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Birthweight trends and their explanatory factors in Hungary between 1999 and 2018: an analysis of the Hungarian Tauffer registry.
Birthweight trends and their explanatory factors in Hungary between 1999 and 2018: an analysis of the Hungarian Tauffer registry.
Fuente:Reproductive Health
Extracto:
Our findings of an increasing birthweight
trend (mostly related to the aging of the mothers) in 1999-2008 may forecast an
increased risk of cardiometabolic diseases in offsprings born in this period. In
contrast, the decreasing birthweight trends after 2008 may reflect some
beneficial effects on perinatal morbidity. However, the long-term effect cannot
be predicted, as the trend is mostly explained by the shorter pregnancies.
institución:(a) Department of Gynaecology and Family Planning, Istenhegyi GeneDiagnostic Center, Budapest, Hungary. (b) Department of Obstetrics and Gynaecology, Tolna County Balassa János Hospital, Szekszárd, Hungary.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
CAPN2 correlates with insulin resistance states in PCOS as evidenced by multi-dataset analysis.
CAPN2 correlates with insulin resistance states in PCOS as evidenced by multi-dataset analysis.
Fuente:Journal of Ovarian Research
Tipo de trabajo:Consenso
Extracto:
This study
highlights the pivotal role of CAPN2 in insulin resistance within the context of
PCOS, emphasizing its importance as both a critical biomarker and a potential
therapeutic target. By identifying CAPN2, our research contributes to the
expanding evidence surrounding the CAPN family, particularly CAPN10, in insulin
resistance studies beyond PCOS. This work enriches our understanding of the
mechanisms underlying insulin resistance, offering insights that bridge gaps in
the current scientific landscape.
institución:(a) Faculty of Life science and Technology, Kunming University of Science and Technology, Kunming, China. luoxi_ypfph@163.com. (b) Medical school, Kunming University of Science and Technology, Kunming, China. luoxi_ypfph@163.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Different Dosages of Progesterone in Luteal Phase Support Reflect Varying Endometrial microRNA Expression in Frozen Embryo Transfer Cycles.
Different Dosages of Progesterone in Luteal Phase Support Reflect Varying Endometrial microRNA Expression in Frozen Embryo Transfer Cycles.
Fuente:International Journal of Molecular Sciences
Extracto:
Given the evident variation in endometrial status and serum
progesterone levels among individuals, analyzing miRNA expression profiles may
address the challenge of inter-personal variation in serum progesterone levels,
to deliver more personalized dosage adjustments and facilitate personalized
luteal phase support in IVF.
Claves:embryo transfer, endometrial receptivity, in vitro fertilization, miRNAs, progesterone
Cita:Int J Mol Sci 2024 Mar 25; 25 (7)
Autor/es:Yang, Wen-Jui (a) Lu, Farn (b)
institución:(a) Department of Infertility and Reproductive Medicine, Taiwan IVF Group Center, Hsinchu 30274, Taiwan. (b) Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
Conflicto:Authors Cai-Yun Wang, Jun-Jie Hong, Tiffany Wang, and Pok Eric Yang were employed by the company Inti Labs in Hsinchu City, Taiwan. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
institución:(a) Institute of Mechanics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria. (b) Institute of Mechanics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Conflicto:The authors declare no potential conflicts of interest.
MicroRNA Expression Profiles in Human Samples and Cell Lines Revealed Nine miRNAs Associated with Cisplatin Resistance in High-Grade Serous Ovarian Cancer.
MicroRNA Expression Profiles in Human Samples and Cell Lines Revealed Nine miRNAs Associated with Cisplatin Resistance in High-Grade Serous Ovarian Cancer.
Fuente:International Journal of Molecular Sciences
Extracto:
These nine miRNAs could be used
as targets for therapy and as markers of cisplatin response.
Claves:cisplatin, high-grade serous ovarian cancer, miRNA inhibitors, miRNAs, ovarian cancer
institución:(a) Department of Biochemistry, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA. (b) Comprehensive Cancer Center, University of Puerto Rico, San Juan, PR 00936, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Stress-Induced Changes in Nucleocytoplasmic Localization of Crucial Factors in Gene Expression Regulation.
Stress-Induced Changes in Nucleocytoplasmic Localization of Crucial Factors in Gene Expression Regulation.
Fuente:International Journal of Molecular Sciences
Extracto:
Understanding these intricate
molecular mechanisms could inform interventions to improve neonatal health
outcomes and mitigate adverse effects of toxic exposure during pregnancy.
Claves:CNOT1 (carbon catabolite repression-negative on TATA-less), PARP-1 (poly-(ADP-ribose) polymerase-1), RPB1 (the largest subunit of RNA polymerase II enzyme), blood vessels, fetal development, maternal smoking, rescue mechanism
Cita:Int J Mol Sci 2024 Mar 31; 25 (7)
Autor/es:Khamit, Ali (a) Chakraborty, Payal (b)
institución:(a) Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, H-6701 Szeged, Hungary. (b) Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, H-6701 Szeged, Hungary.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
PFDN4 as a Prognostic Marker Was Associated with Chemotherapy Resistance through CREBP1/AURKA Pathway in Triple-Negative Breast Cancer.
PFDN4 as a Prognostic Marker Was Associated with Chemotherapy Resistance through CREBP1/AURKA Pathway in Triple-Negative Breast Cancer.
Fuente:International Journal of Molecular Sciences
Extracto:
This study provides insightful evidence for
the value of PFDN4 in poor prognosis and chemotherapy resistance in breast cancer
patients.
Claves:PFDN4, chemotherapy resistance, triple-negative breast cancer
Cita:Int J Mol Sci 2024 Mar 31; 25 (7)
Autor/es:Wang, Shih-Ho (a) Yeh, Cheng-Hsi (b)
institución:(a) Division of General Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan. (b) Division of General Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The Predictive Role of Serum Lipid Levels, p53 and ki-67, According to Molecular Subtypes in Breast Cancer: A Randomized Clinical Study.
The Predictive Role of Serum Lipid Levels, p53 and ki-67, According to Molecular Subtypes in Breast Cancer: A Randomized Clinical Study.
Fuente:International Journal of Molecular Sciences
Extracto:
Tumor grading, Ki-67, p53, and LN
metastases have a predictive nature for OS, while tumor size, tumor grading, and
Ki-67 > 14, and p53+ are predictive for DFS.
institución:(a) IInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania. (b) X Department of General Surgery, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma.
Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma.
Fuente:International Journal of Molecular Sciences
Extracto:
As TMEM230 regulates infiltration,
vascularization, and tissue destruction capacities of diverse cell types in the
brain, TMEM230 is a promising cancer target for heterogeneous HGG tumors.
institución:(a) Institute of Biomedical Technologies, National Research Council of Italy, 20054 Milan, Italy. (b) Institute of Biomedical Technologies, National Research Council of Italy, 20054 Milan, Italy.
Conflicto:The authors declare Patent Application US16/482,455 may represent a potential conflict of interest.
Vitamin D Supplementation for Patients with Dysmenorrhoea
Vitamin D Supplementation for Patients with Dysmenorrhoea
Fuente:Nutrients
Tipo de trabajo:Metanálisis
Extracto:
In conclusion, although substantial heterogeneity
persists, vitamin D supplementation decreased pain intensity in patients with
dysmenorrhea, especially in those with primary dysmenorrhoea.
institución:(a) Family Medicine Department, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan. (b) Department of Obstetrics and Gynecology, National Taiwan University Hospital Yunlin Branch, Yunlin 640203, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Comprehensive analysis of the interaction of antigen presentation during anti-tumour immunity and establishment of AIDPS systems in ovarian cancer.
Comprehensive analysis of the interaction of antigen presentation during anti-tumour immunity and establishment of AIDPS systems in ovarian cancer.
Fuente:Journal of Cellular and Molecular Medicine
Extracto:
The antigen-presenting model obtained by the RSF + Lasso method has the
best C-INDEX, which plays a key role in developing antigen-presenting targeted
drugs in ovarian cancer and improving the treatment outcome of patients.
Claves:AIDPS systems, anti‐tumour immunity, bioinformatics, machine learning, ovarian cancer
Cita:J Cell Mol Med 2024 Apr; 28 (8) : e18309.
Autor/es:Sun, Wenhuizi (a) Xu, Ping (b)
institución:(a) Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. (b) Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Conflicto:The authors confirm that there are no commercial or financial relationships that could be perceived as a potential conflict of interest with the research conducted.
institución:(a) Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. (b) Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Conflicto:There are no competing financial or nonfinancial interests regarding this work.
Sudden Infant Death Syndrome (SIDS): State of the Art and Future Directions.
Sudden Infant Death Syndrome (SIDS): State of the Art and Future Directions.
Fuente:International Journal of Medical Sciences
Extracto:
Likewise, an attempt will be made to
analyze the causes and pathological mechanisms associated with SIDS, as well as
potential approaches and future paths that must be followed to reduce the impact
of this condition.
Autor/es:Fraile-Martinez, Oscar (a) García-Montero, Cielo (b)
institución:(a) Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain. (b) Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
Conflicto:Competing Interests: The authors have declared that no competing interest exists.
Prediction of outcomes for rescue cerclage in cervical insufficiency: A multicenter retrospective study.
Prediction of outcomes for rescue cerclage in cervical insufficiency: A multicenter retrospective study.
Fuente:International Journal of Medical Sciences
Extracto:
Conclusion: The developed logistic regression
models offer a valuable tool for the prognostic assessment of patients undergoing
rescue cerclage, enabling informed clinical decision-making.
institución:(a) Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 06591 Seoul, Republic of Korea. (b) Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary's Hospital College of Medicine, The Catholic University of Korea, 06591 Seoul, Republic of Korea.
Conflicto:Competing Interests: The authors have declared that no competing interest exists.
AI-Generated Draft Replies Integrated Into Health Records and Physicians' Electronic Communication.
AI-Generated Draft Replies Integrated Into Health Records and Physicians' Electronic Communication.
Fuente:Jama Network Open
Extracto:
AND RELEVANCE: In this QI study, GenAI-drafted
replies were associated with significantly increased read time, no change in
reply time, significantly increased reply length, and some perceived benefits.
Rigorous empirical tests are necessary to further examine GenAI's performance.
Future studies should examine patient experience and compare multiple GenAIs,
including those with medical training.
Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e246565.
Autor/es:Tai-Seale, Ming (a) Baxter, Sally L (b)
institución:(a) Department of Family Medicine, University of California San Diego School of Medicine, La Jolla. (b) Department of Medicine, University of California San Diego School of Medicine, La Jolla.
Conflicto:Conflict of Interest Disclosures: Dr Baxter reported receiving nonfinancial support from Topcon and Optomed outside the submitted work. Mr Desai reported receiving personal fees from Pearl Health outside the submitted work. No other disclosures were reported.
Perinatal outcomes after admission with COVID-19 in pregnancy
Perinatal outcomes after admission with COVID-19 in pregnancy
Fuente:Nature Communications
Tipo de trabajo:Estudio de cohortes
Extracto:
We provide strong evidence to recommend continuous
surveillance of pregnancy outcomes in future pandemics and to continue to
recommend SARS-CoV-2 vaccination in pregnancy to protect both mothers and babies.
Cita:Nat Commun 2024 Apr 15; 15 (1) : 3234.
Autor/es:Engjom, Hilde Marie (a) Ramakrishnan, Rema (b)
institución:(a) National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK. (b) Division of Physical and Mental Health, Norwegian Institute of Public Health, 5015, Bergen, Norway.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Exclusive expression of KANK4 promotes myofibroblast mobility in keloid tissues.
Exclusive expression of KANK4 promotes myofibroblast mobility in keloid tissues.
Fuente:Scientific Reports
Extracto:
Our results suggest that the KANK4-mediated
increase in myofibroblast mobility contributes to keloid pathogenesis.
Cita:Sci Rep 2024 Apr 16; 14 (1) : 8725.
Autor/es:Oishi, Mayumi (a) Shinjo, Keiko (b)
institución:(a) Department of Plastic and Reconstructive Surgery, Aichi Children's Health and Medical Center, Obu, Japan. (b) Department of Plastic and Reconstructive Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8560, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Average log change rate of pretreatment squamous cell carcinoma antigen after concurrent chemoradiotherapy in stage IIIC1 cervical squamous cell carcinoma.
Average log change rate of pretreatment squamous cell carcinoma antigen after concurrent chemoradiotherapy in stage IIIC1 cervical squamous cell carcinoma.
Fuente:Scientific Reports
Extracto:
Risk stratification using both pretreatment SCC-Ag levels and / may predict
treatment outcomes of patients with stage IIIC1 SCC.
Cita:Sci Rep 2024 Apr 15; 14 (1) : 8710.
Autor/es:Cho, Oyeon (a) Chun, Mison (b)
institución:(a) Gynecologic Cancer Center, Department of Radiation Oncology, Ajou University of School of Medicine, 164, World cup-ro, Yeongtong-gu, Suwon, 16499, Korea. oyeoncho@ajou.ac.kr. (b) Gynecologic Cancer Center, Department of Radiation Oncology, Ajou University of School of Medicine, 164, World cup-ro, Yeongtong-gu, Suwon, 16499, Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Characterization of genital chlamydia trachomatis infection among women attending infertility and gynecology clinics in Hunan, China.
Characterization of genital chlamydia trachomatis infection among women attending infertility and gynecology clinics in Hunan, China.
Fuente:Bmc Infectious Diseases
Extracto:
Our results revealed a high prevalence, particularly seroprevalence, of C.
trachomatis among women with infertility. Furthermore, we found an association
between C. trachomatis omp1 sense mutations and CIN. Therefore, C. trachomatis
serves as a risk factor for CIN.
institución:(a) Hengyang Medical School, The Affiliated Chenzhou Hospital, Chenzhou No. 1 People's Hospital, University of South China, Chenzhou, China. (b) Hengyang Medical School, The Affiliated Chenzhou Hospital, Chenzhou No. 1 People's Hospital, University of South China, Chenzhou, China.
Conflicto:The authors have no competing interests to declare.
Evaluation of incision healing status after transverse uterine fundal incision for cesarean delivery and postoperative pregnancy: a ten-year single-center retrospective study.
Evaluation of incision healing status after transverse uterine fundal incision for cesarean delivery and postoperative pregnancy: a ten-year single-center retrospective study.
Fuente:Bmc Pregnancy and Childbirth
Extracto:
Certain criteria,
including an appropriate suture method, delayed conception for at least 12
months, evaluation of the TUFI scar at 12 months postoperatively, and cautious
postoperative management, must all be met in order to approve a post-TUFI
pregnancy. Possible scar condition criteria for permitting a subsequent pregnancy
could include the scar thickness being ≥ 70% of the surrounding area on MRI
scans, at least partially resumed blood flow, and no abnormalities on the
sonohysterogram. TRIAL REGISTRATION: Retrospectively registered.
institución:(a) Department of Obstetrics and Gynecology, Takatsuki General Hospital, Takatsuki, Japan. (b) Department of Obstetrics and Gynecology, Takatsuki General Hospital, Takatsuki, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación