CNS Viral Infections-What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches.

CNS Viral Infections-What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches.

Fuente:Cns Drugs

Extracto: Existing physiologically based pharmacokinetic models combined with in vitro pharmacokinetic/pharmacodynamic information can be used to predict drug exposure and evaluate efficacy of antiviral drugs within the CNS, to ultimately optimize the treatments of CNS viral infections.

Cita:CNS Drugs 2024 May; 38 (5) : 349-373.

Autor/es:Sun, Ming (a)
Manson, Martijn L (b)

institución:(a) Division of Systems Pharmacology and Pharmacy, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
(b) Division of Systems Pharmacology and Pharmacy, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Nueva Zelanda

Sitio web:http://dx.doi.org/10.1007/s40263-024-01082-3

Generative adversarial networks for anonymous acneic face dataset generation.

Generative adversarial networks for anonymous acneic face dataset generation.

Fuente:Plos One

Extracto: Moreover, this approach can also be extended to other applications requiring the generation of synthetic medical images.

Cita:PLoS One 2024; 19 (4) : e0297958.

Autor/es:Zein, Hazem (a)
Chantaf, Samer (b)

institución:(a) LISSI Laboratory, Université Paris-Est Créteil, Vitry-sur-Seine, France.
(b) Faculty of Technology, Lebanese University, Saida, Lebanon.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0297958

A comparative analysis of attitudes toward genome-edited food among Japanese public and scientific community.

Fuente:Plos One

Extracto: Understanding gaps between the public and experts' opinions on and interests in GEF provides essential insight for effective communication and acts as the basis for appropriate governance of emerging science and technology.

Cita:PLoS One 2024; 19 (4) : e0300107.

Autor/es:Shineha, Ryuma (a)
Takeda, Kohei F (b)

institución:(a) Research Center on Ethical, Legal and Social Issues, Osaka University, Osaka, Japan.
(b) Research Center on Ethical, Legal and Social Issues, Osaka University, Osaka, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300107

Research ethics review during the COVID-19 pandemic: An international study.

Fuente:Plos One

Extracto: To our knowledge, this is the first international, COVID-19-related study of its kind.

Cita:PLoS One 2024; 19 (4) : e0292512.

Autor/es:Salamanca-Buentello, Fabio (a)
Katz, Rachel (b)

institución:(a) Lunenfeld-Tanenbaum Research Institute, Bridgepoint Collaboratory for Research and Innovation, Sinai Health, Toronto, Canada.
(b) Institute for the History and Philosophy of Science and Technology, University of Toronto, Toronto, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0292512

Grace Under Pressure: a mixed methods impact assessment of a verbatim theatre intervention to improve healthcare workplace culture.

Grace Under Pressure: a mixed methods impact assessment of a verbatim theatre intervention to improve healthcare workplace culture.

Fuente:Bmc Health Services Research

Extracto: Verbatim theatre is effective in raising awareness about difficult workplace behaviour in ways that motivate behaviour change, and hence can be effective in catalysing real improvements in healthcare workplace culture. Creative approaches are recommended for addressing similarly complex challenges in healthcare workforce retention.

Claves:Arts and health, Bullying, Harassment, Healthcare workforce retention, Healthcare workplace culture, Incivility, Psychosocial risk, Verbatim theatre

Cita:BMC Health Serv Res 2024 Apr 16; 24 (1) : 474.

Autor/es:Hooker, Claire (a)
Karageorge, Aspasia (b)

institución:(a) Sydney Health Ethics, School of Public Health, University of Sydney, Camperdown, NSW, 2006, Australia. claire.hooker@sydney.edu.au.
(b) Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.

Conflicto:Dr Renee Lim is Director of Program Development at Pam McLean Centre (PMC). The Grace Under Pressure workplace culture intervention received funding from: NSW Health; Pam McLean Centre; and participating Local Health Districts. PMC provides transparent reporting on Centre programs and activities. There are no other competing interests to declare for any of the authors.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12913-024-10961-w

Components related to ethical decision making in medical science students: A structural equation model.

Components related to ethical decision making in medical science students: A structural equation model.

