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La Sociedad Iberoamericana de Información Científica (SIIC)
selecciona informes completos de calidad recientemente publicados en
fuentes prestigiosas del mundo indizadas por SIIC Data
Bases.
La creciente cantidad de artículos con Acceso Abierto (Open
Access) amplía la oferta de lectura pero a su vez también, entre
tanta abundancia, complica al lector en su encuentro con los estudios
fundamentales. Para facilitarlo, profesionales biomédicos de SIIC
consultan diariamente una profusa cantidad de documentos que nutrirán
Textos completos autorizados (TCA).
Las citas de la sección TCA enlazan de manera legal, autorizada y
gratuita con los textos completos (full text) publicados en
los sitios oficiales de sus respectivas fuentes.
SIIC creó, produjo y opera con exclusividad el software TCA para la
interpretación de los diversos campos documentales que integran la
estructura de un estudio: especialidad, modalidad del estudio,
fuente, fechas de publicación y selección, definición de la fuente,
limitaciones de consulta, resumen en castellano, etc.
Si bien la mayoría de los textos seleccionados corresponden a
artículos originales, revisiones y guías, los lectores también
encontrarán comentarios, entrevistas, notas periodísticas, cartas a
autores u otros textos precursores de debates o aclaratorios.
Sociedad Iberoamericana de Información Científica (SIIC) selects
complete quality-full texts which have been recently published in
renowned sources worldwide and are indexed by SIIC Data
Bases.
The increasing number of Open Access articles widens the reading offer
but, also, such myriad complicates the readers search of fundamental
articles. To facilitate this, SIIC biomedical professionals daily
consult a profuse amount of documents that will feed
Authorized Full Texts (TCA, Spanish acronym).
The citations of the AFT section link legally, authorized and free of
charge with the full texts published in the official web sites of
their corresponding sources.
SIIC created, produced and handles the AFT software that deciphers
the various documentary fields that form part of the structure of a
study: specialty, study style, source, publication and selection
dates, source definition, query limitations, summary in Spanish,
etc.
While most of the selected texts belong to original articles,
reviews, and guidelines, readers will also find commentaries,
interviews, journalistic reports, letters to authors or other texts
that may lead to discussions or clarifications.
Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies.
Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies.
Fuente:Molecular Neurodegeneration
Extracto:
Our findings demonstrate the
suitability of the ProPPr approach in FFPE brain tissue for unbiased discovery of
local proteomes that provide valuable insights into the underlying proteomic
landscape of tauopathies, shedding light on the molecular mechanisms underlying
tau pathology. This first comprehensive characterization of tau-associated
proteomes in a range of distinct tauopathies enhances our understanding of
disease heterogeneity and mechanisms, informing strategies for the development of
diagnostic biomarkers and targeted therapies.
institución:(a) Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. (b) Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Conflicto:Declarations. Ethics approval and consent to participate: All donors had provided written informed consent for the use of autopsy material and of clinical and genetic information for research purposes. Brain tissue was obtained postmortem following IRB review. Consent for publication: All authors read and approved the final manuscript. Competing interests: The authors declare they have no financial competing interests.
Cita:Acta Neuropathol Commun 2025 Mar 13; 13 (1) : 60.
Autor/es:Edminster, Sarah Y (a) Rebbe, Ryan W (b)
institución:(a) Department of Pathology, Los Angeles General Medical Center, Los Angeles, CA, 90033, USA. (b) Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Antisecretory factor as add-on treatment for newly diagnosed glioblastoma, IDH wildtype: study protocol for a randomized double-blind placebo-controlled trial.
Antisecretory factor as add-on treatment for newly diagnosed glioblastoma, IDH wildtype: study protocol for a randomized double-blind placebo-controlled trial.
institución:(a) Department of Neurosurgery, Skåne University Hospital, Lund, Sweden. erik.ehinger@med.lu.se. (b) Glioma Immunotherapy Group, Section of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden. erik.ehinger@med.lu.se.
Conflicto:Declarations. Ethics approval and consent to participate: See Ethics section. Consent for publication: N/A. Competing interests: Peter Siesjö is inventor in US patent application nr: 14/652,868; ANTISECRETORY FACTOR (AF) FOR USE IN THE TREATMENT OF GLIOBLASTOMA. The rest of the authors have no conflicts to disclose.
Pan-Immune-Inflammation Value Predicts 3-Month Functional Outcomes in Patients With Acute Ischemic Stroke Treated With Mechanical Thrombectomy.
Pan-Immune-Inflammation Value Predicts 3-Month Functional Outcomes in Patients With Acute Ischemic Stroke Treated With Mechanical Thrombectomy.
Fuente:Brain and Behavior
Extracto:
Our study revealed that PIV predicts a poor
3-month prognosis in acute ischemic cerebrovascular disease after MT with a
significantly better performance than the widely known systemic
immune-inflammation index, systemic inflammation response index,
platelet/lymphocyte ratio, and neutrophil/lymphocyte ratio. PIV can be a novel
prognostic marker indicating poor prognosis in patients treated with MT.
Claves:acute ischemic stroke, mechanical thrombectomy, pan‐immune‐inflammation value, systemic immune‐inflammation index
institución:(a) Department of Neurology, Konya Training and Research Hospital Baskent University, Konya, Turkey. (b) Department of Emergency Medicine, Konya Training and Research Hospital Baskent University, Konya, Turkey.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association Between Dietary Alcohol Intake and Migraine or Severe Headache Miscellaneous Pain: The NHANES 1999-2004.
Association Between Dietary Alcohol Intake and Migraine or Severe Headache Miscellaneous Pain: The NHANES 1999-2004.
Fuente:Brain and Behavior
Extracto:
There was a significant negative association between dietary alcohol
intake and the odds of having migraine or severe headache.
Claves:NHANES, dietary alcohol intake, migraine, severe headache
Cita:Brain Behav 2025 Mar; 15 (3) : e70400.
Autor/es:Tang, Yi (a) Zhang, Kangrui (b)
institución:(a) Department of Neurology, Hefei Hospital Affiliated to Anhui Medical University (The Second People's Hospital of Hefei), Hefei, China. (b) Department of Neurology, The Fifth Clinical Medical College of Anhui Medical University, Hefei, China.
Conflicto:The study's authors declare that there were no financial or commercial relationships that may be construed as creating a conflict of interest.
Electroencephalographic Resting-State Microstates are Unstable in Visual Snow Syndrome.
Electroencephalographic Resting-State Microstates are Unstable in Visual Snow Syndrome.
Fuente:Brain and Behavior
Extracto:
Visual snow syndrome
(VSS) is a complex disorder, affecting widespread neural network activity. In
VSS, electroencephalography (EEG) microstate analysis revealed unstable
microstates as well as aberrant transition probabilities, indicating disturbed
large-scale network activity. The analysis of microstate dynamics in VSS
complements the results of imaging with high temporal resolution and could
contribute to the development of future treatment approaches.
Autor/es:Aeschlimann, Sarah A (a) Klein, Antonia (b)
institución:(a) Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. (b) Department of Psychology, University of Bern, Bern, Switzerland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Neurology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. (b) Department of Neurology, Guangzhou First People's Hospital, School of Medicine, Guangdong Medical University, Zhanjiang, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Machine learning-driven ultrasound radiomics for assessing axillary lymph node burden in breast cancer.
Machine learning-driven ultrasound radiomics for assessing axillary lymph node burden in breast cancer.
Fuente:Frontiers in Endocrinology
Extracto:
The
combined clinical-radiomics model showed excellent predictive ability and may aid
in optimizing management and treatment decisions for breast cancer patients.
Claves:axillary lymph nodes burden, breast cancer, machine learning, radiomics, ultrasound
institución:(a) The Ultrasound Diagnosis Department of the First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China. (b) The Neurology Department of the First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Age- and Sex-Specific Patterns in Adult Brain Network Segregation.
Age- and Sex-Specific Patterns in Adult Brain Network Segregation.
Fuente:Human Brain Mapping
Extracto:
Given these
findings, future studies should take a more focused approach to examining sex
differences across the lifespan, incorporating multimodal methodologies.
Claves:aging, dedifferentiation, functional connectivity, network segregation, resting‐state, sex differences
Cita:Hum Brain Mapp 2025 Mar; 46 (4) : e70169.
Autor/es:Sidhu, Abhijot Singh (a) Duarte, Kaue T N (b)
institución:(a) Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada. (b) Department of Radiology, University of Calgary, Calgary, Alberta, Canada.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Student engagement in a flipped undergraduate medical classroom to measure optimal video-based lecture length.
Student engagement in a flipped undergraduate medical classroom to measure optimal video-based lecture length.
Fuente:Medical Education Online
Extracto:
Other unmeasured
classroom dynamics need to be considered for further studies that should explore
these interactions in more depth.
Claves:Active learning, flipped classroom, medical education, video-based learning, video-based lecture
Cita:Med Educ Online 2025 Dec; 30 (1) : 2479752.
Autor/es:Gutiérrez-González, Raquel (a) Royuela, Ana (b)
institución:(a) Department of Neurosurgery, Puerta de Hierro University Hospital, IDIPHISA, Majadahonda, Madrid, Spain. (b) Department of Surgery, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain.
Conflicto:No potential conflict of interest was reported by the author(s).
[Clinical Features and Functional Prognosis in Patients with Possible Autoimmune Encephalitis in a Neurological Emergency Department].
[Clinical Features and Functional Prognosis in Patients with Possible Autoimmune Encephalitis in a Neurological Emergency Department].
Fuente:Revista de Neurologia
Tipo de trabajo:Estudio de cohortes
Extracto:
AE represents a rare diagnosis even in
a neurological emergency center; older age, status epilepticus and absence of
headache were associated with poor functional prognosis at discharge.
Autor/es:Robles-Monroy, Paula Catalina (a) Martínez-Angeles, Victoria (b)
institución:(a) Departamento de Neuropsiquiatría, Subdirección de Psiquiatría, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, 14269 Ciudad de México, Mexico. (b) Departamento de Neuropsiquiatría, Subdirección de Psiquiatría, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, 14269 Ciudad de México, Mexico.
Conflicto:Los autores declaran no tener conflictos de interés.
Autor/es:Pérez Delgado, Raquel (a) Peña Segura, Jose Luis (b)
institución:(a) Unidad de Neurometabolismo del Hospital Miguel Servet, 50009 Zaragoza, España. (b) Unidad de Neurometabolismo del Hospital Miguel Servet, 50009 Zaragoza, España.
Conflicto:Los autores declaran no tener conflictos de interés.
Leukoencephalopathy following stereotactic radiosurgery for breast cancer brain metastases: a single-center analysis of 1,077 lesions.
Leukoencephalopathy following stereotactic radiosurgery for breast cancer brain metastases: a single-center analysis of 1,077 lesions.
Fuente:Acta Neurochirurgica
Extracto:
Our findings demonstrated that WBRT plus SRS is associated with higher
leukoencephalopathy rates than SRS alone. This underscores the importance of
carefully weighing the benefits and risks of different ionizing radiation
approaches in the management of brain metastasis from breast cancer.
Claves:Brain metastasis, Breast cancer, Leukoencephalopathy, Radiosurgery
Cita:Acta Neurochir (Wien) 2025 Mar 14; 167 (1) : 73.
Autor/es:Tos, Salem M (a) Hajikarimloo, Bardia (b)
institución:(a) Department of Neurosurgery, University of Virginia, Box 800212, Charlottesville, VA, 22908, USA. (b) Department of Neurosurgery, University of Virginia, Box 800212, Charlottesville, VA, 22908, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Long-term CSF responses in adult patients with spinal muscular atrophy type 2 or 3 on treatment with nusinersen.
Long-term CSF responses in adult patients with spinal muscular atrophy type 2 or 3 on treatment with nusinersen.
