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Exploring the interconnected between type 2 diabetes mellitus and nonalcoholic fatty liver disease: Genetic correlation and Mendelian randomization analysis.
Exploring the interconnected between type 2 diabetes mellitus and nonalcoholic fatty liver disease: Genetic correlation and Mendelian randomization analysis.
Fuente:Medicine
Extracto:
Our study
identified a shared genetic structure between NAFLD and T2DM, providing new
insights into the genetic pathogenesis and mechanisms of NAFLD and T2DM
comorbidities.
Cita:Medicine (Baltimore) 2024 May 10; 103 (19) : e38008.
Autor/es:Ni, Wenjuan (a) Lu, Yao (b)
institución:(a) Department of Endocrinology, First Affiliated Hospital of Baotou Medical Collage, Baotou, Inner Mongolia, China. (b) Baotou Medical Collage, Baotou, Inner Mongolia, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Managing greenhouse gas emissions in the terminal year of life in an overwhelmed health system: a paradigm shift for people and our planet.
Managing greenhouse gas emissions in the terminal year of life in an overwhelmed health system: a paradigm shift for people and our planet.
Fuente:The Lancet. Planetary Health
Extracto:
Our
analysis was done using Canadian data, but the findings can be applied to other
high-income countries.
Cita:Lancet Planet Health 2024 May; 8 (5) : e327-e333.
Autor/es:Sergeant, Myles (a) Ly, Olivia (b)
institución:(a) Department of Family Medicine, Michael G DeGroote School of Medicine, Hamilton, ON, Canada. (b) Department of Family Medicine, Michael G DeGroote School of Medicine, Hamilton, ON, Canada.
Conflicto:Declaration of interests MS is a physician, advocate, and leader of provincial and national health-care sustainability organisations. MS has been paid for seven presentations on topics similar to those of this Viewpoint within the last 36 months. These presentations have been with the Royal Botanical Gardens, University of British Columbia, the American Academy of Family Physicians, Annual Thomas Fear and...
Alice Morgans Fear Memorial Conference, McMaster University's Department of Engineering, McMaster University Care of the Elderly Department, and York University CANSEE Conference. MS holds leadership roles with the Canadian Coalition of Green Health Care (Executive Director) and Partnerships for Environmental Action with Clinicians and Communities for Hospitals/Health Care Facilities (co-lead). OL is a physician with a background in health-care sustainability quality improvement. SK is the co-director of The Starfish, an environmental sustainability charity. SK is also co-lead of Partnerships for Environmental Action with Clinicians and Communities for Hospitals/Health Care Facilities. RJdS is a dietitian and Associate Professor interested in global health and sustainability from the perspective of nutrition. RJdS has served as an external resource person to WHO's Guidelines Advisory Group on trans fats, saturated fats, and polyunsaturated fats. WHO paid for his travel and accommodation to attend meetings from 2012 to 2017 to discuss and present this work. RJdS has presented updates of this work to WHO in 2022; has done contract research for the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism, and Diabetes, Health Canada, and WHO for which he received remuneration; has received speaker's fees from the University of Toronto and McMaster Children's Hospital; has served as an independent director of the Helderleigh Foundation (Canada); serves as a member of the Nutrition Science Advisory Committee to Health Canada (Government of Canada), co-chair of the Method working group of the ADA/EASD Precision Medicine in Diabetes group, and is a co-opted member of the Scientific Advisory Committee on Nutrition Subgroup on the Framework for the Evaluation of Evidence (Public Health England); has held grants from the Canadian Institutes of Health Research, Canadian Foundation for Dietetic Research, Population Health Research Institute, and Hamilton Health Sciences Corporation as a principal investigator; and is a co-investigator on several funded team grants from the Canadian Institutes of Health Research. SSA is a professor of medicine and epidemiology and associate vice-president for global health at McMaster University; holds a Canada Research Chair in Ethnic Diversity and Cardiovascular Disease and the Michael G DeGroote Heart and Stroke Foundation of Canada endowed Chair in Population Health; and has received speaking and consultancy fees from pharmaceutical companies Bayer, Novartis, Servier, and Novo Nordisk.
institución:(a) Guilan University of Medical Sciences, Rasht, Iran. (b) Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Evaluation of the effect of sleeve gastrectomy versus Roux-en-Y gastric bypass in patients with morbid obesity: multicenter comparative study.