Fuente:Plos One

Extracto: Based on the findings of the moral reasoning test, the moral sensation was associated with ethical decision-making, which indicates the necessity of attending to ethical aspects, promoting moral reasoning, sensitivity, and students' accuracy.

Cita:PLoS One 2024; 19 (4) : e0297494.

Autor/es:Parvari, Soraya (a)
Farajidana, Hoorvash (b)

institución:(a) Department of Anatomy, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
(b) Department of Clinical Toxicology, Kosar Hospital Poison Center, Emergency Department, Alborz University of Medical Science, Karaj, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0297494

Effects of different exercise interventions on chemotherapy-related cognitive impairment in patients with breast cancer

Effects of different exercise interventions on chemotherapy-related cognitive impairment in patients with breast cancer

Fuente:Bmj Open

Tipo de trabajo:Revisión sistemática

Extracto: PROSPERO REGISTRATION NUMBER: CRD42023406597.

Claves:Breast tumours, CHEMOTHERAPY, Delirium & cognitive disorders, Patients

Cita:BMJ Open 2024 Apr 17; 14 (4) : e078934.

Autor/es:Dong, Yu (a)
Huang, Hao (b)

institución:(a) The First Hospital of China Medical University, Shenyang, Liaoning, China.
(b) The First Hospital of China Medical University, Shenyang, Liaoning, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-078934

Comparing attitudes towards compulsory interventions in severe and persistent mental illness among psychiatrists in India and Switzerland.

Comparing attitudes towards compulsory interventions in severe and persistent mental illness among psychiatrists in India and Switzerland.

Fuente:Bmc Psychiatry

Extracto: The significant difference in attitudes towards coercive measures among Indian compared to Swiss psychiatrists found in this study might arise from a predominantly more collectivist society in India compared to Switzerland. Moreover, differences in financial resources, the organization of the health care system, and the historical background might have an influence. Continuous and critical reflection on one's own views and behavior is essential, especially if ethical principles and individual rights could be violated through a power imbalance, as in the case of coercive measures.

Claves:Autonomy, Coercion, Depression, India, Psychiatrists, Schizophrenia, Switzerland

Cita:BMC Psychiatry 2024 Apr 18; 24 (1) : 295.

Autor/es:Rickli, Christina (a)
Stoll, Julia (b)

institución:(a) Institute of Biomedical Ethics and History of Medicine, University of Zurich (UZH), Zurich, Switzerland.
(b) Institute of Biomedical Ethics and History of Medicine, University of Zurich (UZH), Zurich, Switzerland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12888-024-05710-6

Decision discovery using clinical decision support system decision log data for supporting the nurse decision-making process.

Decision discovery using clinical decision support system decision log data for supporting the nurse decision-making process.

Fuente:Bmc Medical Informatics and Decision Making

Tipo de trabajo:Guía

Extracto: In this paper, we show that decisions can be discovered from a decision log and visualized for the improvement of the decision-making process of healthcare professionals or to support the periodic evaluation of protocols and guidelines.

Claves:CDSS, DMN, Decision management, Decision mining, Decision-making, Discovery

Cita:BMC Med Inform Decis Mak 2024 Apr 18; 24 (1) : 100.

Autor/es:Berkhout, Matthijs (a)
Smit, Koen (b)

institución:(a) Digital Ethics, HU University of Applied Sciences Utrecht, Heidelberglaan 15, Utrecht, 3584 CS, The Netherlands. Matthijs.berkhout@hu.nl.
(b) Digital Ethics, HU University of Applied Sciences Utrecht, Heidelberglaan 15, Utrecht, 3584 CS, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12911-024-02486-3

Research ethics and artificial intelligence for global health: perspectives from the global forum on bioethics in research.

Research ethics and artificial intelligence for global health: perspectives from the global forum on bioethics in research.

Fuente:Bmc Medical Ethics

Extracto: The 2022 Global Forum on Bioethics in Research illustrated several innovations in ethical governance of AI for global health research, as well as several areas in need of urgent attention internationally. This summary is intended to inform international and domestic efforts to strengthen research ethics and support the evolution of governance leadership to meet the demands of AI in global health research.

