Trials that turn from retrospectively registered to prospectively registered

Trials that turn from retrospectively registered to prospectively registered

Fuente:Trials

Tipo de trabajo:Estudio de cohortes

Extracto: Retroactively prospective trial registration happens in one in 50 trials. While these changes to the start date could be mistakes or legitimate edits based on the most up-to-date information, they could also indicate a retrospectively registered trial that has been made to appear as a prospectively registered trial, which would lead to biases unapparent to reviewers. Our results point to the need for more transparent reporting of changes to a trial's details and have implications for the review and conduct of clinical trials, with our fully automated and freely available tools allowing reviewers or editors to detect these changes. TRIAL REGISTRATION: The preregistered protocol of our study is available via https://osf.io/rvq53 . The most recent version of the protocol lists all deviations from the original study plan, including the rationale behind the changes, and additional analyses that were conducted.

Claves:Clinical trials, Meta-research, Retroactively prospective trial registration, Start date, Trial registries

Cita:Trials 2024 Mar 14; 25 (1) : 189.

Autor/es:Holst, Martin (a)
Carlisle, Benjamin Gregory (b)

institución:(a) Berlin Institute of Health at Charité - Universitätsmedizin Berlin, QUEST Center for Responsible Research, Anna-Louisa-Karsch-Str. 2, 10178, Berlin, Germany. martin.holst@bih-charite.de.
(b) Medizinische Hochschule Hannover, Institute for Ethics, History and Philosophy of Medicine, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. martin.holst@bih-charite.de.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13063-024-08029-5

Recurrent Intensive Care Episodes and Mortality Among Children With Severe Neurologic Impairment.

Recurrent Intensive Care Episodes and Mortality Among Children With Severe Neurologic Impairment.

Fuente:Jama Network Open

Tipo de trabajo:Estudio de cohortes

Extracto: AND RELEVANCE: This cohort study of children with SNI demonstrated a modest dose-dependent association between PICU-CIEs and short-term mortality. These data did not support the conventional wisdom that recurrent PICU admissions are associated with subsequent high mortality risk.

Cita:JAMA Netw Open 2024 Mar 4; 7 (3) : e241852.

Autor/es:Nelson, Katherine E (a)
Zhu, Jingqin (b)

institución:(a) Pediatric Advanced Care Team, Hospital for Sick Children, Toronto, Ontario, Canada.
(b) Division of Paediatric Medicine, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

Conflicto:Conflict of Interest Disclosures: Dr Thomson reported receiving grants from the Agency for Healthcare Research and Quality and the Patient-Centered Outcomes Research Institute outside the submitted work. Dr Cohen reported being a member of the Committee to Evaluate Drugs, which provides advice to Ontario’s Ministry of Health on public drug policy. Dr Feinstein reported receiving grants from the Agency for... or Healthcare Research and Quality outside the submitted work. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.1852

Priority-setting for hospital funding of high-cost innovative drugs and therapeutics: A qualitative institutional case study.

Priority-setting for hospital funding of high-cost innovative drugs and therapeutics: A qualitative institutional case study.

Fuente:Plos One

Extracto: This study identifies values and processes to aid in the development and implementation of institutional resource allocation frameworks for high-cost innovative D&Ts.

Cita:PLoS One 2024; 19 (3) : e0300519.

Autor/es:Razvi, Yasmeen (a)
Horwitz, Simonne L (b)

institución:(a) Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
(b) SickKids Research Institute, Child Health Evaluative Sciences, Toronto, ON, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300519

Understanding, being, and doing of bioethics; a state-level cross-sectional study of knowledge, attitude, and practice among healthcare professionals.

Understanding, being, and doing of bioethics; a state-level cross-sectional study of knowledge, attitude, and practice among healthcare professionals.

Fuente:Bmc Medical Ethics

Extracto: Most HCPs had adequate knowledge of bioethics, which is encouraging and would favor the laying foundation for forming a good bioethics framework. Only 3/5 HCPs demonstrated a favorable attitude, and the observed unethical practice is alarmingly common. A serious consideration to evaluate the compliance level of bioethics practice periodically and measures to educate, sensitize, and train bioethics among HCPs in Maharashtra is warranted.

Claves:Attitude, Bioethics, Healthcare professionals, India, Knowledge, Maharashtra, Practice

Cita:BMC Med Ethics 2024 Mar 18; 25 (1) : 30.

Autor/es:Thangavelu, Poovishnu Devi (a)
Janakiraman, Balamurugan (b)

institución:(a) Center of Bioethics, Faculty of Medicine, University of Porto, Porto, Portugal. vishnudevi25research@gmail.com.
(b) Krishna College of Physiotherapy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, 415539, India. vishnudevi25research@gmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12910-024-01028-w

What are the views of Quebec and Ontario citizens on the tiebreaker criteria for prioritizing access to adult critical care in the extreme context of a COVID-19 pandemic?

Fuente:Bmc Medical Ethics

Extracto: Life cycle was the preferred tiebreaker as this criterion respects intergenerational equity, which was considered relevant when allocating scarce resources to adult patients in a context of extreme pandemic. Priority to young patients is in line with other consultations conducted around the world. Additional studies are needed to further investigate the public acceptability of tiebreaker criteria.

Claves:COVID-19 prioritization, Clinical ethics, Critical care, Democratic deliberation, Tiebreakers

Cita:BMC Med Ethics 2024 Mar 19; 25 (1) : 31.

Autor/es:Calderon Ramirez, Claudia (a)
Farmer, Yanick (b)

institución:(a) Biomedical Sciences Program, Clinical Ethics, Faculty of Medicine, Université de Montréal, Pavillon Roger-Gaudry 2900 Bd Édouard-Montpetit, Montréal, Québec, H3T 1J4, Canada.
(b) Department of Social and Public Communication, Faculty of Communication, succursale Centre-Ville, Université du Québec à Montréal, Montréal, Québec, C.P 8888, H3C 3P8, Canada.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12910-024-01030-2

Evaluating the use of casuistry during moral case deliberation in the ICU: A multiple qualitative case study.

Fuente:Social Science & Medicine (1982)

Extracto: Within education, we should strive to train clinicians and ethics facilitators so that they can recognize and evaluate casuistic arguments.

Claves:Casuistry, Clinical decision-making, Discourse analysis, Evidence-based medicine, Intensive care, Moral case deliberation, The Netherlands

Cita:Soc Sci Med 2024 Mar; 345 : 116662.

Autor/es:Kok, Niek (a)
Hoedemaekers, Cornelia (b)

institución:(a) Radboud University Medical Center, Department of IQ Health, Kapittelweg 54, 6525, EP, Nijmegen, Netherlands. Electronic address: niek.kok@radboudumc.nl.
(b) Radboud University Medical Center, Department of Intensive Care, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1016/j.socscimed.2024.116662

Opening Pandora's box by generating ICU diaries through artificial intelligence: A hypothetical study protocol.

Fuente:Intensive & Critical Care Nursing

Extracto: Generating AI-based entries for ICU diaries is feasible, but raises serious questions about nursing ethics, empathy, data protection, and values of professional nurses. Researchers and developers shall discuss these questions in detail, before starting such projects and opening Pandora's box, that can never be closed afterwards.

Claves:Artificial Intelligence, Coping, Ethics, Intensive care diary, Protocol

Cita:Intensive Crit Care Nurs 2024 Jun; 82 : 103661.

Autor/es:Peschel, Ella (a)
Krotsetis, Susanne (b)

institución:(a) University Hospital of Schleswig-Holstein, Kiel, Germany.
(b) University Hospital of Schleswig-Holstein, Lübeck, Germany.

Conflicto:Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Países Bajos

Sitio web:http://dx.doi.org/10.1016/j.iccn.2024.103661

Assessing the commensurability of theories of consciousness: On the usefulness of common denominators in differentiating, integrating and testing hypotheses.

Fuente:Consciousness and Cognition

Extracto: Despite very different background definitions of consciousness, we conclude that, if attention is paid to the search for a common methological approach to brain-consciousness relationships, it should be possible in principle to overcome the current Babylonian confusion of tongues and eventually integrate and merge different theories.

