The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.

The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.

Fuente:Frontiers in Endocrinology

Tipo de trabajo:Estudio clínico

Extracto: Obesity-associated glycine deficiency impairs the human body's ability to eliminate endogenous and exogenous metabolites/compounds via the glycine conjugation pathway. This impairment is ameliorated when glycine supply is restored after bariatric surgery. These findings imply that dietary glycine supplementation could treat obesity-associated metabolic complications due to the accumulation of intramitochondrial toxic metabolites. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT04660513, identifier NCT04660513.

Claves:acylglycine, bariatric surgery, class III obesity, glycine conjugation, glycine deficiency

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1343738.

Autor/es:Tan, Hong Chang (a)
Hsu, Jean W (b)

institución:(a) Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.
(b) Children's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1343738

Impacts of pro-inflammatory cytokines variant on cardiometabolic profile and premature coronary artery disease

Impacts of pro-inflammatory cytokines variant on cardiometabolic profile and premature coronary artery disease

Fuente:Journal of Cellular and Molecular Medicine

Tipo de trabajo:Revisión sistemática

Extracto: brown race population, Caucasians, obese patients, etc.) with rs1800795 to prevent PCAD.

Claves:Cardiometabolic risk factors, chemokines, coronary artery disease, genetic predisposition to disease

Cita:J Cell Mol Med 2024 Apr; 28 (8) : e18311.

Autor/es:Liu, Yang (a)
Chen, Yuan (b)

institución:(a) Department of Endocrinology, China Resources and WISCO General Hospital, Wuhan, China.
(b) Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/jcmm.18311

Incidence of chemotherapy-related cardiac dysfunction in cancer patients.

Incidence of chemotherapy-related cardiac dysfunction in cancer patients.

Fuente:Clinical Cardiology

Tipo de trabajo:Metanálisis

Extracto: Our meta-analysis unveiled a definitive overall incidence rate of chemotherapy-related cardiac dysfunction in cancer patients. In addition, it was found that the risk of developing this condition escalates within the initial 6 months postchemotherapy, subsequently tapering off to become statistically insignificant after a duration of 6 years.

Claves:cancer, cardiac dysfunction, chemotherapy

Cita:Clin Cardiol 2024 Apr; 47 (4) : e24269.

Autor/es:Deng, Hai-Wei (a)
Fan, Rui (b)

institución:(a) Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
(b) Key Laboratory on Assisted Circulation Ministry of Health, Guangzhou, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1002/clc.24269

Causal relationship of genetically predicted particulate matter 2.5 level with Alzheimer's disease and the mediating effect of dehydroepiandrosterone sulphate.

Causal relationship of genetically predicted particulate matter 2.5 level with Alzheimer's disease and the mediating effect of dehydroepiandrosterone sulphate.

Fuente:Annals of Human Biology

Extracto: Our findings affirm a significant causal association between PM2.5 exposure and AD, with DHEAS playing a mediating role in this relationship.

Claves:Alzheimer’s disease, Mendelian randomisation, ambient particulate matter 2.5, dehydroepiandrosterone sulphate, mediation analysis

Cita:Ann Hum Biol 2024 Feb; 51 (1) : 2337731.

Autor/es:Huang, Zehan (a)
He, Guodong (b)

institución:(a) Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
(b) Research Department of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1080/03014460.2024.2337731

Racial Discrimination and Metabolic Syndrome in Young Black Adults.

Racial Discrimination and Metabolic Syndrome in Young Black Adults.

Fuente:Jama Network Open

Tipo de trabajo:Estudio de cohortes

Extracto: AND RELEVANCE: This study suggests that racial discrimination in late adolescence is associated with MetS among Black young adults through biobehavioral pathways. Thus, health interventions for MetS in Black adults will need to contend with sleep behaviors and inflammatory intermediaries as well as address and reduce exposure to racial discrimination to narrow disparities and promote health equity.

Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e245288.

Autor/es:Heard-Garris, Nia (a)
Yu, Tianyi (b)

institución:(a) Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
(b) Division of Advanced General Pediatrics and Primary Care, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.5288

Semiparametric modeling for the cardiometabolic risk index and individual risk factors in the older adult population: A novel proposal.

Semiparametric modeling for the cardiometabolic risk index and individual risk factors in the older adult population: A novel proposal.

Fuente:Plos One

Extracto: Semiparametric modeling explained 24.5% of the observed deviance, which was higher than the 18.2% explained by the linear model.

Cita:PLoS One 2024; 19 (4) : e0299032.

Autor/es:Tagder, Philippe (a)
Alfonso-Mora, Margareth Lorena (b)

institución:(a) Fisioterapia, Universidad de Boyacá Sede Tunja, Colombia.
(b) Real World Evidence, IQVIA, Belgium.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299032

Therapeutic education of patients with coronary heart disease: Impact of digital platform monitoring in preventing major cardiovascular events in Tunisia: Study protocol.

