The effect of physical activity on cytokine levels in adults living with type 1 diabetes-a preliminary study.

The effect of physical activity on cytokine levels in adults living with type 1 diabetes-a preliminary study.

Fuente:Physiological Reports

Extracto: In conclusion, the findings from this study allow to indicate that moderate level of physical activity may contribute to a reduction in the development of systemic low-grade inflammation in patients with T1DM, and thus, may reduce the risk of CVD.

Claves:cardiovascular disease (CVD), cytokines, fatness, physical activity, type 1 diabetes mellitus (T1DM)

Cita:Physiol Rep 2024 Apr; 12 (8) : e15985.

Autor/es:Kowal, Małgorzata (a)
Woźniacka, Renata (b)

institución:(a) Department of Anthropology, Faculty of Physical Education and Sport, Bronislaw Czech University of Physical Education, Kraków, Poland.
(b) Department at Cosmetology, Faculty of Motor Rehabilitation, Bronislaw Czech University of Physical Education in Krakow, Krakow, Poland.

Conflicto:The authors declare that they have no conflict of interest.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.14814/phy2.15985

Predictors of chronic kidney disease survival in type 2 diabetes

Predictors of chronic kidney disease survival in type 2 diabetes

Fuente:Scientific Reports

Tipo de trabajo:Estudio de cohortes

Extracto: Additionally, the unforeseen findings related to eGFR highlight the ongoing need for research to deepen our understanding of the complexities of kidney disease.

Claves:Cardiovascular disease, Chronic kidney disease, Diabetes mellitus, Survival analysis, eGFR

Cita:Sci Rep 2024 Apr 19; 14 (1) : 9014.

Autor/es:Jairoun, Ammar Abdulrahman (a)
Ping, Chong Chee (b)

institución:(a) Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), 11800, Penang, Minden, Malaysia. Dr_ammar_91_@hotmail.com.
(b) Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), 11800, Penang, Minden, Malaysia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58574-x

Are there lost opportunities in chronic kidney disease? A region-wide cohort study.

Are there lost opportunities in chronic kidney disease? A region-wide cohort study.

Fuente:Bmj Open

Tipo de trabajo:Guía

Extracto: While we noted underdiagnosis and undertreatment of CKD in this large contemporary population, we also identified a substantial realisable potential to improve CKD outcomes and reduce its burden by treating patients early with guideline-directed pharmacological therapy.

Claves:adult nephrology, chronic renal failure, epidemiology

Cita:BMJ Open 2024 Apr 19; 14 (4) : e074064.

Autor/es:Sundström, Johan (a)
Norhammar, Anna (b)

institución:(a) Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden johan.sundstrom@uu.se.
(b) The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Conflicto:Competing interests: JS reports stock ownership in Anagram kommunikation AB and Symptoms Europe AB. AN has participated as a consultant on advisory board committees and educational activities with Astra Zeneca, Novo Nordisk, Boehringer Ingelhim and Eli Lilly. SK has participated as a consultant on advisory board committees and educational activities with AstraZeneca and Novo Nordisk. JB is an employee of... AstraZeneca. TC is an employee and stockowner in Sence Research AB (an independent company in epidemiology and outcomes research) that received funding from AstraZeneca for statistical analysis within this research project. MKS has participated as a consultant on advisory board committees and educational activities with Amgen, AstraZeneca, Boehringer Ingelheim, GSK and NovoNordisk. JÄ has received payment/honoraria from AstraZeneca and Novartis; participated on a data safety monitoring/advisory board for AstraZeneca, Astella and Boehringer Ingelheim. The other authors report no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-074064

A case of pulmonary visceral subpleural hematoma treated by hematoma evacuation during care of post-cardiopulmonary resuscitation.

A case of pulmonary visceral subpleural hematoma treated by hematoma evacuation during care of post-cardiopulmonary resuscitation.

Fuente:Journal of Cardiothoracic Surgery

Extracto: Pulmonary visceral subpleural hematoma may occur during post-cardiopulmonary resuscitation care, including chest compressions and anticoagulant and antiplatelet therapies. In our case, CT-guided puncture and drainage was difficult and surgical treatment by incision of the visceral pleura and hematoma evacuation alone was done successfully.

Claves:Anticoagulant, Antiplatelet, CPR, Chest compression, Visceral subpleural hematoma

Cita:J Cardiothorac Surg 2024 Apr 20; 19 (1) : 256.

Autor/es:Funaki, Yutaka (a)
Hirai, Kyoji (b)

institución:(a) Shock and Trauma Center, Nippon Medical School, Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba, 270-1694, Japan. y-funaki@nms.ac.jp.
(b) Department of Thoracic Surgery, Nippon Medical School, Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba, 270-1694, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13019-024-02769-w

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b.

Fuente:Cellular & Molecular Biology Letters

Extracto: Our results support that Rab4b, by controlling the sorting of the cation-independent mannose-6-phosphate receptor towards VPS52 microdomains, confers a directional specificity for cargo carriers en route to the trans-Golgi network. Given the importance of the endocytic recycling in cell homeostasis, disruption of the Rab4b/Golgi-associated retrograde protein complex-dependent step could have serious consequences in pathologies.

Claves:Trans Golgi network, Cation-independent mannose-6-phosphate receptor, Endosome, VPS52

Cita:Cell Mol Biol Lett 2024 Apr 16; 29 (1) : 54.

Autor/es:Gilleron, Jérôme (a)
Chafik, Abderrahman (b)

institución:(a) Université Côte d'Azur, INSERM, Mediterranean Center of Molecular Medicine (C3M), Team "Insulin Resistance in Obesity and Type 2 Diabetes", Bâtiment Archimed, 151 Route de Saint Antoine de Ginestière, BP 2 3194, 06200, Nice Cedex 03, France. jerome.gilleron@univ-cotedazur.fr.
(b) Université Côte d'Azur, INSERM, Mediterranean Center of Molecular Medicine (C3M), Team "Insulin Resistance in Obesity and Type 2 Diabetes", Bâtiment Archimed, 151 Route de Saint Antoine de Ginestière, BP 2 3194, 06200, Nice Cedex 03, France.

Conflicto:Authors declare there are no competing financial interests in relation to this work.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s11658-024-00574-w

Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.

Fuente:Genome Biology

Extracto: In this study, we identify residues important for GCK metabolic stability and conformational dynamics. These residues could be targeted to modulate GCK activity, and thereby affect glucose homeostasis.

Claves:DMS, GCK, MAVE, Protein dynamics, Protein stability

Cita:Genome Biol 2024 Apr 16; 25 (1) : 98.

Autor/es:Gersing, Sarah (a)
Schulze, Thea K (b)

institución:(a) The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200, Copenhagen, Denmark. sarah.gersing@bio.ku.dk.
(b) The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200, Copenhagen, Denmark.

Conflicto:F.P.R. is a shareholder and advisor for SeqWell, Constantiam, BioSymetrics, and a shareholder of Ranomics, and his lab has received research support from Alnylam, Deep Genomics, Beam Therapeutics, and Biogen Inc. K.L.-L. is a consultant for and holds stock options in Peptone Ltd. The other authors declare that they have no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13059-024-03238-2

How far has diabetes-related foot disease research progressed in Australia? A bibliometric review (1970-2023).

Fuente:Journal of Foot and Ankle Research

Tipo de trabajo:Revisión

Extracto: Australian DFD research increased steadily until more dramatic increases were seen over the past decade. Most research received no funding and mainly investigated etiology, existing treatments or health services. Australian DFD researchers appear to be very productive, particularly in recent times, despite minimal funding indicating their resilience. However, if the field is to continue to rapidly grow and address the very large national DFD burden, much more research funding is needed in Australia, especially targeting prevention and clinical trials of new treatments in DFD.

Claves:Australia, bibliometric analysis, diabetes mellitus, diabetes‐related foot disease, diabetic foot, research

Cita:J Foot Ankle Res 2024 Jun; 17 (2) : e12012.

Autor/es:Tehan, Peta E (a)
Perrin, Byron M (b)

institución:(a) Department of Surgery, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
(b) Department of Rural Health Sciences, La Trobe Rural Health School, Bendigo, Victoria, Australia.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1002/jfa2.12012

Clinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV.

Fuente:Experimental Biology and Medicine (maywood, N.j.)

Extracto: More research work should be carried out to validate co-infection-related cytokines and/or immune markers to SARS-CoV-2 among PLWH.

Claves:COVID-19, HIV/SARS-CoV-2 coinfection, clinical outcomes, immunological response, people living with HIV

Cita:Exp Biol Med (Maywood) 2024; 249 : 10059.

Autor/es:Amegashie, Esimebia Adjovi (a)
Asamoah, Prince (b)

institución:(a) Department of Biochemistry, Cell and Molecular Biology, West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
(b) Department of Biochemistry, Cell and Molecular Biology, West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/ebm.2024.10059

Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing.

Fuente:Science Advances

Extracto: Overall, our work provided insights into genetic characteristics of the Japanese population.

Cita:Sci Adv 2024 Apr 19; 10 (16) : eadi8419.

Autor/es:Liu, Xiaoxi (a)
Koyama, Satoshi (b)

institución:(a) Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
(b) Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1126/sciadv.adi8419

A biosocial analysis of perinatal and late neonatal mortality among Indigenous Maya Kaqchikel communities in Tecpán, Guatemala: a mixed-methods study.