Evaluation of the effect of sleeve gastrectomy versus Roux-en-Y gastric bypass in patients with morbid obesity: multicenter comparative study.
Fuente:Langenbeck's Archives of Surgery
Extracto:
Both surgical
procedures resulted in significant weight loss and improved comorbidities.
However, the improvement in comorbidities was significantly greater in patients
who underwent RYGB than in those who underwent SG, suggesting that the RYGB
technique is preferable. Nevertheless, RYGB requires a high degree of surgical
skill. Therefore, acquiring expertise in the technical facets of the surgery is
essential to achieving favorable outcomes.
Claves:Bariatric surgery, Complications, Gastric bypass, Morbidity and mortality, Sleeve gastrectomy
Cita:Langenbecks Arch Surg 2024 May 10; 409 (1) : 156.
The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry
The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry
Fuente:Molecules (basel, Switzerland)
Tipo de trabajo:Revisión
Extracto:
A specific section is focused on
the synthetic strategies adopted to obtain this versatile chemical portion.
Claves:benzoylpiperidine, benzoylpiperidine-based small molecules, bioisostere, diagnostic agents, drug design, medicinal chemistry, phenyl(piperidin-4-yl)methanone, privileged structure, therapeutic agents
Cita:Molecules 2024 Apr 23; 29 (9)
Autor/es:Bononi, Giulia (a) Lonzi, Chiara (b)
institución:(a) Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. (b) Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A Multi-Faceted Digital Health Solution for Monitoring and Managing Diabetic Foot Ulcer Risk: A Case Series.
A Multi-Faceted Digital Health Solution for Monitoring and Managing Diabetic Foot Ulcer Risk: A Case Series.
Fuente:Sensors (basel, Switzerland)
Tipo de trabajo:Estudio de cohortes
Extracto:
Multi-faceted digital health solutions can
naturally enable and reinforce the integrative foot care guidelines. Multi-modal
sensing across multiple physiologic domains supports the monitoring of foot
health at various stages along the DFU pathogenesis pathway. Furthermore, digital
health solutions equipped with remote patient monitoring unlock new opportunities
for personalizing treatments, providing periodic self-care reinforcement, and
encouraging patient engagement-key tools for improving patient adherence to their
diabetic foot care plan.
Claves:diabetes complications, diabetic foot ulcers (DFU), health technology, neuropathy, plantar pressure, remote patient monitoring (RPM), sensor-based monitoring, temperature monitoring, wearables
Cita:Sensors (Basel) 2024 Apr 23; 24 (9)
Autor/es:Matijevich, Emily (a) Minty, Evan (b)
institución:(a) Orpyx Medical Technologies, Inc., Calgary, AB T2G 1M8, Canada. (b) Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Conflicto:Brock Liden sits on the Clinical Advisory Board of Orpyx Medical Technologies, Inc. Evan Minty is under a consulting agreement with Orpyx Medical Technologies Inc. (in capacity as Medical Director of their RPM service). Minty discloses equity ownership in Orpyx Medical Technologies and has family members in the employ of Orpyx Medical Technologies Inc. Emily Matijevich, Emily Bray, Courtney Bachus,...
and Maryam Hajizadeh are employees of Orpyx Medical Technologies Inc.
Metabolomics Official journal of the Metabolomic Society
Selección SIIC: 16 Mayo, 2024
Metabolomics Official journal of the Metabolomic Society
Characterizing poorly controlled type 2 diabetes using (1)H-NMR metabolomics.
Characterizing poorly controlled type 2 diabetes using (1)H-NMR metabolomics.
Fuente:Metabolomics Official Journal of The Metabolomic Society
Extracto:
These results indicate that inhibited cellular glucose uptake
in poorly controlled type 2 diabetes significantly affects energy-producing
pathways, leading to apoptosis and/or autophagy, ultimately contributing to
kidney and mild liver damage. The study also suggests poor dietary compliance as
a cause of the patient's uncontrolled glycemic state. Collectively these findings
offer a first-time comprehensive overview of urine metabolic changes in poorly
controlled type 2 diabetes and its association with secondary diseases, offering
potential insights for more targeted treatment strategies to prevent disease
progression, treatment efficacy, and diet/treatment compliance.
Claves:Metabolomics, Poorly controlled type 2 diabetes, Proton nuclear magnetic resonance, Urine
Cita:Metabolomics 2024 May 11; 20 (3) : 54.