Claves:Artificial intelligence, Bioethics, Global health, Machine learning, Research ethics

Cita:BMC Med Ethics 2024 Apr 18; 25 (1) : 46.

Autor/es:Shaw, James (a)
Ali, Joseph (b)

institución:(a) Department of Physical Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. Jay.shaw@utoronto.ca.
(b) Joint Centre for Bioethics, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. Jay.shaw@utoronto.ca.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12910-024-01044-w

Acceptance of a Digital Assistant (Anne4Care) for Older Adult Immigrants Living With Dementia: Qualitative Descriptive Study.

Acceptance of a Digital Assistant (Anne4Care) for Older Adult Immigrants Living With Dementia: Qualitative Descriptive Study.

Fuente:Jmir Aging

Extracto: Although older adult immigrants living with dementia had no previous experience with digital assistive technology specifically, the acceptance of the digital personal assistant, called Anne4Care, by older adult immigrants living with dementia was rather high. The digital assistant can be further developed to allow for interactive conversations and for use outside of one's home. Participation of end users during various stages of the development, refinement, and implementation of health technology innovations is of utmost importance to maximize technology acceptance.

Claves:assistive technology, dementia, immigrant, marginalized older adults, technology acceptance

Cita:JMIR Aging 2024 Apr 19; 7 : e50219.

Autor/es:Bults, Marloes (a)
van Leersum, Catharina Margaretha (b)

institución:(a) Technology, Health & Care Research Group, Saxion University of Applied Sciences, Enschede, Netherlands.
(b) Department of Technology, Policy, and Society, Faculty of Behavioural, Management and Social Sciences, University of Twente, Enschede, Netherlands.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:http://dx.doi.org/10.2196/50219

A simulation training of family management for parents of children with epilepsy

A simulation training of family management for parents of children with epilepsy

Fuente:Italian Journal of Pediatrics

Tipo de trabajo:Estudio clínico aleatorizado

Extracto: STOFMS is an effective intervention to improve family management level, treatment adherence and clinical efficacy for children with epilepsy. TRIAL REGISTRATION: The registration number is ChiCTR2200065128. Registered at 18 October 2022, http://www.medresman.org.cn.

Claves:Children, Epilepsy, Family management, Simulation training

Cita:Ital J Pediatr 2024 Apr 19; 50 (1) : 77.

Autor/es:Liu, Hua-Yan (a)
Zeng, Shan (b)

institución:(a) Hunan Children's Hospital, Changsha, Hunan, China.
(b) Hunan Children's Hospital, Changsha, Hunan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13052-024-01646-5

Building a house without foundations? A 24-country qualitative interview study on artificial intelligence in intensive care medicine.

Building a house without foundations? A 24-country qualitative interview study on artificial intelligence in intensive care medicine.

Fuente:Bmj Health & Care Informatics

Extracto: Pouring massive amounts of resources into developing AI without first building the necessary digital infrastructure foundation needed for AI is unethical. Real-world implementation and routine use of AI in the vast majority of ICUs in both HICs and LMICs included in our study is unlikely to occur any time soon. ICUs should not be using AI until certain preconditions are met.

Claves:Artificial intelligence, Information Science

Cita:BMJ Health Care Inform 2024 Apr 19; 31 (1)

Autor/es:McLennan, Stuart (a)
Fiske, Amelia (b)

institución:(a) Institute of History and Ethics in Medicine, Department of Preclinical Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Bavaria, Germany stuart.mclennan@tum.de.
(b) Institute for Biomedical Ethics, University of Basel, Basel, Switzerland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjhci-2024-101052

Advantages and limits of remote consultations for HIV pre-exposure prophylaxis health pathway: ePrEP qualitative study.

Fuente:Journal of Epidemiology and Population Health

Extracto: The initiation and uptake of PrEP among MSM are more effectively influenced by initiatives that provide information, reassurance, and facilitate initial procedures, rather than solely through RC. A strategy combining digital and community-based approaches, along with medical expertise, is recommended to increase PrEP utilization among MSM.

Claves:Community health services, Delivery of health care, HIV, Pre-exposure prophylaxis, Qualitative research, Remote consultation

Cita:J Epidemiol Popul Health 2024 Apr; 72 (2) : 202201.