Claves:Commensurability, Consciousness, Denominator, Inference, Information, Integration, Motor action - Neural representation - Predictive Processing, Workspace

Cita:Conscious Cogn 2024 Mar; 119 : 103668.

Autor/es:Evers, K (a)
Farisco, M (b)

institución:(a) Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden. Electronic address: kathinka.evers@crb.uu.se.
(b) Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden; Bioethics Unit, Biogem, Molecular Biology and Molecular Genetics Research Institute, Ariano Irpino (AV), Italy.

Conflicto:Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1016/j.concog.2024.103668

Mass drug administration for neglected tropical disease control and elimination

Fuente:Bmj Global Health

Tipo de trabajo:Revisión sistemática

Extracto: This is the first systematic review of ethical reasons pertaining to mass drug administration for NTD control and elimination. Due to the diversity of included studies, no general recommendations can be made. Instead, context-specific strategies seem necessary. Alternative approaches tackling socioecological determinants of ill health are needed for long-term sustainability. Future research could benefit from contributions of non-Western philosophies and perspectives by local researchers.

Claves:parasitology, public health, qualitative study, systematic review

Cita:BMJ Glob Health 2024 Mar 13; 9 (3)

Autor/es:Hoefle-Bénard, Juliette (a)
Salloch, Sabine (b)

institución:(a) Institute for Ethics, History and Philosophy of Medicine, Hannover Medical School, Hannover, Germany juliette.hoefle@gmail.com.
(b) Institute for Ethics, History and Philosophy of Medicine, Hannover Medical School, Hannover, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjgh-2023-013439

Generative AI in healthcare: an implementation science informed translational path on application, integration and governance.

Fuente:Implementation Science Is

Extracto: It is strongly argued in this article that generative AI can usher in tremendous healthcare progress, if introduced responsibly. Strategic adoption based on implementation science, incremental deployment and balanced messaging around opportunities versus limitations helps promote safe, ethical generative AI integration. Extensive real-world piloting and iteration aligned to clinical priorities should drive development. With conscientious governance centred on human wellbeing over technological novelty, generative AI can enhance accessibility, affordability and quality of care. As these models continue advancing rapidly, ongoing reassessment and transparent communication around their strengths and weaknesses remain vital to restoring trust, realizing positive potential and, most importantly, improving patient outcomes.

Claves:Generative artificial intelligence, Healthcare, Implementation science, Translation pathway

Cita:Implement Sci 2024 Mar 15; 19 (1) : 27.

Autor/es:Generative artificial intelligence, Healthcare, Implementation science, Translation pathway

institución:Generative artificial intelligence, Healthcare, Implementation science, Translation pathway

Conflicto:The author declares no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13012-024-01357-9

Unpacking the perceptions and experiences of student facilitators in interprofessional education: a qualitative study.

Fuente:Medical Education Online

Extracto: These findings can inform the development of peer teaching training in IPE and stimulate further research in identifying relevant facilitator competencies for optimal delivery of IPE.

Claves:Interprofessional education, cognitive congruence, health professions students, peer teaching, social congruence, student facilitator

Cita:Med Educ Online 2024 Dec 31; 29 (1) : 2330257.

Autor/es:He, Qing (a)
Lei, Junru (b)

institución:(a) Bau Institute of Medical and Health Sciences Education, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
(b) Bau Institute of Medical and Health Sciences Education, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Conflicto:No potential conflict of interest was reported by the author(s).

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1080/10872981.2024.2330257

Gender-sensitive considerations of prehospital teamwork in critical situations.

Fuente:Philosophy, Ethics, and Humanities in Medicine Pehm

Extracto: Team communication problems and teamwork in rescue services are independent of gender. Women seem to have more difficulty with open communication about mistakes because they seem to be subject to higher expectations. Work organization should be adapted to women's needs to enable more effective error management. We conclude that it is necessary to promote a positive error and communication culture to increase patient safety.

Claves:Communication, Error, Gender, Patient safety, Teamwork

Cita:Philos Ethics Humanit Med 2024 Mar 20; 19 (1) : 3.

Autor/es:Zimmer, Matthias (a)
Czarniecki, Daria Magdalena (b)

institución:(a) Department of Internal Medicine I, Ketteler Hospital, Hesse, Germany. zimmer.m@ketteler-krankenhaus.de.
(b) Dr. Senckenberg Institute for History and Ethics of Medicine, Goethe-University Frankfurt, Frankfurt, Hesse, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13010-024-00153-z

The importance of professional responsibility and fetal viability in the management of abortion.

The importance of professional responsibility and fetal viability in the management of abortion.

Fuente:Journal of Perinatal Medicine

Extracto: Using the professional responsibility model, we emphasize the need for nuanced, evidence-based policies that allow abortion management prior to viability without restrictions and allow abortion after viability to protect the pregnant patient's life and health, as well as permitting abortion for serious fetal anomalies.

Claves:abortion, abortion laws, fetus, pregnancy trimester, professional responsibility, viability

Cita:J Perinat Med 2024 Mar 25; 52 (3) : 249-254.

Autor/es:Chervenak, Frank (a)
McLeod-Sordjan, Renee (b)

institución:(a) Northwell, New Hyde Park, NY, USA.
(b) Department of Obstetrics and Gynecology, Lenox Hill Hospital; Zucker School of Medicine;Northwell, 2000 Marcus Ave, Suite 300, New Hyde Park, NY, USA.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1515/jpm-2023-0503

Harnessing artificial intelligence for advancing early diagnosis in hidradenitis suppurativa.

Harnessing artificial intelligence for advancing early diagnosis in hidradenitis suppurativa.

Fuente:Italian Journal of Dermatology and Venereology

Extracto: AI's dynamic nature supports continuous learning, refining diagnostic and treatment strategies, ultimately reshaping standards of care in dermatology.

Cita:Ital J Dermatol Venerol 2024 Feb; 159 (1) : 43-49.

Autor/es:Crovella, Sergio (a)
Suleman, Muhammad (b)

institución:(a) Laboratory of Animal Research Center (LARC), Qatar University, Doha, Qatar - sgrovella@qu.edu.qa.
(b) Laboratory of Animal Research Center (LARC), Qatar University, Doha, Qatar.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.23736/S2784-8671.23.07829-5

The intersection between logical empiricism and qualitative nursing research: a post-structuralist analysis.

The intersection between logical empiricism and qualitative nursing research: a post-structuralist analysis.

Fuente:International Journal of Qualitative Studies On Health and Well-being

Extracto: I advocate for a shift from qualitative positivism towards more interpretive and post-qualitative inquiries, this work proposes new trajectories through interpretive, critical, post-qualitative, and artistic turns in nursing research, aiming to transcend positivist limitations and foster a plurality of perspectives and research as praxis. Implications emphasize the need for nursing researchers to expand methodological horizons, incorporating visual and artistic methods to enrich understanding and representation of health experiences, moving beyond positivist norms towards a more inclusive and ethically sound research paradigm.

Claves:Epistemology, logical empiricism, methodology, nursing research, ontology, postmodernism, qualitative research, research design, social constructivism

Cita:Int J Qual Stud Health Well-being 2024 Dec; 19 (1) : 2315636.

Autor/es:Epistemology, logical empiricism, methodology, nursing research, ontology, postmodernism, qualitative research, research design, social constructivism

institución:Epistemology, logical empiricism, methodology, nursing research, ontology, postmodernism, qualitative research, research design, social constructivism

Conflicto:No potential conflict of interest was reported by the author(s).

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1080/17482631.2024.2315636

Association between domain-specific physical activity and mental health status after embryo transfer in IVF-ET-assisted pregnancy patients.

Association between domain-specific physical activity and mental health status after embryo transfer in IVF-ET-assisted pregnancy patients.

Fuente:Scientific Reports

Extracto: The study indicates that increased engagement in physical activity, specifically activities related to occupation, transportation, and household, may be associated with improved mental health among IVF-ET patients.

Claves:Activity intensity, Domain-specific, Infertility, Mental health, Physical activity

Cita:Sci Rep 2024 Feb 28; 14 (1) : 4928.

Autor/es:Wang, Wei (a)
Yang, Fang (b)

institución:(a) Department of Psychology, Qilu Hospital of Shandong University, Wenhuaxi Road 107, Jinan, 250012, Shandong, China.
(b) Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-55097-3

Relationships between obesity markers and bone parameters in community-dwelling older adults.

Relationships between obesity markers and bone parameters in community-dwelling older adults.

Fuente:Aging Clinical and Experimental Research

Extracto: Our findings indicate that independent of sex and obesity criteria, when significant, being obese seems to lead to higher bone parameters than being non-obese, except for cortical bone density. Thus, in the obese population, assessing cortical density might help the physician to identify bone alteration. Further researches are needed to confirm our findings.

Claves:Aging, Bone architecture, Bone density, Fat mass, Obesity

Cita:Aging Clin Exp Res 2024 Feb 29; 36 (1) : 49.

Autor/es:Lemoine, L (a)
Buckinx, F (b)

institución:(a) Division of Geriatric Medicine, Tours University Medical Centre, Tours, France. lea.lemoine@univ-tours.fr.
(b) CHRU Tours - Service de Médecine Aigue Gériatrique, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044, Tours Cedex 9, France. lea.lemoine@univ-tours.fr.

Conflicto:The authors have not any conflict interest to declare.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s40520-023-02673-8

Current practice of hospital-based palliative care teams: Advance care planning in advanced stages of disease: A retrospective observational study.

Current practice of hospital-based palliative care teams: Advance care planning in advanced stages of disease: A retrospective observational study.

Fuente:Plos One

Extracto: This study provides detailed insight into consultations of palliative care teams and shows that even though most palliative care consultations were requested for advance care planning, consultations focus on end-of-life care and are more crisis-oriented than prevention-oriented. Death often occurs too quickly after consultation for end-of-life preferences to be met and these preferences tend to focus on dying. Educating healthcare professionals on when to initiate advance care planning would promote a more prevention-oriented approach. Defining factors that indicate the need for timely palliative care team consultation and advance care planning could help timely identification and consultation.

Cita:PLoS One 2024; 19 (2) : e0288514.

Autor/es:van Doorne, Iris (a)
Willems, Dick L (b)

institución:(a) Amsterdam UMC Location University of Amsterdam, Internal Medicine, Section of Geriatric Medicine, Amsterdam, The Netherlands.
(b) Amsterdam Public Health, Aging and Later Life, Amsterdam, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0288514

Environmental causality calibration: Advancing WLAN RF fingerprinting for precise indoor localization.

Fuente:Plos One

Extracto: According to experimental test results, the fingerprint database expansion model AeFd proposed in this paper can effectively expand the fingerprint database under different relative humidity levels, thereby significantly enhancing the positioning performance of the system and improving its stability.

Cita:PLoS One 2024; 19 (2) : e0297108.

Autor/es:Fan, Yufeng (a)
Sun, Haotai (b)

institución:(a) Shenyang Fire Science and Technology Research Institute of MEM, Shenyang, China.
(b) Shenyang Aerospace University, School of Computer Science, Shenyang, China.

Conflicto:The author declares that there is no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0297108

IGG in the trenches: Results of an in-depth interview study on the practice, politics, and future of investigative genetic genealogy.

Fuente:Forensic Science International

Extracto: The experiences and perspectives of individuals in the IGG trenches related to these and other issues are potentially useful inputs to ongoing efforts to regulate the technique.

Claves:Consent, IGG, Investigative genetic genealogy, Policy, Privacy

Cita:Forensic Sci Int 2024 Mar; 356 : 111946.

Autor/es:Guerrini, Christi J (a)
Bash Brooks, Whitney (b)

institución:(a) Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA. Electronic address: guerrini@bcm.edu.
(b) Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA.

Conflicto:Declaration of Competing Interests C.J.G. and S.M.F. are members of the Investigative Genetic Genealogy Working Group of the Scientific Working Group on DNA Analysis Methods. A.L.M. is a former member of the FamilyTreeDNA Citizen’s Panel. C.J.G. is a member of the Policy and Practice Subcommittee of the National Technology Validation and Implementation Collaborative Forensic Investigative Genetic Genealogy Technical Validation Working... ng Group. She is also a member of the Advisory Board of the Investigative Genetic Genealogy Accreditation Board.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Irlanda

Sitio web:http://dx.doi.org/10.1016/j.forsciint.2024.111946