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JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases.
JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases.
Fuente:International Journal of Molecular Sciences
Extracto:
Hence, JMJD6 autoantibodies may
reflect inflammation, thereby serving as a potential biomarker for diagnosing
specific inflammation-related diseases, including stroke, AMI, DM, and cancers,
and for prediction of the prognosis in patients with EC.
institución:(a) Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. (b) Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Conflicto:This present study was performed in collaboration with Fujikura Kasei Co., Ltd., and Hideyuki Kuroda is an employee of Fujikura Kasei Co., Ltd. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Extracto:
To
our knowledge, we report the first case of ischemic stroke related to Danon
disease treated with endovascular treatment.
Claves:Cardiomyopathy, Case report, Danon, Lysosomal, Stroke
Cita:J Med Case Rep 2024 May 12; 18 (1) : 244.
Autor/es:Jiménez-Bolaños, Rayco (a) Hernández-Fernández, Francisco (b)
institución:(a) Department of Neurology, Complejo Hospitalario Universitario Insular-Materno Infantil de Canarias, Las Palmas, Spain. (b) Department of Neurology, Complejo Hospitalario Universitario de Albacete, C/Hermanos Falcó 37, 02006, Albacete, Spain. pacohdezfdez@hotmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Effects of repetitive transcranial magnetic stimulation on individual variability of resting-state functional connectivity in major depressive disorder.
Effects of repetitive transcranial magnetic stimulation on individual variability of resting-state functional connectivity in major depressive disorder.
Fuente:Journal of Psychiatry & Neuroscience Jpn
Extracto:
This was, to our knowledge, the first study
to examine individual variability of rs-fc related to rTMS in individuals with
MDD. In contrast to our hypotheses, we found that rTMS increased the individual
variability of rs-fc. Our results suggest that individual variability of the
right sgACC and bilateral precuneus connectivity may be a potential mechanism of
rTMS.
institución:(a) From the Campbell Family Research Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Tan, Blumberger, Hawco); the Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ont. (Downar, Nestor); the Harquail Centre for Neuromodulation, Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont. (Nestor, Blumberger, Hawco); the Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, BC (Vila-Rodriguez); the Department of Psychiatry, University of California, San Diego (Daskalakis); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Blumberger). (b) From the Campbell Family Research Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Tan, Blumberger, Hawco); the Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ont. (Downar, Nestor); the Harquail Centre for Neuromodulation, Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont. (Nestor, Blumberger, Hawco); the Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, BC (Vila-Rodriguez); the Department of Psychiatry, University of California, San Diego (Daskalakis); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Blumberger).
Conflicto:Competing interests:: J. Downar declared grants from the National Institutes of Health (NIH), Canadian Institutes of Health Research (CIHR), Brain Canada, and the Ontario Brain Institute. He also declared consulting fees from TMS Neuro Solutions and Arc Health Partners. He is the co-founder and holds equity in Ampa Health. S. Nestor declared a research project award application to the Labatt...
Family Network for Research on the Biology of Depression, Labatt Family Discovery Program, Department of Psychiatry, University of Toronto. F. Vila-Rodriguez declared support from Seedlings Foundation, CIHR, and Brain Canada. He is a volunteer director with the BC Schizophrenia Society board of directors, and he has received in-kind equipment support from Magventure for investigator-initiated research. Z.J. Daskalakis serves on the advisory board of Brainsway Inc. He also declared receipt of research grant materials from Magventure Inc. and Brainsway Inc. D.M. blumberger declared grants from CIHR, Brain Canada, NIH, and the Patient-Centered Outcomes Research Institute. He is a paid scientific advisory board member of Sooma, and serves as co-chair of the clinical standards committee (unpaid) of the Clinical TMS Society. He has stock options from Sooma and has received in-kind equipment support from Magventure Inc. and Brainsway Inc. for investigator-initiated studies. C. Hawco declared funding from the National Institute of Mental Health, CIHR and Centre for Addiction and Mental Health Foundation paid to his institution. No other competing interests were declared.
SAROS: A dataset for whole-body region and organ segmentation in CT imaging.
SAROS: A dataset for whole-body region and organ segmentation in CT imaging.
Fuente:Scientific Data
Extracto:
The SAROS dataset
serves as an open-access resource for training and evaluating novel segmentation
models, covering various scanner vendors and diseases.
Cita:Sci Data 2024 May 10; 11 (1) : 483.
Autor/es:Koitka, Sven (a) Baldini, Giulia (b)
institución:(a) Institute of Interventional and Diagnostic Radiology and Neuroradiology, University Hospital Essen, Essen, Germany. (b) Institute for Artificial Intelligence in Medicine, University Hospital Essen, Essen, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain.
Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain.
Fuente:The Journal of Headache and Pain
Extracto:
In addition, the review examines
diverse modulation strategies that target the different parts of the IC, thereby
suggesting novel diagnostic and therapeutic management of chronic TNP in the
future.
institución:(a) Department of Medical Neuroscience, College of Medicine, Chungbuk National University, Cheongju, Korea. (b) Department of Medical Neuroscience, College of Medicine, Chungbuk National University, Cheongju, Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical, genetic, and cognitive correlates of seizure occurrences in Phelan-McDermid syndrome.
Clinical, genetic, and cognitive correlates of seizure occurrences in Phelan-McDermid syndrome.
Fuente:Journal of Neurodevelopmental Disorders
Extracto:
These results begin to eludicate
correlates of seizures in individuals with PMS and highlight the importance of
early seizure management. Importantly, presence of seizures was associated with
adaptive and cognitive functioning. A larger cohort might be able to identify
additional associations with medical features. Genetic findings suggest an
increased capability to realize genotype-phenotype relationships when deletion
size is taken into account.
institución:(a) Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. (b) Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Updated safety results from phase 3 lecanemab study in early Alzheimer's disease.
Updated safety results from phase 3 lecanemab study in early Alzheimer's disease.
Fuente:Alzheimer's Research & Therapy
Tipo de trabajo:Estudio abierto
Extracto:
Lecanemab was generally well-tolerated, with the most common adverse
events being infusion-related reactions, ARIA-H, ARIA-E. Clinicians,
participants, and caregivers should understand the incidence, monitoring, and
management of these events for optimal patient care. TRIAL REGISTRATION:
ClinicalTrials.gov numbers: Clarity AD NCT03887455).
Cita:Alzheimers Res Ther 2024 May 10; 16 (1) : 105.
Autor/es:Honig, Lawrence S (a) Sabbagh, Marwan N (b)
institución:(a) Columbia University Irving Medical Center, NYS Center of Excellence for Alzheimer's Disease, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center (PH19), & Department of Neurology, Columbia University Vagelos College of Physicians & Surgeons, 630 West 168th Street (P&S UNIT 16), New York, NY, 10032-3795, USA. lh456@cumc.columbia.edu. (b) Barrow Neurological Institute, Phoenix, AZ, 85013, USA.
Conflicto:LSH receives research funding from Abbvie, Acumen, Alector, Biogen, Bristol-Myers Squibb, Cognition, EIP, Eisai, Ferrer, Genentech/Roche, Janssen/J&J, Transposon, UCB, Vaccinex. LSH is a consultant for Alector, Biogen, Cortexyme, Eisai, Medscape, and Prevail/Lilly. MNS has ownership interest (Stock or stock options): NeuroTau, uMethod Health, Versanum, Athira, TransDermix, Seq BioMarque, NeuroReserve, Cortexyme/Quince Therapeutics, Lighthouse Therapeutics. MNS is a consultant for: Alzheon, Biogen,...
Roche-Genentech, Eisai, KeifeRx, Lilly, Synaptogenix, NeuroTherapia, T3D, Signant Health, Novo Nordisk. MNS receives royalties from Humanix. MNS is a Board of Director for EIP Pharma. CHvD is a consultant for Roche, Eisai, Cerevel, and Ono and receives research support from Biogen, Eisai, Roche, Genentech, Eli Lilly, Janssen, UCB, Cerevel, and Biohaven. RAS is a consultant to: AbbVie, AC Immune, Acumen, Alector, Bristol-Myers Squibb, Genentech, Ionis, Janssen, Oligomerix, Prothena, Roche, Shionogi. RAS receives research funding from the National Institute on Aging (P01AG036694; R01AG054029; R01AG061848, U24AG057437; R01 AG03689), the Alzheimer’s Association, GHR Foundation, Eli Lilly, Eisai – Public-Private Partnership Trial Funding, and. Accelerating Medicines Partnership FNIH. SH, AM, LG, MG, MK, DL, SD, MI, and LK are employees of Eisai. DP is an employee of Clario.
Autor/es:Borowicz-Reutt, Kinga (a) Czernia, Julia (b)
institución:(a) Independent Unit of Experimental Neuropathophysiology, Department of Toxicology, Medical University of Lublin, Jaczewskiego 8b, PL-20-090 Lublin, Poland. (b) Independent Unit of Experimental Neuropathophysiology, Department of Toxicology, Medical University of Lublin, Jaczewskiego 8b, PL-20-090 Lublin, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Human Plasma Butyrylcholinesterase Hydrolyzes Atropine: Kinetic and Molecular Modeling Studies.
Human Plasma Butyrylcholinesterase Hydrolyzes Atropine: Kinetic and Molecular Modeling Studies.
Fuente:Molecules (basel, Switzerland)
Extracto:
In conclusion, the
results provided evidence that plasma BChE slowly hydrolyzes atropine but should
have no significant role in its metabolism under current conditions of medical
use and even under administration of the highest possible doses of this
antimuscarinic drug.
Autor/es:Mukhametgalieva, Aliya (a) Mir, Showkat Ahmad (b)
institución:(a) Laboratory of Biochemical Neuropharmacology, Kazan Federal University, Kremlevskaya Str. 18, 420008 Kazan, Russia. (b) School of Life Sciences, Sambalpur University, Jyotivihar, Burla 768019, India.
Conflicto:The authors declare that they have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper.
Human Activity Recognition in a Free-Living Environment Using an Ear-Worn Motion Sensor.
Human Activity Recognition in a Free-Living Environment Using an Ear-Worn Motion Sensor.
Fuente:Sensors (basel, Switzerland)
Extracto:
This integration facilitates
individualized health assessments, with potential applications in
tele-monitoring, personalized health insights, and optimizing athletic training
regimes.
institución:(a) German Center for Vertigo and Balance Disorders (DSGZ), Ludwig-Maximilians-University of Munich, 81377 Munich, Germany. (b) German Center for Vertigo and Balance Disorders (DSGZ), Ludwig-Maximilians-University of Munich, 81377 Munich, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Improving Eye-Tracking Data Quality: A Framework for Reproducible Evaluation of Detection Algorithms.
Improving Eye-Tracking Data Quality: A Framework for Reproducible Evaluation of Detection Algorithms.
Fuente:Sensors (basel, Switzerland)
Extracto:
Through a detailed and reproducible step-by-step workflow,
we hope to contribute towards significantly improved data quality in scientific
experiments.
Autor/es:Gundler, Christopher (a) Temmen, Matthias (b)
institución:(a) Institute for Applied Medical Informatics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. (b) EyeTrax GmbH & Co. KG, 49076 Osnabrück, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Developing a Novel Prosthetic Hand with Wireless Wearable Sensor Technology Based on User Perspectives: A Pilot Study.
Developing a Novel Prosthetic Hand with Wireless Wearable Sensor Technology Based on User Perspectives: A Pilot Study.
Fuente:Sensors (basel, Switzerland)
Extracto:
Compared
with the Ottobock hand, the proposed hand prosthesis has potential for widespread
applications in people with upper-limb deficiencies.
Claves:electric prosthetic hand, prosthetic hand user perspective, three-dimensional printer, upper-limb deficiency, wireless wearable sensors
Cita:Sensors (Basel) 2024 Apr 26; 24 (9)
Autor/es:Shimizu, Yukiyo (a) Mori, Takahiko (b)
institución:(a) Department of Rehabilitation Medicine, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan. (b) Ibaraki Prefectural University of Health Sciences Hospital, Ami 300-0331, Japan.
Conflicto:Hiroyuki Torishima is the founder and current CEO of Saitama Prosthetics and Orthotics Manufacturing Service Co., Ltd. However, this research was conducted before Saitama Prosthetics and Orthotics Manufacturing Service Co., Ltd. was established. Additionally, the remaining authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict...
of interest.
Rectified Latent Variable Model-Based EMG Factorization of Inhibitory Muscle Synergy Components Related to Aging, Expertise and Force-Tempo Variations.
Rectified Latent Variable Model-Based EMG Factorization of Inhibitory Muscle Synergy Components Related to Aging, Expertise and Force-Tempo Variations.
Fuente:Sensors (basel, Switzerland)
Extracto:
Our results demonstrated that the
inhibitory components in muscle synergies could be shaped by aging and expertise,
and also took part in motor control for adapting to different conditions in
complex tasks.
Claves:inhibitory, motor control, muscle synergy, piano playing, rectified latent variable model
Cita:Sensors (Basel) 2024 Apr 28; 24 (9)
Autor/es:Huang, Subing (a) Guo, Xiaoyu (b)
institución:(a) Department of Electrical Engineering, City University of Hong Kong, Hong Kong, China. (b) Department of Electrical Engineering, City University of Hong Kong, Hong Kong, China.
Conflicto:Arthur D. P. Mak is employed by Cambridgeshire and Peterborough NHS Foundation Trust. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Differentiating Epileptic and Psychogenic Non-Epileptic Seizures Using Machine Learning Analysis of EEG Plot Images.
Differentiating Epileptic and Psychogenic Non-Epileptic Seizures Using Machine Learning Analysis of EEG Plot Images.
Fuente:Sensors (basel, Switzerland)
Extracto:
This investigation demonstrates the high accuracy achievable with CNN
analysis of EEG plot images and the robustness of this approach across EEG
visualization software, laying the groundwork for further subclassification of
seizures using similar approaches in a clinical setting.
institución:(a) Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. (b) Undergraduate Medical Education, Baylor College of Medicine, Houston, TX 77030, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Calibrating Deep Learning Classifiers for Patient-Independent Electroencephalogram Seizure Forecasting.
Calibrating Deep Learning Classifiers for Patient-Independent Electroencephalogram Seizure Forecasting.
Fuente:Sensors (basel, Switzerland)
Extracto:
Although our method still requires at least one
epileptic event per patient to calibrate the forecasting model, we conclude that
focusing on realistic validation methods allows to more reliably compare
different machine learning approaches for seizure prediction, enabling the
implementation of robust and effective forecasting systems that can be used in
daily healthcare practice.
Claves:cross-subject, cross-validation, domain adaptation, electroencephalography, epilepsy, machine learning, model calibration, model validation, seizure prediction, signal processing
Cita:Sensors (Basel) 2024 Apr 30; 24 (9)
Autor/es:Shafiezadeh, Sina (a) Duma, Gian Marco (b)
institución:(a) Department of General Psychology, University of Padova, 35131 Padova, Italy. (b) Epilepsy and Clinical Neurophysiology Unit, Scientific Institute, IRCCS E. Medea, 31015 Conegliano, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Brain Networks Modulation during Simple and Complex Gait: A "Mobile Brain/Body Imaging" Study.
Brain Networks Modulation during Simple and Complex Gait: A "Mobile Brain/Body Imaging" Study.
Fuente:Sensors (basel, Switzerland)
Extracto:
This study advances our understanding
of neural dynamics during overground walking, emphasizing the multidimensional
nature of gait control involving cognitive and affective networks.
institución:(a) Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genoa, Italy. (b) Research Center for Motor Control and Neuroplasticity, KU Leuven, 3001 Leuven, Belgium.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Helping Blind People Grasp: Evaluating a Tactile Bracelet for Remotely Guiding Grasping Movements.
Helping Blind People Grasp: Evaluating a Tactile Bracelet for Remotely Guiding Grasping Movements.
Fuente:Sensors (basel, Switzerland)
Extracto:
While participants were faster
with the auditory commands, they also performed well with the bracelet,
encouraging future development of this system and similar systems.
institución:(a) Institute of Cognitive Science, University of Osnabrück, 49069 Osnabrück, Germany. (b) Institute of Cognitive Science, University of Osnabrück, 49069 Osnabrück, Germany.
Conflicto:Author Silke M. Kärcher is the CEO of feelSpace GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Artificial neural network identified a 20-gene panel in predicting immunotherapy response and survival benefits after anti-PD1/PD-L1 treatment in glioblastoma patients.
Artificial neural network identified a 20-gene panel in predicting immunotherapy response and survival benefits after anti-PD1/PD-L1 treatment in glioblastoma patients.
Fuente:Cancer Medicine
Tipo de trabajo:Estudio clínico
Extracto:
The 20-gene panel developed by the ANN could be a promising biomarker
for predicting immunotherapy response and prognostic benefits in ICI-treated GBM
patients and may guide oncologists to accurately select potential responders for
the preferential use of ICIs.
institución:(a) Department of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking UnionMedical College, Beijing, China. (b) Department of Neurosurgery, Center for Malignant Brain Tumors, National Glioma MDT Alliance, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking UnionMedical College, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Validation and assessment of psychometric properties of the Greek Eating Behaviors Assessment for Obesity (GR-EBA-O).
Validation and assessment of psychometric properties of the Greek Eating Behaviors Assessment for Obesity (GR-EBA-O).
Fuente:Eating and Weight Disorders Ewd
Extracto:
The Greek version
of the EBA-O has demonstrated sound psychometric properties and appears a
reliable and user-friendly tool to identify pathological eating behaviors in
obesity. LEVEL OF EVIDENCE: V, descriptive research.
institución:(a) Eating Disorders Unit, 1st Department of Psychiatry, National and Kapodistrian University of Athens, Eginition Hospital, Vas Sofias 74, 11526, Athens, Greece. (b) Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación