Prevalence and perceptions of flavour capsule cigarettes among adults who smoke in Brazil, Japan, Republic of Korea, Malaysia and Mexico: findings from the ITC surveys.

Prevalence and perceptions of flavour capsule cigarettes among adults who smoke in Brazil, Japan, Republic of Korea, Malaysia and Mexico: findings from the ITC surveys.

Fuente:Bmj Open

Extracto: Our study documented the high prevalence of FCCs in some countries, pointing to the need to develop and implement regulatory strategies to control these attractive products.

Claves:Cross-Sectional Studies, EPIDEMIOLOGY, Health Equity, PUBLIC HEALTH

Cita:BMJ Open 2024 Apr 19; 14 (4) : e083080.

Autor/es:Kyriakos, Christina N (a)
Erinoso, Olufemi (b)

institución:(a) Department of Primary Care and Public Health, Imperial College London, London, UK c.kyriakos20@imperial.ac.uk.
(b) University of Nevada Reno, Reno, Nevada, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-083080

Skeletal, dentoalveolar and soft tissue changes after stabilization splint treatment for patients with temporomandibular joint disorders.

Skeletal, dentoalveolar and soft tissue changes after stabilization splint treatment for patients with temporomandibular joint disorders.

Fuente:Bmc Oral Health

Extracto: SS therapy resulted in significant vertical skeletal and dentoalveolar changes that were manifested mainly by facial height ratio, mandibular and occlusal plane changes, and to a lesser extent, significant anteroposterior skeletal, dentoalveolar, and soft tissue changes in the form of mandibular position, increased overjet and a more retrusive lower lip. These changes should be considered during patients' selection prior to initiating SS therapy.

Claves:Cone-beam computed tomography, Dentoalveolar, Skeletal, Stabilization splint, Temporomandibular joint disorders

Cita:BMC Oral Health 2024 Apr 20; 24 (1) : 479.

Autor/es:Al-Hadad, Saba Ahmed (a)
Ahmed, Madiha Mohammed Saleh (b)

institución:(a) Department of Stomatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.
(b) Department of Orthodontics and Dentofacial Orthopedics, Faculty of Dentistry, Ibb University, IBB, Republic of Yemen.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12903-024-04260-3

Comparison of self-esteem and quality of life in 8-12-year-old children with ADHD with and without learning disorders.

Comparison of self-esteem and quality of life in 8-12-year-old children with ADHD with and without learning disorders.

Fuente:Bmc Psychology

Extracto: Considering the relatively high probability of co-occurrence of ADHD and learning disorders, if one of them is diagnosed in a child, it is possible to look for other disorders in the child in order to avoid the more severe negative effects that this co-occurrence can have on the child by diagnosing it as soon as possible.

Claves:ADHD, Children, Learning disorders, Quality of life, Self-esteem

Cita:BMC Psychol 2024 Apr 20; 12 (1) : 218.

Autor/es:Massoodi, Armon (a)
Moudi, Sussan (b)

institución:(a) Assistant Professor of child and adolescent Psychiatry, Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR, Iran. armonmassodi2@gmail.com.
(b) Associate Professor of Psychiatry, Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s40359-024-01732-7

Self-compassion and grit mediated the relation between mindfulness and mind wandering based on cross-sectional survey data.

Self-compassion and grit mediated the relation between mindfulness and mind wandering based on cross-sectional survey data.

Fuente:Scientific Reports

Extracto: The cross-sectional findings provided initial evidence of mediation by showing that mindfulness and mind wandering were related through self-compassion and grit.

Claves:Grit, Meditators, Mind wandering, Mindfulness, Self-compassion

Cita:Sci Rep 2024 Apr 20; 14 (1) : 9090.

