Internet-delivered therapy for alcohol misuse: engagement, satisfaction, and outcomes when patients select their preference for therapist- or self-guided treatment.

Fuente:Addiction Science & Clinical Practice

Tipo de trabajo:Orientaciones y guía

Extracto: The current study shows that ICBT for alcohol misuse is associated with reduced drinking and comorbid mental health difficulties over time, irrespective of whether patients chose to complete the course on their own or with therapist guidance. TRIAL REGISTRATION NUMBER: NCT04611854 ( https://clinicaltrials.gov/ct2/show/NCT04611854 ).

Claves:Alcohol, Internet-delivered cognitive behaviour therapy, Preference trial, Substance use, Treatment

Cita:Addict Sci Clin Pract 2024 Apr 20; 19 (1) : 30.

Autor/es:Sapkota, Ram P (a)
Lozinski, Tristen (b)

institución:(a) Online Therapy Unit, Department of Psychology, University of Regina, 3737 Wascana Parkway, Regina, SK, S4S 0A2, Canada.
(b) Online Therapy Unit, Department of Psychology, University of Regina, 3737 Wascana Parkway, Regina, SK, S4S 0A2, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13722-024-00456-8

Constitutive NOS Production Is Modulated by Alzheimer's Disease Pathology Depending on APOE Genotype.

Constitutive NOS Production Is Modulated by Alzheimer's Disease Pathology Depending on APOE Genotype.

Fuente:International Journal of Molecular Sciences

Extracto: Our results confirm previous findings that the APOE genotype is linked with different vascular responses to AD pathology.

Claves:Alzheimer’s disease, amyloid β, apolipoprotein E, nitric oxide synthase

Cita:Int J Mol Sci 2024 Mar 27; 25 (7)

Autor/es:Bonomi, Chiara Giuseppina (a)
Martorana, Alessandro (b)

institución:(a) UOSD Memory Clinic, Policlinico Tor Vergata, University of Rome "Tor Vergata", 00133 Rome, Italy.
(b) UOSD Memory Clinic, Policlinico Tor Vergata, University of Rome "Tor Vergata", 00133 Rome, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073725

Neurofilament Light Chains in Systemic Amyloidosis

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión sistemática

Extracto: Therefore, NfL has the potential to be used for the early detection of neuropathy, monitoring treatment effects, and monitoring disease progression in patients with systemic amyloidosis.

Claves:autonomic neuropathy, biomarker, hereditary transthyretin amyloid, immunoglobulin light chain amyloid, neurofilament light chain, polyneuropathy, small fiber neuropathy, systemic amyloidosis, transthyretin gene-variant carrier

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Berends, Milou (a)
Nienhuis, Hans L A (b)

institución:(a) Department of Internal Medicine, Amyloidosis Center of Expertise, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
(b) Department of Internal Medicine, Amyloidosis Center of Expertise, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.

Conflicto:Chafic Karam has served as a consultant and/or advisory board member for Acceleron, Alpine, Alexion, Alnylam, Annexon, Argenx, Astra Zeneca, Corino, Biogen, CSL Behring, Genentech, Ionis, Neuroderm, Novo Nordisk, Pfizer, Sanofi, UCB, Takeda, and Zai lab. He has received research funding from Argenx, Astra Zeneca, Ionis, and Genzyme. The University Medical Center Groningen, which employs Hans Nienhuis, received consultancy and... speaker fees from Pfizer and Alnylam and grant support from Pfizer.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073770

Possible Role of Cannabis in the Management of Neuroinflammation in Patients with Post-COVID Condition.

Fuente:International Journal of Molecular Sciences

Extracto: Antioxidant therapy and cannabinoid-based approaches represent promising areas of research and treatment for mitigating adverse effects, but further studies are needed.

Claves:antioxidant, cannabis, neuroinflammation, post-COVID-19 condition

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Cárdenas-Rodríguez, Noemi (a)
Ignacio-Mejía, Iván (b)

institución:(a) Laboratorio de Neurociencias, Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
(b) Laboratorio de Medicina Traslacional, Escuela Militar de Graduados de Sanidad, UDEFA, Mexico City 11200, Mexico.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073805

Alterations in Proteostasis Mechanisms in Niemann-Pick Type C Disease.

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: This review consolidates current knowledge on proteostasis dysregulation in NPC and underscores the therapeutic landscape targeting diverse facets of this intricate process.

Claves:cholesterol, lysosomal storage diseases (LSDs), lysosome, protein degradation, protein folding

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Servín Muñoz, Iris Valeria (a)
Ortuño-Sahagún, Daniel (b)

institución:(a) Laboratorio de Neuroinmunobiología Molecular, Instituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Mexico.
(b) Laboratorio de Neuroinmunobiología Molecular, Instituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Mexico.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073806

Special Issue "Molecular Mechanism in Epithelial-Mesenchymal Transition (EMT) and Fibrosis".

Fuente:International Journal of Molecular Sciences

Extracto: he process known as epithelial-mesenchymal transition (EMT), fundamental for accurate development during embryogenesis, is involved in several pathological mechanisms, such as severe fibrosis and cancer [...].

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Sisto, Margherita (a)
Lisi, Sabrina (b)

institución:(a) Department of Translational Biomedicine and Neuroscience (DiBraiN), Section of Human Anatomy and Histology, University of Bari "Aldo Moro", Piazza Giulio Cesare 1, I-70124 Bari, Italy.
(b) Department of Translational Biomedicine and Neuroscience (DiBraiN), Section of Human Anatomy and Histology, University of Bari "Aldo Moro", Piazza Giulio Cesare 1, I-70124 Bari, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073808

Neurodegeneration Biomarkers in Adult Spinal Muscular Atrophy (SMA) Patients Treated with Nusinersen.

Fuente:International Journal of Molecular Sciences

Extracto: Further studies are warranted to better understand these findings.

Claves:adult spinal muscular atrophy, biomarkers, nusinersen treatment

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Andrés-Benito, Pol (a)
Vázquez-Costa, Juan Francisco (b)

institución:(a) Neurologic Diseases and Neurogenetics Group, Institute of Biomedical Research (IDIBELL), 08907 Barcelona, Spain.
(b) CIBERNED (Network Centre of Biomedical Research of Neurodegenerative Diseases), Institute of Health Carlos III, 08907 Barcelona, Spain.

Conflicto:This study, led by P.A.-B., I.F. and M.P., has received funding from Biogen S.L., the supplier of the nusinersen drug, and a company that may have a vested interest in the results of this research. Recognizing the potential for a conflict of interest, and in the pursuit of complete transparency, we are disclosing our affiliations with this company. The funders... had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073810

The Influence of Microglia on Neuroplasticity and Long-Term Cognitive Sequelae in Long COVID: Impacts on Brain Development and Beyond.

Fuente:International Journal of Molecular Sciences

Extracto: Together, these complex mechanisms may help us understand consequences of Long COVID for brain development and its association with altered brain plasticity, impacting learning disabilities, neurodevelopmental disorders, as well as cognitive decline in adults.

Claves:SARS-CoV-2, critical periods, microglial function, neurodegenerative diseases, neuroinflammation, neuroplasticity

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Chagas, Luana da Silva (a)
Serfaty, Claudio Alberto (b)

institución:(a) Program of Neuroscience, Department of Neurobiology, Institute of Biology, Federal Fluminense University, Niterói 24210-201, Rio de Janeiro, Brazil.
(b) National Institute of Science and Technology on Neuroimmunomodulation-INCT-NIM, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21041-250, Rio de Janeiro, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073819

Microfluidic Isolation of Neuronal-Enriched Extracellular Vesicles Shows Distinct and Common Neurological Proteins in Long COVID, HIV Infection and Alzheimer's Disease.

Fuente:International Journal of Molecular Sciences

Extracto: This study begins to identify differences and similarities in the neuronal response to LongC versus AD and HIV infection.

Claves:Alzheimer’s disease, HIV, L1CAM, OLINK, extracellular vesicles, long COVID, microfluidics

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Pulliam, Lynn (a)
Sun, Bing (b)

institución:(a) Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA.
(b) Department of Laboratory Medicine, San Francisco VA Health Care System, San Francisco, CA 94121, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073830

The Role of NRF2 in Cerebrovascular Protection: Implications for Vascular Cognitive Impairment and Dementia (VCID).

