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LINC01002 functions as a ceRNA to regulate FRMD8 by sponging miR-4324 for the development of COVID-19.
LINC01002 functions as a ceRNA to regulate FRMD8 by sponging miR-4324 for the development of COVID-19.
Fuente:Virology Journal
Extracto:
SARS-CoV-2 N protein suppressed the induction of IFN-β by regulating LINC01002
which was as a ceRNA, sponging miR-4324 and participating in the regulation of
FRMD8 mRNA. Our discovery provides new insights into early intervention therapy
and drug development on SARS-CoV-2 infection.
institución:(a) Department of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China. (b) Department of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Effectiveness of leuprolide acetate administered monthly compared to three-monthly in the treatment of central precocious puberty: evaluation at the end of treatment.
Effectiveness of leuprolide acetate administered monthly compared to three-monthly in the treatment of central precocious puberty: evaluation at the end of treatment.
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Estudio de cohortes
Extracto:
The
3-monthly treatment showed greater hormonal and growth suppression effects, but
there was no significant difference in PAH between the two groups.
Claves:3-monthly formulation, central precious puberty, effectiveness, leuprolide acetate, monthly formulation
institución:(a) Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, ;Thailand. (b) Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, ;Thailand.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
institución:(a) Department of Urology and Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China. (b) Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Newborn Screening for 6 Lysosomal Storage Disorders in China.
Newborn Screening for 6 Lysosomal Storage Disorders in China.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: In this study, the
combined birth prevalence of the 6 LSDs in Shanghai was remarkably high.
MS/MS-based newborn screening, combined with biochemical and molecular genetic
analysis, successfully identified and characterized newborns who were
screen-positive, which may assist with parental counseling and management
decisions.
Cita:JAMA Netw Open 2024 May 1; 7 (5) : e2410754.
Autor/es:Chang, Siyu (a) Zhan, Xia (b)
institución:(a) Department of Pediatric Endocrinology and Genetics, Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (b) Department of Pediatric Endocrinology and Genetics, Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Conflicto:Conflict of Interest Disclosures: Dr Maegawa reported receiving grants from the National Institutes of Health, Takeda Pharmaceuticals, JCR Pharmaceuticals Co, Sanofi Inc, and Freeline Therapeutics and consulting fees from Lysosomal and Rare Disorders Research and Treatment Center during the conduct of the study. No other disclosures were reported.
The unique association between the level of plateletcrit and the prevalence of diabetic kidney disease: a cross-sectional study.
The unique association between the level of plateletcrit and the prevalence of diabetic kidney disease: a cross-sectional study.
Fuente:Frontiers in Endocrinology
Extracto:
PCT demonstrates a weak diagnostic value for T2DM patients
at risk of developing DKD and experiencing proteinuria, and PLT shows a similarly
modest diagnostic utility for detecting proteinuria. These insights contribute to
a deeper understanding of the complex dynamics involved in DKD. Additionally,
incorporating these markers into routine clinical assessments could enhance risk
stratification, facilitating early interventions and personalized management
strategies.
institución:(a) Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. (b) Beijing University of Chinese Medicine, Beijing, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
institución:(a) Institute of Molecular Biology and Pathology, National Research Council (CNR), c/o Sapienza University of Rome, 00185 Rome, Italy. (b) Obesity and Lipodystrophy Center, Endocrinology Unit, University Hospital of Pisa, 56124 Pisa, Italy.
Conflicto:G.C. has received fees for consulting and/or received travel funds or participated in studies from the following companies, which are involved with lipodystrophy and/or diabetes: Aegerion/Amryt Pharmaceuticals, Novo-Nordisk, and Rhythm Pharmaceuticals. S.M. (Silvia Magno) and C.P. have received travel funds from Amryt Pharmaceuticals, which is involved with lipodystrophy. F.S. has worked as a consultant, participated in studies, and/or received travel...
funds from the following companies, which are involved with lipodystrophy and/or diabetes: Aegerion/Amryt, Novo Nordisk, Lilly, Bruno Pharma, and Pfizer. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Diet and Meal Pattern Determinants of Glucose Levels and Variability in Adults with and without Prediabetes or Early-Onset Type 2 Diabetes: A Pilot Study.
Diet and Meal Pattern Determinants of Glucose Levels and Variability in Adults with and without Prediabetes or Early-Onset Type 2 Diabetes: A Pilot Study.
Fuente:Nutrients
Extracto:
Future research
should evaluate causality with controlled diets.
Autor/es:Santos-Báez, Leinys S (a) Díaz-Rizzolo, Diana A (b)
institución:(a) Division of Endocrinology, Nutrition Obesity Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA. (b) Division of Endocrinology, Nutrition Obesity Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Triglyceride to HDL Cholesterol Ratio for the Identification of MASLD in Obesity: A Liver Biopsy-Based Case-Control Study.
Triglyceride to HDL Cholesterol Ratio for the Identification of MASLD in Obesity: A Liver Biopsy-Based Case-Control Study.
Fuente:Nutrients
Extracto:
In conclusion,
although an elevated TG/HDL-C ratio can be found in patients with MASLD, this
marker did not improve the detection of MASLD in our study population, compared
with either serum TG or HDL-C.
Autor/es:Martínez-Montoro, José Ignacio (a) Martínez-Sánchez, María Antonia (b)
institución:(a) Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Faculty of Medicine, University of Malaga, 29010 Malaga, Spain. (b) Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
The aim is to ensure early treatment
and avoid life-threatening complications.
Claves:ACTH-dependent, Pheochromocytoma, case report, paraneoplastic Cushing´s syndrome
Cita:Pan Afr Med J 2024; 47 : 88.
Autor/es:Rifai, Kaoutar (a) Toulali, Fatima (b)
institución:(a) Service d'Endocrinologie et Maladies Métaboliques, Centre Hospitalo-Universitaire Ibn Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V Souissi, Rabat, Maroc. (b) Service d'Endocrinologie et Maladies Métaboliques, Centre Hospitalo-Universitaire Ibn Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V Souissi, Rabat, Maroc.
Conflicto:Les auteurs ne déclarent aucun conflit d´intérêts.
Extracto:
We will look at topics such as neonatal
anthropometry, thyroid issues, adrenal problems, hypogonadism, bone metabolism
abnormalities, metabolic syndrome resulting from severe obesity caused by
hyperphagia, deficiencies in the GH/IGF-1 axis, and the corresponding responses
to treatment.
Claves:Prader-Willi syndrome (PWS), bone metabolism, genotype-phenotype correlation, growth hormone (GH), hypogonadism, metabolic syndrome, thyroid, type 2 diabetes
institución:(a) Department of Medical and Surgical Sciences for Mother, Children and Adults, Pediatric Unit, University of Modena and Reggio Emilia, Modena, Italy. (b) Department of Pediatrics, University of L'Aquila, L'Aquila, Italy.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Autor/es:Jabbar Al-Rikabi, Saad Ayyal (a) Etemadi, Ali (b)
institución:(a) Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. (b) Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The prevention of adverse pregnancy outcomes by periodontal treatment during pregnancy (PROBE) intervention study-A controlled intervention study: Protocol paper.
The prevention of adverse pregnancy outcomes by periodontal treatment during pregnancy (PROBE) intervention study-A controlled intervention study: Protocol paper.
Fuente:Plos One
Tipo de trabajo:Revisión
Extracto:
CLINICAL TRIALS REGISTRATION: The study was registered on
clinicaltrials.gov (NCT06110143).
institución:(a) The Research Unit for Dietary Studies, The Parker Institute, Copenhagen University Hospital, Copenhagen, Denmark. (b) The Research Unit for Dietary Studies, The Parker Institute, Copenhagen University Hospital, Copenhagen, Denmark.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of neutrophil-lymphocyte ratio with all-cause and cardiovascular mortality in US adults with diabetes and prediabetes
Association of neutrophil-lymphocyte ratio with all-cause and cardiovascular mortality in US adults with diabetes and prediabetes
Fuente:Bmc Endocrine Disorders
Tipo de trabajo:Estudio de cohortes
Extracto:
The findings of this
prospective cohort study conducted in the US indicate a positive association of
elevated NLR levels with heightened risks of overall and cardiovascular mortality
among adults with diabetes and prediabetes. However, potential confounding
factors for NLR and the challenge of monitoring NLR's fluctuations over time
should be further focused.
institución:(a) Department of Endocrinology and Metabolism, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, 510220, Guangdong, China. (b) State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Low ankle-brachial index is associated with higher cardiovascular mortality in individuals with nonalcoholic fatty liver disease.
Low ankle-brachial index is associated with higher cardiovascular mortality in individuals with nonalcoholic fatty liver disease.
Fuente:European Journal of Medical Research
Tipo de trabajo:Estudio de cohortes
Extracto:
Low ABI is independently
associated with higher cardiovascular mortality in NAFLD cases. This correlation
remains significant even in the absence of pre-existing cardiovascular disease or
diabetes.
institución:(a) Department of Geriatric Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China. (b) Department of Geriatric Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
institución:(a) Lipid and Vascular Risk Unit, Department of Endocrinology and Nutrition, Hospital del Mar, 08003 Barcelona, Spain. (b) School of Medicine, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome.
A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome.
Fuente:International Journal of Molecular Sciences
Extracto:
There were
progressive eGFR decrements for PCOS-nonGH, PCOS-GH, and PCOS-SGH in the
follow-up period which, in the presence of additional factors affecting renal
function, may be clinically important in the development of CKD in PCOS.
Autor/es:Butler, Alexandra E (a) Lubbad, Walaa (b)
institución:(a) Research Department, Royal College of Surgeons in Ireland Bahrain, Busaiteen, Adliya P.O. Box 15503, Bahrain. (b) Research Department, Royal College of Surgeons in Ireland Bahrain, Busaiteen, Adliya P.O. Box 15503, Bahrain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases.
JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases.
Fuente:International Journal of Molecular Sciences
Extracto:
Hence, JMJD6 autoantibodies may
reflect inflammation, thereby serving as a potential biomarker for diagnosing
specific inflammation-related diseases, including stroke, AMI, DM, and cancers,
and for prediction of the prognosis in patients with EC.
institución:(a) Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. (b) Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Conflicto:This present study was performed in collaboration with Fujikura Kasei Co., Ltd., and Hideyuki Kuroda is an employee of Fujikura Kasei Co., Ltd. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Extracto:
This
consensus statement establishes a standardized approach to nutritional support,
aiming to optimize outcomes in pediatric cancer patients.
Claves:childhood cancer, nutrition, nutritional support
institución:(a) Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland. (b) Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The Impact of a Nutritional Intervention on Glycemic Control and Cardiovascular Risk Markers in Type 2 Diabetes.
The Impact of a Nutritional Intervention on Glycemic Control and Cardiovascular Risk Markers in Type 2 Diabetes.
Fuente:Nutrients
Tipo de trabajo:Estudio clínico
Extracto:
The individualized nutritional
intervention improved eating habits, anthropometric, biochemical, and
cardiovascular markers in T2D over 12 months, with sustained results during
follow-up. The dietary plan inspired by the Mediterranean and DASH diets
demonstrated good adaptation to the Brazilian food culture and the patients'
socioeconomic contexts. Consistent monitoring and personalized nutritional
management are essential for optimizing long-term outcomes. However, more
clinical trials are necessary in order to optimize the level of evidence for
longitudinal interventions.
institución:(a) Department of Hypertension, State Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil. (b) Department of Hypertension, State Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Effects of Dietary Carbohydrate Concentration and Glycemic Index on Blood Glucose Variability and Free Fatty Acids in Individuals with Type 1 Diabetes.
Effects of Dietary Carbohydrate Concentration and Glycemic Index on Blood Glucose Variability and Free Fatty Acids in Individuals with Type 1 Diabetes.
Fuente:Nutrients
Extracto:
Different diets
may increase the risk of cardiovascular diseases by affecting GI, FFA, and blood
glucose levels.
institución:(a) Department of Nutrition and Dietetics, Faculty of Health Sciences, İstanbul Beykent University, Istanbul 34520, Turkey. (b) Institute of Health Sciences, Acibadem Mehmet Ali Aydınlar University, Istanbul 34450, Turkey.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación