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Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia.
Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia.
Fuente:Scientific Reports
Extracto:
Potential
gene-to-gene interaction and their association with clinical phenotype in women
with FMS should be further investigated in future studies including large sample
sizes.
Claves:Fibromyalgia, Pain genes, Single nucleotide polymorphism
institución:(a) Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos, Av. de Atenas S/N, 28922, Alcorcón, Madrid, Spain. cesar.fernandez@urjc.es. (b) Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, SMI, Aalborg University, Aalborg, Denmark. cesar.fernandez@urjc.es.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Associations between OGTT results during pregnancy and offspring TSH levels
Associations between OGTT results during pregnancy and offspring TSH levels
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Estudio de cohortes
Extracto:
For newborns of women with GDM,
personalized risk assessment for elevated TSH levels can be predicated on the
type and number of abnormal OGTT values. Furthermore, fasting blood glucose
emerges as a critical predictive marker for elevated neonatal TSH status.
Cita:BMC Pregnancy Childbirth 2024 May 17; 24 (1) : 375.
Autor/es:Yang, Meng (a) Cao, Zhongqiang (b)
institución:(a) Institute of Maternal and Child Health, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Health care Hospital, Huazhong University of Science and Technology, Wuhan, 430000, China. (b) Institute of Maternal and Child Health, Tongji Medical College, Wuhan Children's Hospital (Wuhan Maternal and Child Health care Hospital, Huazhong University of Science and Technology, Wuhan, 430000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Nonlinear association of triglyceride-glucose index with hyperuricemia in US adults: a cross-sectional study.
Nonlinear association of triglyceride-glucose index with hyperuricemia in US adults: a cross-sectional study.
Fuente:Lipids in Health and Disease
Extracto:
Additional prospective
studies are required to corroborate the current findings, which indicate a strong
positive connection between TyG and hyperuricemia among adults in the United
States.
Claves:Cross-sectional study, Hyperuricemia, NHANES, Nonlinear, Triglyceride-glucose index
Cita:Lipids Health Dis 2024 May 17; 23 (1) : 145.
Autor/es:Qiu, Linjie (a) Ren, Yan (b)
institución:(a) Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. (b) Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Association between lipid accumulation product and psoriasis among adults: a nationally representative cross-sectional study.
Association between lipid accumulation product and psoriasis among adults: a nationally representative cross-sectional study.
Fuente:Lipids in Health and Disease
Extracto:
This study found that the LAP index and adult psoriasis were
positively correlated, especially in young males without comorbidities.
Therefore, it is proposed that LAP may serve as a biomarker for early diagnosis
of psoriasis and tracking the effectiveness of treatment.
institución:(a) Department of Medical Cosmetology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China. (b) Department of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The association between dietary vitamin B1 intake and constipation: a population-based study.
The association between dietary vitamin B1 intake and constipation: a population-based study.
Fuente:Bmc Gastroenterology
Extracto:
This research uncovered an inverse
correlation between the consumption of vitamin B1 in the diet and the occurrence
of chronic constipation. One potential explanation for this phenomenon is that
the consumption of vitamin B1 in one's diet is linked to the softening of stools
and an augmented occurrence of colonic peristalsis. Additional extensive
prospective research is required to thoroughly examine the significance of
thiamine in long-term constipation.
Claves:Constipation, Cross-sectional study, National Health and Nutrition Examination Survey, Vitamin B1
Cita:BMC Gastroenterol 2024 May 17; 24 (1) : 171.
Autor/es:Du, Wenyi (a) Lu, Lingchen (b)
institución:(a) The Affiliated Stomatological Hospital of Soochow University, Suzhou Stomatological Hospital, Suzhou, Jiangsu, China. (b) Department of General Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Wuxi, Jiangsu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Characterization of the gut microbiota in polycystic ovary syndrome with dyslipidemia.
Characterization of the gut microbiota in polycystic ovary syndrome with dyslipidemia.
Fuente:Bmc Microbiology
Extracto:
The gut microbiota characterizations in patients with PCOS.D differ
from those in patients with PCOS and controls, and those might also be related to
clinical parameters. This may have the potential to become an alternative therapy
to regulate the clinical lipid levels of patients with PCOS in the future.
Claves:Dyslipidemia, Gut microbiota, Polycystic ovary syndrome
Cita:BMC Microbiol 2024 May 17; 24 (1) : 169.