Fuente:Plos One

Tipo de trabajo:Estudio clínico

Extracto: URL: https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=24247.

Cita:PLoS One 2024; 19 (4) : e0300250.

Autor/es:Ghali, Hela (a)
El Hraiech, Aymen (b)

institución:(a) Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
(b) Department of Prevention and Security of Care, Sahloul University Hospital, Sousse, Tunisia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300250

Evaluating the efficacy and safety of mavacamten in hypertrophic cardiomyopathy

Fuente:Plos One

Tipo de trabajo:Revisión sistemática

Extracto: Mavacamten influences diverse facets of HCM comprehensively. Notably, our study delved into the drug's impact on the heart's structural and functional aspects, providing insights that complement prior findings. Further large-scale trials are needed to evaluate the safety profile of Mavacamten.

Cita:PLoS One 2024; 19 (4) : e0301704.

Autor/es:Vyas, Rahul (a)
Panchal, Viraj (b)

institución:(a) Department of Internal Medicine, Louisiana State University, Shreveport, Louisiana, United States of America.
(b) Department of Medicine, Smt. NHL Municipal Medical College and SVPISMR, Ahmedabad, Gujarat, India.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301704

Deep phenotyping of dementia in a multi-ethnic cardiovascular cohort: The Multi-Ethnic Study of Atherosclerosis (MESA).

Fuente:Plos One

Extracto: In a deeply phenotyped cardiovascular cohort we identified the key correlates of dementia beyond age as subclinical atherosclerosis and myocyte damage, vascular function, inflammation, physical activity, hepatic steatosis, and history of cancer.

Cita:PLoS One 2024; 19 (4) : e0298952.

Autor/es:Ostovaneh, Mohammad R (a)
Hughes, Timothy M (b)

institución:(a) Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.
(b) Department of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0298952

Effect of AGTR1 A1166C genetic polymorphism on coronary artery lesions and mortality in patients with acute myocardial infarction.

Fuente:Plos One

Extracto: The AGTR1 A1166C genetic polymorphism is associated with very severe luminal stenosis of the LAD but not with mortality in AMI patients.

Cita:PLoS One 2024; 19 (4) : e0300273.

Autor/es:Tran, Duy Cong (a)
Le, Linh Hoang Gia (b)

institución:(a) Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
(b) Department of Cardiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300273

Gender health gaps in guideline-based inpatient cardiovascular medical and nursing care and implementation strategies to reduce the gap (HeartGap): A mixed methods study protocol.

Fuente:Plos One

Tipo de trabajo:Revisión

Extracto: TRIAL REGISTRATION: The study is registered in the German Register of Clinical Studies (DRKS) under study number DRKS00031317.

Cita:PLoS One 2024; 19 (4) : e0301732.

Autor/es:Sgraja, Sophia (a)
Mollenhauer, Judith (b)

institución:(a) Institute for Epidemiology, Social Medicine and Health Systems Research, Hannover Medical School, Hanover, Germany.
(b) figus-Research Institute for Health- and System Design, Cologne, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301732

Rising trend and regional disparities of the global burden of disease attributable to ambient low temperature, 1990-2019: An analysis of data from the Global Burden of Disease 2019 study.

Rising trend and regional disparities of the global burden of disease attributable to ambient low temperature, 1990-2019: An analysis of data from the Global Burden of Disease 2019 study.

Fuente:Journal of Global Health

Extracto: Our findings emphasise the significance of raising public awareness and prioritising policies to protect global population health from the adverse effects of low temperatures, even in the face of global warming. Particular efforts should be targeted towards individuals with underlying diseases (e.g. cardiovascular diseases) and vulnerable countries or regions (e.g. Central Asia and central Europe).

Cita:J Glob Health 2024 Apr 19; 14 : 04017.

Autor/es:Liu, Jiangdong (a)
Li, Mengmeng (b)

institución:(a) Department of Environmental Health, School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China.
(b) State Key Laboratory of Organ Failure Research, Department of Biostatistics, School of Public Health, Southern Medical University, Guangzhou, China.

Conflicto:Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Scotland

Sitio web:http://dx.doi.org/10.7189/jogh.14.04017

Exploring acupuncture as a treatment for insomnia in perimenopausal women with stable angina pectoris: A protocol for a randomized, double-blind, placebo-controlled clinical trial.

Exploring acupuncture as a treatment for insomnia in perimenopausal women with stable angina pectoris: A protocol for a randomized, double-blind, placebo-controlled clinical trial.

Fuente:Plos One

Tipo de trabajo:Estudio clínico

Extracto: Registered 19 November 2022.

Cita:PLoS One 2024; 19 (4) : e0301827.

