS One 2024; 19 (4) : e0299924.

Autor/es:Hossain, Fariha Binte (a)
Jayasinghe, Sanjay (b)

institución:(a) School of Population Health, UNSW, Sydney, Australia.
(b) National Centre for Immunisation Research and Surveillance (NCIRS), Kids Research, Sydney Children's Hospitals Network, New South Wales, Sydney, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299924

Complex bronchopleural fistulas

Complex bronchopleural fistulas

Fuente:The Journal of International Medical Research

Tipo de trabajo:Caso clínico

Extracto: Our treatment method may be a useful reference for treating complex BPF.

Claves:Bronchopleural fistula, bronchoscopy, empyema, endobronchial valve, individualization, interventional therapy

Cita:J Int Med Res 2024 Apr; 52 (4) : 3000605241245269.

Autor/es:Cao, Miaoying (a)
Yi, Jing (b)

institución:(a) Department of Pulmonary Medicine, Shaoxing People's Hospital, Shaoxing, China.
(b) Department of Pulmonary Medicine, Shaoxing People's Hospital, Shaoxing, China.

Conflicto:Declaration of conflicting interestThe authors declare that there is no conflict of interest.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1177/03000605241245269

Krebs von den Lungen-6 levels at admission predicts exercise-induced hypoxemia before and after discharge in patients with COVID-19.

Krebs von den Lungen-6 levels at admission predicts exercise-induced hypoxemia before and after discharge in patients with COVID-19.

Fuente:Respiratory Investigation

Extracto: Some patients with COVID-19 may continue to experience exercise-induced hypoxemia after discharge. Age, lactate dehydrogenase, and Krebs von den Lungen-6 levels at admission could serve as predictive markers of exercise-induced hypoxemia before and after discharge in these patients.

Claves:6-Min walk test, COVID-19, Exercise-induced hypoxemia, KL-6 levels

Cita:Respir Investig 2024 May; 62 (3) : 369-374.

Autor/es:Morikawa, Keisuke (a)
Tabira, Kazuyuki (b)

institución:(a) Department of Rehabilitation, Matsusaka Municipal Hospital, Tonomachi 1550, Matsusaka, Mie, 515-8544, Japan; Department of Health Science, Kio University Graduate School, Umamichu 4-2-2, Kitakatsuragigun-koryocho, Nara, 635-0832, Japan. Electronic address: morikawagacha@yahoo.co.jp.
(b) Department of Health Science, Kio University Graduate School, Umamichu 4-2-2, Kitakatsuragigun-koryocho, Nara, 635-0832, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Países Bajos

Sitio web:http://dx.doi.org/10.1016/j.resinv.2024.02.011

Rate of severe exacerbations, healthcare resource utilisation and clinical outcomes in patients with COPD in low-income and middle-income countries: results from the EXACOS International Study.

Rate of severe exacerbations, healthcare resource utilisation and clinical outcomes in patients with COPD in low-income and middle-income countries: results from the EXACOS International Study.

Fuente:Bmj Open Respiratory Research

Extracto: DISCUSSION: The findings presented here indicate that effective treatment strategies to prevent severe exacerbations in patients with COPD remain a significant unmet need in low-income and middle-income countries.

Claves:COPD Exacerbations

Cita:BMJ Open Respir Res 2024 Apr 18; 11 (1)

Autor/es:Athanazio, Rodrigo Abensur (a)
Bernal Villada, Laura (b)

institución:(a) Pulmonology Division, Heart Institute-InCor-Clinical Hospital, Faculty of Medicine, Universidade de São Paulo, São Paulo, Brazil rodrigo.athanazio@hc.fm.usp.br.
(b) Respiratory & Immunology, AstraZeneca, Bogota, Colombia.

Conflicto:Competing interests: RAA reports financial support from AstraZeneca, Chiesi, GlaxoSmithKline, Novartis and Boehringer Ingelheim for speaking engagements; and research grants from GlaxoSmithKline and AstraZeneca. LBV is an employee of AstraZeneca. SNA reports financial support from Boehringer Ingelheim for congress attendance and speaking engagements; financial support from Novartis, Teva, AstraZeneca, GlaxoSmithKline and Boehringer Ingelheim for serving as a consultant; and research... grants from AstraZeneca, GlaxoSmithKline and Boehringer Ingelheim. MS reports financial support from GlaxoSmithKline for congress attendance and speaking engagements, and from AstraZeneca for assistance with medical education programmes. JD reports financial support from GlaxoSmithKline for serving as a medical adviser and for congress attendance; research grants from AstraZeneca; financial support from Octapharma for congress attendance and speaking engagements; financial support from Boehringer Ingelheim for congress attendance; and financial support from Grifols for congress attendance. LN-A reports financial support from AstraZeneca, Novartis and Boehringer Ingelheim for congress attendance and speaking engagements; financial support from AstraZeneca, GlaxoSmithKline and Boehringer Ingelheim for serving as a consultant; and research grants from Novartis, GlaxoSmithKline, Boehringer Ingelheim and AstraZeneca. HF is an employee of AstraZeneca and owns stock in AstraZeneca.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjresp-2023-002101

Profound hypoxemia and hypotension during posterior spinal fusion in a spinal muscular atrophy child with severe scoliosis

Profound hypoxemia and hypotension during posterior spinal fusion in a spinal muscular atrophy child with severe scoliosis

Fuente:Bmc Anesthesiology

Tipo de trabajo:Caso clínico

Extracto: Spinal fusion surgery is beneficial for SMA patients in preventing scoliosis progression and improving ventilation. However, severe scoliosis and thoracic deformities put them at risk of both hemodynamic and respiratory instability during surgical positioning. When advanced monitoring like TEE is not practical intraoperatively, preoperative imaging may help with differential diagnosis, and guide the surgical positioning to minimize mechanical compression of the thoracic cavity, thereby helping the patient complete the surgery safely.

Claves:Case report, Hypoxemia, Scoliosis, Spinal muscular atrophy, Surgical positioning

Cita:BMC Anesthesiol 2024 Apr 18; 24 (1) : 148.

Autor/es:Shu, Qian (a)
Dong, Yulei (b)

institución:(a) Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
(b) Department of Orthopedic Surgery, Peking Union Medical College Hospital, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12871-024-02537-2

Development and application of a deep learning-based comprehensive early diagnostic model for chronic obstructive pulmonary disease.

Development and application of a deep learning-based comprehensive early diagnostic model for chronic obstructive pulmonary disease.

Fuente:Respiratory Research

Tipo de trabajo:Estudio clínico

Extracto: We developed and implemented a data fusion strategy to construct a state-of-the-art COPD diagnostic model integrating deep learning features, radiomics features, and questionnaire variables. Our data fusion strategy proved effective, and the model can be easily deployed in clinical settings. TRIAL REGISTRATION: Not applicable. This study is NOT a clinical trial, it does not report the results of a health care intervention on human participants.

Claves:COPD, Data fusion, Deep learning, Diagnostic

Cita:Respir Res 2024 Apr 18; 25 (1) : 167.

Autor/es:Zhu, Zecheng (a)
Zhao, Shunjin (b)

institución:(a) Center of Clinical Big Data and Analytics of The Second Affiliated Hospital and Department of Big Data in Health Science School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
(b) Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Lanxi Branch (Lanxi People's Hospital), Hangzhou, Zhejiang, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12931-024-02793-3

PTMs of PD-1/PD-L1 and PROTACs application for improving cancer immunotherapy.

PTMs of PD-1/PD-L1 and PROTACs application for improving cancer immunotherapy.

Fuente:Frontiers in Immunology

Extracto: PROTACs could be a novel strategy to combine with radiotherapy, chemotherapy and immunotherapy for cancer patients.

Claves:PD-1, PD-L1, PROTAC, immunotherapy, ubiquitination

Cita:Front Immunol 2024; 15 : 1392546.

Autor/es:Ren, Xiaohui (a)
Wang, Lijuan (b)

institución:(a) Department of Respiratory Medicine, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
(b) Department of Hospice Care, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1392546