Eight weeks of treatment with mineralocorticoid receptor blockade does not alter vascular function in individuals with and without type 2 diabetes.

Eight weeks of treatment with mineralocorticoid receptor blockade does not alter vascular function in individuals with and without type 2 diabetes.

Fuente:Physiological Reports

Extracto: As the individuals with type 2 diabetes did not have vascular dysfunction, these results might not apply to individuals with vascular dysfunction.

Claves:aldosterone, endothelial function, mineralocorticoid receptor, type 2 diabetes

Cita:Physiol Rep 2024 Apr; 12 (7) : e16010.

Autor/es:Finsen, Stine H (a)
Hansen, Mie R (b)

institución:(a) Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
(b) Department of Nephrology, Odense University Hospital, Odense, Denmark.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.14814/phy2.16010

The Senescent Heart-"Age Doth Wither Its Infinite Variety".

The Senescent Heart-"Age Doth Wither Its Infinite Variety".

Fuente:International Journal of Molecular Sciences

Extracto: Incisive studies on the molecular basis of cardiovascular aging and dysregulated fibroblast function in the senescent heart would pave the way for effective strategies to mitigate cardiovascular diseases in a rapidly growing elderly population.

Claves:DDR2, aging, cardiac fibroblasts, cardiac fibrosis, cardiac myocytes, collagen, senescence, vascular cells

Cita:Int J Mol Sci 2024 Mar 22; 25 (7)

Autor/es:Vijayakumar, Anupama (a)
Wang, Mingyi (b)

institución:(a) Cardiovascular Genetics Laboratory, Department of Biotechnology, Bhupat and Jyothi Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.
(b) Laboratory of Cardiovascular Science, National Institute on Aging/National Institutes of Health, Baltimore, MD 21224, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073581

Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism.

Fuente:International Journal of Molecular Sciences

Extracto: In-depth understanding of the role and mechanism of exercise in improving DN would pave the way for formulating safe and effective exercise programs for the treatment and prevention of DN.

Claves:AMPK, MicroRNAs, Sirt1, diabetic nephropathy, exercise, exerkine, gut microbiota, heat shock protein, metabolites, nitric oxide, renin-angiotensin system

Cita:Int J Mol Sci 2024 Mar 23; 25 (7)

Autor/es:Li, Ruo-Ying (a)
Guo, Liang (b)

institución:(a) School of Exercise and Health, Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai 200438, China.
(b) Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073605

The Novel SSTR3 Agonist ITF2984 Exerts Antimitotic and Proapoptotic Effects in Human Non-Functioning Pituitary Neuroendocrine Tumor (NF-PitNET) Cells.

Fuente:International Journal of Molecular Sciences

Extracto: In conclusion, our data support a possible use of ITF2984 in the pharmacological treatment of NF-PitNET.

Claves:ITF2984, NF-PitNETs, SSTRs

Cita:Int J Mol Sci 2024 Mar 23; 25 (7)

Autor/es:Di Muro, Genesio (a)
Catalano, Rosa (b)

institución:(a) Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
(b) Department of Experimental Medicine, University Sapienza of Rome, 00100 Rome, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073606

Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience.

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Consenso

Extracto: The standardization of treatment protocols and consensus guidelines are essential to ensure reproducibility and comparability across studies.

Claves:Necrobiosis Lipoidica, PDT, diabetes, pain, photodynamic therapy, ulcer, wound healing

Cita:Int J Mol Sci 2024 Mar 23; 25 (7)

Autor/es:Li Pomi, Federica (a)
Motolese, Alfonso (b)

institución:(a) Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy.
(b) Dermatology Unit, Department of Surgery, Infermi Hospital, AUSL Romagna, 47923 Rimini, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073608

Aflibercept Off-Target Effects in Diabetic Macular Edema: An In Silico Modeling Approach.

Fuente:International Journal of Molecular Sciences

Extracto: Given the role of VEGFR1 signaling on the modulation of inflammatory-related pathways, IAI may offer therapeutic advantages for DME through sustained VEGFR1 pathway inhibition.

Claves:TPMS, angiogenesis, blood–retinal barrier permeability, inflammation, intravitreal aflibercept injection, machine learning, oxidative stress, systems biology, vascular endothelial growth factor

Cita:Int J Mol Sci 2024 Mar 23; 25 (7)

Autor/es:Blanot, Morgane (a)
Casaroli-Marano, Ricardo Pedro (b)

institución:(a) Anaxomics Biotech S.L., 08007 Barcelona, Spain.
(b) Department of Surgery (FMCS), Universitat de Barcelona, 08007 Barcelona, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073621

Exploring the Impact of Alternative Sources of Dietary Nitrate Supplementation on Exercise Performance.

Fuente:International Journal of Molecular Sciences

Extracto: Red spinach and green spinach have been shown to improve exercise performance or accelerate recovery after physical exertion in healthy subjects (including athletes).

