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Ketone body levels and its associations with cardiac markers following an acute myocardial infarction: a post hoc analysis of the EMMY trial.
Ketone body levels and its associations with cardiac markers following an acute myocardial infarction: a post hoc analysis of the EMMY trial.
Fuente:Cardiovascular Diabetology
Extracto:
This post hoc analysis showed that SGLT2i increased 3-βOHB levels after AMI
compared to placebo. Higher baseline 3-βOHB levels were inversely associated with
cardiac function at follow-up, whereas a sustained increase in 3-βOHB levels over
time improved these markers. This highlights the importance of investigating
ketone body metabolism in different post-MI phases. Although more pronounced
effect of 3-βOHB on cardiac markers was observed in the SGLT2i group, further
research is required to explore this interaction effect.
institución:(a) Interdisciplinary Metabolic Medicine Trials Unit, Medical University of Graz, Graz, Austria. (b) Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Conflicto:H.S. is on the advisory board and speaker’s bureau of by Boehringer Ingelheim, NovoNordisk, Sanofi-Aventis, Amgen, AstraZeneca, Bayer, Eli Lilly, Cancom, MSD, and Daiichi Sankyo. D.V.L. is on the advisory board and speakers’ bureau of Abiomed, AstraZeneca, Bayer, Daiichi Sankyo, Orion, Sanofi, and Servier and receives consulting fees from Recardio Inc, Bayer, TLL, Vaxxinity Inc. Other authors report no competing...
ting interests related to this study.
Diagnostic and referral pathways in patients with rare lipodystrophy and insulin-resistance syndromes: key milestones assessed from a national reference center.
Diagnostic and referral pathways in patients with rare lipodystrophy and insulin-resistance syndromes: key milestones assessed from a national reference center.
Fuente:Orphanet Journal of Rare Diseases
Extracto:
The national rare disease database provides an
important tool for assessment of care pathways in patients with lipodystrophy and
rare insulin-resistance syndromes in France. Improving knowledge to reduce
diagnostic delay is an important objective of the PRISIS reference center.
Claves:Age, Diagnosis, Diagnostic delay, Insulin-resistance, Lipodystrophy, National health database, Rare diseases, Reference center, Referral
institución:(a) Saint-Antoine Hospital, Reference Center for Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS), Department of Endocrinology, Assistance Publique-Hôpitaux de Paris (AP-HP), 184 rue du Faubourg Saint-Antoine, 75012, Paris, France. bruno.donadille@aphp.fr. (b) Saint-Antoine Hospital, Reference Center for Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS), Department of Endocrinology, Assistance Publique-Hôpitaux de Paris (AP-HP), 184 rue du Faubourg Saint-Antoine, 75012, Paris, France.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Relationship between Thyroid Feedback Quantile-based Index and cardiovascular diseases in a population with normal thyroid function: Evidence from the National Health and Nutrition Examination Survey 2007-2012.
Relationship between Thyroid Feedback Quantile-based Index and cardiovascular diseases in a population with normal thyroid function: Evidence from the National Health and Nutrition Examination Survey 2007-2012.
Fuente:Clinical Cardiology
Extracto:
The levels of TFQI are strongly connected to the prevalence of CVD,
indicating that energy metabolism may be related to the occurrence of CVD.
institución:(a) Jinan University, Guangdong, Guangzhou, China. (b) Department of Cardiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Challenges in the postsurgical recovery of cushing syndrome: glucocorticoid withdrawal syndrome.
Challenges in the postsurgical recovery of cushing syndrome: glucocorticoid withdrawal syndrome.
Fuente:Frontiers in Endocrinology
Extracto:
This mini review will discuss
the clinical characteristics, pathophysiology, and management of glucocorticoid
withdrawal syndrome while highlighting recent data in the field.
Autor/es:Zhang, Catherine D (a) Ioachimescu, Adriana G (b)
institución:(a) Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, United States. (b) Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Effects of immune checkpoint inhibitor associated endocrinopathies on cancer survival.
Effects of immune checkpoint inhibitor associated endocrinopathies on cancer survival.
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Estudio de cohortes
Extracto:
Women may have
increased risk of endocrine irAEs secondary to ICI treatment. This is the first
study to compare the effects of endocrine irAEs with non-endocrine irAEs on
survival. Development of endocrine irAEs may confer survival benefit in ICI
treatment and future, prospective studies are needed to elucidate this.
institución:(a) Department of Endocrinology, Imperial College Healthcare NHS Trust, London, United Kingdom. (b) Department of Endocrinology, Imperial College Healthcare NHS Trust, London, United Kingdom.
Conflicto:AC declares grants for consultancies/advisory boards from BMS, MSD, OncoC4, IQVIA, AstraZeneca. He also declares speaker fees from AstraZeneca, EISAI and Pierre-Fabre. DJP reports grants from GSK, BMS, and MSD (institutions) for supporting academic trials in oncology; personal payment from Wiley for Editor in Chief role unrelated to the topic of this manuscript; consulting fees from Mina Therapeutics, EISAI, H3B,...
