Amyloid-Forming Corpora Amylacea and Spheroid-Type Amyloid Deposition

Amyloid-Forming Corpora Amylacea and Spheroid-Type Amyloid Deposition

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: In contrast, we hypothesize that while amyloid-forming CA and spheroid-type amyloid deposits are formed, in part, through common mechanisms, the latter are pathological.

Claves:amyloid, beta-2 micro-globulin, corpora amylacea, functional amyloids, lactoferrin, lysosome, macrophage, pulmonary surfactant protein

Cita:Int J Mol Sci 2024 Apr 4; 25 (7)

Autor/es:Ichimata, Shojiro (a)
Hata, Yukiko (b)

institución:(a) Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
(b) Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074040

Domains in Action: Understanding Ddi1's Diverse Functions in the Ubiquitin-Proteasome System.

Fuente:International Journal of Molecular Sciences

Extracto: Here, we highlight the recent discoveries, which shed new light on the structure and biological functions of the Ddi1 protein.

Claves:DNA-damage inducible protein 1 (Ddi1), retroviral-like protease domain (RVP), ubiquitin (Ub), ubiquitin associated domain (UBA), ubiquitin-like domain (UBL), ubiquitin-proteasome system (UPS)

Cita:Int J Mol Sci 2024 Apr 6; 25 (7)

Autor/es:Fabijan, Artur (a)
Polis, Bartosz (b)

institución:(a) Department of Neurosurgery, Polish-Mother's Memorial Hospital Research Institute, 93-338 Lodz, Poland.
(b) Department of Neurosurgery, Polish-Mother's Memorial Hospital Research Institute, 93-338 Lodz, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074080

MGMT ProFWise: Unlocking a New Application for Combined Feature Selection and the Rank-Based Weighting Method to Link MGMT Methylation Status to Serum Protein Expression in Patients with Glioblastoma.

Fuente:International Journal of Molecular Sciences

Extracto: The computational results indicate that the proposed approach provides 14 shared serum biomarkers that may be helpful for diagnostic, prognostic, and/or predictive operations for GBM-related processes, given further validation.

Claves:MGMT, feature selection, glioblastoma, machine learning, pattern recognition, protein, proteomic

Cita:Int J Mol Sci 2024 Apr 6; 25 (7)

Autor/es:Tasci, Erdal (a)
Shah, Yajas (b)

institución:(a) Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
(b) Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074082

The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds.

Fuente:International Journal of Molecular Sciences

Extracto: Detailed characterization and optimization of lead compounds, considering both hydroxamic acids and other diverse structures, are in progress for further exploration.

Claves:insulin-regulated aminopeptidase (IRAP), ultra-high-throughput screening (uHTS)

Cita:Int J Mol Sci 2024 Apr 6; 25 (7)

Autor/es:Gising, Johan (a)
Honarnejad, Saman (b)

institución:(a) The Beijer Laboratory, Science for Life Laboratory, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden.
(b) Pivot Park Screening Centre, Kloosterstraat 9, 5349 AB Oss, The Netherlands.

Conflicto:Authors Saman Honarnejad and Maaike Bras were employed by the company Pivot Park Screening Centre B.V. Authors Gemma L. Baillie, Stuart P. McElroy, Philip S. Jones and Angus Morrison were employed by the company BioAscent Discovery Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as... a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074084

DKK3 Expression in Glioblastoma: Correlations with Biomolecular Markers.

Fuente:International Journal of Molecular Sciences

Extracto: Modulation of this pathway through the expression of DKK3 could represent a new tailored therapeutic strategy in the treatment of glioblastoma.

Claves:DKK3, IDH status, WNT pathway, glioblastoma, glioma, survival

Cita:Int J Mol Sci 2024 Apr 7; 25 (7)

Autor/es:Caffo, Maria (a)
Casili, Giovanna (b)

institución:(a) Unit of Neurosurgery, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98100 Messina, Italy.
(b) Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98100 Messina, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074091

X-Linked Epilepsies

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: This review could support clinicians in the genetic diagnosis and treatment of patients with epilepsy featuring X-linked inheritance.

Claves:X-linked, developmental and epileptic encephalopathies (DEEs), epilepsy, genetics

Cita:Int J Mol Sci 2024 Apr 8; 25 (7)

Autor/es:Bernardo, Pia (a)
Cuccurullo, Claudia (b)

institución:(a) Pediatric Psychiatry and Neurology Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital, 80129 Naples, Italy.
(b) Neurology and Stroke Unit, Ospedale del Mare Hospital, ASL Napoli 1 Centro, 80147 Naples, Italy.