Autor/es:Theron, Isabella J (a) Mason, Shayne (b)
institución:(a) Human Metabolomics, Department of Biochemistry, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa. (b) Human Metabolomics, Department of Biochemistry, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Long-term impact of COVID-19 pandemic on secular changes in metabolic parameters in Japanese workers Tokushima Cohort Study.
Long-term impact of COVID-19 pandemic on secular changes in metabolic parameters in Japanese workers Tokushima Cohort Study.
Fuente:The Journal of Medical Investigation Jmi
Extracto:
Our findings suggest that
there was an apparent metabolic impact of the COVID-19 pandemic on DBP increment
in Japanese workers. In addition, COVID-19 may have influenced males and females
differently in relation to glucose metabolism and anthropometric measurements
related to obesity / adiposity. J. Med. Invest. 71 : 47-53, February, 2024.
institución:(a) Clinical Research Center for Diabetes, Tokushima University Hospital, Tokushima, Japan (AH, MF). (b) Clinical Research Center for Diabetes, Tokushima University Hospital, Tokushima, Japan (AH, MF).
The journal of maternal-fetal & neonatal medicine the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Selección SIIC: 16 Mayo, 2024
The journal of maternal-fetal & neonatal medicine the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Reproductive and fetal outcomes in women with epilepsy
Reproductive and fetal outcomes in women with epilepsy
Fuente:The Journal of Maternal-fetal & Neonatal Medicine The Official Journal of The European Association of Perinatal Medicine, The Federation of Asia and Oceania Perinatal Societies, The International Society of Perinatal Obstetricians
Tipo de trabajo:Revisión sistemática
Extracto:
Pregnant women affected by epilepsy
encounter a higher risk of adverse obstetric outcomes and fetal complications.
Therefore, it is crucial to develop appropriate prevention and intervention
strategies prior to or during pregnancy to minimize the negative impacts of
epilepsy on maternal and fetal health.
institución:(a) Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China. (b) Department of Radiology, Guangxi International Zhuang Medical Hospital, Nanning, China.
Indian journal of dental research official publication of Indian Society for Dental Research
Selección SIIC: 16 Mayo, 2024
Indian journal of dental research official publication of Indian Society for Dental Research
Comparison of the Oral Hygiene Status in Children With and Without Juvenile Diabetes - A Comparative Study.
Comparison of the Oral Hygiene Status in Children With and Without Juvenile Diabetes - A Comparative Study.
Fuente:Indian Journal of Dental Research Official Publication of Indian Society For Dental Research
Extracto:
No
statistically significant differences were noted in the gingival condition and
dental caries experience between the children with and without juvenile diabetes
(P = 0.820; 0.504; 0.422). However, the overall oral hygiene status was found to
be poor in children with juvenile diabetes (P = 0.003). No significant
differences were observed in the gingival status and the dental caries prevalence
between the two groups.
Cita:Indian J Dent Res 2023 Oct 1; 34 (4) : 410-412.
institución:(a) Department of Pedodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India. (b) Department of Pedodontics, Saveetha Dental College and Hospital, Saveetha University, Chennai, Tamil Nadu, India.
Journal of the American Board of Family Medicine JABFM
Selección SIIC: 16 Mayo, 2024
Journal of the American Board of Family Medicine JABFM
Research to Improve Clinical Care in Family Medicine: Big Data, Telehealth, Artificial Intelligence, and More.
Research to Improve Clinical Care in Family Medicine: Big Data, Telehealth, Artificial Intelligence, and More.
Fuente:Journal of The American Board of Family Medicine Jabfm
Extracto:
Several articles report
on inappropriate testing for common health problems; are you following
recommendations for ordering Pulmonary Function Tests, mt-sDNA for colon cancer
screening, and HIV testing?
Cita:J Am Board Fam Med 2024 Mar-Apr; 37 (2) : 161-164.
Autor/es:Bowman, Marjorie A (a) Seehusen, Dean A (b)
institución:Bowman, Marjorie A (a) Seehusen, Dean A (b)
Conflicto:Conflict of interest: The authors are editors of the JABFM.
Journal of the American Board of Family Medicine JABFM
Selección SIIC: 16 Mayo, 2024
Journal of the American Board of Family Medicine JABFM
Empowering Low-Income Patients with Home Blood Pressure Monitors to Improve Hypertension Control.
Empowering Low-Income Patients with Home Blood Pressure Monitors to Improve Hypertension Control.
Fuente:Journal of The American Board of Family Medicine Jabfm
Tipo de trabajo:Revisión
Extracto:
DISCUSSION: The provision
of free home BP monitors to low-income patients may feasibly and effectively
improve BP control and therapy adherence.
Claves:Blood Pressure, Hypertension, Minority Health, Patient Adherence, Primary Health Care, Prospective Studies, Surveys and Questionnaires, Telemedicine, Vulnerable Populations
Cita:J Am Board Fam Med 2024 Mar-Apr; 37 (2) : 187-195.
Autor/es:Sarkar, Arindam (a) Nwokocha, Chinwe (b)
institución:(a) From the Baylor College of Medicine, Department of Family and Community Medicine, Houston TX (AS, CN, SGN, LG). (b) From the Baylor College of Medicine, Department of Family and Community Medicine, Houston TX (AS, CN, SGN, LG).
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Journal of the American Board of Family Medicine JABFM
Selección SIIC: 16 Mayo, 2024
Journal of the American Board of Family Medicine JABFM
The Role of Telehealth in Improving Care Connections and Outcomes for Community Health Center Patients with Diabetes.
The Role of Telehealth in Improving Care Connections and Outcomes for Community Health Center Patients with Diabetes.
Fuente:Journal of The American Board of Family Medicine Jabfm
Extracto:
Telehealth can be a
highly effective, patient-centered form of care for people with diabetes.
Telehealth can play a critical role in keeping vulnerable patients with diabetes
connected to their care team and involved in care and may be an important tool
for reducing health disparities.
Claves:Chronic Disease, Community Health Centers, Continuity of Patient Care, Diabetes Mellitus, Health Care Disparities, Health Inequities, Linear Regression, Patient Care Team, Patient-Centered Care, Quality Improvement, Retrospective Studies, Social Determinants of Health, Telemedicine
Cita:J Am Board Fam Med 2024 Mar-Apr; 37 (2) : 206-214.
Autor/es:Simon, Jodi (a) Eggleston, Alice (b)
institución:(a) From the AllianceChicago, Chicago, IL (JS, AE, DB, PD, DTL, T-YY, JM); RUSH University Medical Center, Chicago, IL (PD); AllianceChicago, Northwestern University Feinberg School of Medicine, Division of General Internal Medicine, Chicago, IL (DTL). jsimon@alliancechicago.org. (b) From the AllianceChicago, Chicago, IL (JS, AE, DB, PD, DTL, T-YY, JM); RUSH University Medical Center, Chicago, IL (PD); AllianceChicago, Northwestern University Feinberg School of Medicine, Division of General Internal Medicine, Chicago, IL (DTL).
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Journal of the American Board of Family Medicine JABFM
Selección SIIC: 16 Mayo, 2024
Journal of the American Board of Family Medicine JABFM
Self-Management Support Improves Diabetes Outcomes Without Exacerbating Inequities.
Self-Management Support Improves Diabetes Outcomes Without Exacerbating Inequities.
Fuente:Journal of The American Board of Family Medicine Jabfm
Tipo de trabajo:Estudio clínico aleatorizado
Extracto:
This suggests CTH-like programs can enhance
diabetes outcomes in community health centers without exacerbating inequities for
those with low health literacy.
Claves:Body Mass Index, California, Community Health Centers, Community-Based Research, Diabetes Mellitus, Endocrinology, Family Medicine, Hb A1c, Health Inequities, Health Literacy, Lifestyle, Patient Education, Patient-Centered Care, Primary Health Care, Regression Analysis, Self-Management, Surveys and Questionnaires
Cita:J Am Board Fam Med 2024 Mar-Apr; 37 (2) : 303-308.
institución:(a) From the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA (DK); Department of Family and Community Medicine, University of California, San Francisco, San Francisco, CA (DHS, MBP). devikakk07@gmail.com. (b) From the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA (DK); Department of Family and Community Medicine, University of California, San Francisco, San Francisco, CA (DHS, MBP).
Prescription and Dispensation of QT-Prolonging Medications in Individuals Receiving Hemodialysis.
Prescription and Dispensation of QT-Prolonging Medications in Individuals Receiving Hemodialysis.
Fuente:Jama Network Open
Extracto:
AND RELEVANCE: In this
cross-sectional study, QT-prolonging medications for individuals with
dialysis-dependent kidney failure were commonly prescribed by nonnephrology
clinicians and from nonacute settings. Prescriptions for potentially interacting
medications often originated from different prescribers. Strategies aimed at
minimizing high-risk medication-prescribing practices in the population
undergoing dialysis are needed.
Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e248732.
Autor/es:Wang, Virginia (a) Wang, Chin-Hua Lily (b)
institución:(a) Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina. (b) Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Conflicto:Conflict of Interest Disclosures: Dr V. Wang reported receiving grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH); the Patient-Centered Outcomes Research Institute (PCORI); the Department of Veterans Affairs; the Robert Wood Johnson Foundation; and the National Committee for Quality Assurance outside the submitted work. Dr Assimon reported receiving honoraria from...
the American Society of Nephrology and the International Society of Nephrology outside the submitted work and holding stock options in Aetion, Inc. Dr Pun reported receiving grants for investigator-initiated research from Medtronic, personal fees for research consulting from Fresenius Medical Care North America, and speaker honoraria from the National Kidney Foundation outside the submitted work. Dr Winkelmayer reported receiving personal fees from Actos, Akebia, Ardelyx, AstraZeneca, Bayer, Boehringer Ingelheim, Cadrenal, GSK, Eli Lilly, Merck, Natera, Novartis, Otsuka, Pharmacosmos, Unicycive, Vera, and Zydus outside the submitted work. Dr Flythe reported receiving grants from the NIDDK, NIH, and the PCORI during the conduct of the study and receiving funding from the Fresenius Medical Care Medical Advisory Board outside the submitted work. No other disclosures were reported.
Pharmacotherapy and clinical outcomes of hospitalized COVID-19 patients in Chile during the first wave of pandemic.
Pharmacotherapy and clinical outcomes of hospitalized COVID-19 patients in Chile during the first wave of pandemic.
Fuente:Revista Medica de Chile
Tipo de trabajo:Guía
Extracto:
The
patterns of use of drugs to treat COVID-19 in Chile during the first wave of the
pandemic were very dynamic and followed the international, evidence-based
guidelines. The low mortality rate indicates that the clinical management of
hospitalized patients was adequate.
Cita:Rev Med Chil 2023 May; 151 (5) : 541-550.
Autor/es:Muñoz, Daniel (a) Cano, Catalina (b)
institución:(a) Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile. (b) Escuela de Química y Farmacia, Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile.
Extracto:
The analysis will be based on the experience
of a series of cases of metformin-associated lactic acidosis treated at a
hospital clinical center in Chile.
Cita:Rev Med Chil 2023 May; 151 (5) : 618-627.
Autor/es:Ávila, Eduardo (a) Roessler B, Eric (b)
institución:(a) Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. (b) Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
institución:(a) Medicina Interna, Hospital Regional Leonardo Guzmán, Universidad de Antofagasta, Antofagasta, Chile. (b) Universidad de Antofagasta, Antofagasta, Chile.
Clusters from chronic conditions in the Danish adult population.
Clusters from chronic conditions in the Danish adult population.
Fuente:Plos One
Extracto:
Our work constitutes a step in
the process of characterizing multimorbidity populations, leading to increased
comprehension of the nature of multimorbidity, and towards potential applications
to individual-based care, prevention, the development of clinical guidelines, and
population management.
Cita:PLoS One 2024; 19 (4) : e0302535.
Autor/es:Stockmarr, Anders (a) Frølich, Anne (b)
institución:(a) Department of Applied Mathematics and Computer Science, Technical University of Denmark, Lyngby, Denmark. (b) Innovation and Research Centre for Multimorbidity, Slagelse Hospital, Slagelse, Denmark.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prednisone use, disease activity and the occurrence of hyperglycaemia and diabetes in patients with early rheumatoid arthritis: a 10-year subanalysis of the BeSt study.
Prednisone use, disease activity and the occurrence of hyperglycaemia and diabetes in patients with early rheumatoid arthritis: a 10-year subanalysis of the BeSt study.
Fuente:Rmd Open
Extracto:
In non-diabetic early RA patients, the
use of prednisone was not associated with developing hyperglycaemia or diabetes.
However, high DAS increased the risk of diabetes. Potential risks associated with
prednisone use may have been mitigated by its effect on DAS.
Autor/es:van der Pol, Joy Ardjuna (a) Allaart, Cornelia F (b)
institución:(a) Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands j.a.van_der_pol@lumc.nl. (b) Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación