CXCR6-positive circulating mucosal-associated invariant T cells can identify patients with non-small cell lung cancer responding to anti-PD-1 immunotherapy.

Fuente:Journal of Experimental & Clinical Cancer Research Cr

Extracto: CD8+MAIT cells are a potential predictive biomarker for patients with NSCLC responding to anti-PD-1 therapy. The correlation between CD8+MAIT cells and immunotherapy sensitivity may be ascribed to high CXCR6 expression.

Claves:CXCR6, Circulating mucosal-associated invariant T cells, Immunotherapy, Non-small cell lung cancer, Single-cell RNA-sequencing

Cita:J Exp Clin Cancer Res 2024 May 3; 43 (1) : 134.

Autor/es:Qu, Jingjing (a)
Wu, Binggen (b)

institución:(a) Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, P. R. China.
(b) The Clinical Research Center for Respiratory Diseases of Zhejiang Province, Hangzhou, Zhejiang, 310003, P. R. China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13046-024-03046-3

Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study).

Fuente:Acta Oncologica (stockholm, Sweden)

Tipo de trabajo:Estudio de cohortes

Extracto: INTERPRETATION: S-1 is a safe and effective FP alternative when mCRC patients are forced to discontinue 5-FU or capecitabine due to cardiotoxicity and can be safely used in the standard recommended regimens, settings, and schedules.

Cita:Acta Oncol 2024 May 2; 63 : 248-258.

Autor/es:Kinos, Sampsa (a)
Hagman, Helga (b)

institución:(a) Department of Oncology, Tays Cancer Center, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland.
(b) Department of Oncology, Skåne University Hospital, Malmö, Sweden.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suecia

Sitio web:http://dx.doi.org/10.2340/1651-226X.2024.24023

Analysis of cases with co-infection of COVID-19 and pulmonary aspergillosis.

Fuente:The New Microbiologica

Extracto: In addition to specimen culture in the lower respiratory tract, the 1,3-β-D-glucan antigen test can serve as an important screening indicator for early CAPA diagnosis in non-granulocytopenia patients.

Claves:CAPA, COVID-19, diagnosis, infections, risk factors

Cita:New Microbiol 2024 May; 47 (1) : 98-102.

Autor/es:Zheng Hu, Hui (a)
Wu, Li Bo (b)

institución:(a) Department of Clinical Laboratory, Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang 712000, Shaanxi, China.
(b) Department of Clinical Laboratory, Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang 712000, Shaanxi, China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Italia

Sitio web:

A bibliometric and visual analysis of research trends and hotspots of familial hypertrophic cardiomyopathy

Fuente:Medicine

Tipo de trabajo:Revisión

Extracto: These insights are instrumental in steering future research directions in this area.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e37969.

Autor/es:Chen, Cong (a)
Liu, Yang (b)

institución:(a) College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
(b) Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037969

Long-term follow-up of patients with Brugada syndrome: Foremost risk factors associated with overall arrhythmic events.

Fuente:Medicine

Extracto: Given the higher risk of poor prognosis, we recommend additional measures in patients with BS who have these features.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e37990.

Autor/es:Camkiran, Volkan (a)
Ozden, Ozge (b)

institución:(a) Department of Cardiology, Goztepe Medicalpark Hospital, Istanbul, Turkey.
(b) Department of Cardiology, Memorial Bahcelievler Hospital, Istanbul, Turkey.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037990

Advances in systemic immune inflammatory indices in non-small cell lung cancer

Fuente:Medicine

Tipo de trabajo:Revisión

Extracto: This paper reviews the impact of SII on the development, progression, and prognosis of non-small cell lung cancer.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e37967.

Autor/es:Mao, Kai-Yun (a)
Cao, Yuan-Chao (b)

institución:(a) First Clinical Medical College, Gannan Medical University, Ganzhou, China.
(b) First Clinical Medical College, Gannan Medical University, Ganzhou, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037967

Exploring the multi-targeting phytoestrogen potential of Calycosin for cancer treatment

Fuente:Medicine

Tipo de trabajo:Revisión

Extracto: The objective of this review is to present a synthesis of the current understanding of the antitumor mechanism of CA and its research progress.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e38023.

Autor/es:Ren, Fangbing (a)
Ma, Yanhui (b)

institución:(a) Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, Weifang, China.
(b) Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000038023

Age-specific and cause-specific mortality contributions to the socioeconomic gap in life expectancy in Germany, 2003-21: an ecological study.

Fuente:The Lancet. Public Health

Extracto: FUNDING: German Cancer Aid and European Research Council.

Cita:Lancet Public Health 2024 May; 9 (5) : e295-e305.

Autor/es:Tetzlaff, Fabian (a)
Sauerberg, Markus (b)

institución:(a) Division of Social Determinants of Health, Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany. Electronic address: TetzlaffF@rki.de.
(b) Research Area of Ageing, Mortality and Population Dynamics, Federal Institute for Population Research (BiB), Wiesbaden, Germany.

Conflicto:Declaration of interests We declare no competing interests.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1016/S2468-2667(24)00049-5

The association between disability and mortality: a mixed-methods study.

Fuente:The Lancet. Public Health

Tipo de trabajo:Revisión sistemática

Extracto: FUNDING: National Institute for Health and Care Research, Rhodes Scholarship, Indonesia Endowment Funds for Education, Foreign, Commonwealth and Development Office (Programme for Evidence to Inform Disability Action), and the Arts and Humanities Research Council.

Cita:Lancet Public Health 2024 May; 9 (5) : e306-e315.

Autor/es:Kuper, Hannah (a)
Rotenberg, Sara (b)

institución:(a) Department of Population Health, International Centre for Evidence in Disability, London School of Hygiene & Tropical Medicine, London, UK; Missing Billion Initiative, Seattle, WA, USA. Electronic address: hannah.kuper@lshtm.ac.uk.
(b) Department of Population Health, International Centre for Evidence in Disability, London School of Hygiene & Tropical Medicine, London, UK; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Conflicto:Declaration of interests We declare no competing interests.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1016/S2468-2667(24)00054-9

Burden of cardiovascular disease attributed to air pollution

Fuente:Globalization and Health

Tipo de trabajo:Revisión sistemática

Extracto: Ambient air pollution is an underestimated but significant and modifiable contributor to CVDs burden and public health costs. This should not only be considered an environmental problem but also as an important risk factor for a significant increase in CVD cases and mortality. The findings of the systematic review highlighted the opportunity to apply more preventive measures in the public health sector to reduce the footprint of CVDs in human society.

Claves:Air pollution, Burden of disease, Cardiovascular disease, Disability, Mortality

Cita:Global Health 2024 May 3; 20 (1) : 37.

Autor/es:Khoshakhlagh, Amir Hossein (a)
Mohammadzadeh, Mahdiyeh (b)

institución:(a) Department of Occupational Health Engineering, School of Health, Kashan University of Medical Sciences, Kashan, Iran.
(b) Department of Health in Emergencies and Disasters, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. m.mohammadzadeh997@gmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12992-024-01040-0

Chromosome-Y haplogroups in Asturias (Northern Spain) and their association with severe COVID-19.

Fuente:Molecular Genetics and Genomics Mgg

Extracto: These results indicate that Y-chromosome variants could serve as markers to define the risk of developing a severe form of COVID-19.

Claves:COVID-19, Chromosome-Y, Haplogroups, Hypertension

Cita:Mol Genet Genomics 2024 May 4; 299 (1) : 49.

Autor/es:González-Fernández, Mar (a)
Vázquez-Coto, Daniel (b)

institución:(a) Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain.
(b) Instituto de Investigación Sanitaria del Principado de Asturias, ISPA, Oviedo, Spain.

Conflicto:None of the authors have competing interests related to this work.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s00438-024-02143-4

The relation of a cerebrospinal fluid profile associated with Alzheimer's disease with cognitive function and neuropsychiatric symptoms in sporadic cerebral amyloid angiopathy.

Fuente:Alzheimer's Research & Therapy

Extracto: In participants with sCAA, a CSF biomarker profile associated with AD does not impact global cognition or specific cognitive domains, or the presence of neuropsychiatric symptoms.

Cita:Alzheimers Res Ther 2024 May 4; 16 (1) : 99.

Autor/es:De Kort, Anna M (a)
Kaushik, Kanishk (b)

institución:(a) Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands.
(b) Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13195-024-01454-3

SC-Track: a robust cell-tracking algorithm for generating accurate single-cell lineages from diverse cell segmentations.

Fuente:Briefings in Bioinformatics

Extracto: These features together make SC-Track a robust cell-tracking algorithm that works well with noisy cell instance segmentation and classification predictions from CNNs to generate accurate single-cell lineages and classifications.

Claves:cell cycle, cell division, convolutional neural networks, deep learning, single-cell tracking, timelapse microscopy imaging

Cita:Brief Bioinform 2024 Mar 27; 25 (3)

Autor/es:Li, Chengxin (a)
Xie, Shuang Shuang (b)

institución:(a) Department of Cardiovascular Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, P. R. China.
(b) Centre for Cellular Biology and Signalling, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, P. R. China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1093/bib/bbae192

The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.

The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.

Fuente:Frontiers in Endocrinology

Tipo de trabajo:Estudio clínico

Extracto: Obesity-associated glycine deficiency impairs the human body's ability to eliminate endogenous and exogenous metabolites/compounds via the glycine conjugation pathway. This impairment is ameliorated when glycine supply is restored after bariatric surgery. These findings imply that dietary glycine supplementation could treat obesity-associated metabolic complications due to the accumulation of intramitochondrial toxic metabolites. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT04660513, identifier NCT04660513.

Claves:acylglycine, bariatric surgery, class III obesity, glycine conjugation, glycine deficiency

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1343738.

Autor/es:Tan, Hong Chang (a)
Hsu, Jean W (b)

institución:(a) Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.
(b) Children's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1343738

Impacts of pro-inflammatory cytokines variant on cardiometabolic profile and premature coronary artery disease

Impacts of pro-inflammatory cytokines variant on cardiometabolic profile and premature coronary artery disease

Fuente:Journal of Cellular and Molecular Medicine

Tipo de trabajo:Revisión sistemática

Extracto: brown race population, Caucasians, obese patients, etc.) with rs1800795 to prevent PCAD.

Claves:Cardiometabolic risk factors, chemokines, coronary artery disease, genetic predisposition to disease

Cita:J Cell Mol Med 2024 Apr; 28 (8) : e18311.

Autor/es:Liu, Yang (a)
Chen, Yuan (b)

institución:(a) Department of Endocrinology, China Resources and WISCO General Hospital, Wuhan, China.
(b) Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/jcmm.18311

Incidence of chemotherapy-related cardiac dysfunction in cancer patients.

Incidence of chemotherapy-related cardiac dysfunction in cancer patients.

Fuente:Clinical Cardiology

Tipo de trabajo:Metanálisis

Extracto: Our meta-analysis unveiled a definitive overall incidence rate of chemotherapy-related cardiac dysfunction in cancer patients. In addition, it was found that the risk of developing this condition escalates within the initial 6 months postchemotherapy, subsequently tapering off to become statistically insignificant after a duration of 6 years.

Claves:cancer, cardiac dysfunction, chemotherapy

Cita:Clin Cardiol 2024 Apr; 47 (4) : e24269.

Autor/es:Deng, Hai-Wei (a)
Fan, Rui (b)

institución:(a) Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
(b) Key Laboratory on Assisted Circulation Ministry of Health, Guangzhou, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1002/clc.24269

Causal relationship of genetically predicted particulate matter 2.5 level with Alzheimer's disease and the mediating effect of dehydroepiandrosterone sulphate.

Causal relationship of genetically predicted particulate matter 2.5 level with Alzheimer's disease and the mediating effect of dehydroepiandrosterone sulphate.

Fuente:Annals of Human Biology

Extracto: Our findings affirm a significant causal association between PM2.5 exposure and AD, with DHEAS playing a mediating role in this relationship.

Claves:Alzheimer’s disease, Mendelian randomisation, ambient particulate matter 2.5, dehydroepiandrosterone sulphate, mediation analysis

Cita:Ann Hum Biol 2024 Feb; 51 (1) : 2337731.

Autor/es:Huang, Zehan (a)
He, Guodong (b)

institución:(a) Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
(b) Research Department of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1080/03014460.2024.2337731

Racial Discrimination and Metabolic Syndrome in Young Black Adults.

Racial Discrimination and Metabolic Syndrome in Young Black Adults.

Fuente:Jama Network Open

Tipo de trabajo:Estudio de cohortes

Extracto: AND RELEVANCE: This study suggests that racial discrimination in late adolescence is associated with MetS among Black young adults through biobehavioral pathways. Thus, health interventions for MetS in Black adults will need to contend with sleep behaviors and inflammatory intermediaries as well as address and reduce exposure to racial discrimination to narrow disparities and promote health equity.

Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e245288.

Autor/es:Heard-Garris, Nia (a)
Yu, Tianyi (b)

institución:(a) Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
(b) Division of Advanced General Pediatrics and Primary Care, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.5288

Semiparametric modeling for the cardiometabolic risk index and individual risk factors in the older adult population: A novel proposal.

Semiparametric modeling for the cardiometabolic risk index and individual risk factors in the older adult population: A novel proposal.

Fuente:Plos One

Extracto: Semiparametric modeling explained 24.5% of the observed deviance, which was higher than the 18.2% explained by the linear model.

Cita:PLoS One 2024; 19 (4) : e0299032.

Autor/es:Tagder, Philippe (a)
Alfonso-Mora, Margareth Lorena (b)

institución:(a) Fisioterapia, Universidad de Boyacá Sede Tunja, Colombia.
(b) Real World Evidence, IQVIA, Belgium.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299032

Therapeutic education of patients with coronary heart disease: Impact of digital platform monitoring in preventing major cardiovascular events in Tunisia: Study protocol.

Fuente:Plos One

Tipo de trabajo:Estudio clínico

Extracto: URL: https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=24247.

Cita:PLoS One 2024; 19 (4) : e0300250.

Autor/es:Ghali, Hela (a)
El Hraiech, Aymen (b)

institución:(a) Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
(b) Department of Prevention and Security of Care, Sahloul University Hospital, Sousse, Tunisia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300250