Claves:Amaranthus, alternative dietary nitrate, athletes, exercise performance, nitrate, recovery, spinach

Cita:Int J Mol Sci 2024 Mar 25; 25 (7)

Autor/es:Jędrejko, Maciej (a)
Jędrejko, Karol (b)

institución:(a) Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 Str., 30-688 Kraków, Poland.
(b) Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 Str., 30-688 Kraków, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073650

Unveiling Anti-Diabetic Potential of Baicalin and Baicalein from Baikal Skullcap: LC-MS, In Silico, and In Vitro Studies.

Fuente:International Journal of Molecular Sciences

Extracto: Additionally, we have identified six flavonoid molecules with substantial potential for drug development, thereby augmenting the T2DM pharmacotherapeutic arsenal and promoting the integration of herb-derived treatments into modern pharmacology.

Claves:LC–MS, PTP1B, anti-diabetic mechanisms, cellular assay, molecular docking, network pharmacology

Cita:Int J Mol Sci 2024 Mar 25; 25 (7)

Autor/es:Zhao, Wencheng (a)
Cui, Huizi (b)

institución:(a) Edmond H. Fischer Signal Transduction Laboratory, Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
(b) Edmond H. Fischer Signal Transduction Laboratory, Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073654

Molecular Mechanisms of Neuroprotection after the Intermittent Exposures of Hypercapnic Hypoxia.

Fuente:International Journal of Molecular Sciences

Extracto: Combining hypercapnic hypoxia with pharmacological modulators of neuro/cardio/cytoprotection signaling pathways is likely to be promising for translating experimental research into clinical medicine.

Claves:A1 adenosine receptors, HIF-1α, antioxidant systems, apoptosis inhibition, blood–brain barrier permeability, chaperones, endoplasmic reticulum, hypercapnia, hypoxia, mitochondrial ATP-dependent potassium channels, neuroprotection

Cita:Int J Mol Sci 2024 Mar 25; 25 (7)

Autor/es:Tregub, Pavel P (a)
Kulikov, Vladimir P (b)

institución:(a) Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
(b) Brain Science Institute, Research Center of Neurology, 125367 Moscow, Russia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073665

The PD-1/PD-L1 Axis in the Biology of MASLD.

Fuente:International Journal of Molecular Sciences

Extracto: The aim of this review is to illustrate the main pathogenetic mechanisms by which the immune system promotes the progression of MASLD and the transition to HCC, as well as to discuss the possible therapeutic applications of PD-1/PD-L1 target therapy to activate T cells and reinvigorate immune surveillance against cancer.

Claves:CD8+ T cells exhausted, HCC, MASH, MASLD, PD-1, PD-L1, T Reg cells, cytotoxic lymphocytes

Cita:Int J Mol Sci 2024 Mar 25; 25 (7)

Autor/es:Pipitone, Rosaria Maria (a)
Lupo, Giulia (b)

institución:(a) Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Piazza delle Cliniche, 90127 Palermo, Italy.
(b) Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Piazza delle Cliniche, 90127 Palermo, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073671

Underlying Mechanisms behind the Brain-Gut-Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update.

Fuente:International Journal of Molecular Sciences

Extracto: Finally, hepatokines are decisive in improving or not improving the progression of this disease through the regulation of pro-inflammatory and anti-inflammatory organokines.

Claves:MAFLD, brain–gut–liver axis, diabetes, dyslipidemia, insulin resistance, metabolic-associated fatty liver disease, obesity, organokines

Cita:Int J Mol Sci 2024 Mar 26; 25 (7)

Autor/es:De Cól, Júlia Pauli (a)
de Lima, Enzo Pereira (b)

institución:(a) Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), São Paulo 17525-902, Brazil.
(b) Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), São Paulo 17525-902, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073694

Hypervolemia in Dialysis Patients Impairs STAT3 Signaling and Upregulates miR-142-3p: Effects on IL-10 and IL-6.

Fuente:International Journal of Molecular Sciences

Extracto: How far degradative mechanisms induced by elevated miR-142-3p levels contribute to an inefficient anti-inflammatory IL-10 signaling remains elusive.

Claves:IL-10, IL-6, SOCS3, STAT3, chronic kidney failure, hemodialysis, hypervolemia, inflammation, miR-142

Cita:Int J Mol Sci 2024 Mar 27; 25 (7)

Autor/es:Ulrich, Christof (a)
Fiedler, Roman (b)

institución:(a) Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
(b) Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.

Conflicto:Authors Roman Fiedler and Matthias Girndt were also employees of KfH Nierenzentrum Halle, the outpatient dialysis center of the University medicine of Halle. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073719

MicroRNA Associations with Preterm Labor-A Systematic Review.

Fuente:International Journal of Molecular Sciences

Extracto: In conclusion, this comprehensive analysis lays the foundation for subsequent research, intervention strategies and improved outcomes in the realm of preterm labor.

Claves:MicroRNA expression, pregnancy, preterm labor

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Kondracka, Adrianna (a)
Stupak, Aleksandra (b)

institución:(a) Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.
(b) Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073755

Substance P Concentration in Gestational Diabetes and Excessive Gestational Weight Gain and Its Impact on Neonatal Anthropometry.