Autor/es:Cheung, Rebecca Y M (a)
Djekou, Lemuela (b)

institución:(a) School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK. rebecca.cheung@reading.ac.uk.
(b) School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58395-y

Pain experiences of marginalized children in the emergency department

Pain experiences of marginalized children in the emergency department

Fuente:Plos One

Tipo de trabajo:Revisión

Extracto: Results of this scoping review will inform subsequent quantitative and qualitative studies regarding pain experiences and treatment of marginalized children in the ED.

Cita:PLoS One 2024; 19 (4) : e0296518.

Autor/es:Kammerer, Elise (a)
Elliott, Sarah A (b)

institución:(a) Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
(b) Alberta Research Centre for Health Evidence, Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0296518

Exploring adolescent mental health during the COVID-19 crisis - strengths and difficulties.

Exploring adolescent mental health during the COVID-19 crisis - strengths and difficulties.

Fuente:Frontiers in Public Health

Extracto: Our study contributes to understanding the psychosocial impact of the COVID-19 pandemic on German adolescents. Compared to other symptoms, we observed a particular worsening in "Emotional Symptoms" based on our data. Despite the moderate correlation between parental and self-reported evaluations, there appears to be a certain discrepancy in the perception of adolescent quality of life. Therefore, it seems prudent to assess both the external and self-reported evaluations and amalgamate the results from both parties to obtain a comprehensive problem profile of the individual. These findings underscore the importance of using country-specific cutoff values and reaffirm the utility of the SDQ as a valuable assessment tool, even within the unique circumstances posed by a pandemic.

Claves:COVID-19 pandemic, SDQ-questionnaire, adolescents, crisis, mental health, mental health assessment

Cita:Front Public Health 2024; 12 : 1357766.

Autor/es:Loy, Johanna K (a)
Klam, Janina (b)

institución:(a) Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
(b) Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2024.1357766

Exploring women's experiences of care during hospital childbirth in rural Tanzania: a qualitative study.

Exploring women's experiences of care during hospital childbirth in rural Tanzania: a qualitative study.

Fuente:Bmc Pregnancy and Childbirth

Extracto: The experiences of care described by women during childbirth varied from one woman to the other. Expectations towards empathic care seemed low, and the little interaction women had during labour and birth was therefore often appreciated and mistreatment normalized. Potential co-designed interventions should include strategies to (i) empower women to voice their needs during childbirth and (ii) support healthcare providers to have competencies to be more responsive to women's needs.

Claves:Birth companionship, Childbirth, Co-design, Quality improvement, Respectful care, Rural health services, Tanzania, Women’s experiences

Cita:BMC Pregnancy Childbirth 2024 Apr 19; 24 (1) : 290.

Autor/es:Metta, Emmy (a)
Unkels, Regine (b)

institución:(a) Department of Behavioural Sciences, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
(b) Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12884-024-06396-0

Risk factors of reattempt among suicide attempters in South Korea

Risk factors of reattempt among suicide attempters in South Korea

Fuente:Plos One

Tipo de trabajo:Estudio de cohortes

Extracto: Various risk factors including demographics, clinical characteristics, and medications should be considered to prevent suicide reattempts among suicide attempters, and patients with depressive disorder should be monitored more closely.

Cita:PLoS One 2024; 19 (4) : e0300054.

Autor/es:Kim, Min Ji (a)
Yang, Jeong Hun (b)

institución:(a) Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
(b) Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.

Conflicto:I have read the journal’s policy and the authors of this manuscript have the following competing interests: MJ Koh, Y Kim, and B Lee are employees of Janssen Korea Ltd. YM Ahn declared a research fund from Janssen Korea Ltd. and participated in speakers’ events in Janssen Korea Ltd, Lundbeck Korea Co., Ltd., and Korea Otsuka Pharmaceutical. The remaining authors... hors have nothing to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300054

Joint transformer architecture in brain 3D MRI classification: its application in Alzheimer's disease classification.

Joint transformer architecture in brain 3D MRI classification: its application in Alzheimer's disease classification.

Fuente:Scientific Reports

Extracto: Our proposed method offers researchers an approach to more efficient early clinical diagnosis and interventions.

Claves:Alzheimer’s disease, MRI, Sequence classification, Transfer learning, Vision transformer

Cita:Sci Rep 2024 Apr 18; 14 (1) : 8996.

Autor/es:Alp, Sait (a)
Akan, Taymaz (b)

institución:(a) Department of Computer Engineering, Erzurum Technical University, Erzurum, Turkey.
(b) Division of Clinical Informatics, Department of Medicine, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, 71103-4228, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59578-3

Moderated moderation modelling of subjective social status, pocket money and depressive symptoms of university students in Ghana.

Moderated moderation modelling of subjective social status, pocket money and depressive symptoms of university students in Ghana.

Fuente:Frontiers in Public Health

Extracto: The study findings call on stakeholders in education to explore funding opportunities and to examine ways of empowering parents (financially) to adequately support the students. Health educationists and promoters, including psychologists, school counsellors and parents could compliment these efforts by helping to train and empower students through self-regulation or management skills to help improve their well-being. Continuous efforts are required to improve the financial status and mental health of students.

Claves:adulthood, mental health, pocket money, social status, university students

Cita:Front Public Health 2024; 12 : 1325441.

Autor/es:Quansah, Frank (a)
Srem-Sai, Medina (b)

institución:(a) Department of Educational Foundations, University of Education, Winneba, Ghana.
(b) Department of Health, Physical Education, Recreation and Sports, University of Education, Winneba, Ghana.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2024.1325441

Sex differences in cognitive decline among middle-aged and older adults

Sex differences in cognitive decline among middle-aged and older adults

Fuente:Age and Ageing

Tipo de trabajo:Estudio de cohortes

Extracto: However, we identified heterogeneity across birth cohorts and regions.

Claves:cognition, cognitive decline, dementia, older people, sex differences

Cita:Age Ageing 2024 Apr 1; 53 (4)

Autor/es:Wolfova, Katrin (a)
Frycova, Barbora (b)

institución:(a) Department of Epidemiology, Second Faculty of Medicine, Charles University, Prague 150 06, Czech Republic.
(b) Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague 100 00, Czech Republic.

Conflicto:None.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1093/ageing/afae078

A longitudinal cohort study on the use of health and care services by older adults living at home with/without dementia before and during the COVID-19 pandemic: the HUNT study.

A longitudinal cohort study on the use of health and care services by older adults living at home with/without dementia before and during the COVID-19 pandemic: the HUNT study.

Fuente:Bmc Health Services Research

Extracto: Older adults experienced an immediate reduction in the use of health and care services, other than GP contacts, during the first wave of the COVID-19 pandemic. Within primary care services, people with dementia demonstrated a more pronounced reduction than that observed in people without dementia; otherwise, the variations related to age and dementia status were small. Both groups returned to services levels similar to those during the pre-pandemic period within one year after the lockdown. The increase in GP contacts may indicate a need to reallocate resources to primary health services during future pandemics. TRIAL REGISTRATION: The study is registered at ClinicalTrials.gov, with the identification number NCT04792086.

Claves:COVID-19, Dementia, Health care services, Longitudinal cohort study, Older adults

Cita:BMC Health Serv Res 2024 Apr 19; 24 (1) : 485.

Autor/es:Ibsen, Tanja Louise (a)
Strand, Bjørn Heine (b)

institución:(a) The Norwegian National Centre for Ageing and Health (Ageing and Health), Vestfold Hospital Trust, Tønsberg, Norway. tanja.ibsen@aldringoghelse.no.
(b) The Norwegian National Centre for Ageing and Health (Ageing and Health), Vestfold Hospital Trust, Tønsberg, Norway.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12913-024-10846-y

Stability of transcranial magnetic stimulation electroencephalogram evoked potentials in pediatric epilepsy.

Stability of transcranial magnetic stimulation electroencephalogram evoked potentials in pediatric epilepsy.