Autor/es:Yang, Tianjin (a) Li, Guanjian (b)
institución:(a) Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. (b) Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis.
Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis.
Fuente:Bmc Infectious Diseases
Tipo de trabajo:Revisión
Extracto:
The current study demonstrated that the
clinical and laboratory profiles of DF and DHF are significantly distinct.
Significant predictors of DHF were advanced age, diabetes mellitus, ascites,
pleural effusion, thick gallbladder and delayed hospitalization. The
identification of these factors at early stage provides opportunities for the
clinicians to identify high risk patients and to reduce dengue-related morbidity
and mortality.
Claves:Dengue, Dengue fever, Dengue hemorrhagic fever, Mortality, Pakistan, Severe dengue
Cita:BMC Infect Dis 2024 May 17; 24 (1) : 500.
Autor/es:Riaz, Muhammad (a) Harun, Sabriah Noor Binti (b)
institución:(a) Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Palau Penang, Malaysia. (b) Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry.
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry.
Fuente:Acta Neuropathologica
Extracto:
This
work represents an extensive resource that will enable the re-interpretation of
published data, improve reproducibility in Tau research, and overall accelerate
scientific progress.
Claves:Antibody validation, Immunohistochemistry, Phosphorylation, Splice isoforms, Tau, Western blot
Cita:Acta Neuropathol 2024 May 18; 147 (1) : 87.
Autor/es:Ellis, Michael J (a) Lekka, Christiana (b)
institución:(a) JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK. (b) Islet Biology Group, Department of Clinical & Biomedical Sciences, Exeter Centre of Excellence in Diabetes (EXCEED), University of Exeter, RILD Building, Exeter, UK.
Conflicto:This work was partly funded by a collaborative agreement between the University of Oxford and UCB BioPharma. UCB staff were not involved in the design of the experiments, analysis of the data or interpretation of the results. The authors declare no other competing interests.
Development and Validation of a Nomogram for Predicting Nutritional Risk Based on Frailty Scores in Older Stroke Patients.
Development and Validation of a Nomogram for Predicting Nutritional Risk Based on Frailty Scores in Older Stroke Patients.
Fuente:Aging Clinical and Experimental Research
Extracto:
Elderly individuals recovering from
stroke often experience significant nutritional deficiencies. The nomogram we
devised accurately assesses this risk by combining physiological, psychological,
and biochemical metrics. It equips healthcare providers with the means to
actively screen for and manage the nutritional care of these patients. This tool
is instrumental in swiftly identifying those in urgent need of targeted
nutritional support, which is essential for optimizing their recovery and
managing their nutrition more effectively.
Claves:Elderly people, Frailty, Nomogram, Nutritional risk, Primary care, Stroke
Cita:Aging Clin Exp Res 2024 May 18; 36 (1) : 112.
Autor/es:Liu, Lei (a) He, Chunyu (b)
institución:(a) Chengdu Medical College, Chengdu, 610083, Sichuan, China. (b) Chengdu Medical College, Chengdu, 610083, Sichuan, China. 1125662859@qq.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Appendicular lean mass and the risk of stroke and Alzheimer's disease: a mendelian randomization study.
Appendicular lean mass and the risk of stroke and Alzheimer's disease: a mendelian randomization study.
Fuente:Bmc Geriatrics
Extracto:
The two-sample MR analysis indicated that genetically predicted
ALM was negatively related to AIS and AD. And the subgroup analysis of AIS
revealed a negative causal effect of genetically predicted ALM on LAS or SVS.
Future studies are required to further investigate the underlying mechanisms.
institución:(a) Department of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. (b) Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
AI-enhanced integration of genetic and medical imaging data for risk assessment of Type 2 diabetes.
AI-enhanced integration of genetic and medical imaging data for risk assessment of Type 2 diabetes.
Fuente:Nature Communications
Extracto:
Moreover, we introduce an accessible online risk assessment tool for T2D,
facilitating broader applicability and dissemination of our findings.
Cita:Nat Commun 2024 May 18; 15 (1) : 4230.
Autor/es:Huang, Yi-Jia (a) Chen, Chun-Houh (b)
institución:(a) Institute of Public Health, National Yang-Ming Chiao-Tung University, Taipei, Taiwan. (b) Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A randomized controlled trial to compare the effects of time-restricted eating versus Mediterranean diet on symptoms and quality of life in bipolar disorder.
A randomized controlled trial to compare the effects of time-restricted eating versus Mediterranean diet on symptoms and quality of life in bipolar disorder.
Fuente:Bmc Psychiatry
Tipo de trabajo:Orientaciones y guía
Extracto:
TRIAL REGISTRATION:
ClinicalTrials.gov ID NCT06188754.
institución:(a) Department of Psychology, University of California, Berkeley, USA. sljohnson@berkeley.edu. (b) Centre for Mental Health, Swinburne University, Melbourne, VIC, 3122, Australia.
Conflicto:SJ has received funding from Genentech/LaRoche, NIMH, the NCI, the NSF, Peder Sather Fund, and NARSAD (none of which focus on circadian rhythms or dietary intervention). LJK has received funding from NIMH, NICHD, NIA, NSF, UC Berkeley Radical Ideas in Brain Science Award, UC Berkeley Hellman Family Faculty Fund Award, UC Berkeley Junior Faculty Research Grant, UC-Mexus Collaborative Grant, Fonds...
France-Berkeley Fund, Berkeley Faculty Research Fund for Biological Sciences, Juvenile Diabetes Research Foundation, Donations from Optoceutics Inc, Sona Inc, and Intuitive Foundation (none of which focus on bipolar disorder). SP is a consultant for Hooke London, the author of The Circadian Code and The Circadian Diabetes Code, but none of those engagements overlap with protocol, and none focus on bipolar disorder. Others have no conflicts to report that are relevant to this work. Potential conflicts of interest will be reviewed by the University of California Committee on Conflicts of Interest annually, and their guidance will be followed in managing potential conflicts.
institución:(a) Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany. Theresa.ester@med.uni-tuebingen.de. (b) Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, Eberhard Karls University Tübingen, Tübingen, Germany. Theresa.ester@med.uni-tuebingen.de.
Conflicto:GR is a co-founder and shareholder and works for Neuroelectrics, a company developing medical devices for NIBS. RS works for Neuroelectrics. Outside of the current work, MH reports research grants from Boehringer Ingelheim and Sanofi to the University Hospital of Tübingen, participation in advisory board for Boehringer Ingelheim, Sanofi and Amryt, and lecture fees from Amryt, Bayer, Sanofi, Eli Lilly,...
, Novartis, Novo Nordisk and Boehringer Ingelheim. TEN, KB, RV, CD, ALB, CP, HP and SK report no conflict of interest.
Circulating total and H-specific GDF15 levels are elevated in subjects with MASLD but not in hyperlipidemic but otherwise metabolically healthy subjects with obesity.
Circulating total and H-specific GDF15 levels are elevated in subjects with MASLD but not in hyperlipidemic but otherwise metabolically healthy subjects with obesity.
Fuente:Cardiovascular Diabetology
Extracto:
Serum GDF15 levels do not differ in relation to weight
status in hyperlipidemic but otherwise metabolically healthy individuals. In
contrast, GDF15 levels are significantly increased in MASLD patients at baseline
and they remain significantly higher compared to healthy participants during
OGTT, pointing to a role for GDF15 as a mitokine with important roles in the
pathophysiology and possibly therapeutics of MASLD. Trial registration
ClinicalTrials.gov NCT03986684, NCT04430946.
institución:(a) Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, SL418, Boston, MA, 02215, USA. (b) Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, SL418, Boston, MA, 02215, USA.
Conflicto:CB, KS, VG, LV-V, SS and IAA have nothing to declare. MAC is an employee of and holds stock in Labcorp. AK has received grants through his institution and consulting fees from Novo Nordisk, Pharmaserve Lilly, Elpen pharmaceuticals, as well as consulting fees from Astra Zeneca, MSD, Sanofi, Bausch Health, Ethicon, Galenica Pharma, and Epsilon Health. None is related to...
the work presented herein. CSM reports grants through his institution from Merck and Boehringer Ingellheim, grants through his institution and personal consulting fees from Coherus Inc., AltrixBio, and reports personal consulting fees and support with research reagents from Ansh Inc., reports personal consulting fees from Genfit, Lumos, Amgen, Corcept, Intercept, 89Bio, AstraZeneca and Regeneron, reports travel support and fees from TMIOA, Elsevier, College Internationale Research Servier and the Cardio Metabolic Health Conference. None is related to the work presented herein.