Fuente:International Journal of Molecular Sciences

Extracto: To our knowledge, it is the first study assessing substance P concentration in GDM and EGWG patients.

Claves:excessive gestational weight gain, fetal programming, gestational diabetes mellitus, substance P

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Niebrzydowska-Tatus, Magdalena (a)
Pełech, Aleksandra (b)

institución:(a) Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.
(b) Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073759

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment.

Fuente:International Journal of Molecular Sciences

Extracto: The role of macronutrients, micronutrients, vitamins, and selected substances, such as omega-3 fatty acids, coenzyme Q10, and alpha-lipoic acid, was taken into consideration, which outlined the minimum range of tests that ought to be performed on patients in order to either directly or indirectly determine the severity of malnutrition in this group of patients.

Claves:alpha-lipoic acid, coenzyme Q10, immune system, immunomodulation, macroelements, microelements, nutrients, omega-3 acids, type 2 diabetes, vitamins

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Napiórkowska-Baran, Katarzyna (a)
Treichel, Paweł (b)

institución:(a) Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University Toruń, 85-067 Bydgoszcz, Poland.
(b) Student Research Club of Clinical Immunology, Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University Toruń, 85-067 Bydgoszcz, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073769

The Role of Endocrine Disruption Chemical-Regulated Aryl Hydrocarbon Receptor Activity in the Pathogenesis of Pancreatic Diseases and Cancer.

Fuente:International Journal of Molecular Sciences

Extracto: This review comprehensively examines the involvement of AHR in EDC exposure-mediated regulation of pancreatic pathogenesis, emphasizing AHR as a potential therapeutic target for the pathogenesis of pancreatic diseases and cancer.

Claves:aryl hydrocarbon receptor, endocrine disrupting chemicals, environmental toxicants, pancreas, pancreatic cancer, pancreatic injury, pancreatitis

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:aryl hydrocarbon receptor, endocrine disrupting chemicals, environmental toxicants, pancreas, pancreatic cancer, pancreatic injury, pancreatitis

institución:aryl hydrocarbon receptor, endocrine disrupting chemicals, environmental toxicants, pancreas, pancreatic cancer, pancreatic injury, pancreatitis

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073818

Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide, and Glucagon Receptor Agonists in Metabolic Dysfunction-Associated Steatotic Liver Disease: Novel Medication in New Liver Disease Nomenclature.

Fuente:International Journal of Molecular Sciences

Extracto: Finally, we discuss the current challenges and future perspectives pertinent to this growing area of research and clinical medicine.

Claves:glucagon receptor (GCGR), glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), metabolic dysfunction-associated steatotic liver disease, type 2 diabetes mellitus

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Chrysavgis, Lampros G (a)
Kazanas, Spyridon (b)

institución:(a) First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital Laiko, 115 27 Athens, Greece.
(b) First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital Laiko, 115 27 Athens, Greece.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073832

Gestational Diabetes Mellitus and Colostral Appetite-Regulating Adipokines.

Fuente:International Journal of Molecular Sciences

Extracto: The shift between ghrelin and other appetite-regulating hormones might translate into altered ability to regulate energy balance, affecting offspring's metabolic homeostasis.

Claves:adipokines, gestational diabetes mellitus, human milk, lifestyle diseases

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Lis-Kuberka, Jolanta (a)
Berghausen-Mazur, Marta (b)

institución:(a) Division of Chemistry and Immunochemistry, Department of Biochemistry and Immunochemistry, Wroclaw Medical University, M. Skłodowskiej-Curie 48/50, 50-369 Wroclaw, Poland.
(b) Department of Neonatology, J. Gromkowski Provincial Specialist Hospital, Koszarowa 5, 51-149 Wroclaw, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073853

Association between PD-L1 Expression and the Prognosis and Clinicopathologic Features of Non-Clear Cell Renal Cell Carcinoma.

Fuente:International Journal of Molecular Sciences

Extracto: However, no differences in overall survival for PD-L1-positive pRCC patients with compared to PD-L1-negative patients were observed in tumor cells or TIMCs.

Claves:PD-L1, chromophobe renal cell carcinoma, papillary renal cell carcinoma, renal cell carcinoma

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Chrabańska, Magdalena (a)
Szweda-Gandor, Nikola (b)

institución:(a) Department of Pathomorphology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
(b) Department and Clinic of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, 40-055 Zabrze, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073916

Cell Death in Acute Organ Injury and Fibrosis.

Fuente:International Journal of Molecular Sciences

Extracto: issue fibrosis is characterized by the excessive accumulation of extracellular matrix in various organs, including the lungs, liver, skin, kidneys, pancreas, and heart, ultimately leading to organ failure [...].

Cita:Int J Mol Sci 2024 Apr 1; 25 (7)

Autor/es:Yasuma, Taro (a)
Gabazza, Esteban C (b)

institución:(a) Department of Immunology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu 514-8507, Japan.
(b) Department of Diabetes and Endocrinology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu 514-8507, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073930