Fuente:Scientific Reports

Extracto: This study serves as a critical starting point, demonstrating the feasibility of designing efficient TMS-EEG studies that use a relatively small number of pulses to study pediatric epilepsy and potentially other pediatric groups.

Cita:Sci Rep 2024 Apr 20; 14 (1) : 9045.

Autor/es:She, Xiwei (a)
Nix, Kerry C (b)

institución:(a) Department of Neurology, Stanford University, Stanford, CA, USA.
(b) Department of Neurology, Stanford University, Stanford, CA, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59468-8

Digital quantification of the MMSE interlocking pentagon areas: a three-stage algorithm.

Fuente:Scientific Reports

Extracto: The QIP algorithm can serve as a useful tool for enhancing the scoring of performance in the PCT.

Claves:Aging, Mini-mental state examination, Pentagon copying test, Perceptual speed

Cita:Sci Rep 2024 Apr 19; 14 (1) : 9038.

Autor/es:Kim, Namhee (a)
Truty, Timothy (b)

institución:(a) Michael Reese Foundation Center for Health Equity Research, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL, 60064, USA. Namhee.Kim@rosalindfranklin.edu.
(b) Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59194-1

Applicability and clinical utility of the German rivermead post-concussion symptoms questionnaire in proxies of children after traumatic brain injury: an instrument validation study.

Applicability and clinical utility of the German rivermead post-concussion symptoms questionnaire in proxies of children after traumatic brain injury: an instrument validation study.

Fuente:Bmc Neurology

Extracto: The German RPQ proxy is a psychometrically reliable and valid instrument for assessing PCS in children after TBI. Therefore, RPQ self- and proxy-ratings can be used to assess PCS in childhood as well as along the lifespan of an individual after TBI.

Claves:Children, Proxy rating, Psychometric properties, Rivermead post-concussion symptoms Questionnaire, Traumatic brain injury

Cita:BMC Neurol 2024 Apr 19; 24 (1) : 133.

Autor/es:Bockhop, Fabian (a)
Greving, Sven (b)

institución:(a) University Medical Center Göttingen, Göttingen, Germany.
(b) University Medical Center Göttingen, Göttingen, Germany.

Conflicto:The authors have no competing interests to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12883-024-03587-2

Development and initial validation of the cannabis-related psychosis risk literacy scale (CPRL): a multinational psychometric study.

Development and initial validation of the cannabis-related psychosis risk literacy scale (CPRL): a multinational psychometric study.

Fuente:Bmc Psychiatry

Tipo de trabajo:Revisión

Extracto: The newly developed CPRL scale offers a valid and reliable instrument for assessing and better understanding literacy about cannabis-related psychosis risk among Arabic-speaking young adults. We believe that this new scale is suitable as a screening tool of literacy, as an instrument for measuring the effect of public education interventions aimed at promoting cannabis-related psychosis risk literacy among young people, and as a research tool to facilitate future studies on the topic with a wider application.

Claves:Cannabis, Cannabis-related psychosis risk, Literacy, Psychometric evaluation, Psychosis, Scale development

Cita:BMC Psychiatry 2024 Apr 19; 24 (1) : 298.

Autor/es:Fekih-Romdhane, Feten (a)
Alhuwailah, Amthal (b)

institución:(a) Faculty of Medicine of Tunis, Tunis Al Manar University, Tunis, Tunisia. feten.fekih@gmail.com.
(b) The Tunisian Center of Early Intervention in Psychosis, Department of Psychiatry Ibn Omrane, Razi Hospital, Tunis, Tunisia. feten.fekih@gmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12888-024-05727-x

Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration.

Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration.

Fuente:Molecular Neurodegeneration

Extracto: Therefore, we propose ferroptosis as the culprit behind the post-COVID-19 trajectory of aging and neurodegeneration and melatonin, a well-fitting ferroptosis inhibitor, as a potential treatment.

Cita:Mol Neurodegener 2024 Apr 19; 19 (1) : 36.

Autor/es:Yehia, Asmaa (a)
Abulseoud, Osama A (b)

institución:(a) Department of Neuroscience, Graduate School of Biomedical Sciences, Mayo Clinic College of Medicine, Phoenix, AZ, 58054, USA.
(b) Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13024-024-00728-6

Distributions of recorded pain in mental health records: a natural language processing based study.

Distributions of recorded pain in mental health records: a natural language processing based study.

Fuente:Bmj Open

Extracto: The findings of this study show sociodemographic and diagnostic differences in recorded pain. Specifically, lower documentation across certain groups indicates the need for better screening protocols and training on recognising varied pain presentations. Additionally, targeting improved detection of pain for minority and disadvantaged groups by care providers can promote health equity.

Claves:Chronic Pain, EPIDEMIOLOGY, Electronic Health Records, MENTAL HEALTH, Natural Language Processing

Cita:BMJ Open 2024 Apr 19; 14 (4) : e079923.

Autor/es:Chaturvedi, Jaya (a)
Stewart, Robert (b)

institución:(a) Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK jaya.1.chaturvedi@kcl.ac.uk.
(b) Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.

Conflicto:Competing interests: This paper represents independent research part-funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funders had no... no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-079923

Influence of age and cognitive demand on motor decision making under uncertainty: a study on goal directed reaching movements.

Influence of age and cognitive demand on motor decision making under uncertainty: a study on goal directed reaching movements.

Fuente:Scientific Reports

Extracto: The outcomes of this study provide a differentiated picture of the distinct and joint effects of aging and cognitive demand during motor decision making.

Cita:Sci Rep 2024 Apr 20; 14 (1) : 9119.

Autor/es:Krüger, Melanie (a)
Puri, Rohan (b)

institución:(a) Institute of Sports Science, Faculty of Humanities, Leibniz University Hannover, Am Moritzwinkel 6, 30167, Hannover, Germany. melanie.krueger@sportwiss.uni-hannover.de.
(b) Sensorimotor Neuroscience and Ageing Research Laboratory, School of Psychological Sciences, College of Health and Medicine, University of Tasmania, Hobart, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59415-7

Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.

Fuente:Scientific Reports

Extracto: Our results reveal a new epigenetic target for treating PGRN-deficient forms of FTD and provide mechanistic insight to aid in translating this discovery into therapeutics.

Cita:Sci Rep 2024 Apr 20; 14 (1) : 9064.

Autor/es:Rosenthal, Zachary C (a)
Fass, Daniel M (b)

institución:(a) Chemical Neurobiology Laboratory, Precision Therapeutics Unit, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
(b) Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA, USA.

Conflicto:S.J.H. serves on the scientific advisory board (SAB) of Proximity Therapeutics, Psy Therapeutics, Frequency Therapeutics, Souvien Therapeutics, Sensorium Therapeutics, 4 M Therapeutics, Ilios Therapeutics, and Entheos Labs, none of whom were involved in the present study. S.J.H. has also received speaking or consulting fees from Amgen, AstraZeneca, Biogen, Merck, Regenacy Pharmaceuticals, Syros Pharmaceuticals, Juvenescence Life, as well as sponsored research or... r gift funding from AstraZeneca, JW Pharmaceuticals, Lexicon Pharmaceuticals, Vesigen Therapeutics, Compass Pathways, Atai Life Sciences, and Stealth Biotherapeutics. The funders had no role in the design or content of this article, or the decision to submit this review for publication. J.H. is a cofounder of Reelin Therapeutics, which did not provide funding and was not involved in these studies in any way. R.M. is a SAB member and equity holder of Regenacy Pharmaceuticals, ERX Pharmaceuticals, and Frequency Therapeutics. R.M. and N.C.P. are inventors on patent applications related to the CoraFluor TR-FRET probes used in this work. An invention disclosure around novel BET bromodomain compositions and therapeutic uses has been submitted to Massachusetts General Brigham Innovation. All other authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59110-7