Assessment between antiseptic and normal saline for negative pressure wound therapy with instillation and dwell time in diabetic foot infections.
Assessment between antiseptic and normal saline for negative pressure wound therapy with instillation and dwell time in diabetic foot infections.
Fuente:Scientific Reports
Extracto:
The findings of the study suggest that the use
of either PHMB-B or normal saline as an instillation solution in NPWTi-d for DFIs
shows promise and effectiveness, yet no clinical distinction was observed between
the two solutions.
Claves:Diabetic foot infection, Instillation and dwell time, Negative pressure wound therapy, PHMB
Cita:Sci Rep 2024 May 19; 14 (1) : 11423.
Autor/es:Zhao, Jingchun (a) Shi, Kai (b)
institución:(a) Department of Burn Surgery, the First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, People's Republic of China. (b) Department of Burn Surgery, the First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A Comprehensive Review on Weight Gain following Discontinuation of Glucagon-Like Peptide-1 Receptor Agonists for Obesity.
A Comprehensive Review on Weight Gain following Discontinuation of Glucagon-Like Peptide-1 Receptor Agonists for Obesity.
Fuente:Journal of Obesity
Extracto:
Clinical studies should
emphasize the downside of these views we highlighted, and mechanistic studies
must be carried out for a better outcome with GLP-1RA from the laboratory to the
bedside.
Cita:J Obes 2024; 2024 : 8056440.
Autor/es:Clinical studies should
emphasize the downside of these views we highlighted, and mechanistic studies
must be carried out for a better outcome with GLP-1RA from the laboratory to the
bedside.
institución:Clinical studies should
emphasize the downside of these views we highlighted, and mechanistic studies
must be carried out for a better outcome with GLP-1RA from the laboratory to the
bedside.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China. (b) Department of Nephrology, The Second Hospital of Longyan, Longyan, Fujian 364000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Balance performance, falls-efficacy and social participation in patients with type 2 diabetes mellitus with and without vestibular dysfunction.
Balance performance, falls-efficacy and social participation in patients with type 2 diabetes mellitus with and without vestibular dysfunction.
Fuente:Peerj
Extracto:
The presence of VD in T2DM patients
was associated with decreased physical balance performances and increased social
and QoL disengagement. Comprehensive management related to balance and FE, as
well as the monitoring to support social participation and QoL, should be
emphasized in patients with T2DM with VD.
Claves:Falls-efficacy, Quality of life, Social participation, Type 2 diabetes mellitus, Vestibular dysfunction, Balance performance
institución:(a) Physiotherapy, Muhammadiyah University of Surakarta, Surakarta, Central Java, Indonesia. (b) Physical Therapy, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom, Thailand.
Conflicto:The authors declare there are no competing interests.
A national audit of facilities, human and material resources for the comprehensive management of diabetes in Ghana-A 2023 update.
A national audit of facilities, human and material resources for the comprehensive management of diabetes in Ghana-A 2023 update.
Fuente:Plos One
Tipo de trabajo:Guía
Extracto:
An urgent multisectoral collaboration,
including prioritisation of resources at the facility level, to promote and
achieve acceptable comprehensive diabetes care is required.
Cita:PLoS One 2024; 19 (5) : e0303624.
Autor/es:Yorke, Ernest (a) Akpalu, Josephine (b)
institución:(a) Department of Medicine & Therapeutics, University of Ghana Medical School, College of Health Sciences, Accra, Ghana. (b) Department of Medicine & Therapeutics, University of Ghana Medical School, College of Health Sciences, Accra, Ghana.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Exploring the path to optimal diabetes care by unravelling the contextual factors affecting access, utilisation, and quality of primary health care in West Africa
Exploring the path to optimal diabetes care by unravelling the contextual factors affecting access, utilisation, and quality of primary health care in West Africa
Fuente:Plos One
Tipo de trabajo:Revisión
Extracto:
This review protocol aims to systematically examine and assess the
factors that impact the access, utilisation, and standard of primary healthcare
services for diabetes in West Africa.
Cita:PLoS One 2024; 19 (5) : e0294917.
Autor/es:Abdul-Samed, Abdul-Basit (a) Peprah, Ellen Barnie (b)
institución:(a) Ghana College of Physicians and Surgeons, Accra, Ghana. (b) Ghana College of Physicians and Surgeons, Accra, Ghana.