Fuente:Journal of Neurology
Extracto:
The present multi-proteomic analysis contributes to the understanding
of the molecular mechanisms underlying nusinersen's therapeutic effects and
offers potential biomarkers for monitoring treatment response in SMA.
institución:(a) Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. (b) Department of Neurology, Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
Conflicto:Declarations. Conflict of interest: G. Cebulla, L. Hai, U. Warnken, C. Güngör, and D.C. Hoffmann report no disclosures. M. Korporal-Kuhnke reports speaker honoraria from Novartis, BMS and Merck, all outside the present work. B. Wildemann reports research support from DFG, BMBF, Dietmar-Hopp-Stiftung, Klaus-Tschita-Stiftung, Merck, Novartis, Roche, and speaker honoraria form Alexion, Merck, INSTAND, Novartis, and Roche, all outside the present...
nt work. W. Wick reports consulting honoraria outside the present work from Enterome, Roche, and Servier. T. Kessler reports no disclosures. M. Weiler reports consultant honoraria from Biogen and Roche, and speaker honoraria and travel support for conference attendance from Biogen, all outside the present work. Ethical approval: This prospective exploratory monocentric study was approved by the institutional ethics board (University of Heidelberg; S-554/2018). The study conforms with The Code of Ethics of the World Medical Association (Declaration of Helsinki). Consent to participate: Written informed consent was obtained from all individual participants included in the study. Consent to publish: Consent to publish was obtained from all participants.
High resolution autoradiography of [(18)F]MK-6240 and [(18)F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity.
High resolution autoradiography of [(18)F]MK-6240 and [(18)F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity.
Fuente:Acta Neuropathologica
Extracto:
Both the tracers showed strong binding to AD tau aggregates and no
or minimal binding to non-AD tauopathies which corroborates with other studies.
institución:(a) Department of Neurosurgery, University Hospital Wuerzburg, Josef-Schneider-Str. 11, Wuerzburg, 97080, Germany. xenia.hautmann@uk-augsburg.de. (b) Center of Neurosurgery, University Hospital of Cologne, Cologne, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Laboratory of Medical Genetics in Clinical Practice, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, 45110, Greece. (b) Laboratory of Medical Genetics in Clinical Practice, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, 45110, Greece.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
CLASSIFICATION OF EVIDENCE: This study provides Class II
evidence that for patients with ION, the K-FLC index can distinguish between
MS/CISwc and MOGAD.
Autor/es:Demortiere, Sarah (a) Stolowy, Natacha (b)
institución:(a) Department of Neurology, University Hospital of Marseille, France. (b) Department of Ophtalmology, University Hospital of Marseille, France.
Conflicto:The authors report no relevant disclosures. Go to Neurology.org/N for full disclosures.
Estimating the Burden of Common Mental Disorders Attributable to Lifestyle Factors: Protocol for the Global Burden of Disease Lifestyle and Mental Disorder (GLAD) Project.
Estimating the Burden of Common Mental Disorders Attributable to Lifestyle Factors: Protocol for the Global Burden of Disease Lifestyle and Mental Disorder (GLAD) Project.
Fuente:Jmir Research Protocols
Extracto:
Our
comprehensive, collaborative approach allows for the concurrent execution of a
harmonized statistical analysis protocol across multiple, internationally
renowned epidemiological cohorts. These results will be used to inform the GBD
study and incorporate lifestyle risk factors for CMD in the GBD digital platform.
Consequently, given the worldwide influence of the GBD study, findings from the
GLAD project can offer valuable insights to policy makers worldwide around
lifestyle-based mental health care. INTERNATIONAL REGISTERED REPORT IDENTIFIER
(IRRID): DERR1-10.2196/65576.
Claves:anxiety, burden of disease, depression, diet, epidemiology, lifestyle, mental disorders, mental health
Cita:JMIR Res Protoc 2025 Mar 14; 14 : e65576.
Autor/es:Ashtree, Deborah N (a) Orr, Rebecca (b)
institución:(a) IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia. (b) IMPACT (the Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia.
Identifying potential key metabolic pathways and biomarkers in glaucoma
Identifying potential key metabolic pathways and biomarkers in glaucoma
Fuente:Bmj Open Ophthalmology
Tipo de trabajo:Revisión sistemática
Extracto:
This study underscores the central
role of metabolic dysfunction in POAG, highlighting specific metabolites and
pathways that could serve as biomarkers for early diagnosis and therapeutic
intervention. Future research should prioritise longitudinal studies and
untargeted metabolomic profiling to further deepen our understanding of metabolic
changes and their contributions to glaucoma progression. PROSPERO REGISTRATION
NUMBER: CRD42024512098.
institución:(a) Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden. (b) Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
