Antitumoral Activity of the Universal Methyl Donor S-Adenosylmethionine in Glioblastoma Cells.

Fuente:Molecules (basel, Switzerland)

Extracto: In light of these results, AdoMet could be considered a potential adjuvant in GBM therapy.

Claves:DNA damage response, S-Adenosylmethionine, cell cycle arrest and apoptosis, glioblastoma, homologous recombination repair, mitotic catastrophe

Cita:Molecules 2024 Apr 10; 29 (8)

Autor/es:Mosca, Laura (a)
Pagano, Cristina (b)

institución:(a) Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 7, 80138 Naples, Italy.
(b) Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/molecules29081708

Role of Insulin Use and Social Determinants of Health on Non-melanoma Skin Cancer: Results From the Behavioral Risk Factor Surveillance System.

Fuente:Cancer Control Journal of The Moffitt Cancer Center

Extracto: Our findings suggest that socioeconomic differences related to the healthcare system and behavioral patterns are linked to discrepancies in the use of insulin and the development of NMSC.

Claves:behavioral risk factor surveillance system, diabetes, health inequity, insulin use, non-melanoma skin cancer, social determinants of health

Cita:Cancer Control 2024 Jan-Dec; 31 : 10732748241249896.

Autor/es:Massouh, Nour (a)
Jaffa, Ayad A (b)

institución:(a) Epidemiology and Population Health Department, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon. RINGGOLD: 11238
(b) Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. RINGGOLD: 11238

Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1177/10732748241249896

Doping yesterday, today, tomorrow: A challenge for the clinical laboratory.

Fuente:The Malaysian Journal of Pathology

Extracto: Finally, a glance into genetic doping illustrates a likely future and imminent practice.

Cita:Malays J Pathol 2024 Apr; 46 (1) : 1-10.

Autor/es:Finally, a glance into genetic doping illustrates a likely future and imminent practice.

institución:Finally, a glance into genetic doping illustrates a likely future and imminent practice.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Malasia

Sitio web:

[Calciphylaxis, risk factors, treatment and outcomes. Retrospective study of 39 patients].

Fuente:Medicina

Tipo de trabajo:Revisión

Extracto: We observed a high proportion of patients with NUC, in relation to what is reported in the literature, and that half received vitamin K antagonists. The histological diagnosis was made with one biopsy in most of the cases, as the surgical technique for taking the sample, the Von Kossa staining and the evaluation by an expert pathologist were the key of it.

Claves:calcifying arteriolopathy, calciphylaxis, chronic kidney disease

Cita:Medicina (B Aires) 2024; 84 (2) : 196-205.

Autor/es:Torre, Ana C (a)
Bastard, Dolores P (b)

institución:(a) Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. E-mail: ana.torre@hospitalitaliano.org.ar.
(b) Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Formato:Informe impreso

Idioma:spa

País de fuente:Argentina

Sitio web:

Primary hyperparathyroidism in pregnancy

Fuente:Medicina

Tipo de trabajo:Caso clínico

Extracto: In most cases, parathyroidectomy is the treatment of choice.

Claves:cerebral venous thrombosis, hypercalcemia, parathyroid adenoma, preeclampsia, pregnancy, primary hyperparathyroidism

Cita:Medicina (B Aires) 2024; 84 (2) : 342-346.

Autor/es:Pereyra, Pilar de Las Mercedes (a)
Aciar, María de Los Ángeles (b)

institución:(a) Servicio de Endocrinología y Metabolismo, Hospital Público Materno Infantil de Salta, Salta, Argentina. E-mail: pilar_pereyra75@hotmail.com.
(b) Servicio de Endocrinología y Metabolismo, Hospital Público Materno Infantil de Salta, Salta, Argentina.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Argentina

Sitio web:

[Multiple endocrine neoplasia and very early onset inflammatory bowel disease. An unexpected association].

Fuente:Medicina

Extracto: The presence of these two clinical entities cannot be attributed to a single genetic cause.

Claves:RET proto-oncogene, multiple endocrine neoplasia 2A, primary immunodeficiency, very early onset inflammatory bowel disease

Cita:Medicina (B Aires) 2024; 84 (2) : 347-350.

Autor/es:Rossi, Santiago I (a)
Baleani, Silvia (b)

institución:(a) Unidad 5, Clínica Médica, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina. E-mail: santiagorossi.pediatria@gmail.com.
(b) Unidad 5, Clínica Médica, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.

Formato:Informe impreso

Idioma:spa

País de fuente:Argentina

Sitio web:

2023 Fukushima Medical University International Symposium on the Fukushima Health Management Survey, "Thinking Together about Health, Life, and our Future in Fukushima".

Fuente:Fukushima Journal of Medical Science

Extracto: The fifth annual symposium convened at FMU's Ekimae Campus on Saturday, 4 March 2023, with the theme, "Thinking Together about Health, Life and our Future in Fukushima."

Cita:Fukushima J Med Sci 2024; 70 (2) : 107-109.

Autor/es:Shimabukuro, Michio (a)
Kamiya, Kenji (b)

institución:(a) Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University School of Medicine.
(b) Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Japón

Sitio web:http://dx.doi.org/10.5387/fms.24-00007

Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells.

Fuente:Cell Death & Disease

Extracto: Moreover, transcriptomic analyses highlighted a novel subset of genes commonly modulated in 3D spheroids and potentially capable of driving ferroptosis protection in LUAD-CSCs, thus allowing to better understand the mechanisms of CSC-mediated drug resistance in tumors.

Cita:Cell Death Dis 2024 Apr 29; 15 (4) : 303.

Autor/es:Ascenzi, Francesca (a)
Esposito, Antonella (b)

institución:(a) Translational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
(b) Department of Clinical and Molecular Medicine, Sant' Andrea Hospital-Sapienza University of Rome, Rome, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41419-024-06667-w

Diastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the emergency department.

Fuente:Bmc Emergency Medicine

Tipo de trabajo:Revisión

Extracto: The D/S ratio is a practical bedside scoring system in the PED and had good discriminative ability in predicting the progression of septic shock and in-hospital mortality in PED patients. Further validation is essential in other settings.

Claves:Children, Emergency department setting, Hemodynamics, Mortality, Predictors, Progression, Sepsis, Septic shock, Shock

Cita:BMC Emerg Med 2024 May 1; 24 (1) : 78.

Autor/es:Mu, Chun-Ting (a)
Lin, Ying-Jui (b)

institución:(a) Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
(b) College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12873-024-00995-y

Bone Loss after Solid Organ Transplantation

Fuente:Endocrinology and Metabolism (seoul, Korea)

Tipo de trabajo:Revisión

Extracto: This detailed review serves as an essential resource for those involved in the complex multidisciplinary care of transplant recipients.

Claves:Bone loss, Bone mineral density, Fractures, Osteoporosis, Transplantation

Cita:Endocrinol Metab (Seoul) 2024 Apr; 39 (2) : 267-282.

Autor/es:Kim, Kyoung Jin (a)
Ha, Jeonghoon (b)

institución:(a) Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
(b) Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Conflicto:CONFLICTS OF INTEREST No potential conflict of interest relevant to this article was reported.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Corea del Sur

Sitio web:http://dx.doi.org/10.3803/EnM.2024.1939

[Interdisciplinary Management of Orbital Diseases].

Fuente:Laryngo- Rhino- Otologie

Extracto: The authors tried to highlight the relevant facts despite the shortness of the text.

Cita:Laryngorhinootologie 2024 May; 103 (S 01) : S43-S99.

Autor/es:Eckstein, A (a)
Welkoborsky, H-J (b)

institución:Eckstein, A (a)
Welkoborsky, H-J (b)

Conflicto:A. Eckstein erklärt: Vortragshonorare: Sanofi, Amgen,Sling. Mitarbeit an klinischen Studien: Amgen, Immunovant, Novartis.H.-J. Welboborsky war 2021-2022 Präsident der Deutschen Gesellschaft für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie.

Formato:Informe impreso

Idioma:ger

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1055/a-2216-8879

Nongestational ovarian choriocarcinoma with bilateral teratoma

Fuente:Medicine

Tipo de trabajo:Revisión

Extracto: NGCO should be considered if a female patient exhibits irregular vaginal bleeding and masses in the adnexal area. The present case and our literature review also highlighted that fertility-sparing surgery and multidrug chemotherapy are effective methods for treating NGCO.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e36996.

Autor/es:Ao, Xue (a)
Hu, Sha (b)

institución:(a) Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
(b) Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000036996

AI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data.

Fuente:Briefings in Bioinformatics

Extracto: In particular, the efficacy of triptolide, OTS-167, quinacrine, granisetron and A-443654 offer a potential avenue for targeted therapies against breast CSCs.

Claves:artificial intelligence, breast cancer, cancer stem cells, domain adaptation, drug repurposing, transcriptomics

Cita:Brief Bioinform 2024 Mar 27; 25 (3)

Autor/es:Li, Zhongxiao (a)
Napolitano, Antonella (b)

institución:(a) Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955, Saudi Arabia.
(b) Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, 23955, Saudi Arabia.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1093/bib/bbae207

Prevalence of multidrug-resistant bacterial infections in diabetic foot ulcers

Prevalence of multidrug-resistant bacterial infections in diabetic foot ulcers

Fuente:International Wound Journal

Tipo de trabajo:Metanálisis

Extracto: Our study also indicated that peripheral vascular disease, peripheral neuropathy, nephropathy, osteomyelitis, Wagner's grade, previous hospitalization, and previous use of antibacterial drugs were associated with MDR bacterial infections in patients with DFUs.

Claves:MDR bacteria, diabetic foot ulcers, prevalence, risk factors

Cita:Int Wound J 2024 Apr; 21 (4) : e14864.

Autor/es:Yang, Shaoling (a)
Hu, Liye (b)

institución:(a) Department of Endocrinology, The Bethune International Peace Hospital, Shijiazhuang, China.
(b) Department of Endocrinology, The Bethune International Peace Hospital, Shijiazhuang, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/iwj.14864

Factors associated with venous collaterals in patients with cerebral venous thrombosis.

Factors associated with venous collaterals in patients with cerebral venous thrombosis.

Fuente:Plos One

Tipo de trabajo:Estudio de cohortes

Extracto: In this cohort, the prevalence of venous collaterals was 25.3%. Occlusion in the superior sagittal sinus and hormonal exposure were independently associated with venous collaterals in patients with cerebral venous thrombosis.

Cita:PLoS One 2024; 19 (4) : e0302162.

Autor/es:Petchprom, Phirat (a)
Sanghan, Nuttha (b)

institución:(a) Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand.
(b) Division of Neuroradiology, Department of Radiology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0302162

The influence of diagnostic subgroups, patient- and hospital characteristics for the validity of cardiovascular diagnoses-Data from a Norwegian hospital trust.

Fuente:Plos One

Extracto: The diagnoses of acute myocardial infarction and stroke had excellent validity when placed during hospital stays. Similarly, heart failure diagnoses had excellent validity when echocardiography was performed before placing the diagnosis, while overall the diagnoses of heart failure and transient ischemic attack were less valid. In conclusion, the results indicate that cardiovascular diagnoses based on objective findings such as acute myocardial infarction and stroke have excellent validity and may be used as endpoints in clinical epidemiological studies with less rigid validation.

Cita:PLoS One 2024; 19 (4) : e0302181.

Autor/es:Rye, Cathrine Sæthern (a)
Ofstad, Anne Pernille (b)

institución:(a) Department of Medicine, Namsos Hospital, Nord-Trøndelag Hospital Trust, Namsos, Norway.
(b) Clinic of Cardiology, St. Olavs University Hospital, Trondheim, Norway.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0302181

Cardiovascular safety of evogliptin dual and triple therapy in patients with type 2 diabetes

Cardiovascular safety of evogliptin dual and triple therapy in patients with type 2 diabetes

Fuente:Bmj Open

Tipo de trabajo:Estudio de cohortes

Extracto: These findings suggest that dual or triple therapies of evogliptin for the management of type 2 diabetes in routine clinical practice present no cardiovascular harms, but could alternatively offer cardiovascular benefits in this patient population.

Claves:CARDIOLOGY, CLINICAL PHARMACOLOGY, Diabetes & endocrinology

Cita:BMJ Open 2024 Apr 15; 14 (4) : e077084.

Autor/es:Park, Sohee (a)
Jeong, Han Eol (b)

institución:(a) School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
(b) Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK.

Conflicto:Competing interests: HEJ and I-SO report the receipt of research funding from the National Research Foundation of South Korea, outside the submitted work. J-YS reports the receipt of research funding from the Ministry of Food and Drug Safety, Ministry of Health and Welfare, National Research Foundation and Government-wide R&D Fund for Infectious Disease Research of South Korea, as well as... grants from Amgen, Pfizer, GSK and Yungjin, outside the submitted work. Authors disclose no other relevant potential conflicts of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-077084

Long-term trajectories of peak expiratory flow rate in older men and women show linear decline mainly determined by baseline levels.

Long-term trajectories of peak expiratory flow rate in older men and women show linear decline mainly determined by baseline levels.

Fuente:Aging Clinical and Experimental Research

Tipo de trabajo:Estudio de cohortes

Extracto: Trajectories in both men and women differ mainly in baseline level of PEFR and not in rate of decline over time. Therefore, one PEFR measurement might be sufficient to give an indication of the trajectory that an older adult is likely to follow.

Claves:Ageing, Community-dwelling, Peak expiratory flow rate, Trajectories

Cita:Aging Clin Exp Res 2024 Apr 16; 36 (1) : 93.

Autor/es:van Schoor, Natasja M (a)
de Jongh, Renate T (b)

institución:(a) Epidemiology and Data Science, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. nm.vanschoor@amsterdamumc.nl.
(b) Aging & Later Life, Amsterdam Public Health Research Institute, De Boelelaan 1117, Amsterdam, The Netherlands. nm.vanschoor@amsterdamumc.nl.

Conflicto:The authors declare that they do not have competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s40520-024-02735-5

Comprehensive geriatric assessment of older patients with renal disease: a cross-sectional survey.

Comprehensive geriatric assessment of older patients with renal disease: a cross-sectional survey.

Fuente:Scientific Reports

Extracto: Regression analysis revealed that the scores of activities of daily living (P = 0.024), nutritional status (P = 0.000), total social support (P = 0.014), and objective support (P = 0.000) decreased with a decline in renal function.

Cita:Sci Rep 2024 Apr 16; 14 (1) : 8758.

Autor/es:Chen, Xiaoyu (a)
Hu, Yingchun (b)

institución:(a) Department of Nephropathy and Rheumatology Immunology, Jiulongpo People's Hospital, Chongqing, China.
(b) Department of Cardiovascular, Nanfang Hospital, Southern Medical University, Guangzhou, China. yingchunh2013@163.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59370-3

Percutaneous kyphoplasty through unilateral puncture on the convex side for the treatment of painful osteoporotic vertebral compression fracture with scoliosis.

Percutaneous kyphoplasty through unilateral puncture on the convex side for the treatment of painful osteoporotic vertebral compression fracture with scoliosis.

Fuente:Bmc Musculoskeletal Disorders

Extracto: Combining with the proper assessment of the pre-injured life status of patients, PKP surgery using unilateral puncture on the convex side for the treatment of P-OVCF with scoliosis can achieve safe, excellent clinical, and radiographic outcomes.

Claves:Convex side, Painful osteoporotic vertebral compression fractures, Scoliosis, percutaneous kyphoplasty, Unilateral puncture

Cita:BMC Musculoskelet Disord 2024 Apr 16; 25 (1) : 294.

Autor/es:Li, Qiuhan (a)
Wang, Song (b)

institución:(a) Department of Clinical skills center, Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, Sichuan, China.
(b) Department of Orthopedics Surgery, Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, Sichuan, China. Jasewangspine@swmu.edu.cn.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12891-024-07399-w