Interaction of Neisseria meningitidis carrier and disease isolates of MenB cc32 and MenW cc22 with epithelial cells of the nasopharyngeal barrier.

Interaction of Neisseria meningitidis carrier and disease isolates of MenB cc32 and MenW cc22 with epithelial cells of the nasopharyngeal barrier.

Fuente:Frontiers in Cellular and Infection Microbiology

Extracto: Moreover, we found that the representative meningococcal isolates tested in this study did not damage the epithelial barrier, as shown by TEER measurement, FITC-dextran permeability assays, and expression of cell-junction components.

Claves:Neisseria meningitidis, air-liquid-interface, clonal complexes, epithelial barrier, transmigration

Cita:Front Cell Infect Microbiol 2024; 14 : 1389527.

Autor/es:Peters, Simon (a)
Mohort, Katherina (b)

institución:(a) Institute for Hygiene and Microbiology, Julius-Maximilian University Wuerzburg, Wuerzburg, Germany.
(b) Institute for Hygiene and Microbiology, Julius-Maximilian University Wuerzburg, Wuerzburg, Germany.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fcimb.2024.1389527

The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps.

The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Fuente:Frontiers in Immunology

Extracto: Oxidative stress plays an important role in the development of CRSwNP by promoting various types of inflammation. The oxidative stress of nasal polyps comes from epithelial cells and macrophages. Antioxidant therapy may be a promising strategy for treating CRSwNP.

Claves:CRSwNP, Nrf2, macrophages, nasal epithelial cells, oxidative stress

Cita:Front Immunol 2024; 15 : 1380846.

Autor/es:Zhou, Jing (a)
Zhou, Jiao (b)

institución:(a) Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
(b) Upper Respiratory Tract Laboratory of Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1380846

Investigation of epidemiological and clinical characteristics of people infected with SARS-CoV-2 during the second pandemic of COVID-19 in Chengdu, China.

Investigation of epidemiological and clinical characteristics of people infected with SARS-CoV-2 during the second pandemic of COVID-19 in Chengdu, China.

Fuente:Frontiers in Public Health

Extracto: The SARS-CoV-2 infected individuals in Chengdu, China, during the second pandemic of COVID-19 had mild clinical symptoms and a short course of disease. Furthermore, compared with the first infection, re-infection cases had mild symptoms, low incidences of complications, short fever duration, and course of disease.

Claves:COVID-19, SARS-CoV-2, clinical characteristics, epidemiological characteristics, first infection, re-infection

Cita:Front Public Health 2024; 12 : 1394762.

Autor/es:Li, Cheng (a)
Zhou, Tao (b)

institución:(a) Department of Infectious Diseases, The Third People's Hospital of Chengdu, Chengdu, China.
(b) Department of Infectious Diseases, The Third People's Hospital of Chengdu, Chengdu, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2024.1394762

Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015-2021.

Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015-2021.

Fuente:Influenza and Other Respiratory Viruses

Extracto: In Mongolia, RSV is an important pathogen causing more severe LRTI in children under 6 months of age. Codetection of RSV or influenza virus and S.p. was not associated with increased severity.

Claves:influenza virus, lower respiratory tract infections, respiratory syncytial virus

Cita:Influenza Other Respir Viruses 2024 May; 18 (5) : e13303.

Autor/es:Do, Lien Anh Ha (a)
Tsedenbal, Naranzul (b)

institución:(a) New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.
(b) Department of Paediatrics, The University of Melbourne, Parkville, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/irv.13303

The Detection of Influenza Virus Before and During the COVID-19 Pandemic in Cameroon.

Fuente:Influenza and Other Respiratory Viruses

Extracto: The COVID-19 pandemic had a significant impact on the seasonal influenza by changing the seasonality of the virus and reducing its detection rates.

Claves:COVID‐19 pandemic, Cameroon, SARS‐CoV‐2, epidemiology, influenza

Cita:Influenza Other Respir Viruses 2024 May; 18 (5) : e13313.

Autor/es:Monamele, Gwladys Chavely (a)
Tsafack, Desmon Toutou (b)

institución:(a) Virology Service, Centre Pasteur of Cameroon, Yaounde, Cameroon.
(b) Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/irv.13313

Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia.

Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia.

Fuente:The Pediatric Infectious Disease Journal

Extracto: Caution is needed in interpreting antibody responses in pneumococcal infections.

Cita:Pediatr Infect Dis J 2024 Feb 1; 43 (2) : e67-e70.

Autor/es:Carter, Michael J (a)
Shrestha, Sonu (b)

institución:(a) Paediatric Intensive Care, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
(b) Oxford Vaccine Group, Department of Paediatrics, University of Oxford.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/INF.0000000000004185

Artificial intelligence augmented home sleep apnea testing device study (AISAP study).

Artificial intelligence augmented home sleep apnea testing device study (AISAP study).

Fuente:Plos One

Extracto: The WVU-device demonstrated good accuracy in predicting REI when compared to an approved HSAT device, even in patients with darker skin tones.

Cita:PLoS One 2024; 19 (5) : e0303076.

Autor/es:Sharma, Sunil (a)
Olgers, Kassandra (b)

institución:(a) Division of Pulmonary, Critical Care and Sleep Medicine, West Virginia University, Morgantown, WV, United States of America.
(b) Division of Pulmonary, Critical Care and Sleep Medicine, West Virginia University, Morgantown, WV, United States of America.

Conflicto:Sunil Sharma, M.D. is on the speaker bureau for Zoll Respicardia Inc No other COI to report

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303076

Controlling COVID-19 outbreaks in the correctional setting: A mathematical modelling study.

Fuente:Plos One

Extracto: These results have informed public health policy for respiratory pathogens in Australian correctional systems.

Cita:PLoS One 2024; 19 (5) : e0303062.

Autor/es:Bretaña, Neil Arvin (a)
Kwon, Jisoo A (b)

institución:(a) Allied Health and Human Performance, University of South Australia, Australia.
(b) Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303062

Strategies to address recruitment to a randomised trial of surgical and non-surgical treatment for cancer: results from a complex recruitment intervention within the Mesothelioma and Radical Surgery 2 (MARS 2) study.

Strategies to address recruitment to a randomised trial of surgical and non-surgical treatment for cancer: results from a complex recruitment intervention within the Mesothelioma and Radical Surgery 2 (MARS 2) study.

Fuente:Bmj Open

Tipo de trabajo:Estudio aleatorizado

Extracto: With bespoke support to overcome identified issues, recruitment to a challenging RCT of surgery versus no surgery in a thoracic cancer setting with a complex recruitment pathway and multiple health professional involvement is possible. TRIAL REGISTRATION NUMBER: ISRCTN ISRCTN44351742, Clinical Trials.gov NCT02040272.

Claves:Clinical Trial, ONCOLOGY, QUALITATIVE RESEARCH, Randomized Controlled Trial, Thoracic surgery

Cita:BMJ Open 2024 May 16; 14 (5) : e079108.

Autor/es:Mills, Nicola (a)
Farrar, Nicola (b)

institución:(a) Bristol Medical School, University of Bristol Faculty of Health Sciences, Bristol, UK nicola.mills@bristol.ac.uk.
(b) Bristol Medical School, University of Bristol Faculty of Health Sciences, Bristol, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-079108

Domiciliary monitoring of exhaled nitric oxide in the management of asthma: a pilot study.

Domiciliary monitoring of exhaled nitric oxide in the management of asthma: a pilot study.

Fuente:Bmc Pulmonary Medicine

Extracto: The daily home monitoring of Fe(NO50) in asthmatic patients showed significant circadian rhythm, and the sensitivity of Fe(NO50) in evaluating the response to treatment was higher than mSpirometry. The daily and weekly variation rates of Fe(NO50) change dynamically with time, which may be used to assess the condition of asthma.

Claves:Asthma, Biomarker, FeNO50, Home monitoring, Mobile spirometry

Cita:BMC Pulm Med 2024 May 17; 24 (1) : 244.

Autor/es:Li, Hongwen (a)
Lin, Jiangtao (b)

institución:(a) Department of Geriatric Respiratory Disease, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, China.
(b) Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, No 2, East Yinghua Road, Chaoyang District, Beijing, 100029, China. jiangtao_l@263.net.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12890-024-03031-8

Antibiotic susceptibility patterns and trends of the gram-negative bacteria isolated from the patients in the emergency departments in China: results of SMART 2016-2019.

Antibiotic susceptibility patterns and trends of the gram-negative bacteria isolated from the patients in the emergency departments in China: results of SMART 2016-2019.

Fuente:Bmc Infectious Diseases

Tipo de trabajo:Guía

Extracto: Gram-negative bacteria collected from Chinese EDs exhibited high resistance to commonly used antibiotics. Susceptibilities were organ specific for different infection sites, knowledge which will be useful for guiding empirical therapies in the clinic.

Claves:Antibiogram, Antibiotic-Resistance, Carbapenem, Cephalosporin, OSWIA, SMART

Cita:BMC Infect Dis 2024 May 17; 24 (1) : 501.

Autor/es:Fu, Ying (a)
Zhao, Feng (b)

institución:(a) Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310016, Hangzhou, Zhejiang Province, China.
(b) Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, 310016, Hangzhou, Zhejiang Province, China.

Conflicto:Pengcheng Li is an employee of MSD China. All other authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12879-024-09294-0

Establishment and validation of a predictive model for tracheotomy in critically ill patients and analysis of the impact of different tracheotomy timing on patient prognosis.

Establishment and validation of a predictive model for tracheotomy in critically ill patients and analysis of the impact of different tracheotomy timing on patient prognosis.

Fuente:Bmc Anesthesiology

Extracto: The prediction model constructed and validated based on the MIMIC-IV database can accurately predict the outcome of tracheotomy in critically ill patients. Meanwhile, early tracheotomy in critically ill patients does not improve survival outcomes but has potential advantages in shortening the duration of hospitalization, IMV, and sedation.

Claves:Intensive care unit, Invasive mechanical ventilation, MIMIC-IV database, Predictive model, Timing of tracheotomy, Tracheotomy

Cita:BMC Anesthesiol 2024 May 17; 24 (1) : 175.

Autor/es:Chen, Xing-Hua (a)
Zhao, Jing-Jing (b)

institución:(a) Department of Intensive Care Unit, Hefei Hospital Affiliated to Anhui Medical University, The Second People's Hospital of Hefei, Hefei, Anhui, 230011, China.
(b) Department of Intensive Care Unit, Hefei Hospital Affiliated to Anhui Medical University, The Second People's Hospital of Hefei, Hefei, Anhui, 230011, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12871-024-02558-x

A prospective, open-label, randomized clinical trial to evaluate the efficacy and safety of remimazolam in patients undergoing EBUS-TBNA: REST trial design.

A prospective, open-label, randomized clinical trial to evaluate the efficacy and safety of remimazolam in patients undergoing EBUS-TBNA: REST trial design.

Fuente:Bmc Pulmonary Medicine

Extracto: Prospectively registered on 15 February 2024.

Claves:Endobronchial ultrasonography, Protocol, Pulmonary medicine, Remimazolam, Sedation

Cita:BMC Pulm Med 2024 May 17; 24 (1) : 243.

Autor/es:Seol, Hee Yun (a)
Hong, Kyung Soo (b)

institución:(a) Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
(b) Division of Pulmonary and Critical Care Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12890-024-03067-w

Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro.

Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro.

Fuente:Particle and Fibre Toxicology

Extracto: It also highlights that even in a healthy population these particles have the potential to induce this type II response and initiate an immune response following exposure to IAP.

Claves:Disease model, Healthy, In vitro, Indoor air pollution, Inhalation, Lung, Particulate matter

Cita:Part Fibre Toxicol 2024 May 17; 21 (1) : 25.

Autor/es:Meldrum, Kirsty (a)
Evans, Stephen J (b)

institución:(a) In Vitro Toxicology Group, Swansea University Medical School, Swansea University, Singleton Park Campus, Swansea, Wales, SA2 8PP, UK. kirsty.meldrum@swansea.ac.uk.
(b) In Vitro Toxicology Group, Swansea University Medical School, Swansea University, Singleton Park Campus, Swansea, Wales, SA2 8PP, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12989-024-00584-8

SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure.

SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure.

Fuente:Trials

Extracto: TRIAL STATUS: Currently enrolling.

Claves:Acute respiratory failure, CDP-choline, COVID-19, Citicoline, Hypoxemia, Influenza, Lung, SARS CoV-2

Cita:Trials 2024 May 18; 25 (1) : 328.

Autor/es:Pannu, Sonal (a)
Exline, Matthew C (b)

institución:(a) Division of Pulmonary, Critical Care and Sleep Medicine of the Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
(b) Division of Pulmonary, Critical Care and Sleep Medicine of the Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.

Conflicto:I.C.D. is the sole inventor on a patent (US 10,874,684) covering use of citicoline as an ARDS therapeutic, which is assigned to the OSU Innovation Foundation. As such, there is the potential that both could profit from the trial should it result in out-licensing of the technology. However, Dr. Davis is not involved in patient enrollment or data analysis and... the OSU Innovation Foundation has played no role in developing or conducting the trial.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13063-024-08155-0

Molecular mechanism of radiation tolerance in lung adenocarcinoma cells using single-cell RNA sequencing.

Molecular mechanism of radiation tolerance in lung adenocarcinoma cells using single-cell RNA sequencing.

Fuente:Journal of Cellular and Molecular Medicine

Extracto: We identified two cellular subpopulations associated with radiotherapy tolerance, which may shed light on the molecular mechanisms of radiotherapy tolerance in LUAD and provide new clinical perspectives.

Claves:TP53, cell subpopulation, lung adenocarcinoma, radiotolerance, single‐cell RNA sequencing

Cita:J Cell Mol Med 2024 May; 28 (10) : e18378.

Autor/es:Chang, Feiyun (a)
Xi, Bozhou (b)

institución:(a) Department of Thoracic Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
(b) The Second Clinical Medical School, Shanxi Medical University, Taiyuan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/jcmm.18378

Diagnosis of Angioimmunoblastic T Cell Lymphoma After Receiving First Dose of Pfizer/BioNTech (BNT162b2) Vaccine

Diagnosis of Angioimmunoblastic T Cell Lymphoma After Receiving First Dose of Pfizer/BioNTech (BNT162b2) Vaccine

Fuente:Journal of Investigative Medicine High Impact Case Reports

Tipo de trabajo:Caso clínico

Extracto: Given the rarity of AITL and the heterogeneity of molecular findings, more studies are needed to establish such an association.

Claves:hematology oncology, immunology, pathology

Cita:J Investig Med High Impact Case Rep 2024 Jan-Dec; 12 : 23247096241231645.

Autor/es:Khatri, Jai Kumar (a)
Tahboub, Ihab (b)

institución:(a) Marshall University, Huntington, WV, USA.
(b) Marshall University, Huntington, WV, USA.

Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1177/23247096241231645

An exosomes-related lncRNA prognostic model correlates with the immune microenvironment and therapy response in lung adenocarcinoma.

An exosomes-related lncRNA prognostic model correlates with the immune microenvironment and therapy response in lung adenocarcinoma.

Fuente:Clinical and Experimental Medicine

Extracto: Our study pioneers an ER-lncRNA-related prognostic model for LUAD, proposing that ERS-based risk stratification could inform personalized treatment strategies to improve patient outcomes.

Claves:Exosome, Long non-coding RNA, Lung adenocarcinoma, Prognostic model, Tumor immune microenvironment

Cita:Clin Exp Med 2024 May 18; 24 (1) : 104.

Autor/es:Chu, Daifang (a)
Chen, Liulin (b)

institución:(a) Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Air Force Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China.
(b) Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Air Force Military Medical University, 569 Xinsi Road, Xi'an, 710038, Shaanxi, China.

Conflicto:The authors have no relevant financial or non-financial interests to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.1007/s10238-024-01319-x

Nitrous oxide respiration in acidophilic methanotrophs.

Nitrous oxide respiration in acidophilic methanotrophs.

Fuente:Nature Communications

Extracto: Such metabolic capability enables these bacteria to simultaneously reduce the release of the key greenhouse gases CO(2), CH(4,) and N(2)O.

Cita:Nat Commun 2024 May 18; 15 (1) : 4226.

Autor/es:Awala, Samuel Imisi (a)
Gwak, Joo-Han (b)

institución:(a) Department of Biological Sciences and Biotechnology, Chungbuk National University, 1 Chungdae-ro, Seowon-Gu, Cheongju, 28644, Republic of Korea.
(b) Center for Ecology and Environmental Toxicology, Chungbuk National University, 1 Chungdae-Ro, Seowon-Gu, Cheongju, 28644, South Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48161-z

Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC.

Fuente:Nature Communications

Extracto: Overall, our findings implicate mitochondrial cysteine metabolism in the induction of ferroptosis and reveal a mechanism of mitochondrial resilience in response to nutrient stress.

Cita:Nat Commun 2024 May 18; 15 (1) : 4244.

Autor/es:Ward, Nathan P (a)
Yoon, Sang Jun (b)

institución:(a) Department of Metabolism & Physiology, Moffitt Cancer Center, Tampa, FL, USA. nathan.ward@moffitt.org.
(b) Department of Metabolism & Physiology, Moffitt Cancer Center, Tampa, FL, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48695-2