Autor/es:Shi, Rui (a)
Meng, Wenyi (b)

institución:(a) Department of School of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
(b) TCM Cardiovascular Clinical Medicine Research Center of Jilin Province, Changchun, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301827

Role of oral health in heart and vascular health: A population-based study.

Fuente:Plos One

Extracto: Oral health improvement may reduce the risk of cardiac conditions. This underscores oral health's role in multidisciplinary disease management.

Cita:PLoS One 2024; 19 (4) : e0301466.

Autor/es:Ghanem, Amr Sayed (a)
Németh, Orsolya (b)

institución:(a) Department of Health Informatics, Institute of Health Sciences, Faculty of Health Sciences, University of Debrecen, Debrecen, Hungary.
(b) Department of Community Dentistry, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301466

Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study.

Cardiovascular outcomes following hospitalisation for exacerbation of bronchiectasis: a territory-wide study.

Fuente:Bmj Open Respiratory Research

Tipo de trabajo:Estudio de cohortes

Extracto: Patients who were hospitalised for exacerbation of bronchiectasis were at significantly increased risk of AMI, CHF and CVE over a 5-year follow-up period.

Claves:Bronchiectasis

Cita:BMJ Open Respir Res 2024 Apr 18; 11 (1)

Autor/es:Kwok, Wang Chun (a)
Tsui, Chung Ki (b)

institución:(a) Department of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
(b) Department of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjresp-2023-001804

The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial.

Fuente:Signal Transduction and Targeted Therapy

Extracto: Such effects were associated with specific T-cell re-distribution, EGF/CTLA-4 cytokine compensation, and regulation of metabolism pathways.

Cita:Signal Transduct Target Ther 2024 Apr 19; 9 (1) : 93.

Autor/es:Cheng, Bo (a)
Li, Caichen (b)

institución:(a) Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.
(b) Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41392-024-01799-z

Late-stage meta-C-H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step.

Late-stage meta-C-H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step.

Fuente:Nature Communications

Extracto: Moreover, productive late-stage modulation of key biological characteristics of drug candidates upon remote C-H alkylation proves viable, highlighting the major benefits of our approach to offer in drug development programmes.

Cita:Nat Commun 2024 Apr 18; 15 (1) : 3349.

Autor/es:Guillemard, Lucas (a)
Ackermann, Lutz (b)

institución:(a) Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
(b) Institut für Organische und Biomolekulare Chemie and Wöhler Research Institute for Sustainable Chemistry (WISCh), Georg-August-Universität Göttingen, Göttingen, Germany. lutz.ackermann@chemie.uni-goettingen.de.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-46697-8

Detecting m(6)A at single-molecular resolution via direct RNA sequencing and realistic training data.

Fuente:Nature Communications

Extracto: Compared to existing methods, mAFiA also demonstrates improved accuracy in measuring site-level m(6)A stoichiometry in biological samples.

Cita:Nat Commun 2024 Apr 18; 15 (1) : 3323.

Autor/es:Chan, Adrian (a)
Naarmann-de Vries, Isabel S (b)

institución:(a) Klaus Tschira Institute for Integrative Computational Cardiology, University of Heidelberg, Heidelberg, Germany.
(b) Klaus Tschira Institute for Integrative Computational Cardiology, University of Heidelberg, Heidelberg, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-47661-2

Electrophysiological cardiovascular MR

Electrophysiological cardiovascular MR

Fuente:Scientific Reports

Tipo de trabajo:Orientaciones y guía

Extracto: Hence, nsWHcs can be considered a key component in order to advance EP-CMR towards the ultimate goal of targeted substrate-based ablation procedures.

Claves:CMR-guided intervention, Cardiovascular magnetic resonance imaging, Compressed SENSE, EP-CMR, Isthmus-dependent atrial flutter, Non-selective SSFP, Radiofrequency ablation, Whole heart imaging

Cita:Sci Rep 2024 Apr 18; 14 (1) : 8974.

Autor/es:Jahnke, Cosima (a)
Darma, Angeliki (b)

institución:(a) Department of Electrophysiology, HELIOS Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289, Leipzig, Germany.
(b) Department of Electrophysiology, HELIOS Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289, Leipzig, Germany.

Conflicto:Christian Stehning and Jouke Smink are employees of Philips Healthcare. All other authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59230-0

Impact of insertion into the left internal jugular vein in chemoport-associated infections: a retrospective single-center study of 1690 cases.

Fuente:Scientific Reports

Extracto: Using the right internal jugular vein rather than the left internal jugular vein when performing chemoport insertion might reduce subsequent infections.

Claves:Chemoport, Infection, Internal jugular vein

Cita:Sci Rep 2024 Apr 18; 14 (1) : 8925.

Autor/es:Kim, Gwon-Min (a)
Song, Seunghwan (b)

institución:(a) Medical Research Institute, Pusan National University, Busan, Republic of Korea.
(b) Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59749-2