Astra Zeneca, DaVolterra, Avamune, BMS, Roche for supporting research in oncology unrelated to topic of the manuscript; speaker's fees from Roche, BMS, EISAI, and Ewopharma unrelated to the topic of the manuscript; travel support from MSD and Bayer; and participation on advisory board for Astra Zeneca, EISAI, H3B. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Vascular complications in craniopharyngioma-resected paediatric patients: a single-center experience.
Vascular complications in craniopharyngioma-resected paediatric patients: a single-center experience.
Fuente:Frontiers in Endocrinology
Extracto:
CP patients undergoing neurosurgery are at risk of
developing DVT and vascular alterations, thus careful follow-up is mandatory. In
our study, we found that the phase of transition from central diabetes insipidus
to a syndrome of inappropriate antidiuretic hormone secretion may be a period of
significant risk for DVT occurrence. Careful vascular follow-up is mandatory in
CP-operated patients.
Claves:craniopharyngioma, deep venous thrombosis, neurosurgery, paediatric neuro-oncology, vascular complications
institución:(a) Department of Health Sciences, University of Florence, Florence, Italy. (b) Neuro-oncology Department, Meyer Children's Hospital IRCCS, Florence, Italy.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study.
The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study.
Fuente:Frontiers in Endocrinology
Extracto:
Our
study observed a causal relationship between hyperthyroidism and all-cause heart
failure. Hyperthyroidism may associate with heart failure genetically.
institución:(a) Department of Health Management, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China. (b) Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Causal Relationship between Sex Hormones and Risk of Developing Common Neurodegenerative Diseases: A Mendelian Randomization Study.
Causal Relationship between Sex Hormones and Risk of Developing Common Neurodegenerative Diseases: A Mendelian Randomization Study.
Fuente:Journal of Integrative Neuroscience
Extracto:
Elevated BT is associated
with a reduced risk of developing ALS. Further research is needed to investigate
the underlying mechanisms of action for this correlation and how it can be used
as a potential target of action to reduce the risk of developing ALS.
Claves:causal effect, mendelian randomization (MR), neurodegenerative diseases (NDs), sex hormones
Cita:J Integr Neurosci 2024 Apr 12; 23 (4) : 78.
Autor/es:Huang, Qiang (a) Li, Qiong (b)
institución:(a) Department of Neurology, The First People's Hospital of Jinzhong, 030600 Jinzhong, Shanxi, China. (b) Department of Endocrinology, The First People's Hospital of Jinzhong, 030600 Jinzhong, Shanxi, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The evaluation of goal-directed activities to promote well-being and health in heart failure: EUROIA scale.
The evaluation of goal-directed activities to promote well-being and health in heart failure: EUROIA scale.
Fuente:Journal of Patient-reported Outcomes
Tipo de trabajo:Estudio clínico
Extracto:
The
EUROIA provides a preliminary taxonomy of goal-directed activities that promote
HRQL among CHF patients independently from a current gold standard state-based
measure. CLINICAL TRIAL REGISTRATION: NCT01864369; https://classic.
CLINICALTRIALS: gov/ct2/show/NCT01864369 .
institución:(a) Behavioral Cardiology Research Unit, Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada. rob.nolan@uhn.ca. (b) Institute of Medical Science, University of Toronto Faculty of Medicine, Toronto, ON, Canada. rob.nolan@uhn.ca.
Conflicto:The authors have no relevant financial or non-financial interests to declare.
Effect of vitamin D in addition to letrozole on the ovulation rate of women with polycystic ovary syndrome
Effect of vitamin D in addition to letrozole on the ovulation rate of women with polycystic ovary syndrome
Fuente:Bmj Open
Tipo de trabajo:Estudio multicéntrico
Extracto:
TRIAL
REGISTRATION NUMBER: NCT04650880.
Claves:GYNAECOLOGY, General endocrinology, REPRODUCTIVE MEDICINE
Cita:BMJ Open 2024 Apr 29; 14 (4) : e070801.
Autor/es:Ko, Jennifer K Y (a) Yung, Sofie S F (b)
institución:(a) Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. (b) Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Geriatrics and Internal medicine, Sorlandet Hospital Arendal, Kristiansand, Agder, Norway susanne.sorensen.hernes@sshf.no. (b) Department of Clinical Sciences, University of Bergen, Bergen, Norway.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers.
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers.
Fuente:Nature Communications
Extracto:
We also demonstrate that the wider consequence of any protein-altering
intervention on well-being and morbidity is required to interpret any utility of
proteins as potential future targets for therapeutic prevention.
Cita:Nat Commun 2024 Apr 29; 15 (1) : 3621.
Autor/es:Smith-Byrne, Karl (a) Hedman, Åsa (b)
institución:(a) Cancer Epidemiology Unit, Oxford Population Health, University of Oxford, Oxford, UK. karl.smith-byrne@ndph.ox.ac.uk. (b) External Science and Innovation, Pfizer Worldwide Research, Development and Medical, Stockholm, Sweden.
Conflicto:Å.H., M.D., J.B., X.J.M. and A.M. are employees at Pfizer Inc., the remaining authors declare no competing interests.
Cognitive profile in multiple sclerosis and post-COVID condition: a comparative study using a unified taxonomy.
Cognitive profile in multiple sclerosis and post-COVID condition: a comparative study using a unified taxonomy.
Fuente:Scientific Reports
Extracto:
Further comparative studies addressing the mechanisms related
to cognitive dysfunction and fatigue may be of interest to advance the knowledge
of these disorders and develop new therapies.
Claves:COVID-19, Cognition, Fatigue, Long COVID, Multiple sclerosis
Cita:Sci Rep 2024 Apr 29; 14 (1) : 9806.
Autor/es:Delgado-Alonso, Cristina (a) Delgado-Alvarez, Alfonso (b)
institución:(a) Department of Neurology, Hospital Clínico San Carlos, Instituto de Investigacion Sanitaria "San Carlos" (IdISSC), C/Profesor Martín Lagos, 28040, Madrid, Spain. (b) Department of Neurology, Hospital Clínico San Carlos, Instituto de Investigacion Sanitaria "San Carlos" (IdISSC), C/Profesor Martín Lagos, 28040, Madrid, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Mortality and re-fracture rates in low trauma hip fracture.
Mortality and re-fracture rates in low trauma hip fracture.
Fuente:Bmc Geriatrics
Tipo de trabajo:Estudio de cohortes
Extracto:
Patients with low-trauma hip fractures have shown a high rate of mortality in the
first year. Considering the increase in the incidence of hip fractures with age,
comprehensive strategies are needed to prevent fractures caused by minor trauma
in the elderly population.
Claves:Death, Hip fracture, Incidence, One-year survival, Osteoporosis, Re-fracture
institución:(a) Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. (b) Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Diabetes and the social, biologic, and behavioral determinants of endometrial cancer in the United States.
Diabetes and the social, biologic, and behavioral determinants of endometrial cancer in the United States.
Fuente:Bmc Cancer
Extracto:
Our results revealed
the importance of adopting a comprehensive approach to the study of the
associated factors of endometrial cancer by including social, biologic, and
behavioral determinants of health. The observed social inequity in endometrial
cancer among women needs to be addressed through effective policies and changes
in social structures to advocate for a standardized healthcare system that
ensures equitable access to preventive measures and quality of care.
Claves:Behavioral risk factor Surveillance System (BRFSS), Diabetes, Endometrial cancer, Obesity, Race, Social determinants of Health, Weighted Chi-square test, Weighted logistic regression
Cita:BMC Cancer 2024 Apr 29; 24 (1) : 540.
Autor/es:Massouh, Nour (a) Jaffa, Ayad A (b)
institución:(a) Epidemiology and Population Health Department, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon. (b) Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus.
Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus.
Fuente:Cardiovascular Diabetology
Extracto:
Weight loss following treatment with liraglutide was
associated with reduced circulating levels of sCD163 when compared to the same
extent of weight loss after lifestyle changes. This might contribute to reduced
cardiometabolic risk in individuals receiving treatment with liraglutide.
Claves:GLP-1 analogue, Immune cells, Obesity, T2DM, Weight loss
institución:(a) Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway. (b) Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Endocrinology, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310052, China. (b) Department of Endocrinology, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310052, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prognosis of Methanol Poisoning in a Developing Setting.
Prognosis of Methanol Poisoning in a Developing Setting.
Fuente:Archives of Iranian Medicine
Tipo de trabajo:Estudio de cohortes
Extracto:
Besides LOC, patients
with any abnormality in their brain CT scan on admission were found to be at
higher risk of death, and patients with supratentorial edema were at risk of
longer LOS. Brain CT-scan on admission should be considered as a part of the
routine procedure during the management of methanol-poisoning.
Autor/es:Sasani, Mohammad Reza (a) Molavi Vardanjani, Hossein (b)
institución:(a) Medical Imaging Research Center, Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. (b) Department of MPH, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes.
Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes.
Fuente:Frontiers in Endocrinology
Extracto:
Physical
exercise had clinically relevant impact on the accuracy of the investigated
continuous glucose monitoring systems and their ability to accurately detect
hypoglycemia.
Claves:accuracy, continuous glucose monitoring, exercise, hypoglycemia, mean absolute relative difference, type 1 diabetes
Autor/es:Maytham, Kaisar (a) Hagelqvist, Per G (b)
institución:(a) Clinical Research, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Copenhagen, Denmark. (b) Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Conflicto:SE is currently employed by Novo Nordisk and holds stock in Novo Nordisk. UP-b has served on advisory boards for and/or received lecture fees from Novo Nordisk and Sanofi. FK has served on advisory panels at, been part of speaker’s bureaus for, served as a consultant to, and/or received research support from AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Gubra, MSD/Merck,...
k, Novo Nordisk, Sanofi, ShouTi, Zealand Pharma and Zucara. TV has served on scientific advisory panels at, been part of speaker’s bureaus for, served as a consultant to, and/or received research support from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Gilead, GSK, Mundipharma, MSD/Merck, Novo Nordisk, Sanofi, and Sun Pharmaceuticals. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.