Conflicto:None of the authors has conflicts of interest to declare in relation to the present review.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074110

A Pilot Analysis of Whole Transcriptome of Human Cryopreserved Sperm.

Fuente:International Journal of Molecular Sciences

Extracto: The gene ontology analysis disclosed that cryopreservation alters transcripts of pathways important for fertility (i.e., spermatogenesis, sperm motility, mitochondria function, fertilization, calcium homeostasis, cell differentiation, and early embryo development), although the increase of some transcripts involved in immune response can compensate for the harmful effects of freezing.

Claves:fertility preservation, human sperm, microarray, sperm, sperm cryopreservation, sperm donation, transcriptome

Cita:Int J Mol Sci 2024 Apr 8; 25 (7)

Autor/es:Stigliani, Sara (a)
Amaro, Adriana (b)

institución:(a) SS Physiopathology of Human Reproduction, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genova, Italy.
(b) SSD Regolazione dell'Espressione Genica, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074131

Impact of Short-Term Creatine Supplementation on Muscular Performance among Breast Cancer Survivors.

Impact of Short-Term Creatine Supplementation on Muscular Performance among Breast Cancer Survivors.

Fuente:Nutrients

Extracto: Seven days of creatine supplementation does not influence muscular performance among BC survivors.

Claves:breast cancer, cancer treatment, creatine, muscular performance, oncology, strength, supplementation

Cita:Nutrients 2024 Mar 27; 16 (7)

Autor/es:Parsowith, Emily J (a)
Stock, Matt S (b)

institución:(a) Cognition, Neuroplasticity, and Sarcopenia (CNS) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, FL 32816, USA.
(b) Cognition, Neuroplasticity, and Sarcopenia (CNS) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, FL 32816, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070979

Impact of Melatonin Supplementation on Sports Performance and Circulating Biomarkers in Highly Trained Athletes

Fuente:Nutrients

Tipo de trabajo:Revisión sistemática

Extracto: Nevertheless, an indirect effect of melatonin supplementation in sports performance could be evaluated through improvements in health biomarkers.

Claves:antioxidant, health biomarkers, highly trained athletes, inflammatory response, melatonin, oxidative stress, safety, sports performance, sports supplementation

Cita:Nutrients 2024 Mar 30; 16 (7)

Autor/es:Celorrio San Miguel, Ana M (a)
Roche, Enrique (b)

institución:(a) Department of Chemistry, Polytechnic Secondary Education High School, 42004 Soria, Spain.
(b) Doctoral School, University of León, Campus de Vegazana, 24071 Leon, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16071011

Online Questionnaire with Fibromyalgia Patients Shows Negative Correlations between Disease Severity and Adherence to Mediterranean Diet.

Fuente:Nutrients

Extracto: A propensity score analysis indicates a positive influence of the MedDiet against FM severity, thus unveiling the need for well-designed intervention studies to evaluate the therapeutic potential of different dietary patterns.

Claves:body mass index, dietary supplements, food habits, lifestyle, pain

Cita:Nutrients 2024 Apr 6; 16 (7)

Autor/es:Proietti, Elisa (a)
Rapallo, Fabio (b)

institución:(a) Department of Internal Medicine (DIMI), University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy.
(b) Department of Economics (DIEC), University of Genova, Via Vivaldi, 5, 16126 Genova, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16071078

Glycated serum protein is independently associated with progressive infarction in patients with acute ischemic stroke.

Glycated serum protein is independently associated with progressive infarction in patients with acute ischemic stroke.

Fuente:The Journal of International Medical Research

Extracto: GSP might be an independent predictor for PI in certain patients with acute ischemic stroke.

Claves:Progressive infarction, anterior circulation small vessel occlusion, early neurological deterioration, glycated serum protein, large artery atherosclerosis, posterior circulation small vessel occlusion

Cita:J Int Med Res 2024 Apr; 52 (4) : 3000605241245299.

Autor/es:Zou, Keji (a)
Wei, Caixia (b)

institución:(a) Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. RINGGOLD: 117970
(b) Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. RINGGOLD: 117970

Conflicto:Declaration of conflicting interestThe authors declare that there is no conflict of interest.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1177/03000605241245299

Identification and characterization of novel genetic variants in the first Chinese family of mucopolysaccharidosis IIIC (Sanfilippo C syndrome).

Identification and characterization of novel genetic variants in the first Chinese family of mucopolysaccharidosis IIIC (Sanfilippo C syndrome).

Fuente:Journal of Cellular and Molecular Medicine

Extracto: Moreover, this study helps to depict the natural history of Chinese MPS IIIC populations.

Claves:HGSNAT, MPS IIIC, lysosome, mucopolysaccharidosis, transmembrane, variant

Cita:J Cell Mol Med 2024 Apr; 28 (8) : e18307.

Autor/es:Zhao, Hongjun (a)
Wang, Lijing (b)

institución:(a) Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, China.
(b) Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/jcmm.18307

Pathway-based stratification of gliomas uncovers four subtypes with different TME characteristics and prognosis.

Fuente:Journal of Cellular and Molecular Medicine

Extracto: It might serve as a reliable prognostic classifier and provide rational design of individualized treatment, and follow-up scheduling for patients with gliomas.

Claves:gliomas, hypoxia, immune responses, metabolism, tumour microenvironment

Cita:J Cell Mol Med 2024 Apr; 28 (8) : e18208.

Autor/es:Huang, Ruoyu (a)
Han, Bo (b)

institución:(a) Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
(b) Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/jcmm.18208

A 78-year-old woman with diffuse white matter infiltration and predominant involvement of bilateral temporo-parieto-occipital regions.

Fuente:Journal of Cellular and Molecular Medicine

Extracto: The case we report here carries new knowledge about this tumour which may, in fact, occur in elderly patients, be devoid of evocative genomic abnormalities reported in children and harbour a misleading mutation.

Claves:DNA methylation, FGFR1 tandem duplication, elderly patient, paediatric‐type glioma

Cita:J Cell Mol Med 2024 Apr; 28 (8) : e18245.

Autor/es:Paoli, Charlotte (a)
Mc Leer, Anne (b)

institución:(a) Laboratoire Central d'Anatomie Pathologique, Department of Pathology and Molecular Oncology, University Hospital of Nice, Université Côte d'Azur, Nice, France.
(b) Grenoble Alpes University Hospital Pathology Department, Institute for Advanced Biosciences UGA/INSERM U1209/CNRS 5309, Grenoble Alpes University, Grenoble, France.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/jcmm.18245

The plasma miRNome and venous thromboembolism in high-grade glioma: miRNA Sequencing of a nested case-control cohort.

Fuente:Journal of Cellular and Molecular Medicine

Extracto: Therewith, we here provide one of the largest and deepest peripheral blood miRNA datasets of high-grade glioma patients so far, in which we identified first VTE biomarker candidates that can serve as the starting point for future research.

Claves:cancer, high‐grade glioma, microRNA, venous thromboembolism

Cita:J Cell Mol Med 2024 Apr; 28 (8) : e18149.

Autor/es:Erhart, Friedrich (a)
Widhalm, Georg (b)

institución:(a) Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
(b) Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.

Conflicto:M.H. is employed by TAmiRNA GmbH and is a company shareholder. A.D. is employed by TAmiRNA GmbH. M.P. has received honoraria for lectures, consultation or advisory board participation from the following for‐profit companies: Bayer, Bristol‐Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, BMJ Journals, MedMedia, Astra Zeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Sanofi, Merck Sharp &... rp & Dome, Tocagen, Adastra, Gan & Lee Pharmaceuticals. All other authors declare that the research was conducted in the absence of any other commercial, financial or personal relationships that could be construed as a potential competing interest.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/jcmm.18149

Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO).

Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO).

Fuente:Bmc Neurology

Extracto: Apart from overweight and obesity at the age of 18 years, we did not observe considerable associations with MS risk. The proportion of cases that can be explained by childhood and adolescence factors examined in this study was low. Further investigations of the association between the onset of overweight and obesity in childhood and adolescence and its interaction with physical activity and MS risk seem worthwhile.

Claves:Adolescence, Childhood, Epidemiology, Multiple Sclerosis

Cita:BMC Neurol 2024 Apr 13; 24 (1) : 123.

Autor/es:Holz, Anja (a)
Obi, Nadia (b)

institución:(a) Institute of Medical Biometry and Epidemiology (IMBE), University Medical Center Hamburg-Eppendorf (UKE), Martinistr. 52, 20246, Hamburg, Germany. a.holz@uke.de.
(b) Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. a.holz@uke.de.

Conflicto:Financial interests: C.H. has received research funding and speaker honoraria from Novartis, Merck, and Roche. The other authors have no relevant financial or non-financial interests to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12883-024-03620-4

Factors affecting resolution of oculomotor nerve palsy following endovascular embolization of posterior communicating artery aneurysms.

Factors affecting resolution of oculomotor nerve palsy following endovascular embolization of posterior communicating artery aneurysms.

Fuente:Neurologia

Extracto: Endovascular embolization of Pcom aneurysms concomitant with OMNP can effectively improve the OMNP symptoms, especially for patients with moderate and a shorter history of OMNP. Younger age, degree of oculomotor nerve palsy at onset, and time from onset to treatment may significantly affect recovery of oculomotor nerve palsy.

Claves:Aneurisma intracraneal, Arteria comunicante posterior, Embolización intravascular, Endovascular embolization, Factores, Factors, Intracranial aneurysms, Oculomotor nerve palsy, Parálisis oculomotora, Posterior communicating artery

Cita:Neurologia (Engl Ed) 2024 May; 39 (4) : 315-320.

Autor/es:Chen, C G (a)
Wang, J W (b)

institución:(a) Department of Neurosurgery, Liaoyang City Central Hospital, Liaoyang City 111200, Liaoning Province, China.
(b) Department of Neurosurgery, The First Hospital of Hebei Medical University, China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:España

Sitio web:http://dx.doi.org/10.1016/j.nrleng.2021.07.006

Concomitant treatment with safinamide and antidepressant drugs: Safety data from real clinical practice.

Fuente:Neurologia

Tipo de trabajo:Revisión

Extracto: Our real clinical practice study suggests that concomitant use of safinamide with antidepressant drugs in PD patients seemed to be safe and well tolerated, even in the long term. However, caution is warranted, individualizing treatment regimens and monitoring the potential appearance of adverse effects.

Claves:Depresión, Depression, Enfermedad de Parkinson, Parkinson's disease, Safinamida, Safinamide, Serotonin syndrome, Síndrome serotoninérgico

Cita:Neurologia (Engl Ed) 2024 May; 39 (4) : 340-344.

Autor/es:Pérez-Torre, P (a)
López-Sendón, J L (b)

institución:(a) Movement Disorders Unit, Neurology Department, Ramón y Cajal Hospital, Madrid, Spain. Electronic address: paulaptorre@gmail.com.
(b) Movement Disorders Unit, Neurology Department, Ramón y Cajal Hospital, Madrid, Spain.

Formato:Informe impreso

Idioma:Inglés

País de fuente:España

Sitio web:http://dx.doi.org/10.1016/j.nrleng.2021.08.005

Intra and inter-rater remote assessment of bradykinesia in Parkinson's disease.

Fuente:Neurologia

Extracto: Furthermore, this study demonstrated the need for a group with prior training and experience, along with indicating the importance for the development of a clinical protocol that can use telemedicine for the evaluation of individuals with PD, as well as the inclusion of a specialized mediating group. In Addition, this research helps to the development of a valid remote assessment of bradykinesia.

Claves:Bradicinesia, Bradykinesia, Enfermedad de Parkinson, Evaluación remota, Parkinson's disease, Remote assessment, Telemedicina, Telemedicine

Cita:Neurologia (Engl Ed) 2024 May; 39 (4) : 345-352.

Autor/es:Luiz, L M D (a)
Marques, I A (b)

institución:(a) Centre for Innovation and Technology Assessment in Health, Faculty of Electrical Engineering, Federal University of Uberlândia, Uberlândia, Brazil. Electronic address: luizamaire@gmail.com.
(b) Centre for Innovation and Technology Assessment in Health, Faculty of Electrical Engineering, Federal University of Uberlândia, Uberlândia, Brazil.

Formato:Informe impreso

Idioma:Inglés

País de fuente:España

Sitio web:http://dx.doi.org/10.1016/j.nrleng.2021.08.006

Value of long non-coding RNA HAS2-AS1 as a diagnostic and prognostic marker of glioma.

Fuente:Neurologia

Extracto: Normal tissues could be clearly distinguished from glioma tissues based on HAS2-AS1 expression. Moreover, overexpression of HAS2-AS1 indicated poor prognosis in glioma patients. Therefore, HAS2-AS1 could be used as a diagnostic and prognostic marker for glioma.

Claves:ARNncl HAS2-AS1, Biomarcador, Biomarker, Glioma, lncRNA HAS2-AS1

Cita:Neurologia (Engl Ed) 2024 May; 39 (4) : 353-360.

Autor/es:You, A (a)
Gu, J (b)

institución:(a) The Fourth Department of Neurosurgery, Tangshan Gongren Hospital, 063000 Tangshan, China.
(b) The Fourth Department of Neurosurgery, Tangshan Gongren Hospital, 063000 Tangshan, China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:España

Sitio web:http://dx.doi.org/10.1016/j.nrleng.2021.06.008