Fuente:International Journal of Molecular Sciences

Extracto: Finally, we summarize the clinical potential of NRF2 activators in VCID.

Claves:aging, blood–brain barrier, lymphatic system, neuroinflammation, oxidative stress, perivascular macrophage

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Hu, Yizhou (a)
Zhang, Feng (b)

institución:(a) Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15216, USA.
(b) Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA 15216, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073833

Unlocking Precision Medicine: Liquid Biopsy Advancements in Renal Cancer Detection and Monitoring.

Fuente:International Journal of Molecular Sciences

Extracto: This review aims to discuss and highlight recent advancements in liquid biopsy for RCC, exploring their strengths and weaknesses in the comprehensive management of this disease.

Claves:circulating tumor cells, diagnosis, exosomes, liquid biopsy, microRNA, prognosis, renal cell carcinoma

Cita:Int J Mol Sci 2024 Mar 30; 25 (7)

Autor/es:Crocetto, Felice (a)
Falcone, Alfonso (b)

institución:(a) Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", 80131 Naples, Italy.
(b) Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", 80131 Naples, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073867

Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?

Fuente:International Journal of Molecular Sciences

Extracto: However, clinical efficacy that is less than with conventional treatment, selection of amyloid-positive trial patients with non-specific amyloid-PET imaging, and uncertain therapy-induced removal of cerebral amyloids in clinical trials cast doubt on this anti-Alzheimer's antibody therapy and hence on the amyloid hypothesis, calling for a more thorough investigation of the negative impact of this type of therapy on the brain.

Claves:ARIA, ATN, Alzheimer’s disease, CDR-SB, MICD, MMSE, RCT, amyloid-PET

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Høilund-Carlsen, Poul F (a)
Alavi, Abass (b)

institución:(a) Department of Nuclear Medicine, Odense University Hospital, 5000 Odense C, Denmark.
(b) Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, University of Southern Denmark, 5230 Odense M, Denmark.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073892

Association between Parkinson's Disease and Cancer: New Findings and Possible Mediators.

Fuente:International Journal of Molecular Sciences

Extracto: Identification of these factors and investigation of their mechanisms of action would lead to the discovery of new targets for the treatment of both diseases.

Claves:BAP1, Parkinson’s disease, cancer, malignant melanoma, melatonin, neurotrophic factors, synucleins, transcription factors, ubiquitin–proteasome system

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Surguchov, Andrei (a)
Surguchev, Alexei A (b)

institución:(a) Department of Neurology, Kansas University Medical Center, Kansas City, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
(b) Department of Surgery, Section of Otolaryngology, Yale School of Medicine, Yale University, New Haven, CT 06520, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073899

Targeting Group 3 Medulloblastoma by the Anti-PRUNE-1 and Anti-LSD1/KDM1A Epigenetic Molecules.

Fuente:International Journal of Molecular Sciences

Extracto: Our study demonstrates that the usage of PRUNE-1 and LSD1/KDM1A inhibitors in combination represents a novel therapeutic approach for these highly aggressive metastatic MB tumors.

Claves:KDM1A, Prune-1, TGF-β, epigenetics, immune system, medulloblastoma, metastasis

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Bibbò, Francesca (a)
Asadzadeh, Fatemeh (b)

institución:(a) Department of Molecular Medicine and Medical Biotechnological DMMBM, University Federico II of Naples, 80131 Naples, Italy.
(b) CEINGE Biotecnologie Avanzate "Franco Salvatore", 80131 Naples, Italy.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073917

Synthetic Derivatives of Natural ent-Kaurane Atractyligenin Disclose Anticancer Properties in Colon Cancer Cells, Triggering Apoptotic Cell Demise.

Fuente:International Journal of Molecular Sciences

Extracto: The data reported here provide evidence that di-oxidized compounds induced apoptotic cell death, as demonstrated by the appearance of condensed and fragmented DNA in treated cells, as well as the activation of caspase-3 and fragmentation of its target PARP-1.

Claves:Caco-2, HCT116, Poly [ADP-ribose] polymerase 1, apoptotic cell death, atractyligenin derivatives, chromatin fragmentation

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Badalamenti, Natale (a)
Maggio, Antonella (b)

institución:(a) Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, Italy.
(b) NBFC-National Biodiversity Future Center, Piazza Marina 60, 90133 Palermo, Italy.

Conflicto:The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073925

Is There a Place for Lewy Bodies before and beyond Alpha-Synuclein Accumulation? Provocative Issues in Need of Solid Explanations.

Fuente:International Journal of Molecular Sciences

Extracto: These revisited concepts may be helpful in the process of validating which proteins, organelles, and pathways are likely to be involved in the damage to meso-striatal dopamine neurons and other brain regions involved in PD.

Claves:autophagoproteasosome, autophagosome, endosome, lysosome, mitochondria, multivesicular bodies, phagophore, poly-ubiquitin, retromer, sequestosome (p62)

Cita:Int J Mol Sci 2024 Apr 1; 25 (7)

Autor/es:Lenzi, Paola (a)
Lazzeri, Gloria (b)

institución:(a) Human Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
(b) Human Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073929

The MDM2-p53 Axis Represents a Therapeutic Vulnerability Unique to Glioma Stem Cells.

Fuente:International Journal of Molecular Sciences

Extracto: Our results, which suggest that non-stem, bulk tumor cells are less sensitive to MDM2 inhibitors, may help guide the selection of glioblastoma patients suitable for MDM2 inhibitor therapy.

Claves:HDM2, brain tumor, chemotherapy, glioblastoma-initiating cells, p53 activator, wild-type p53

Cita:Int J Mol Sci 2024 Apr 2; 25 (7)

Autor/es:Nakagawa-Saito, Yurika (a)
Mitobe, Yuta (b)

institución:(a) Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
(b) Department of Molecular Cancer Science, School of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073948

Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability.

Fuente:International Journal of Molecular Sciences

Extracto: In neurodevelopment, ROBO2 plays a crucial role in episodic learning and memory, so its down-regulation, caused by miR-25, could have a fundamental role in the intellectual disability that, until now, has been considered idiopathic.

Claves:ROBO2, idiopathic intellectual disability, miR-25, neural progenitor cells, olfactory neuroepithelium

Cita:Int J Mol Sci 2024 Apr 2; 25 (7)

Autor/es:Ordoñez-Razo, Rosa María (a)
Gutierrez-López, Yessica (b)

institución:(a) Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Mexico City CP 06725, Mexico.
(b) Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Mexico City CP 06725, Mexico.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073953

Association between Intracellular Calcium Signaling and Tumor Recurrence in Human Non-Functioning Pituitary Adenomas.

Fuente:International Journal of Molecular Sciences

Extracto: We conclude that this finding may be a useful tool for predicting the clinicopathologic behavior of CNFPAs, by testing the variation of cellular responsiveness to hypothalamic secretagogues.

Claves:CNFPA, PitNET, calcium, cell signaling, endocrine disruption, hormone secretion, non-secreting pituitary adenoma, silent pituitary adenoma

Cita:Int J Mol Sci 2024 Apr 3; 25 (7)

Autor/es:Santiago-Andres, Yorgui (a)
Aquiles, Ana (b)

institución:(a) Laboratorio de Neuroendocrinología Comparada, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico.
(b) Posgrado en Ciencias Biológicas, Unidad de Posgrado, Edificio D, 1° Piso, Circuito de Posgrados, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073968

The Plight of the Metabolite: Oxidative Stress and Tear Film Destabilisation Evident in Ocular Allergy Sufferers across Seasons in Victoria, Australia.

Fuente:International Journal of Molecular Sciences

Extracto: Such metabolipodome findings may pave new and exciting ways for effective diagnostics and therapeutics for OA sufferers in the future.

Claves:human tears, immunometabolism, inflammation, lipidomics, mass spectrometry, metabolomics, ocular allergy, oxidative stress, tear film

Cita:Int J Mol Sci 2024 Apr 4; 25 (7)

Autor/es:Aydin, Esrin (a)
Callahan, Damien L (b)

institución:(a) NeuroAllergy Research Lab (NARL), School of Life and Environmental Sciences, Deakin University, Geelong 3217, Australia.
(b) School of Medicine, Deakin University, Waurn Ponds 3216, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074019