Autor/es:Faussat, Cathie (a)
Bonnin, Alicia (b)

institución:(a) Inserm Team Research U1259 MAVIVH - Morphogenèse et Antigénicitédu VIH et des Virus des Hépatites, Faculty of Medicine of Tours, Tours, France; Prevention and Public Health Department - Regional University Hospital Centre (CHRU) of Tours, Tours, France. Electronic address: cathie.faussat@univ-tours.fr.
(b) EA 7505 - EES - Education-Ethics-Health Research Team, Faculty of Medicine of Tours, Tours, France. Electronic address: alicia.bonnin@univ-tours.fr.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Francia

Sitio web:http://dx.doi.org/10.1016/j.jeph.2024.202201

Institutional Priority-Setting for Novel Drugs and Therapeutics

Fuente:International Journal of Health Policy and Management

Tipo de trabajo:Revisión sistemática

Extracto: The rising cost of novel drugs and therapeutics underscores the need for robust, evidence-based, and ethically defensible decision-making processes for health technology funding, particularly at the hospital level. Our study highlights practices and themes to aid decision-makers in thinking critically about institutional, substantive, procedural, and operational considerations in support of legitimate decisions about institutional funding of high-cost drugs and therapeutics, as well as opportunities and challenges that exist for paediatric and rare disease populations.

Claves:Health Technology Assessment, High-Cost Drugs, Institutional Policy, Paediatrics, Rare/Orphan Diseases, Resource Allocation

Cita:Int J Health Policy Manag 2024; 13 : 7494.

Autor/es:Wang, Daniel E (a)
Hassanein, Maram (b)

institución:(a) Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
(b) Department of Bioethics, The Hospital for Sick Children, Toronto, ON, Canada.

Conflicto:Authors declare that they have no competing interests.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Irán

Sitio web:http://dx.doi.org/10.34172/ijhpm.2024.7494

Identifying research gaps in climate-related mental health outcomes in North America and Europe: a qualitative framework analysis.

Fuente:The Lancet. Planetary Health

Tipo de trabajo:Consenso

Extracto: FUNDING: Imperial College London, the Wellcome Trust, and the Planetary Health Alliance via Harvard University.

Cita:Lancet Planet Health 2024 Apr; 8 Suppl 1 : S21.

Autor/es:Modi, Tulsi (a)
Pressburger, Leeya (b)

institución:(a) Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: tulsi.modi@jhu.edu.
(b) Department of International Relations, School of Advanced International Studies, Johns Hopkins University, Baltimore, MD, USA.

Conflicto:Declaration of interests TM leads the Planetary Health Alliance, part of Connecting Climate Minds. All other authors declare no competing interests.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Países Bajos

Sitio web:http://dx.doi.org/10.1016/S2542-5196(24)00086-X

Safety: A collective and embedded competency. An ethnographic study of safety practices at an industrial workplace in the Netherlands.

Safety: A collective and embedded competency. An ethnographic study of safety practices at an industrial workplace in the Netherlands.

Fuente:Journal of Safety Research

Extracto: Overall, the results indicate that social interactions among employees, leaders, and management within the organization play an important role in workplace safety. The analysis highlights the value of vulnerability and trust in relationships at work to be able to learn and develop safety procedures that align with local demands. PRACTICAL APPLICATIONS: This study emphasizes the need for participatory approaches in creating safer and healthier workplaces. The cocreation of occupational health and safety (OHS) rules and procedures, however, can only function if they are combined with a responsive leadership style.

Claves:Accountability, Collectivity, Ethnography, Organizational learning, Safety management, Situated work practices, Tacit knowledge, Workplace health

Cita:J Safety Res 2024 Feb; 88 : 93-102.

Autor/es:Biermann-Teuscher, Dorit (a)
Thissen, Lotte (b)

institución:(a) Department of Health, Ethics and Society, Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Maastricht University, the Netherlands.
(b) Department of Health, Ethics and Society, Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Maastricht University, the Netherlands.

Conflicto:Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1016/j.jsr.2023.10.012

The association of resilience and positive mental health in systemic sclerosis: A Scleroderma Patient-centered Intervention Network (SPIN) cohort cross-sectional study.

The association of resilience and positive mental health in systemic sclerosis: A Scleroderma Patient-centered Intervention Network (SPIN) cohort cross-sectional study.

Fuente:Journal of Psychosomatic Research

Extracto: People with worse disease severity and patient-reported outcomes reported substantially lower resilience, except a class of people with high disease severity, fatigue, pain, and sleep disturbance but positive mental health and high resilience.

Claves:Mental health, Resilience, Scleroderma, Systemic sclerosis

Cita:J Psychosom Res 2024 Apr; 179 : 111648.

Autor/es:Neyer, Marieke A (a)
Henry, Richard S (b)

institución:(a) Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Electronic address: marieke.neyer@mail.mcgill.ca.
(b) Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Electronic address: richard.henry@mail.mcgill.ca.

Conflicto:Declaration of competing interest The authors have no competing interests to report.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1016/j.jpsychores.2024.111648

Palliative psychiatry for a patient with treatment-refractory schizophrenia and severe chronic malignant catatonia

Palliative psychiatry for a patient with treatment-refractory schizophrenia and severe chronic malignant catatonia

Fuente:Annals of Palliative Medicine

Tipo de trabajo:Caso clínico

Extracto: This case permits discussion of palliative interventions in patients with SPMI such as treatment-refractory psychotic disorders who likely cannot achieve a quality of life that is acceptable to them. Here, it can be justified to prioritize relief of suffering and prevention of further burdensome interventions over treatment of the SPMI symptoms such as catatonia and even over keeping the patient alive.

Claves:Palliative psychiatry, case report, end-of-life care, severe and persistent mental illness (SPMI), treatment-refractory schizophrenia

Cita:Ann Palliat Med 2024 Mar; 13 (2) : 433-439.

Autor/es:Elgudin, Junona (a)
Johnsen, Clark (b)

institución:(a) Department of Psychiatry, New York-Presbyterian/Weill Cornell Medicine, New York, NY, USA.
(b) Department of Psychiatry, Weill Cornell Medicine, New York, NY, USA.

Formato:Informe impreso

Idioma:Inglés

País de fuente:China

Sitio web:http://dx.doi.org/10.21037/apm-23-586

Planting the Seed for Blood Pressure Control: The Role of Plant-Based Nutrition in the Management of Hypertension.

Planting the Seed for Blood Pressure Control: The Role of Plant-Based Nutrition in the Management of Hypertension.

Fuente:Current Cardiology Reports

Extracto: Future work to promote infrastructural change that supports incorporating evidence-based nutrition into medical education, clinical care, and society at large can support these efforts.

Claves:Cardiovascular disease prevention, Dietary behavior change, Dietary guidelines, Hypertension treatment, Lifestyle medicine, Whole-food, plant-based diet

Cita:Curr Cardiol Rep 2024 Mar; 26 (3) : 121-134.

Autor/es:Charles, Justin A (a)
Habibullah, Nilofer Khan (b)

institución:(a) Department of Family Medicine and Public Health, UC San Diego Health, San Diego, CA, USA. justin.a.charles92@gmail.com.
(b) American International Medical University, Gros Islet, Saint Lucia.

Conflicto:J.A.C. and N.K.H. hold voluntary positions on the American College of Lifestyle Medicine (ACLM) Trainees Executive Board and received support for attending national conferences. JC has also received a grant from ACLM and serves as a voluntary medical consultant for ActualFood. Both ACLM and ActualFood promote the use of whole-food, plant-based nutrition but did not provide support for the present... manuscript. B.D. has received a grant from the Karuna Foundation, book royalties from The Book Publishing Company Book, Healthy Living Publications, and HCI Books, consulting fees from Food Revolution Network and ACLM, honoraria for lectures from Physician’s Committee for Responsible Medicine (PCRM) and Plantrician Project, and leadership roles in Physicians Association for Nutrition, ACLM and PCRM, and owns shares in Virchew Dog Food. Her grant, books, consulting work, lectures, and leadership roles for these entities promote the use of whole-food plant-based nutrition, but none of these entities provided support for the present manuscript. The other authors confirm that there is no conflict of interest between them.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1007/s11886-023-02008-z