Fuente:Bmj Global Health

Extracto: Structural social forces influence neonatal vulnerability in rural Guatemala. When coupled with healthcare system shortcomings, these forces increase mistrust and mortality. Collaborative relationships among healthcare staff, traditional midwives and families may disrupt this cycle.

Claves:Child health, Obstetrics, Other study design, Paediatrics

Cita:BMJ Glob Health 2024 Apr 17; 9 (4)

Autor/es:Venzor Strader, Anahí (a)
Sotz, Magda (b)

institución:(a) Department of Global Health and Social Medicine "Blavatnik Institute", Harvard Medical School, Boston, Massachusetts, USA anahiiven@gmail.com.
(b) Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.

Conflicto:Competing interests: AVS, ACM, HG and MS have no competing interests to report. PR reports research support from: NIH/NICHD, NIH/NIEHS, NIH/NIDDK, the Google Nonprofit Foundation, the World Diabetes Foundation and the Academy of Nutrition and Dietetics. ACCL reports her research work is financially supported by the following institutions: NIH/NICHD, WHO, Bill & Melinda Gates Foundation and Johns Hopkins University. None... of these institutions were involved in the design or implementation of this project.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjgh-2023-013940

Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications.

Fuente:Cell Death & Disease

Extracto: In the present review, we briefly outlined the properties of MSCs-derived exosomes, provided a thorough summary of their biological functions and potential uses in diabetes and its related complications.

Cita:Cell Death Dis 2024 Apr 17; 15 (4) : 271.

Autor/es:Jiao, Yu-Rui (a)
Chen, Kai-Xuan (b)

institución:(a) Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
(b) Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41419-024-06659-w

Polygenic scores for cardiovascular risk factors improve estimation of clinical outcomes in CCB treatment compared to pharmacogenetic variants alone.

Fuente:The Pharmacogenomics Journal

Extracto: Incorporating polygenic scores for adiposity and lipoprotein A may improve risk estimates of key clinical outcomes in CCB treatment such as treatment discontinuation and heart failure, compared to pharmacogenetic variants alone.

Cita:Pharmacogenomics J 2024 Apr 17; 24 (3) : 12.

Autor/es:Türkmen, Deniz (a)
Bowden, Jack (b)

institución:(a) Epidemiology & Public Health Group, Department of Clinical & Biomedical Science, Faculty of Health & Life Sciences, University of Exeter, Exeter, UK.
(b) Exeter Diabetes Group (ExCEED), Department of Clinical & Biomedical Science, Faculty of Health & Life Sciences, University of Exeter, Exeter, UK.

Conflicto:Jack Bowden is employed part-time by Novo Nordisk, his company work is unrelated to that presented here.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1038/s41397-024-00333-2

Profile of Patients with Maxillofacial Space Infections and Associated Risk Factors.

Fuente:Thescientificworldjournal

Extracto: Our study showed that the age of the patient and evidence of bacterial culture were potential predictors of prolonged hospital stay among patients operated for maxillofacial space infections.

Cita:ScientificWorldJournal 2024; 2024 : 9304671.

Autor/es:Gadicherla, Srikanth (a)
Manglani, Kirti (b)

institución:(a) Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
(b) Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1155/2024/9304671

Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study.

Fuente:Health Technology Assessment (winchester, England)

Tipo de trabajo:Revisión sistemática

Extracto: Intravenous zoledronate treatment was generally more acceptable to patients and found to be the most effective bisphosphonate and with greater adherence; however, the cost-effectiveness relative to oral alendronate is limited by its higher zoledronate hospital administration costs. FUTURE WORK: Further research is needed to support people to make decisions influencing treatment selection, effectiveness and optimal long-term care, together with the clinical and cost-effectiveness of intravenous zoledronate administered in a non-hospital (community) setting. LIMITATIONS: Lack of clarity and limitations in the many studies included in the systematic review may have under-interpreted some of the findings relating to effects of bisphosphonates. TRIAL REGISTRATION: This trial is registered as ISRCTN10491361. FUNDING: This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: NIHR127550) and is published in full in Health Technology Assessment; Vol. 28, No. 21. See the NIHR Funding and Awards website for further award information.

Claves:ADHERENCE, ALENDRONATE, BISPHOSPHONATE, COMPLIANCE, HEALTH-ECONOMICS, IBANDRONATE, INTRAVENOUS, MIXED METHODS, OSTEOPOROSIS, PERSISTENCE, QUALITATIVE, RISEDRONATE, ZOLEDRONATE

Cita:Health Technol Assess 2024 Apr; 28 (21) : 1-169.

Autor/es:Sahota, Opinder (a)
Narayanasamy, Melanie (b)

institución:(a) Department of Health Care for Older People, Nottingham University Hospitals NHS Trust, Nottingham, UK.
(b) Business School, University of Nottingham, Nottingham, UK.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.3310/WYPF0472

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.

Fuente:The Journal of Experimental Medicine

Extracto: Our findings suggest that PD-1 and PD-L1 are essential for preventing early-onset T1D but that, unlike PD-1 deficiency, PD-L1 deficiency does not lead to fatal autoimmunity with extensive leukocytic dysregulation.

Cita:J Exp Med 2024 Jun 3; 221 (6)

Autor/es:Johnson, Matthew B (a)
Ogishi, Masato (b)

institución:(a) Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Exeter, UK. ROR: https://ror.org/03yghzc09
(b) St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University New York, NY, USA. ROR: https://ror.org/0420db125

Conflicto:Disclosures: C. Speake reported personal fees from Vertex Pharmaceuticals and GentiBio outside the submitted work. M.S. Anderson reported other from Merck, Inc. outside the submitted work. R.A. Oram reported grants from Randox, and personal fees from Sanofi, Provention Bio, and Janssen outside the submitted work; and that Randox are licensing knowhow relating to T1D polygenic scores from the University of... Exeter. No other disclosures were reported.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1084/jem.20231704

Multimodal In-Vehicle Hypoglycemia Warning for Drivers With Type 1 Diabetes: Design and Evaluation in Simulated and Real-World Driving.

Fuente:Jmir Human Factors

Extracto: Despite the mixed results, this paper highlights the potential of implementing voice assistant-based health warnings in cars and advocates for multimodal alerts to enhance hypoglycemia management while driving. TRIAL REGISTRATION: ClinicalTrials.gov NCT05183191; https://classic.clinicaltrials.gov/ct2/show/NCT05183191, ClinicalTrials.gov NCT05308095; https://classic.clinicaltrials.gov/ct2/show/NCT05308095.

Claves:ambient lighting, diabetes, digital health, emotional reaction, health state, hypoglycemia, implementation, in-vehicle technology, mobile phone, technology acceptance, voice assistant, warning

Cita:JMIR Hum Factors 2024 Apr 18; 11 : e46967.

Autor/es:Bérubé, Caterina (a)
Maritsch, Martin (b)

institución:(a) Centre for Digital Health Interventions, Department of Management, Technology and Economics, ETH Zurich, Zurich, Switzerland.
(b) Centre for Digital Health Interventions, Department of Management, Technology and Economics, ETH Zurich, Zurich, Switzerland.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:http://dx.doi.org/10.2196/46967

Coin-sized, fully integrated, and minimally invasive continuous glucose monitoring system based on organic electrochemical transistors.

Fuente:Science Advances

Extracto: Last, we discuss how OECT technology can help push the limit of detection of current wearable electrochemical biosensors, especially when operating in complicated conditions.

Cita:Sci Adv 2024 Apr 19; 10 (16) : eadl1856.

Autor/es:Bai, Jing (a)
Liu, Dingyao (b)

institución:(a) Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
(b) Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1126/sciadv.adl1856

A review on associated factors and management measures for sarcopenia in type 2 diabetes mellitus.

Fuente:Medicine

Extracto: This article reviews the relevant factors and management measures of sarcopenia in T2DM patients, in order to achieve early detection, diagnosis, and intervention.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37666.

Autor/es:Zhang, Yi (a)
Zhang, Kemeng (b)

institución:Zhang, Yi (a)
Zhang, Kemeng (b)

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037666

Retrospective analysis of predictive factors for AVF dysfunction in patients undergoing MHD.

Fuente:Medicine

Extracto: Advanced age, coexisting diabetes, hyperlipidemia, blood D-D levels, and hyperphosphatemia are independent risk factors for AVF dysfunction in patients undergoing MHD.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37737.

Autor/es:Wang, Liqin (a)
Yang, Yanna (b)

institución:(a) Hemodialysis Center, Hefei Third Clinical College (Hefei Third People's Hospital), Anhui Medical University, Hefei, China.
(b) Department of Nephrology, Hefei Third Clinical College (Hefei Third People's Hospital), Anhui Medical University, Hefei, China.

Conflicto:All authors declare that they have no conflict of interest.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037737

Association of carpal tunnel syndrome risk factors with treatment modality selection focusing on corticosteroid injection and surgery: A nationwide population-based study.

Fuente:Medicine

Extracto: For these patients, clinicians should proactively consider an operation to reduce the long-term discomfort and economic burdens.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37781.

Autor/es:Doh, Chang Hyun (a)
Kim, Ye-Jee (b)

institución:(a) Department of Orthopaedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
(b) Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037781